DE69328436T2 - 6-(substituiertes methylen) peneme und zwischenprodukte - Google Patents
6-(substituiertes methylen) peneme und zwischenprodukteInfo
- Publication number
- DE69328436T2 DE69328436T2 DE69328436T DE69328436T DE69328436T2 DE 69328436 T2 DE69328436 T2 DE 69328436T2 DE 69328436 T DE69328436 T DE 69328436T DE 69328436 T DE69328436 T DE 69328436T DE 69328436 T2 DE69328436 T2 DE 69328436T2
- Authority
- DE
- Germany
- Prior art keywords
- penemes
- intermediate products
- substituted methylene
- methylene
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 125000001570 methylene group Chemical class [H]C([H])([*:1])[*:2] 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Ink Jet (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929222700A GB9222700D0 (en) | 1992-10-29 | 1992-10-29 | Chemical compounds |
| PCT/EP1993/002894 WO1994010178A1 (en) | 1992-10-29 | 1993-10-20 | 6-(substituted methylene) penems and intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69328436D1 DE69328436D1 (de) | 2000-05-25 |
| DE69328436T2 true DE69328436T2 (de) | 2000-10-19 |
Family
ID=10724235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69328436T Expired - Fee Related DE69328436T2 (de) | 1992-10-29 | 1993-10-20 | 6-(substituiertes methylen) peneme und zwischenprodukte |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US5602250A (de) |
| EP (1) | EP0666862B1 (de) |
| JP (1) | JP3488457B2 (de) |
| KR (1) | KR100295710B1 (de) |
| CN (3) | CN1044247C (de) |
| AP (1) | AP438A (de) |
| AT (1) | ATE191914T1 (de) |
| AU (1) | AU687365B2 (de) |
| BR (1) | BR1100542A (de) |
| CA (1) | CA2147755C (de) |
| CZ (1) | CZ293106B6 (de) |
| DE (1) | DE69328436T2 (de) |
| DK (1) | DK0666862T3 (de) |
| ES (1) | ES2145064T3 (de) |
| FI (1) | FI114638B (de) |
| GB (1) | GB9222700D0 (de) |
| GR (1) | GR3033448T3 (de) |
| HK (1) | HK1012375A1 (de) |
| HU (1) | HUT71467A (de) |
| IL (1) | IL107431A (de) |
| MA (1) | MA23017A1 (de) |
| MX (1) | MX9306679A (de) |
| MY (1) | MY117265A (de) |
| NO (1) | NO306903B1 (de) |
| NZ (1) | NZ257109A (de) |
| PH (1) | PH30919A (de) |
| PL (1) | PL177840B1 (de) |
| PT (1) | PT666862E (de) |
| RU (1) | RU2133750C1 (de) |
| SA (1) | SA93140373B1 (de) |
| SI (1) | SI9300574A (de) |
| SK (1) | SK281870B6 (de) |
| TW (1) | TW400332B (de) |
| WO (1) | WO1994010178A1 (de) |
| ZA (1) | ZA937993B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| GB9326248D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Plc | Pharmaceutical formulations |
| US6472383B1 (en) | 1994-04-25 | 2002-10-29 | Smithkline Beecham P.L.C. | Pharmaceutical formulations |
| WO1995028935A1 (en) * | 1994-04-25 | 1995-11-02 | Smithkline Beecham Plc | Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections |
| US6969303B1 (en) * | 1994-10-12 | 2005-11-29 | Nextec, Inc. | Method and composition for removing coatings which contain hazardous elements |
| WO2002028868A1 (fr) * | 2000-10-03 | 2002-04-11 | Elena Alexandrovna Izakson | Derives de thiazine |
| ES2316599T3 (es) | 2001-09-14 | 2009-04-16 | Glaxo Group Limited | Derivados de fenetanolamina para el tratamiento de enfermedades respiratorias. |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| FR2844807B1 (fr) * | 2002-09-23 | 2005-11-11 | Rambach Alain | Procede de detection de microorganismes resistants a la meticilline |
| AU2004240924A1 (en) | 2003-05-16 | 2004-12-02 | Wyeth Holdings Corporation | Process for synthesizing beta-lactamase inhibitor intermediates |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| US8722884B2 (en) * | 2005-12-01 | 2014-05-13 | Verastem, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| EP2316821A1 (de) * | 2009-10-27 | 2011-05-04 | Novartis AG | Verfahren zur Herstellung organischer Verbindungen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2541924A (en) * | 1948-09-17 | 1951-02-13 | Lilly Co Eli | Synthesis of substituted imidazoles |
| GB1403841A (en) * | 1973-03-22 | 1975-08-28 | Ici Ltd | Imidazo heterocyclic derivatives |
| US4137320A (en) * | 1974-02-07 | 1979-01-30 | Plantex, Ltd. | Pharmaceutical compositions containing imidazo(2,1-b)thiazoles and process for reducing blood sugar levels therewith |
| DE2949167A1 (de) * | 1978-12-08 | 1980-06-26 | Ciba Geigy Ag | Photographisches material fuer das silberfarbbleichverfahren |
| FI82471C (fi) * | 1984-01-26 | 1991-03-11 | Beecham Group Plc | Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater. |
| US5015473A (en) * | 1984-01-30 | 1991-05-14 | Pfizer Inc. | 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof |
| GB8518421D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| GB8518416D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| JP2000500443A (ja) | 1995-11-08 | 2000-01-18 | スミスクライン・ビーチャム・コーポレイション | ３−フェニル−１−メチレンジオキシフェニル−インダン−２−カルボン酸誘導体の製造プロセス |
-
1992
- 1992-10-29 GB GB929222700A patent/GB9222700D0/en active Pending
-
1993
- 1993-10-15 PH PH47096A patent/PH30919A/en unknown
- 1993-10-20 SK SK540-95A patent/SK281870B6/sk not_active IP Right Cessation
- 1993-10-20 EP EP93923504A patent/EP0666862B1/de not_active Expired - Lifetime
- 1993-10-20 WO PCT/EP1993/002894 patent/WO1994010178A1/en active IP Right Grant
- 1993-10-20 NZ NZ257109A patent/NZ257109A/en not_active IP Right Cessation
- 1993-10-20 PT PT93923504T patent/PT666862E/pt unknown
- 1993-10-20 ES ES93923504T patent/ES2145064T3/es not_active Expired - Lifetime
- 1993-10-20 AU AU53355/94A patent/AU687365B2/en not_active Ceased
- 1993-10-20 RU RU95110049A patent/RU2133750C1/ru active
- 1993-10-20 CA CA002147755A patent/CA2147755C/en not_active Expired - Fee Related
- 1993-10-20 CZ CZ19951053A patent/CZ293106B6/cs not_active IP Right Cessation
- 1993-10-20 JP JP51063794A patent/JP3488457B2/ja not_active Expired - Fee Related
- 1993-10-20 DK DK93923504T patent/DK0666862T3/da active
- 1993-10-20 KR KR1019950701652A patent/KR100295710B1/ko not_active IP Right Cessation
- 1993-10-20 US US08/428,101 patent/US5602250A/en not_active Expired - Lifetime
- 1993-10-20 AT AT93923504T patent/ATE191914T1/de not_active IP Right Cessation
- 1993-10-20 DE DE69328436T patent/DE69328436T2/de not_active Expired - Fee Related
- 1993-10-20 PL PL93308643A patent/PL177840B1/pl not_active IP Right Cessation
- 1993-10-20 HU HU9501226A patent/HUT71467A/hu unknown
- 1993-10-27 MX MX9306679A patent/MX9306679A/es not_active IP Right Cessation
- 1993-10-27 MY MYPI93002250A patent/MY117265A/en unknown
- 1993-10-27 MA MA23323A patent/MA23017A1/fr unknown
- 1993-10-27 ZA ZA937993A patent/ZA937993B/xx unknown
- 1993-10-28 CN CN93119574A patent/CN1044247C/zh not_active Expired - Fee Related
- 1993-10-28 AP APAP/P/1993/000585A patent/AP438A/en active
- 1993-10-28 IL IL10743193A patent/IL107431A/en not_active IP Right Cessation
- 1993-10-29 SI SI9300574A patent/SI9300574A/sl unknown
- 1993-10-30 TW TW082109081A patent/TW400332B/zh not_active IP Right Cessation
- 1993-11-27 SA SA93140373A patent/SA93140373B1/ar unknown
-
1995
- 1995-04-28 NO NO951634A patent/NO306903B1/no not_active IP Right Cessation
- 1995-04-28 FI FI952063A patent/FI114638B/fi active IP Right Grant
- 1995-05-24 US US08/448,941 patent/US6600035B1/en not_active Expired - Fee Related
- 1995-05-24 US US08/448,730 patent/US6037469A/en not_active Expired - Fee Related
-
1997
- 1997-05-13 BR BR1100542-4A patent/BR1100542A/pt active IP Right Grant
-
1998
- 1998-08-11 CN CN98118447A patent/CN1102595C/zh not_active Expired - Fee Related
- 1998-08-11 CN CNB001068075A patent/CN1143851C/zh not_active Expired - Fee Related
- 1998-12-16 HK HK98113576A patent/HK1012375A1/xx not_active IP Right Cessation
-
2000
- 2000-05-19 GR GR20000401136T patent/GR3033448T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |