ES8605374A1 - Un metodo de produccion de una solucion inyectable de un antraciclina glicosido - Google Patents

Un metodo de produccion de una solucion inyectable de un antraciclina glicosido

Info

Publication number
ES8605374A1
ES8605374A1 ES547578A ES547578A ES8605374A1 ES 8605374 A1 ES8605374 A1 ES 8605374A1 ES 547578 A ES547578 A ES 547578A ES 547578 A ES547578 A ES 547578A ES 8605374 A1 ES8605374 A1 ES 8605374A1
Authority
ES
Spain
Prior art keywords
dynorubicine
subyl
virals
doxorubicin
sugar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547578A
Other languages
English (en)
Spanish (es)
Other versions
ES547578A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8605374A1 publication Critical patent/ES8605374A1/es
Publication of ES547578A0 publication Critical patent/ES547578A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES547578A 1984-10-22 1985-10-03 Un metodo de produccion de una solucion inyectable de un antraciclina glicosido Expired ES8605374A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ES8605374A1 true ES8605374A1 (es) 1986-03-16
ES547578A0 ES547578A0 (es) 1986-03-16

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547578A Expired ES8605374A1 (es) 1984-10-22 1985-10-03 Un metodo de produccion de una solucion inyectable de un antraciclina glicosido

Country Status (35)

Country Link
US (4) US4675311A (OSRAM)
JP (1) JPH0611700B2 (OSRAM)
KR (1) KR920005813B1 (OSRAM)
CN (1) CN85107562B (OSRAM)
AT (1) AT401345B (OSRAM)
AU (1) AU572003B2 (OSRAM)
BE (1) BE903484A (OSRAM)
BG (1) BG60934B2 (OSRAM)
CA (1) CA1248453A (OSRAM)
CH (1) CH667594A5 (OSRAM)
CS (1) CS270421B2 (OSRAM)
DE (1) DE3536896C2 (OSRAM)
DK (1) DK165620C (OSRAM)
ES (1) ES8605374A1 (OSRAM)
FI (2) FI853913A7 (OSRAM)
FR (1) FR2571966B1 (OSRAM)
GB (2) GB8426672D0 (OSRAM)
GR (1) GR852549B (OSRAM)
HK (1) HK94390A (OSRAM)
HU (1) HU197988B (OSRAM)
IE (1) IE56992B1 (OSRAM)
IL (1) IL76732A (OSRAM)
IT (1) IT1186779B (OSRAM)
MY (1) MY103956A (OSRAM)
NL (1) NL191308C (OSRAM)
NO (1) NO170616C (OSRAM)
NZ (1) NZ213885A (OSRAM)
PH (1) PH23982A (OSRAM)
PT (1) PT81347B (OSRAM)
RU (2) RU1836088C (OSRAM)
SE (1) SE467520B (OSRAM)
SG (1) SG80290G (OSRAM)
UA (2) UA19169A (OSRAM)
YU (1) YU46160B (OSRAM)
ZA (1) ZA858033B (OSRAM)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DE3777365D1 (de) * 1986-12-05 1992-04-16 Erba Carlo Spa Einspritzbare fertig brauchbare loesungen, die ein antracyclineglykosid als mittel gegen krebs enthalten.
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
EP0954283B1 (en) 1996-12-30 2007-03-21 Battelle Memorial Institute Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
DE60321450D1 (de) 2002-02-22 2008-07-17 Schering Corp Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung
DK1474995T3 (da) * 2003-05-06 2013-02-18 Gumlink As Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
ATE471740T1 (de) * 2003-09-25 2010-07-15 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
BRPI0605832A2 (pt) * 2005-05-11 2009-05-26 Sicor Inc glicosìdeos de antraciclina liofilizados estáveis
JP4778053B2 (ja) 2005-07-14 2011-09-21 リセラ，インコーポレイテッド 局所的脂肪組織処置のための徐放性増強脂肪分解処方物
RU2450013C2 (ru) * 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CA2687291A1 (en) * 2007-05-16 2008-11-20 Ktb Tumorforschungsgesellschaft Mbh Low-viscous anthracycline formulation
ES2439497T3 (es) * 2007-09-04 2014-01-23 Meiji Seika Pharma Co., Ltd. Preparación de una inyección, de una solución para inyección y de un kit de inyección
CN101835474A (zh) * 2007-10-26 2010-09-15 辉瑞产品公司 用于在狗中治疗淋巴瘤的伊达比星
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
BR112012017556A2 (pt) * 2010-01-15 2016-08-16 Lithera Inc formulações de torta liofilizada
EP2646012A4 (en) 2010-11-24 2014-12-10 Neothetics Inc MONOTHERAPEUTIC FORMULATIONS OF SELECTIVE, LIPOPHILIC AND PROLONGED BETA AGONISTS AND METHODS OF COSMETIC TREATMENT OF SILHOUETTE ADPOSITY AND REINFORCEMENT
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
JP6433913B2 (ja) 2012-12-13 2018-12-05 サイトレックス コーポレイション アントラサイクリン製剤
KR20210059035A (ko) 2013-06-05 2021-05-24 싸이트알엑스 코포레이션 암 치료용 세포독성제

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
GR79729B (OSRAM) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Also Published As

Publication number Publication date
SE8504945D0 (sv) 1985-10-21
IT8522507A0 (it) 1985-10-16
SG80290G (en) 1990-11-23
ZA858033B (en) 1986-06-25
UA34419C2 (uk) 2001-03-15
NO170616C (no) 1992-11-11
AU572003B2 (en) 1988-04-28
IL76732A0 (en) 1986-02-28
JPH0611700B2 (ja) 1994-02-16
NL191308C (nl) 1995-05-16
YU46160B (sh) 1993-05-28
UA19169A (uk) 1997-12-25
DK165620C (da) 1993-06-01
KR860003014A (ko) 1986-05-19
US4675311A (en) 1987-06-23
US5091372A (en) 1992-02-25
FR2571966B1 (fr) 1988-04-15
GB8525709D0 (en) 1985-11-20
SE8504945L (sv) 1986-04-23
KR920005813B1 (ko) 1992-07-20
ATA303285A (de) 1996-01-15
PT81347B (pt) 1987-11-11
IE852593L (en) 1986-04-22
CH667594A5 (de) 1988-10-31
RU1836088C (ru) 1993-08-23
CA1248453A (en) 1989-01-10
GR852549B (OSRAM) 1986-02-24
PH23982A (en) 1990-02-09
GB2165751B (en) 1988-08-17
FI853913A7 (fi) 1986-04-23
AT401345B (de) 1996-08-26
DK481585A (da) 1986-04-23
IL76732A (en) 1989-07-31
FR2571966A1 (fr) 1986-04-25
FI854035L (fi) 1986-04-23
YU164485A (en) 1987-10-31
JPS61246129A (ja) 1986-11-01
NZ213885A (en) 1988-05-30
NO170616B (no) 1992-08-03
BG60934B2 (bg) 1996-06-28
DE3536896A1 (de) 1986-04-24
CS756585A2 (en) 1989-11-14
NO854194L (no) 1986-04-23
CN85107562A (zh) 1986-07-23
PT81347A (en) 1985-11-01
NL191308B (nl) 1994-12-16
FI853913A0 (fi) 1985-10-08
DK165620B (da) 1992-12-28
GB2165751A (en) 1986-04-23
CS270421B2 (en) 1990-06-13
US4840938A (en) 1989-06-20
IT1186779B (it) 1987-12-16
IE56992B1 (en) 1992-02-26
HK94390A (en) 1990-11-23
NL8502869A (nl) 1986-05-16
DK481585D0 (da) 1985-10-21
ES547578A0 (es) 1986-03-16
SE467520B (sv) 1992-08-03
CN85107562B (zh) 1988-06-01
FI854035A0 (fi) 1985-10-16
MY103956A (en) 1993-10-30
DE3536896C2 (de) 1996-11-14
FI86252B (fi) 1992-04-30
FI86252C (fi) 1992-08-10
GB8426672D0 (en) 1984-11-28
HUT40759A (en) 1987-02-27
US5091373A (en) 1992-02-25
RU2101018C1 (ru) 1998-01-10
BE903484A (fr) 1986-04-21
AU4880585A (en) 1986-05-01
HU197988B (en) 1989-07-28

Similar Documents

Publication Publication Date Title
ES8605374A1 (es) Un metodo de produccion de una solucion inyectable de un antraciclina glicosido
Bertazzoli et al. Different incidence of breast carcinomas or fibroadenomas in daunomycin or adriamycin treated rats
RU2000131681A (ru) Тритерпеновые композиции и способы их применения
FR2309234A1 (fr) Glucosides antitumoraux et leur procede de preparation
FR2325659A1 (fr) Nouvelles glycosides antitumorales de la serie anthracycline et procede pour leur preparation
RU2100366C1 (ru) Антрациклиновые гликозиды и их фармацевтически приемлемые кислотно-аддитивные соли, способ их получения, дииодопромежуточное соединение и способ его получения
NO170913C (no) Fremgangsmåte for fremstilling av en injiserbar opplösning inneholdende etantitumorantracyklin-glykosid
CA978783A (en) Device for supplying treatment agent to ligno-cellulose containing material
BE841415A (fr) Procede de preparation d'ethers cellulosiques absorbant de l'eau
IL33371A0 (en) New process for the preparation of daunorubicin
BE795455A (fr) Procede de preparation de polyalkylene-ethers purs
BE820324A (fr) Ethers 2-carbalcoxy-amino-benzimidazolyl-5(6)-amino-phenyliquesa action anthelmintique et leur procede de preparation
JPS579725A (en) Method of promoting oral absorption of glycoside and related antibiotics
IT1009544B (it) Procedimento per la eliminazione delle tensioni in pietre dure per il montaggio di perni in orologeria costituite da cristalli di ossidi metallici lavorate con elevata sol lecitazione del materiale
AU624839B2 (en) Morpholino derivatives of rhodomycins, processes for their preparation and their use
SU502277A1 (ru) Способ приготовлени тонких срезов тканей
LING et al. COLLAGEN AND GROUND SUBSTANCE IN THE PROCESS OF FRACTURE HEALING (AN EXPERIMENTAL STUDY)
LIU THE CHANGE IN EPITHELIUM OF DUODENAL ULCER DURING HEALING PROCESS
PT76113A (en) Process for preparing daunorubicin and doxorubicin analogues and of pharmaceutical compositions containing the same
BE763170A (fr) Procede de preparation de benzoate de sodium pur
IT1109045B (it) Procedimento chimico per l'isolamento della specie botanica digitalis lanata del glicoside lanatoside c e sua trasformazione in desacetil-lanatoside c(deslanoside)
CHUN et al. Hyperbaric oxygen therapy in systemic scleroderma
BE813605A (fr) Procede de preparation de polyethers purs
AU465205B2 (en) Improved process for the preparation of glucoside derivatives of thiocolchicine
BA97188B1 (bs) Postupak za dobijanje sterilnog rastvora za injekcije koji sadrzi antraciklinske glikozide

Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20051123