ES8601995A1 - Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinas - Google Patents
Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinasInfo
- Publication number
- ES8601995A1 ES8601995A1 ES531458A ES531458A ES8601995A1 ES 8601995 A1 ES8601995 A1 ES 8601995A1 ES 531458 A ES531458 A ES 531458A ES 531458 A ES531458 A ES 531458A ES 8601995 A1 ES8601995 A1 ES 8601995A1
- Authority
- ES
- Spain
- Prior art keywords
- triazolo
- substituted
- new
- phthalazine derivatives
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8201273 | 1982-01-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES531458A0 ES531458A0 (es) | 1985-11-01 |
| ES8601995A1 true ES8601995A1 (es) | 1985-11-01 |
Family
ID=10527683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531458A Expired ES8601995A1 (es) | 1982-01-18 | 1984-04-10 | Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinas |
Country Status (20)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1194310B (it) * | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| BR9710729A (pt) * | 1996-07-25 | 1999-08-17 | Merck Sharp & Dohme | Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto |
| US6465462B1 (en) | 1996-07-25 | 2002-10-15 | Merck Sharp & Dohme Ltd. | Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAα5 receptor subtype |
| EP0986562B1 (en) * | 1997-05-08 | 2002-08-07 | MERCK SHARP & DOHME LTD. | Substituted 1,2,4-triazolo 3,4-a]phthalazine derivatives as gaba alpha 5 ligands |
| GB9715977D0 (en) | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| ES2137113B1 (es) * | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
| GB9726699D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| AU1041599A (en) * | 1997-11-13 | 1999-06-07 | Jose Luis Castro Pineiro | Therapeutic uses of triazolo-pyridazine derivatives |
| GB9723999D0 (en) | 1997-11-13 | 1998-01-14 | Merck Sharp & Dohme | Therapeutic use |
| GB9726701D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| US6110915A (en) * | 1997-12-18 | 2000-08-29 | Merck & Co., Inc. | Antiemetic use of triazolo-pyridazine derivatives |
| WO1999036423A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| GB9801208D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801202D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| PL341652A1 (en) | 1998-01-21 | 2001-04-23 | Merck Sharp & Dohme | Derivatives of triazolopyridazine as ligands for gaba receptors |
| GB9801234D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801210D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801397D0 (en) * | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801538D0 (en) | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
| KR20010041234A (ko) | 1998-02-25 | 2001-05-15 | 더블유. 지. 콜 | 치환된 1,2,4-트리아졸로[3,4-ａ]피리다진 |
| AU746719B2 (en) * | 1998-02-25 | 2002-05-02 | Merck Sharp & Dohme Limited | Substituted 1,2,4-triazolo(3,4-a)pyridazine |
| WO2000027849A2 (en) | 1998-11-12 | 2000-05-18 | Merck & Co., Inc. | Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same |
| GB9824897D0 (en) | 1998-11-12 | 1999-01-06 | Merck Sharp & Dohme | Therapeutic compounds |
| GB9929569D0 (en) * | 1999-12-14 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| GB0028583D0 (en) | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
| CA2442264A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | A method of treating cancer |
| WO2002083140A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20060142178A1 (en) * | 2002-04-08 | 2006-06-29 | Barnett Stanley F | Method of treating cancer |
| US20050054647A1 (en) * | 2002-12-27 | 2005-03-10 | Detlev Schuppan | New pharmaceutical combination |
| BRPI0514586A (pt) * | 2004-09-02 | 2008-06-17 | Altana Pharma Ag | triazolftalazinas |
| NZ555661A (en) * | 2005-01-05 | 2010-11-26 | Nycomed Gmbh | Triazolophthalazines as PDE2-inhibitors |
| US7671050B2 (en) * | 2005-01-05 | 2010-03-02 | Nycomed Gmbh | Triazolophthalazines |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| CN103694244B (zh) * | 2014-01-09 | 2016-03-30 | 郑州大学 | 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途 |
| CN104016986B (zh) * | 2014-03-13 | 2016-02-03 | 郑州大学 | 3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途 |
| EP4279074A1 (en) * | 2022-05-19 | 2023-11-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Azolo compounds for treatment of fibrotic diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB629177A (en) * | 1945-12-21 | 1949-09-14 | Ciba Ltd | Manufacture of new hydrazine compounds and derivatives thereof |
| US2484029A (en) * | 1945-12-21 | 1949-10-11 | Ciba Pharm Prod Inc | Hydrazine derivatives of pyridazine compounds |
| JPS5132598A (en) * | 1974-09-13 | 1976-03-19 | Eisai Co Ltd | Toriazoro * 3 44 ee * futarajinjudotai no goseiho |
| JPS603080B2 (ja) * | 1976-08-10 | 1985-01-25 | 三菱化学株式会社 | Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類 |
| GR70309B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1979-10-29 | 1982-09-08 | Dow Chemical Co |
-
1983
- 1983-01-12 FI FI830100A patent/FI81350C/fi not_active IP Right Cessation
- 1983-01-12 PH PH28380A patent/PH21834A/en unknown
- 1983-01-13 AT AT83100232T patent/ATE22562T1/de not_active IP Right Cessation
- 1983-01-13 GR GR70257A patent/GR78442B/el unknown
- 1983-01-13 EP EP83100232A patent/EP0085840B1/en not_active Expired
- 1983-01-13 NZ NZ203021A patent/NZ203021A/en unknown
- 1983-01-13 ZA ZA83224A patent/ZA83224B/xx unknown
- 1983-01-13 DE DE8383100232T patent/DE3366494D1/de not_active Expired
- 1983-01-13 CA CA000419398A patent/CA1214168A/en not_active Expired
- 1983-01-14 NO NO830110A patent/NO161674C/no unknown
- 1983-01-17 IL IL67697A patent/IL67697A/xx unknown
- 1983-01-17 HU HU83141A patent/HU193033B/hu not_active IP Right Cessation
- 1983-01-17 IE IE82/83A patent/IE55032B1/en not_active IP Right Cessation
- 1983-01-18 DK DK017983A patent/DK163145C/da not_active IP Right Cessation
- 1983-01-18 PT PT76107A patent/PT76107A/pt unknown
- 1983-01-18 JP JP58005413A patent/JPS58124786A/ja active Granted
- 1983-01-18 KR KR1019830000174A patent/KR890000184B1/ko not_active Expired
- 1983-01-18 AU AU10550/83A patent/AU564026B2/en not_active Ceased
-
1984
- 1984-04-10 ES ES531458A patent/ES8601995A1/es not_active Expired
-
1987
- 1987-10-20 US US07/112,015 patent/US4788186A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |