RU95110049A - 6-(замещенные метилен)пенемы, способ их получения, промежуточные продукты, фармкомпозиция, способ лечения - Google Patents

6-(замещенные метилен)пенемы, способ их получения, промежуточные продукты, фармкомпозиция, способ лечения

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Publication number
RU95110049A
RU95110049A RU95110049/04A RU95110049A RU95110049A RU 95110049 A RU95110049 A RU 95110049A RU 95110049/04 A RU95110049/04 A RU 95110049/04A RU 95110049 A RU95110049 A RU 95110049A RU 95110049 A RU95110049 A RU 95110049A
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RU
Russia
Prior art keywords
hydrogen
penemes
ris
treatment
production
Prior art date
Application number
RU95110049/04A
Other languages
English (en)
Other versions
RU2133750C1 (ru
Inventor
Джон Перримен Брум Найджел
Gb]
Петер Харрингтон Фрэнк
Original Assignee
Смитклайн Бичам Плс (Gb)
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Плс (Gb), Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс (Gb)
Publication of RU95110049A publication Critical patent/RU95110049A/ru
Application granted granted Critical
Publication of RU2133750C1 publication Critical patent/RU2133750C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Ink Jet (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Соединения формулы I, в которых Rявляется водородом или органическим заместителем; Rпредставляет собой конденсированную бициклическую систему гетероциклических колец общей формулы (а), где Rи Rнезависимо друг от друга означают водород или один или более заместителей, замещающих атомы водорода в показанной системе колец; m равно 2 или 3; p равно 0, 1 или 2; и Rпредставляет собой водород, солеобразующий катион или эфирообразующий катион или эфирообразующую группу; символ =/= показывает, что двойная связь может быть или E, или Z конфигурации.

Claims (1)

  1. Соединения формулы I, в которых R1 является водородом или органическим заместителем; R2 представляет собой конденсированную бициклическую систему гетероциклических колец общей формулы (а), где R4 и R5 независимо друг от друга означают водород или один или более заместителей, замещающих атомы водорода в показанной системе колец; m равно 2 или 3; p равно 0, 1 или 2; и R3 представляет собой водород, солеобразующий катион или эфирообразующий катион или эфирообразующую группу; символ =/= показывает, что двойная связь может быть или E, или Z конфигурации.
RU95110049A 1992-10-29 1993-10-20 6-(замещенные метилен)пенемы, способ их получения, промежуточные продукты и фармацевтическая композиция RU2133750C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9222700.8 1992-10-29
GB929222700A GB9222700D0 (en) 1992-10-29 1992-10-29 Chemical compounds
PCT/EP1993/002894 WO1994010178A1 (en) 1992-10-29 1993-10-20 6-(substituted methylene) penems and intermediates

Publications (2)

Publication Number Publication Date
RU95110049A true RU95110049A (ru) 1997-01-10
RU2133750C1 RU2133750C1 (ru) 1999-07-27

Family

ID=10724235

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95110049A RU2133750C1 (ru) 1992-10-29 1993-10-20 6-(замещенные метилен)пенемы, способ их получения, промежуточные продукты и фармацевтическая композиция

Country Status (35)

Country Link
US (3) US5602250A (ru)
EP (1) EP0666862B1 (ru)
JP (1) JP3488457B2 (ru)
KR (1) KR100295710B1 (ru)
CN (3) CN1044247C (ru)
AP (1) AP438A (ru)
AT (1) ATE191914T1 (ru)
AU (1) AU687365B2 (ru)
BR (1) BR1100542A (ru)
CA (1) CA2147755C (ru)
CZ (1) CZ293106B6 (ru)
DE (1) DE69328436T2 (ru)
DK (1) DK0666862T3 (ru)
ES (1) ES2145064T3 (ru)
FI (1) FI114638B (ru)
GB (1) GB9222700D0 (ru)
GR (1) GR3033448T3 (ru)
HK (1) HK1012375A1 (ru)
HU (1) HUT71467A (ru)
IL (1) IL107431A (ru)
MA (1) MA23017A1 (ru)
MX (1) MX9306679A (ru)
MY (1) MY117265A (ru)
NO (1) NO306903B1 (ru)
NZ (1) NZ257109A (ru)
PH (1) PH30919A (ru)
PL (1) PL177840B1 (ru)
PT (1) PT666862E (ru)
RU (1) RU2133750C1 (ru)
SA (1) SA93140373B1 (ru)
SI (1) SI9300574A (ru)
SK (1) SK281870B6 (ru)
TW (1) TW400332B (ru)
WO (1) WO1994010178A1 (ru)
ZA (1) ZA937993B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028868A1 (fr) * 2000-10-03 2002-04-11 Elena Alexandrovna Izakson Derives de thiazine

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
GB9326248D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
WO1995028935A1 (en) * 1994-04-25 1995-11-02 Smithkline Beecham Plc Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections
US6472383B1 (en) 1994-04-25 2002-10-29 Smithkline Beecham P.L.C. Pharmaceutical formulations
US6969303B1 (en) * 1994-10-12 2005-11-29 Nextec, Inc. Method and composition for removing coatings which contain hazardous elements
KR100912324B1 (ko) 2001-09-14 2009-08-14 글락소 그룹 리미티드 호흡기 질환 치료용 펜에탄올아민 유도체
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
FR2844807B1 (fr) * 2002-09-23 2005-11-11 Rambach Alain Procede de detection de microorganismes resistants a la meticilline
JP2007501635A (ja) * 2003-05-16 2007-02-01 ワイス・ホールディングズ・コーポレイション β−ラクタマーゼ阻害剤中間体を合成するための方法
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US8722884B2 (en) * 2005-12-01 2014-05-13 Verastem, Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
EP2316821A1 (en) * 2009-10-27 2011-05-04 Novartis AG Process for the manufacture of organic compounds

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US2541924A (en) * 1948-09-17 1951-02-13 Lilly Co Eli Synthesis of substituted imidazoles
GB1403841A (en) * 1973-03-22 1975-08-28 Ici Ltd Imidazo heterocyclic derivatives
US4137320A (en) * 1974-02-07 1979-01-30 Plantex, Ltd. Pharmaceutical compositions containing imidazo(2,1-b)thiazoles and process for reducing blood sugar levels therewith
DE2949167A1 (de) * 1978-12-08 1980-06-26 Ciba Geigy Ag Photographisches material fuer das silberfarbbleichverfahren
FI82471C (fi) * 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
US5015473A (en) * 1984-01-30 1991-05-14 Pfizer Inc. 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
GB8518421D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
JP2000500443A (ja) 1995-11-08 2000-01-18 スミスクライン・ビーチャム・コーポレイション ３−フェニル−１−メチレンジオキシフェニル−インダン−２−カルボン酸誘導体の製造プロセス

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028868A1 (fr) * 2000-10-03 2002-04-11 Elena Alexandrovna Izakson Derives de thiazine

Also Published As

Publication number Publication date
SA93140373B1 (ar) 2005-06-07
AP9300585A0 (en) 1993-10-31
AU687365B2 (en) 1998-02-26
CZ105395A3 (en) 1996-04-17
GB9222700D0 (en) 1992-12-09
FI952063A0 (fi) 1995-04-28
FI952063A (fi) 1995-06-27
DK0666862T3 (da) 2000-09-11
PH30919A (en) 1997-12-23
KR100295710B1 (ko) 2001-10-24
CN1089267A (zh) 1994-07-13
JPH08502504A (ja) 1996-03-19
HUT71467A (en) 1995-11-28
KR950704332A (ko) 1995-11-17
NO951634D0 (no) 1995-04-28
CZ293106B6 (cs) 2004-02-18
IL107431A (en) 1999-05-09
US6600035B1 (en) 2003-07-29
CN1102595C (zh) 2003-03-05
MY117265A (en) 2004-06-30
SI9300574A (en) 1994-06-30
EP0666862B1 (en) 2000-04-19
JP3488457B2 (ja) 2004-01-19
US6037469A (en) 2000-03-14
CA2147755C (en) 2004-12-07
CN1143851C (zh) 2004-03-31
WO1994010178A1 (en) 1994-05-11
HK1012375A1 (en) 1999-07-30
ZA937993B (en) 1995-03-22
GR3033448T3 (en) 2000-09-29
MX9306679A (es) 1994-04-29
DE69328436D1 (de) 2000-05-25
NO306903B1 (no) 2000-01-10
HU9501226D0 (en) 1995-06-28
ATE191914T1 (de) 2000-05-15
PL177840B1 (pl) 2000-01-31
FI114638B (fi) 2004-11-30
CN1227842A (zh) 1999-09-08
PT666862E (pt) 2000-08-31
CN1289766A (zh) 2001-04-04
IL107431A0 (en) 1994-01-25
SK54095A3 (en) 1995-09-13
US5602250A (en) 1997-02-11
TW400332B (en) 2000-08-01
ES2145064T3 (es) 2000-07-01
EP0666862A1 (en) 1995-08-16
CA2147755A1 (en) 1994-05-11
AU5335594A (en) 1994-05-24
SK281870B6 (sk) 2001-08-06
DE69328436T2 (de) 2000-10-19
CN1044247C (zh) 1999-07-21
PL308643A1 (en) 1995-08-21
NZ257109A (en) 1997-01-29
BR1100542A (pt) 2002-04-02
RU2133750C1 (ru) 1999-07-27
NO951634L (no) 1995-04-28
AP438A (en) 1995-11-24
MA23017A1 (fr) 1994-07-01

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