KR100211437B1 - 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도 - Google Patents

축합 헤테로시클릭 화합물, 그의 제조방법 및 용도 Download PDF

Info

Publication number
KR100211437B1
KR100211437B1 KR1019910020944A KR910020944A KR100211437B1 KR 100211437 B1 KR100211437 B1 KR 100211437B1 KR 1019910020944 A KR1019910020944 A KR 1019910020944A KR 910020944 A KR910020944 A KR 910020944A KR 100211437 B1 KR100211437 B1 KR 100211437B1
Authority
KR
South Korea
Prior art keywords
alkyl
amino
substituted
group
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019910020944A
Other languages
English (en)
Korean (ko)
Other versions
KR920009823A (ko
Inventor
기이찌 고또
유우지 이시하라
마사오미 미야모또
Original Assignee
우메모토 요시마사
다케다 야쿠힝 고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우메모토 요시마사, 다케다 야쿠힝 고교 가부시키가이샤 filed Critical 우메모토 요시마사
Publication of KR920009823A publication Critical patent/KR920009823A/ko
Application granted granted Critical
Publication of KR100211437B1 publication Critical patent/KR100211437B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019910020944A 1990-11-22 1991-11-22 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도 Expired - Fee Related KR100211437B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP31989790 1990-11-22
JP90-319897 1990-11-22
JP7028691 1991-01-14
JP91-70286 1991-01-14
JP20935891 1991-08-21
JP91-209358 1991-08-21
JP91-243768 1991-09-24
JP24376891 1991-09-24

Publications (2)

Publication Number Publication Date
KR920009823A KR920009823A (ko) 1992-06-25
KR100211437B1 true KR100211437B1 (ko) 1999-08-02

Family

ID=27465225

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910020944A Expired - Fee Related KR100211437B1 (ko) 1990-11-22 1991-11-22 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도

Country Status (19)

Country Link
US (1) US5273974A (enExample)
EP (1) EP0487071B1 (enExample)
JP (1) JP2650537B2 (enExample)
KR (1) KR100211437B1 (enExample)
CN (1) CN1036458C (enExample)
AT (1) ATE124695T1 (enExample)
AU (1) AU643337B2 (enExample)
CA (1) CA2055947C (enExample)
DE (1) DE69111029T2 (enExample)
DK (1) DK0487071T3 (enExample)
ES (1) ES2074205T3 (enExample)
FI (2) FI102965B (enExample)
GR (1) GR3017366T3 (enExample)
HU (2) HU214573B (enExample)
IE (1) IE68346B1 (enExample)
NO (1) NO179868C (enExample)
NZ (1) NZ240676A (enExample)
RU (1) RU2095361C1 (enExample)
TW (1) TW197435B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965574A (en) * 1996-08-13 1999-10-12 Chen; Yuhpyng Liang Heteroaryl amines as novel acetylcholinesterase inhibitors
TW263504B (enExample) * 1991-10-03 1995-11-21 Pfizer
US5462934A (en) * 1992-03-09 1995-10-31 Takeda Chemical Industries Condensed heterocyclic ketone derivatives and their use
TW218875B (enExample) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
ATE194982T1 (de) 1992-04-24 2000-08-15 Takeda Chemical Industries Ltd Benzoxazepin-derivate als cholinesterase- inhibitoren
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
US5620973A (en) * 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
CN1191243C (zh) * 1994-07-27 2005-03-02 范德比尔特大学 用作抗炎剂的二氢苯并呋喃和相关化合物
US5674891A (en) * 1994-07-27 1997-10-07 The Procter & Gamble Company Dihydrobenzothiophene compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
PT966435E (pt) 1996-12-18 2005-06-30 Yissum Res Dev Co Derivados aminoindano
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
WO1998031356A1 (en) * 1997-01-17 1998-07-23 Takeda Chemical Industries, Ltd. Idebenone containing combination agent for treating alzheimer's disease
US5962535A (en) * 1997-01-17 1999-10-05 Takeda Chemical Industries, Ltd. Composition for alzheimer's disease
EP0975624A1 (en) * 1997-04-17 2000-02-02 Takeda Chemical Industries, Ltd. Thermogenic composition and benzazepine thermogenics
RU2222815C2 (ru) * 1997-10-09 2004-01-27 Дексел Фарма Текнолоджис Элтиди. Лекарственная форма для доставки и непосредственного локализованного освобождения желаемого агента в желудочно-кишечном тракте животного и способ доставки желаемого агента в желудочно-кишечный тракт животного (варианты)
AU1721399A (en) * 1997-12-19 1999-07-12 G.D. Searle & Co. Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides
CA2329624A1 (en) 1998-04-23 1999-10-28 Koki Kato Pharmaceutical composition for neurotrophic action
EP1891954A3 (en) 1998-09-30 2009-01-14 Takeda Pharmaceutical Company Limited Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
DE60014043T2 (de) * 1999-03-03 2005-09-29 Eisai Co., Ltd. Flouride von 4-substituierten piperidin-derivaten
US20040063699A1 (en) * 2000-07-04 2004-04-01 Naoki Tarui Gpr14 antagonist
US20040053826A1 (en) * 2000-08-10 2004-03-18 Yoshio Matsumoto Uses of polypeptides
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
MXPA04006344A (es) 2001-12-28 2005-03-31 Takeda Pharmaceutical Preventivos/remedios para la perturbacion de miccion.
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
DE60335679D1 (de) * 2002-04-16 2011-02-17 Schering Corp Tricyclischer Thrombinrezeptorantagonist
USRE42327E1 (en) 2002-06-14 2011-05-03 Toyama Chemical Co., Ltd. Medicinal compositions improving brain function and method for improving brain function
ATE441417T1 (de) 2002-12-20 2009-09-15 Glaxo Group Ltd Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
EP1956904B1 (en) * 2005-12-09 2017-04-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Low-dose ladostigil for the treatment of mild cognitive impairment
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
CN102099339A (zh) * 2008-07-18 2011-06-15 武田药品工业株式会社 苯并氮杂衍生物及其作为组胺h3拮抗剂的用途
EP2533645B1 (en) 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.
CN109880635B (zh) * 2019-03-19 2021-02-02 石家庄晶奥量新材料有限公司 含有二苯并呋喃并含氧杂环类液晶化合物和组合物及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4208417A (en) * 1978-06-29 1980-06-17 Pharmindustrie Indole derivatives and their use as anxiolytics
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
CA2023492A1 (en) * 1989-08-31 1991-03-01 Barry Clifford Lange Herbicidal glutarimides
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines

Also Published As

Publication number Publication date
GR3017366T3 (en) 1995-12-31
FI102965B1 (fi) 1999-03-31
FI982436L (fi) 1998-11-10
US5273974A (en) 1993-12-28
EP0487071B1 (en) 1995-07-05
CA2055947A1 (en) 1992-05-23
NO914558D0 (no) 1991-11-21
AU8804591A (en) 1992-05-28
HU913643D0 (en) 1992-02-28
ES2074205T3 (es) 1995-09-01
NO179868B (no) 1996-09-23
DE69111029T2 (de) 1995-12-14
RU2095361C1 (ru) 1997-11-10
EP0487071A1 (en) 1992-05-27
NO914558L (no) 1992-05-25
JP2650537B2 (ja) 1997-09-03
CN1036458C (zh) 1997-11-19
ATE124695T1 (de) 1995-07-15
FI102965B (fi) 1999-03-31
NZ240676A (en) 1993-05-26
KR920009823A (ko) 1992-06-25
CN1062143A (zh) 1992-06-24
FI915488A0 (fi) 1991-11-21
JPH05140149A (ja) 1993-06-08
HU211130A9 (en) 1995-10-30
FI915488L (fi) 1992-05-23
IE914053A1 (en) 1992-06-03
NO179868C (no) 1997-01-02
HUT59676A (en) 1992-06-29
CA2055947C (en) 2002-03-12
HU214573B (hu) 2000-04-28
IE68346B1 (en) 1996-06-12
DE69111029D1 (de) 1995-08-10
AU643337B2 (en) 1993-11-11
DK0487071T3 (da) 1995-10-30
FI982436A7 (fi) 1998-11-10
FI982436A0 (fi) 1998-11-10
TW197435B (enExample) 1993-01-01

Similar Documents

Publication Publication Date Title
KR100211437B1 (ko) 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도
US6180647B1 (en) Substituted benzolactam compounds as substance P antagonists
US5985894A (en) N-substituted quinolines
RU2100357C1 (ru) Гетероариламины или их фармацевтически приемлемые соли и фармацевтическая композиция на их основе
JPH0819099B2 (ja) アザビシクロキノロンカルボン酸化合物製造用中間体
HK128797A (en) 7-piperazinyl- or 7-morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents
HU206355B (en) Process for producing physostigmine analogs and pharmaceutical compositions comprising such compounds
JP3014001B2 (ja) 興奮性アミノ酸拮抗剤
US5106856A (en) [(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
RU2161154C2 (ru) Новые производные пиридоновых карбоновых кислот, способ и промежуточные для их получения, фармацевтическая композиция и способ лечения инфекционных заболеваний
RU2284325C2 (ru) Производные фенил-3-аминометил-хинолона-2 в качестве ингибиторов no-синтетазы, способ их получения, биологически активные соединения и фармацевтическая композиция на их основе
EP0567090B1 (en) Benzoxazepine derivatives as cholinesterase inhibitors
EP0566069A1 (en) Tachykinin receptor antagonists, isoquinolones and their production
US4778812A (en) 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives thereof
EP0556813B1 (en) Amphoteric tricyclic compounds as antihistaminic and antiallergic agents
EP0430485A2 (en) Quinoline compound
US6288225B1 (en) Substituted benzolactam compounds as substance P antagonists
EP0197318B1 (en) Benzo[C]-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
JP3057828B2 (ja) １−（ピリジニルアルキル）−１ｈ−インドール類、インドリン類および関連類似体
EP0440145A1 (en) Hexahydropyrrolo[2,3-b]indole carbamates,-ureas,-amides and related compounds, a process for their preparation and their use as medicaments
US6436954B1 (en) Benzoquinolizidine and benzoindolizidine derivatives and therapeutic uses thereof
US3869461A (en) Intermediates for quinine, quinidine and derivatives thereof
TWI402264B (zh) 芳基甲基苯并喹唑啉酮ｍ１受體之正向異位性調節劑
JPWO1993013101A1 (ja) ピリドンカルボン酸化合物、およびその医薬用途、ならびにスピロ化合物
KR20100015933A (ko) Ｎｋ3 길항제로서의 이소퀴놀리논 유도체

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20020504

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20020504

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000