ES8800660A1 - Procedimiento para la obtencion de amidas - Google Patents

Procedimiento para la obtencion de amidas

Info

Publication number
ES8800660A1
ES8800660A1 ES557167A ES557167A ES8800660A1 ES 8800660 A1 ES8800660 A1 ES 8800660A1 ES 557167 A ES557167 A ES 557167A ES 557167 A ES557167 A ES 557167A ES 8800660 A1 ES8800660 A1 ES 8800660A1
Authority
ES
Spain
Prior art keywords
optionally substituted
phenyl
alkyl
amides
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557167A
Other languages
English (en)
Other versions
ES557167A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES557167A0 publication Critical patent/ES557167A0/es
Publication of ES8800660A1 publication Critical patent/ES8800660A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE FORMULA (I), DE SUS DIASTEREISOMEROS, RACEMICOS, ENANTIOMEROS Y SALES DE ADICION DE ACIDO. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA R1NHR2, EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA AMINA TERCIARIA, A UNA TEMPERATURA COMPRENDIDA ENTRE C5JC Y 180JC, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE A Y B REPRESENTAN NITROGENO O GRUPO CH, E, V, W, Z, X, R, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES Y M VALE 0 O 1 Y N 0-2. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICOS COMO TRANQUILIZANTES.
ES557167A 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas Expired ES8800660A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR858508111A FR2582514B1 (fr) 1985-05-30 1985-05-30 Medicaments a base d'amides, nouveaux amides et leur preparation

Publications (2)

Publication Number Publication Date
ES557167A0 ES557167A0 (es) 1987-11-16
ES8800660A1 true ES8800660A1 (es) 1987-11-16

Family

ID=9319678

Family Applications (7)

Application Number Title Priority Date Filing Date
ES555558A Expired ES8704732A1 (es) 1985-05-30 1986-05-30 Procedimiento para la obtencion de amidas derivadas de la quinoleina
ES555557A Expired ES8704731A1 (es) 1985-05-30 1986-05-30 Procedimiento para la obtencion de amidas
ES557167A Expired ES8800660A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas
ES557166A Expired ES8705225A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas
ES557170A Expired ES8705228A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas derivadas de la quinoleina
ES557169A Expired ES8705227A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas
ES557168A Expired ES8705226A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES555558A Expired ES8704732A1 (es) 1985-05-30 1986-05-30 Procedimiento para la obtencion de amidas derivadas de la quinoleina
ES555557A Expired ES8704731A1 (es) 1985-05-30 1986-05-30 Procedimiento para la obtencion de amidas

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES557166A Expired ES8705225A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas
ES557170A Expired ES8705228A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas derivadas de la quinoleina
ES557169A Expired ES8705227A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas
ES557168A Expired ES8705226A1 (es) 1985-05-30 1986-10-31 Procedimiento para la obtencion de amidas

Country Status (20)

Country Link
US (3) US4788204A (es)
EP (2) EP0205375B1 (es)
JP (2) JPS625946A (es)
AT (2) ATE40689T1 (es)
AU (2) AU579473B2 (es)
CA (2) CA1264160A (es)
DE (2) DE3662045D1 (es)
DK (2) DK252386A (es)
ES (7) ES8704732A1 (es)
FR (1) FR2582514B1 (es)
GR (2) GR861369B (es)
HU (2) HU195642B (es)
IL (2) IL78968A (es)
MA (2) MA20697A1 (es)
NO (2) NO862133L (es)
NZ (2) NZ216331A (es)
PT (2) PT82673B (es)
SU (7) SU1440342A3 (es)
TN (2) TNSN86080A1 (es)
ZA (2) ZA863993B (es)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
HU199424B (en) * 1987-04-24 1990-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing quinoline thioethers and pharmaceutical compositions comprising such compounds
HU199423B (en) * 1987-04-24 1990-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 3-amino-4-/ethylthio/-quinoline and pharmaceutical compositions comprising such compounds
GB8726735D0 (en) * 1987-11-14 1987-12-16 Wellcome Found Pesticidal compounds
US5081121A (en) * 1988-05-24 1992-01-14 Tatsushi Osawa 4(1h)-quinolone derivatives
FR2636327A1 (fr) * 1988-09-13 1990-03-16 Rhone Poulenc Sante Derives de quinoleine, leurs procedes de preparation et les medicaments les contenant
JP2669905B2 (ja) * 1989-09-01 1997-10-29 ファナック株式会社 リレーの溶着検出方法
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP0575097B1 (en) * 1992-06-19 2000-11-02 Eli Lilly And Company 2,3-Bis-carboxamidomethyl substituted oxiranes as inhibitors of HIV protease and their use for the treatment of AIDS
JP3408300B2 (ja) * 1993-11-10 2003-05-19 シチズン時計株式会社 プリンタ
DE4420337A1 (de) * 1994-06-10 1995-12-14 Bayer Ag N-Heterocyclyl-heteroaryloxyacetamide
US5658902A (en) * 1994-12-22 1997-08-19 Warner-Lambert Company Quinazolines as inhibitors of endothelin converting enzyme
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
US5648448A (en) * 1995-06-06 1997-07-15 Hitachi Chemical Company, Ltd. Method of preparation of polyquinolines
US5776946A (en) * 1995-08-28 1998-07-07 Mcgeer; Patrick L. Peripheral benzodiazepine receptor ligands as antiinflammatory agents
FR2750427B1 (fr) * 1996-06-28 1998-08-07 Synthelabo Derives de 1-oxo-1, 2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
US5998624A (en) * 1997-05-07 1999-12-07 Emory University Haloisoquinoline carboxamide
ZA9810490B (en) 1997-12-03 1999-05-20 Dainippon Pharmaceutical Co 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
FR2778564B1 (fr) * 1998-05-13 2001-07-13 Sanofi Sa Utilisation de composes reduisant l'apoptose
WO1999058117A1 (fr) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Utilisation de composes reduisant l'apoptose
FR2779963A1 (fr) 1998-06-22 1999-12-24 Centre Nat Rech Scient Utilisation d'un compose possedant une affinite pour le recepteur mitochondrial des benzodiazepines en therapie du cancer
AU2185100A (en) 1998-12-18 2000-07-12 Scios Inc. Agonists and antagonists of peripheral-type benzodiazepine receptors
US6297256B1 (en) * 1999-06-15 2001-10-02 Neurogen Corporation Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
AR026748A1 (es) 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
EP1110552A1 (en) * 1999-12-22 2001-06-27 Aventis Pharma S.A. Use of a compound with affinity for the mitochondrial benzodiazepine receptor in cancer therapy
WO2002000623A2 (en) * 2000-06-26 2002-01-03 Neurogen Corporation Aryl fused substituted 4-oxy-pyridines
KR20050013260A (ko) 2002-06-28 2005-02-03 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 및 이의 용도
TW200500343A (en) * 2002-12-20 2005-01-01 Vertex Pharma Caspase inhibitors and uses thereof
CA2505195C (en) * 2002-12-23 2012-07-10 Icagen, Inc. Quinazolinones as potassium channel modulators
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
US7423176B2 (en) * 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1889837A1 (en) * 2006-07-10 2008-02-20 Pharmeste S.r.l. VR1 vanilloid receptor antagonists with a iononic substructure
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DE2361438C3 (de) * 1973-12-10 1979-12-13 Hoechst Ag, 6000 Frankfurt 4-Hydroxychinoün- und 4-Hydroxytetrahydrochinolin-N^N-dimethylcarbamate, Verfahren zu ihrer Herstellung und diese enthaltende insektizide Mittel
DE2411662A1 (de) 1974-03-12 1975-09-25 Lechler Elring Dichtungswerke Vorrichtung zum einseitigen anheben und lenkbarmachen einer palette insbesondere einer rollpalette
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FR2471981A1 (fr) * 1979-12-21 1981-06-26 Pharmindustrie Nouveaux derives de la (piperidyl-4)-2 (quinolyl-4)-1 ethanone, produits intermediaires et procedes pour leur preparation, et leur utilisation comme medicaments
FR2485014A1 (fr) * 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments
FR2525595A1 (fr) * 1982-04-27 1983-10-28 Pharmuka Lab Nouveaux derives d'arene et d'heteroarenecarboxamides et leur utilisation comme medicaments
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0135975B1 (en) * 1983-09-29 1988-09-14 Akzo N.V. Quinazoline and isoquinoline derivatives
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation

Also Published As

Publication number Publication date
IL78968A0 (en) 1986-09-30
PT82673B (pt) 1988-08-17
DK252286D0 (da) 1986-05-29
DK252286A (da) 1986-12-01
SU1470182A3 (ru) 1989-03-30
SU1614759A3 (ru) 1990-12-15
ES557167A0 (es) 1987-11-16
HU195642B (en) 1988-06-28
AU579472B2 (en) 1988-11-24
ES8705227A1 (es) 1987-05-01
GR861369B (en) 1986-09-29
PT82673A (fr) 1986-06-01
PT82674B (pt) 1988-08-17
ES557169A0 (es) 1987-05-01
ES555558A0 (es) 1987-04-16
DE3666813D1 (en) 1989-12-14
ATE47840T1 (de) 1989-11-15
US4728647A (en) 1988-03-01
HUT42071A (en) 1987-06-29
US4788204A (en) 1988-11-29
PT82674A (fr) 1986-06-01
EP0210084B1 (fr) 1989-02-08
IL78968A (en) 1989-07-31
ES8705228A1 (es) 1987-05-01
JPS6264A (ja) 1987-01-06
SU1440342A3 (ru) 1988-11-23
MA20697A1 (fr) 1986-12-31
JPS625946A (ja) 1987-01-12
EP0205375A1 (fr) 1986-12-17
IL78969A (en) 1989-07-31
ES8704731A1 (es) 1987-04-16
ES8705226A1 (es) 1987-05-01
SU1508957A3 (ru) 1989-09-15
FR2582514A1 (fr) 1986-12-05
TNSN86080A1 (fr) 1990-01-01
CA1264160A (fr) 1990-01-02
ES555557A0 (es) 1987-04-16
AU579473B2 (en) 1988-11-24
EP0210084A1 (fr) 1987-01-28
CA1251206A (fr) 1989-03-14
ZA863992B (en) 1987-01-28
ES557166A0 (es) 1987-05-01
SU1544186A3 (ru) 1990-02-15
ES8704732A1 (es) 1987-04-16
IL78969A0 (en) 1986-09-30
DE3662045D1 (en) 1989-03-16
HUT42072A (en) 1987-06-29
NZ216330A (en) 1989-04-26
SU1470183A3 (ru) 1989-03-30
SU1537135A3 (ru) 1990-01-15
HU195641B (en) 1988-06-28
NO862134L (no) 1986-12-01
AU5803086A (en) 1986-12-04
ES8705225A1 (es) 1987-05-01
EP0205375B1 (fr) 1989-11-08
GR861368B (en) 1986-09-29
NO862133L (no) 1986-12-01
ES557168A0 (es) 1987-05-01
AU5803186A (en) 1986-12-04
ATE40689T1 (de) 1989-02-15
FR2582514B1 (fr) 1988-02-19
MA20696A1 (fr) 1986-12-31
US4788199A (en) 1988-11-29
DK252386D0 (da) 1986-05-29
ZA863993B (en) 1987-01-28
NZ216331A (en) 1989-04-26
TNSN86081A1 (fr) 1990-01-01
ES557170A0 (es) 1987-05-01
DK252386A (da) 1986-12-01

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