ES8705462A1 - Un procedimiento para la preparacion de 16,17-acetales de derivados de pregnano - Google Patents

Un procedimiento para la preparacion de 16,17-acetales de derivados de pregnano

Info

Publication number
ES8705462A1
ES8705462A1 ES543499A ES543499A ES8705462A1 ES 8705462 A1 ES8705462 A1 ES 8705462A1 ES 543499 A ES543499 A ES 543499A ES 543499 A ES543499 A ES 543499A ES 8705462 A1 ES8705462 A1 ES 8705462A1
Authority
ES
Spain
Prior art keywords
acetals
preparation
pregnane derivatives
obtained therefrom
compounds obtained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543499A
Other languages
English (en)
Other versions
ES543499A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SICOR Societa Italiana Corticosteroidi SRL
Original Assignee
SICOR Societa Italiana Corticosteroidi SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11180389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8705462(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SICOR Societa Italiana Corticosteroidi SRL filed Critical SICOR Societa Italiana Corticosteroidi SRL
Publication of ES543499A0 publication Critical patent/ES543499A0/es
Publication of ES8705462A1 publication Critical patent/ES8705462A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 16,17-ACETALES DE DERIVADOS DE PREGNANO. CONSISTE EN HACER REACCIONAR LOS 16,17-ACETONIDOS CON ALDEHIDOS DE FORMULA R1CHO, EN UNA SOLUCION ACUOSA DE ACIDO FLUORHIDRICO O CLORHIDRICO Y A UNA TEMPERATURA COMPRENDIDA ENTRE C70JC Y 20JC, PARA OBTENER 16A,17B-BUTILDENDIOXI-11B,21-DIHIDROXIPREGNA-1,4-DIEN-3,20-DIONA O BUDESONIDA DE FORMULA (I). TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES TERAPEUTICOS.
ES543499A 1984-06-11 1985-05-24 Un procedimiento para la preparacion de 16,17-acetales de derivados de pregnano Expired ES8705462A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21343/84A IT1196142B (it) 1984-06-11 1984-06-11 Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti

Publications (2)

Publication Number Publication Date
ES543499A0 ES543499A0 (es) 1987-05-01
ES8705462A1 true ES8705462A1 (es) 1987-05-01

Family

ID=11180389

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543499A Expired ES8705462A1 (es) 1984-06-11 1985-05-24 Un procedimiento para la preparacion de 16,17-acetales de derivados de pregnano

Country Status (11)

Country Link
US (2) US4695625A (es)
EP (1) EP0164636B1 (es)
JP (1) JPS6140299A (es)
AT (1) ATE56725T1 (es)
CA (1) CA1336513C (es)
DE (1) DE3579750D1 (es)
DK (1) DK163433C (es)
ES (1) ES8705462A1 (es)
FI (1) FI81809C (es)
IT (1) IT1196142B (es)
NO (1) NO164905C (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
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IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
JPS6369953A (ja) * 1986-09-11 1988-03-30 Kobe Steel Ltd 方向性の優れたアルミニウム合金の製造法
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
JPS63156725A (ja) * 1986-12-16 1988-06-29 シコ−ル　ソシエテ　イタリア−ナ　コルテイコステロイデイ　エス・ピ−・エ− 抗炎症剤
JPH01129688A (ja) * 1987-11-16 1989-05-22 Mitsubishi Electric Corp 画像信号受信装置
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GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
UA45311C2 (uk) * 1993-04-02 2002-04-15 Бік Гульден Ломберг Хеміше Фабрік Гмбх 16<font face="Symbol">a</font>,17-ЦИКЛОГЕКСИЛМЕТИЛЕНДІОКСИ-11<font face="Symbol">b</font>,21-ДИГІДРОКСИПРЕГНА-1,4-ДІЄН-3,20-ДІОН, СПОСІБ ЙОГО ОДЕРЖАННЯ, ЛІКАРСЬКИЙ ЗАСІБ
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
DE19635498A1 (de) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
IT1291288B1 (it) * 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
IT1302657B1 (it) * 1998-10-13 2000-09-29 Farmabios Srl Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r.
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
US6883516B2 (en) 2000-04-27 2005-04-26 Chrysalis Technologies Incorporated Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
MY136453A (en) 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
SK286694B6 (sk) * 2000-05-22 2009-03-05 Chiesi Farmaceutici S.P.A. Aerosólový farmaceutický prostriedok
AU2953602A (en) * 2000-11-10 2002-05-21 Byk Gulden Lomberg Chem Fab Process for the production of 16,17-((cyclohexylmethylen)bis(oxy))-11,21-dihydroxy-pregna- 1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
SI1273292T1 (en) * 2001-07-02 2004-12-31 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
EP1275656A1 (en) * 2001-07-11 2003-01-15 Genchem Pharma Limited Preparation of 9alpha-fluoro-11beta-hydroxypregnane 16,17-acetal derivatives
JP3749243B2 (ja) * 2001-09-03 2006-02-22 松下電器産業株式会社 半導体発光デバイス，発光装置及び半導体発光デバイスの製造方法
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
PT3536344T (pt) * 2002-03-01 2020-03-26 Chiesi Farm Spa Formulação superfina de formoterol
WO2004033478A2 (en) * 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
US7367334B2 (en) 2003-08-27 2008-05-06 Philip Morris Usa Inc. Fluid vaporizing device having controlled temperature profile heater/capillary tube
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
WO2007054974A2 (en) * 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters
JP2009512733A (ja) * 2005-11-02 2009-03-26 シコール インコーポレイティド シクレソニドの改良された製造法
US20070232578A1 (en) * 2006-02-15 2007-10-04 Pierluigi Rossetto Crystalline forms of ciclesonide
ITMI20080645A1 (it) * 2008-04-11 2009-10-12 Ind Chimica Srl Procedimento per la preparazione di budesonide
CN101279997B (zh) * 2008-05-29 2011-08-24 鲁南制药集团股份有限公司 布地奈德的一种制备方法
CN101863952B (zh) * 2010-04-30 2013-04-17 湖北葛店人福药业有限责任公司 布地奈德的制备方法
CN102060906B (zh) * 2010-12-23 2013-01-16 鲁南贝特制药有限公司 一种r布地奈德的制备方法
US10233210B2 (en) 2015-01-30 2019-03-19 Coral Drugs Pvt. Ltd. Process for preparation of glucocorticoid steroids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (es) * 1972-05-19 1975-08-18 Bofors Ab
SE378110B (es) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
DK176716B1 (da) * 2007-09-03 2009-04-14 Viking Life Saving Equip As Redningsflådesystem

Also Published As

Publication number Publication date
DK243085A (da) 1985-12-12
EP0164636A3 (en) 1986-10-08
EP0164636A2 (en) 1985-12-18
FI852093L (fi) 1985-12-12
ATE56725T1 (de) 1990-10-15
NO164905C (no) 1990-11-28
ES543499A0 (es) 1987-05-01
FI852093A0 (fi) 1985-05-24
FI81809B (fi) 1990-08-31
NO852327L (no) 1985-12-12
DE3579750D1 (de) 1990-10-25
JPS6140299A (ja) 1986-02-26
NO164905B (no) 1990-08-20
DK243085D0 (da) 1985-05-30
IT8421343A1 (it) 1985-12-11
JPH0213680B2 (es) 1990-04-04
IT1196142B (it) 1988-11-10
DK163433C (da) 1992-07-27
US4835145A (en) 1989-05-30
IT8421343A0 (it) 1984-06-11
US4695625A (en) 1987-09-22
FI81809C (fi) 1990-12-10
DK163433B (da) 1992-03-02
CA1336513C (en) 1995-08-01
EP0164636B1 (en) 1990-09-19

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20070210