AU572003B2 - Pharmaceutical compositions containing anthracycline glycosides - Google Patents

Pharmaceutical compositions containing anthracycline glycosides

Info

Publication number
AU572003B2
AU572003B2 AU48805/85A AU4880585A AU572003B2 AU 572003 B2 AU572003 B2 AU 572003B2 AU 48805/85 A AU48805/85 A AU 48805/85A AU 4880585 A AU4880585 A AU 4880585A AU 572003 B2 AU572003 B2 AU 572003B2
Authority
AU
Australia
Prior art keywords
pharmaceutical compositions
compositions containing
anthracycline glycosides
containing anthracycline
glycosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU48805/85A
Other languages
English (en)
Other versions
AU4880585A (en
Inventor
Carlo Confalonieri
Luciano Gambini
Gaetano Gatti
Diego Oldani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of AU4880585A publication Critical patent/AU4880585A/en
Application granted granted Critical
Publication of AU572003B2 publication Critical patent/AU572003B2/en
Assigned to PHARMACIA S.P.A. reassignment PHARMACIA S.P.A. Alteration of Name(s) in Register under S187 Assignors: FARMITALIA CARLO ERBA S.R.L.
Assigned to PHARMACIA & UPJOHN S.P.A. reassignment PHARMACIA & UPJOHN S.P.A. Alteration of Name(s) in Register under S187 Assignors: PHARMACIA S.P.A.
Assigned to PHARMACIA ITALIA S.P.A. reassignment PHARMACIA ITALIA S.P.A. Alteration of Name(s) in Register under S187 Assignors: PHARMACIA & UPJOHN S.P.A.
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU48805/85A 1984-10-22 1985-10-17 Pharmaceutical compositions containing anthracycline glycosides Expired AU572003B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions
GB8426672 1984-10-22

Publications (2)

Publication Number Publication Date
AU4880585A AU4880585A (en) 1986-05-01
AU572003B2 true AU572003B2 (en) 1988-04-28

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48805/85A Expired AU572003B2 (en) 1984-10-22 1985-10-17 Pharmaceutical compositions containing anthracycline glycosides

Country Status (35)

Country Link
US (4) US4675311A (OSRAM)
JP (1) JPH0611700B2 (OSRAM)
KR (1) KR920005813B1 (OSRAM)
CN (1) CN85107562B (OSRAM)
AT (1) AT401345B (OSRAM)
AU (1) AU572003B2 (OSRAM)
BE (1) BE903484A (OSRAM)
BG (1) BG60934B2 (OSRAM)
CA (1) CA1248453A (OSRAM)
CH (1) CH667594A5 (OSRAM)
CS (1) CS270421B2 (OSRAM)
DE (1) DE3536896C2 (OSRAM)
DK (1) DK165620C (OSRAM)
ES (1) ES8605374A1 (OSRAM)
FI (2) FI853913A7 (OSRAM)
FR (1) FR2571966B1 (OSRAM)
GB (2) GB8426672D0 (OSRAM)
GR (1) GR852549B (OSRAM)
HK (1) HK94390A (OSRAM)
HU (1) HU197988B (OSRAM)
IE (1) IE56992B1 (OSRAM)
IL (1) IL76732A (OSRAM)
IT (1) IT1186779B (OSRAM)
MY (1) MY103956A (OSRAM)
NL (1) NL191308C (OSRAM)
NO (1) NO170616C (OSRAM)
NZ (1) NZ213885A (OSRAM)
PH (1) PH23982A (OSRAM)
PT (1) PT81347B (OSRAM)
RU (2) RU1836088C (OSRAM)
SE (1) SE467520B (OSRAM)
SG (1) SG80290G (OSRAM)
UA (2) UA34419C2 (OSRAM)
YU (1) YU46160B (OSRAM)
ZA (1) ZA858033B (OSRAM)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
PT86285B (pt) * 1986-12-05 1990-11-07 Erba Farmitalia Processo para a preparacao de solucoes injectaveis contendo um glicosido antraciclinico anti-tumor
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300362B1 (en) 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
ES2285743T3 (es) 1996-12-30 2007-11-16 Battelle Memorial Institute Uso de un farmaco anticancerigeno no encapsulado para la preparacion de una formulacion para tratar neoplasias mediante inhlacion.
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
CN101172104B (zh) 2002-02-22 2013-04-03 默沙东公司 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
ATE520702T1 (de) * 2003-07-02 2011-09-15 Solux Corp Thermisch stabiles kristallines epirubicin- hydrochlorid und herstellungsverfahren dafür
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
ES2344899T3 (es) * 2003-09-25 2010-09-09 Astellas Pharma Inc. Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii.
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
CA2606390A1 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
PL1921919T3 (pl) 2005-07-14 2012-09-28 Lithera Inc Ulepszona lipolityczna formulacja o podtrzymywanym uwalnianiu do traktowania lokalnej tkanki tłuszczowej
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
EP2152312B1 (en) * 2007-05-16 2014-12-31 KTB Tumorforschungsgesellschaft mbH Low-viscous anthracycline formulation
EP2184066B1 (en) * 2007-09-04 2013-11-06 Meiji Seika Pharma Co., Ltd. Injection, injection solution and injection kit preparation
KR20100058662A (ko) * 2007-10-26 2010-06-03 화이자 프로덕츠 인코포레이티드 개에게서 림프종을 치료하기 위한 이다루비신
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
MX2012008171A (es) * 2010-01-15 2012-12-17 Lithera Inc Formulaciones aglomeradas liofilizadas.
JP2013543897A (ja) 2010-11-24 2013-12-09 リセラ，インク． 脂肪症及び輪郭の膨れの美容処置のための、選択的な、親油性の、及び長時間作用性のベータアゴニストの単剤療法製剤、及び方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
WO2014093815A1 (en) 2012-12-13 2014-06-19 Cytrx Corporation Anthracycline formulations
US10278981B2 (en) 2013-06-05 2019-05-07 Cytrx Corporation Cytotoxic agents for the treatment of cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8412782A (en) * 1981-05-28 1982-12-02 Farmitalia Carlo Erba S.P.A. Anthracycline clycosides
AU8297882A (en) * 1982-04-19 1983-10-27 Pharmacia & Upjohn S.P.A. 4:-iodo derivatives of anthra cycline glycosides
AU2216483A (en) * 1982-12-20 1984-06-28 Ohio State University Research Foundation, The Anthracylinone antibiotics

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
FI75834C (fi) * 1982-05-24 1988-08-08 Erba Farmitalia Foerfarande foer framstaellning av antracyklinglykosidfoereningar.
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8412782A (en) * 1981-05-28 1982-12-02 Farmitalia Carlo Erba S.P.A. Anthracycline clycosides
AU8297882A (en) * 1982-04-19 1983-10-27 Pharmacia & Upjohn S.P.A. 4:-iodo derivatives of anthra cycline glycosides
AU2216483A (en) * 1982-12-20 1984-06-28 Ohio State University Research Foundation, The Anthracylinone antibiotics

Also Published As

Publication number Publication date
DK165620B (da) 1992-12-28
YU46160B (sh) 1993-05-28
US5091372A (en) 1992-02-25
RU1836088C (ru) 1993-08-23
FI853913A0 (fi) 1985-10-08
RU2101018C1 (ru) 1998-01-10
DE3536896C2 (de) 1996-11-14
IL76732A (en) 1989-07-31
FI86252C (fi) 1992-08-10
SE467520B (sv) 1992-08-03
YU164485A (en) 1987-10-31
FI86252B (fi) 1992-04-30
US5091373A (en) 1992-02-25
UA34419C2 (uk) 2001-03-15
NL8502869A (nl) 1986-05-16
PT81347A (en) 1985-11-01
DK481585A (da) 1986-04-23
IT1186779B (it) 1987-12-16
GB2165751B (en) 1988-08-17
JPS61246129A (ja) 1986-11-01
IE56992B1 (en) 1992-02-26
NO854194L (no) 1986-04-23
US4675311A (en) 1987-06-23
NO170616B (no) 1992-08-03
FI854035A0 (fi) 1985-10-16
IL76732A0 (en) 1986-02-28
DE3536896A1 (de) 1986-04-24
FR2571966A1 (fr) 1986-04-25
NO170616C (no) 1992-11-11
ATA303285A (de) 1996-01-15
IT8522507A0 (it) 1985-10-16
GB2165751A (en) 1986-04-23
AU4880585A (en) 1986-05-01
CA1248453A (en) 1989-01-10
BE903484A (fr) 1986-04-21
CN85107562B (zh) 1988-06-01
DK165620C (da) 1993-06-01
GB8426672D0 (en) 1984-11-28
IE852593L (en) 1986-04-22
DK481585D0 (da) 1985-10-21
FR2571966B1 (fr) 1988-04-15
CS756585A2 (en) 1989-11-14
JPH0611700B2 (ja) 1994-02-16
SE8504945D0 (sv) 1985-10-21
SE8504945L (sv) 1986-04-23
ES8605374A1 (es) 1986-03-16
PT81347B (pt) 1987-11-11
NL191308C (nl) 1995-05-16
ES547578A0 (es) 1986-03-16
GB8525709D0 (en) 1985-11-20
CH667594A5 (de) 1988-10-31
CN85107562A (zh) 1986-07-23
FI853913A7 (fi) 1986-04-23
ZA858033B (en) 1986-06-25
MY103956A (en) 1993-10-30
US4840938A (en) 1989-06-20
HUT40759A (en) 1987-02-27
KR860003014A (ko) 1986-05-19
UA19169A (uk) 1997-12-25
BG60934B2 (bg) 1996-06-28
FI854035L (fi) 1986-04-23
GR852549B (OSRAM) 1986-02-24
CS270421B2 (en) 1990-06-13
KR920005813B1 (ko) 1992-07-20
NL191308B (nl) 1994-12-16
SG80290G (en) 1990-11-23
NZ213885A (en) 1988-05-30
HK94390A (en) 1990-11-23
HU197988B (en) 1989-07-28
PH23982A (en) 1990-02-09
AT401345B (de) 1996-08-26

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE SECTION 70 APPLICATION FORM

NDA Extension of term for standard patent accepted (sect.70)

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Extension date: 20060923

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