FI102678B1 - Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdisteInfo
- Publication number
- FI102678B1 FI102678B1 FI900577A FI900577A FI102678B1 FI 102678 B1 FI102678 B1 FI 102678B1 FI 900577 A FI900577 A FI 900577A FI 900577 A FI900577 A FI 900577A FI 102678 B1 FI102678 B1 FI 102678B1
- Authority
- FI
- Finland
- Prior art keywords
- hydroxymethylindazole
- benzyl
- preparation
- intermediate compound
- therapeutically useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8947620A IT1230441B (it) | 1989-02-07 | 1989-02-07 | Eteri della serie dell'indazolo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI900577A0 FI900577A0 (fi) | 1990-02-06 |
| FI102678B1 true FI102678B1 (fi) | 1999-01-29 |
| FI102678B FI102678B (fi) | 1999-01-29 |
Family
ID=11261479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI900577A FI102678B (fi) | 1989-02-07 | 1990-02-06 | Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyy li-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US4999367A (de) |
| EP (1) | EP0382276B1 (de) |
| JP (1) | JP2870925B2 (de) |
| KR (1) | KR0145525B1 (de) |
| CN (2) | CN1046505C (de) |
| AR (1) | AR247386A1 (de) |
| AT (1) | ATE127115T1 (de) |
| AU (1) | AU624895B2 (de) |
| BG (1) | BG50273A3 (de) |
| CA (1) | CA2009503C (de) |
| CZ (1) | CZ280121B6 (de) |
| DD (2) | DD291995A5 (de) |
| DE (2) | DE382276T1 (de) |
| DK (1) | DK0382276T3 (de) |
| EG (1) | EG19170A (de) |
| ES (1) | ES2020171T3 (de) |
| FI (1) | FI102678B (de) |
| GE (1) | GEP19971030B (de) |
| GR (2) | GR910300073T1 (de) |
| HU (1) | HU204793B (de) |
| IL (1) | IL93132A (de) |
| IN (1) | IN170957B (de) |
| IT (1) | IT1230441B (de) |
| LT (1) | LT3604B (de) |
| LV (1) | LV10612B (de) |
| NZ (1) | NZ232258A (de) |
| PE (1) | PE25091A1 (de) |
| PH (1) | PH26552A (de) |
| PL (2) | PL163730B1 (de) |
| PT (1) | PT93067B (de) |
| RO (1) | RO106252B1 (de) |
| RU (3) | RU2066318C1 (de) |
| SK (1) | SK278441B6 (de) |
| UA (1) | UA26852C2 (de) |
| YU (1) | YU47943B (de) |
| ZA (1) | ZA90644B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1253703B (it) * | 1991-04-22 | 1995-08-23 | Angelini Francesco Ist Ricerca | Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie |
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| US5943270A (en) * | 1997-11-26 | 1999-08-24 | Intel Corporation | Two-transistor DRAM cell for logic process technology |
| US7514463B2 (en) | 2004-08-20 | 2009-04-07 | University Of Kansas | Lonidamine analogues and their use in male contraception and cancer treatment |
| ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
| KR101640844B1 (ko) | 2008-03-07 | 2016-07-19 | 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 | 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1, ｃｘ3ｃｒ1 및 ｐ40의 발현을 기초로 한 질환들의 치료에서 이의 용도 |
| KR101581828B1 (ko) * | 2008-03-07 | 2015-12-31 | 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 | 신규한 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1, ｃｘ3ｃｒ1 및 ｐ40의 발현을 기초로 한 질환들의 치료에서 이의 용도 |
| CA2715065C (en) | 2008-03-07 | 2017-06-27 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression mcp-1 and cx3cr1 |
| ES2481393T3 (es) | 2009-08-03 | 2014-07-30 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Procedimiento para la preparación de 1-bencil-3-hidroximetil-1H-indazol y sus derivados y productos intermedios de magnesio requeridos |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| ES2656292T3 (es) | 2012-05-01 | 2018-02-26 | Translatum Medicus Inc. | Métodos de tratamiento y diagnóstico de enfermedades oculares que causan ceguera |
| JP2015521183A (ja) | 2012-05-18 | 2015-07-27 | サノフイ | ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用 |
| CN104302625B (zh) | 2012-05-18 | 2017-04-19 | 赛诺菲 | 吡唑衍生物及其作为lpar5拮抗剂的用途 |
| CN108047136B (zh) * | 2017-12-20 | 2021-07-09 | 长春普华制药股份有限公司 | 一种苄达酸的精制方法 |
| CA3144861A1 (en) | 2019-06-25 | 2020-12-30 | Translatum Medicus, Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
| CN113929627A (zh) * | 2021-10-19 | 2022-01-14 | 吕梁学院 | 一种宾达利的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL28032A (en) * | 1966-08-29 | 1971-08-25 | Acraf | Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof |
| US3470298A (en) * | 1969-01-29 | 1969-09-30 | Acraf | Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids |
| IT1131779B (it) | 1980-07-29 | 1986-06-25 | Acraf | Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione |
| IT1189052B (it) | 1981-11-27 | 1988-01-28 | Acraf | Trattamento della cataratta |
| IT1194564B (it) | 1983-04-18 | 1988-09-22 | Acraf | Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa |
| IT1197805B (it) | 1986-08-01 | 1988-12-06 | Acraf | Metodo per il tratamento di lenti a contatto |
-
1989
- 1989-02-07 IT IT8947620A patent/IT1230441B/it active
-
1990
- 1990-01-22 IL IL9313290A patent/IL93132A/en not_active IP Right Cessation
- 1990-01-23 DK DK90200167.6T patent/DK0382276T3/da active
- 1990-01-23 ES ES90200167T patent/ES2020171T3/es not_active Expired - Lifetime
- 1990-01-23 EP EP90200167A patent/EP0382276B1/de not_active Expired - Lifetime
- 1990-01-23 DE DE199090200167T patent/DE382276T1/de active Pending
- 1990-01-23 DE DE69021902T patent/DE69021902T2/de not_active Expired - Lifetime
- 1990-01-23 AT AT90200167T patent/ATE127115T1/de not_active IP Right Cessation
- 1990-01-24 US US07/470,118 patent/US4999367A/en not_active Expired - Lifetime
- 1990-01-26 NZ NZ232258A patent/NZ232258A/en unknown
- 1990-01-29 ZA ZA90644A patent/ZA90644B/xx unknown
- 1990-01-30 IN IN81/CAL/90A patent/IN170957B/en unknown
- 1990-01-30 PE PE1990164654A patent/PE25091A1/es unknown
- 1990-02-02 AU AU49066/90A patent/AU624895B2/en not_active Expired
- 1990-02-05 PL PL90285287A patent/PL163730B1/pl unknown
- 1990-02-05 PL PL90283638A patent/PL163720B1/pl unknown
- 1990-02-05 YU YU20690A patent/YU47943B/sh unknown
- 1990-02-05 RO RO144074A patent/RO106252B1/ro unknown
- 1990-02-06 EG EG6290A patent/EG19170A/xx active
- 1990-02-06 BG BG91122A patent/BG50273A3/xx unknown
- 1990-02-06 CZ CS90563A patent/CZ280121B6/cs not_active IP Right Cessation
- 1990-02-06 HU HU90689A patent/HU204793B/hu unknown
- 1990-02-06 JP JP2027007A patent/JP2870925B2/ja not_active Expired - Lifetime
- 1990-02-06 FI FI900577A patent/FI102678B/fi active IP Right Grant
- 1990-02-06 PH PH40002A patent/PH26552A/en unknown
- 1990-02-06 PT PT93067A patent/PT93067B/pt active IP Right Grant
- 1990-02-06 SK SK563-90A patent/SK278441B6/sk not_active IP Right Cessation
- 1990-02-06 AR AR90316095A patent/AR247386A1/es active
- 1990-02-06 RU SU904743128A patent/RU2066318C1/ru active
- 1990-02-06 UA UA4743128A patent/UA26852C2/uk unknown
- 1990-02-07 DD DD90337657A patent/DD291995A5/de unknown
- 1990-02-07 KR KR1019900001453A patent/KR0145525B1/ko not_active IP Right Cessation
- 1990-02-07 CN CN90100599A patent/CN1046505C/zh not_active Expired - Fee Related
- 1990-02-07 DD DD90342349A patent/DD295363A5/de unknown
- 1990-02-07 CA CA002009503A patent/CA2009503C/en not_active Expired - Lifetime
- 1990-12-20 US US07/632,117 patent/US5112986A/en not_active Expired - Lifetime
-
1991
- 1991-06-05 RU SU914895526A patent/RU2055071C1/ru active
- 1991-06-05 RU SU914895540A patent/RU2044729C1/ru active
- 1991-11-15 GR GR91300073T patent/GR910300073T1/el unknown
-
1993
- 1993-06-22 LV LVP-93-647A patent/LV10612B/lv unknown
- 1993-07-26 GE GEAP19931214A patent/GEP19971030B/en unknown
- 1993-08-17 LT LTIP872A patent/LT3604B/lt not_active IP Right Cessation
- 1993-09-15 CN CN93117740A patent/CN1034016C/zh not_active Expired - Fee Related
-
1995
- 1995-11-22 GR GR950403284T patent/GR3018165T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI |
|
| FG | Patent granted |
Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI |