KR100211437B1 - 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도 - Google Patents

축합 헤테로시클릭 화합물, 그의 제조방법 및 용도 Download PDF

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Publication number
KR100211437B1
KR100211437B1 KR1019910020944A KR910020944A KR100211437B1 KR 100211437 B1 KR100211437 B1 KR 100211437B1 KR 1019910020944 A KR1019910020944 A KR 1019910020944A KR 910020944 A KR910020944 A KR 910020944A KR 100211437 B1 KR100211437 B1 KR 100211437B1
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KR
South Korea
Prior art keywords
alkyl
amino
substituted
group
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019910020944A
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English (en)
Korean (ko)
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KR920009823A (ko
Inventor
기이찌 고또
유우지 이시하라
마사오미 미야모또
Original Assignee
우메모토 요시마사
다케다 야쿠힝 고교 가부시키가이샤
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Publication of KR920009823A publication Critical patent/KR920009823A/ko
Application granted granted Critical
Publication of KR100211437B1 publication Critical patent/KR100211437B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019910020944A 1990-11-22 1991-11-22 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도 Expired - Fee Related KR100211437B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP31989790 1990-11-22
JP90-319897 1990-11-22
JP7028691 1991-01-14
JP91-70286 1991-01-14
JP20935891 1991-08-21
JP91-209358 1991-08-21
JP24376891 1991-09-24
JP91-243768 1991-09-24

Publications (2)

Publication Number Publication Date
KR920009823A KR920009823A (ko) 1992-06-25
KR100211437B1 true KR100211437B1 (ko) 1999-08-02

Family

ID=27465225

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910020944A Expired - Fee Related KR100211437B1 (ko) 1990-11-22 1991-11-22 축합 헤테로시클릭 화합물, 그의 제조방법 및 용도

Country Status (19)

Country Link
US (1) US5273974A (enExample)
EP (1) EP0487071B1 (enExample)
JP (1) JP2650537B2 (enExample)
KR (1) KR100211437B1 (enExample)
CN (1) CN1036458C (enExample)
AT (1) ATE124695T1 (enExample)
AU (1) AU643337B2 (enExample)
CA (1) CA2055947C (enExample)
DE (1) DE69111029T2 (enExample)
DK (1) DK0487071T3 (enExample)
ES (1) ES2074205T3 (enExample)
FI (2) FI102965B (enExample)
GR (1) GR3017366T3 (enExample)
HU (2) HU214573B (enExample)
IE (1) IE68346B1 (enExample)
NO (1) NO179868C (enExample)
NZ (1) NZ240676A (enExample)
RU (1) RU2095361C1 (enExample)
TW (1) TW197435B (enExample)

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TW218875B (enExample) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
ATE194982T1 (de) 1992-04-24 2000-08-15 Takeda Chemical Industries Ltd Benzoxazepin-derivate als cholinesterase- inhibitoren
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
US5620973A (en) * 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
NZ290080A (en) * 1994-07-27 1999-04-29 Procter & Gamble Dihydrobenzo(thio)furan derivatives and pharmaceutical compositions
US5674891A (en) * 1994-07-27 1997-10-07 The Procter & Gamble Company Dihydrobenzothiophene compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
DE69738275T2 (de) 1996-12-18 2008-08-28 Teva Pharmaceutical Industries Ltd. Aminoindanderivate
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
EP0952826B1 (en) * 1997-01-17 2001-11-14 Takeda Chemical Industries, Ltd. Idebenone containing combination agent for treating alzheimer's disease
US5962535A (en) * 1997-01-17 1999-10-05 Takeda Chemical Industries, Ltd. Composition for alzheimer's disease
EP0975624A1 (en) * 1997-04-17 2000-02-02 Takeda Chemical Industries, Ltd. Thermogenic composition and benzazepine thermogenics
RU2222815C2 (ru) * 1997-10-09 2004-01-27 Дексел Фарма Текнолоджис Элтиди. Лекарственная форма для доставки и непосредственного локализованного освобождения желаемого агента в желудочно-кишечном тракте животного и способ доставки желаемого агента в желудочно-кишечный тракт животного (варианты)
ES2195428T3 (es) * 1997-12-19 2003-12-01 Searle & Co Metodo para preparar oxidos de tetrahidrobenzotiepina enriquecidos enantiometricamente.
AU3534799A (en) 1998-04-23 1999-11-08 Takeda Chemical Industries Ltd. Pharmaceutical composition for neurotrophic action
EP1604653A1 (en) 1998-09-30 2005-12-14 Takeda Pharmaceutical Company Limited Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
WO2000051985A1 (en) * 1999-03-03 2000-09-08 Eisai Co., Ltd. Fluorides of 4-substituted piperidine derivatives
AU2001271018A1 (en) * 2000-07-04 2002-01-14 Takeda Chemical Industries Ltd. Gpr14 antagonist
EP1308513A4 (en) * 2000-08-10 2008-07-09 Takeda Pharmaceutical APPLICATION OF POLYPEPTIDES
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
KR100614862B1 (ko) 2001-12-28 2006-08-22 다케다 야쿠힌 고교 가부시키가이샤 배뇨 장애 예방제/치료제
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
SI2065384T1 (sl) * 2002-04-16 2011-05-31 Schering Corp Tricikliäśni trombin receptor antagonist
KR100935615B1 (ko) 2002-06-14 2010-01-07 토야마 케미칼 컴퍼니 리미티드 뇌기능을 개선하는 의약조성물 및 뇌기능을 개선하기 위한방법
CA2509413C (en) 2002-12-20 2012-05-01 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
EP1956904B1 (en) * 2005-12-09 2017-04-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Low-dose ladostigil for the treatment of mild cognitive impairment
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
EP2326625A1 (en) * 2008-07-18 2011-06-01 Takeda Pharmaceutical Company Limited Benzazepine derivatives and their use as hstamine h3 antagonists
CN102905532A (zh) 2010-02-09 2013-01-30 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US10159648B2 (en) 2015-05-22 2018-12-25 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CN109880635B (zh) * 2019-03-19 2021-02-02 石家庄晶奥量新材料有限公司 含有二苯并呋喃并含氧杂环类液晶化合物和组合物及应用

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Also Published As

Publication number Publication date
CN1062143A (zh) 1992-06-24
NO914558L (no) 1992-05-25
EP0487071B1 (en) 1995-07-05
CA2055947C (en) 2002-03-12
AU8804591A (en) 1992-05-28
IE68346B1 (en) 1996-06-12
ES2074205T3 (es) 1995-09-01
DK0487071T3 (da) 1995-10-30
NZ240676A (en) 1993-05-26
NO914558D0 (no) 1991-11-21
JPH05140149A (ja) 1993-06-08
CN1036458C (zh) 1997-11-19
HUT59676A (en) 1992-06-29
FI102965B1 (fi) 1999-03-31
TW197435B (enExample) 1993-01-01
FI982436L (fi) 1998-11-10
IE914053A1 (en) 1992-06-03
FI982436A0 (fi) 1998-11-10
KR920009823A (ko) 1992-06-25
HU211130A9 (en) 1995-10-30
DE69111029D1 (de) 1995-08-10
FI982436A7 (fi) 1998-11-10
AU643337B2 (en) 1993-11-11
GR3017366T3 (en) 1995-12-31
RU2095361C1 (ru) 1997-11-10
HU214573B (hu) 2000-04-28
NO179868C (no) 1997-01-02
NO179868B (no) 1996-09-23
US5273974A (en) 1993-12-28
HU913643D0 (en) 1992-02-28
EP0487071A1 (en) 1992-05-27
FI915488A0 (fi) 1991-11-21
CA2055947A1 (en) 1992-05-23
ATE124695T1 (de) 1995-07-15
FI915488L (fi) 1992-05-23
DE69111029T2 (de) 1995-12-14
FI102965B (fi) 1999-03-31
JP2650537B2 (ja) 1997-09-03

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