ES8601701A1 - Un metodo para tratar un concentrado de fibrinogeno - Google Patents
Un metodo para tratar un concentrado de fibrinogenoInfo
- Publication number
- ES8601701A1 ES8601701A1 ES538803A ES538803A ES8601701A1 ES 8601701 A1 ES8601701 A1 ES 8601701A1 ES 538803 A ES538803 A ES 538803A ES 538803 A ES538803 A ES 538803A ES 8601701 A1 ES8601701 A1 ES 8601701A1
- Authority
- ES
- Spain
- Prior art keywords
- plasma
- heat treatment
- compositions obtained
- instance
- fractions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/12—Microwaves
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
METODO DE TRATAR UN CONCENTRADO DE FIBRINOGENO. COMPRENDE: LIOFILIZAR EL CONCENTRADO DE FIBRINOGENO, SEGUIDO DEL CALENTAMIENTO DEL CONCENTRADO DE FIBRINOGENO A UNA TEMPERATURA PREDETERMINADA DE 60C, DURANTE UN PERIODO DE TIEMPO SUFICIENTE PARA CONVERTIR EN NO INFECCIOSO AL VIRUS DE LA HEPATITIS NO DEL TIPO A, AL VIRUS DE LA HEPATITIS NO DEL TIPO B, O A UN VIRUS RELACIONADO CON EL CITOMEGALOVIRUS DEL SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (AIDS) O AL VIRUS DE EPTSTEIN-BARR, PRESENTE EN EL CONCENTRADO DE FIBRINOGENO. EL CONCENTRADO EMPLEADO ES UNA FRACCION DE PLASMA QUE CONTIENE UNA RELACION DE UNIDADES ANTIHEMOFILICAS DE CUALQUIER ENZIMA DE COAGULACION DE LA SANGRE DE 10:1 A 500:1, EMPLEANDOSE UN CONCENTRADO PURIFICADO HASTA UNA ACTIVIDAD DE FACTOR ANTIHEMOFILICO POR PESO UNITARIO DE PROTEINA MAYOR QUE LA CONCENTRACION DE DICHO FACTOR EN EL PLASMA HUMANO NORMAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06377863 US4456590B2 (en) | 1981-11-02 | 1982-05-13 | Heat treatment of lyphilized blood clotting factor viii concentrate |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8601701A1 true ES8601701A1 (es) | 1985-11-01 |
ES538803A0 ES538803A0 (es) | 1985-11-01 |
Family
ID=23490802
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522310A Granted ES522310A0 (es) | 1982-05-13 | 1983-05-12 | Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo. |
ES535745A Expired ES8505821A1 (es) | 1982-05-13 | 1984-09-07 | Un metodo de producir una vacuna para la hepatitis |
ES538803A Granted ES538803A0 (es) | 1982-05-13 | 1984-12-19 | Un metodo para tratar un concentrado de fibrinogeno |
ES538802A Expired ES8601700A1 (es) | 1982-05-13 | 1984-12-19 | Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre |
ES538801A Expired ES8601699A1 (es) | 1982-05-13 | 1984-12-19 | Un metodo para tratar un concentrado del factor viii de coagulacion de la sangre |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522310A Granted ES522310A0 (es) | 1982-05-13 | 1983-05-12 | Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo. |
ES535745A Expired ES8505821A1 (es) | 1982-05-13 | 1984-09-07 | Un metodo de producir una vacuna para la hepatitis |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538802A Expired ES8601700A1 (es) | 1982-05-13 | 1984-12-19 | Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre |
ES538801A Expired ES8601699A1 (es) | 1982-05-13 | 1984-12-19 | Un metodo para tratar un concentrado del factor viii de coagulacion de la sangre |
Country Status (19)
Country | Link |
---|---|
US (1) | US4456590B2 (es) |
EP (2) | EP0171506B1 (es) |
JP (1) | JPS58213721A (es) |
AR (1) | AR230186A1 (es) |
AT (1) | AT392905B (es) |
AU (3) | AU554282B2 (es) |
BE (1) | BE896724A (es) |
BR (1) | BR8302504A (es) |
CA (1) | CA1203165A (es) |
CH (1) | CH665125A5 (es) |
DE (3) | DE3364057D1 (es) |
DK (1) | DK171796B1 (es) |
ES (5) | ES522310A0 (es) |
FR (1) | FR2526660B1 (es) |
GB (2) | GB2120254B (es) |
IE (1) | IE55008B1 (es) |
LU (1) | LU84804A1 (es) |
MX (1) | MX172861B (es) |
ZA (1) | ZA833315B (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
US4456590B2 (en) * | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate | |
US4994438A (en) * | 1981-11-02 | 1991-02-19 | Cedars Sinai Medical Center | Heat treatment of lyophilized plasma fractions |
DE3230849A1 (de) * | 1982-08-19 | 1984-02-23 | Behringwerke Ag, 3550 Marburg | Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung |
CA1207662A (en) * | 1982-12-02 | 1986-07-15 | Ricardo H. Landaburu | Hepatitis b and non-a-non-b-safe biological products |
US4615886A (en) * | 1983-08-31 | 1986-10-07 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus |
JPS6054287B2 (ja) * | 1983-10-19 | 1985-11-29 | 株式会社ミドリ十字 | 血漿蛋白の加熱処理方法 |
US4490361A (en) * | 1983-12-02 | 1984-12-25 | Alpha Therapeutic Corporation | Virus inactivating heat treatment of plasma fractions |
AT385657B (de) * | 1984-03-09 | 1988-05-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
US5281579A (en) * | 1984-03-23 | 1994-01-25 | Baxter International Inc. | Purified virus-free hemoglobin solutions and method for making same |
JPS61501510A (ja) * | 1984-03-23 | 1986-07-24 | バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテッド | ビ−ルスリスクを減らしたヘモグロビンおよびその製造方法 |
US4831012A (en) * | 1984-03-23 | 1989-05-16 | Baxter International Inc. | Purified hemoglobin solutions and method for making same |
NL8401066A (nl) * | 1984-04-04 | 1985-11-01 | Stichting Centraal Lab | Werkwijze ter bereiding van preparaten, die de humorale en cellulaire immuunreaktiviteit vergroten. |
US5185160A (en) * | 1984-06-21 | 1993-02-09 | Prp, Inc. | Platelet membrane microvesicles |
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
AT390001B (de) * | 1984-09-28 | 1990-03-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern |
AT390373B (de) * | 1984-10-02 | 1990-04-25 | Schwab & Co Gmbh | Verfahren zur pasteurisation von plasmaproteinen bzw. von plasmaproteinfraktionen |
DE3577801D1 (de) * | 1985-08-05 | 1990-06-28 | Immuno Ag | Verfahren zur herstellung von praeparationen auf basis von blutgerinnungsfaktoren. |
CA1276563C (en) * | 1985-09-30 | 1990-11-20 | Stanley E. Charm | High temperature, short time heating system and method of sterilizing heat-sensitive biological fluids |
EP0225581A3 (en) * | 1985-11-30 | 1989-05-24 | Green Cross Corporation | Method for the heat-treatment of immunoglobulins and immunoglobulin product |
DK595285D0 (da) * | 1985-12-20 | 1985-12-20 | Nordisk Gentofte | Injicerbart og varmebehandet igg-praeparat og fremgangsmaade til fremstilling af samme |
DK155886D0 (da) * | 1986-04-04 | 1986-04-04 | Bo Arne Hofmann | Vaccine og fremgangsmaade til fremstilling af denne |
AT391808B (de) * | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
US5118795A (en) * | 1987-05-15 | 1992-06-02 | University Of Southern California | Sequential heat treatment of blood-clotting factor products |
US5097018A (en) * | 1988-05-12 | 1992-03-17 | University Of Southern California | Sequential heat treatment of blood-clotting factor products |
AU2251288A (en) * | 1987-05-15 | 1988-12-06 | Alan I. Rubinstein | Sequential improved method for treatment of human blood- clotting factor products |
US5099002A (en) * | 1987-05-15 | 1992-03-24 | University Of Southern California | Sequential improved method for treatment of human blood-clotting factor products |
US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
US4861867A (en) * | 1988-02-03 | 1989-08-29 | Baxter International, Inc. | Purified hemoglobin solutions and method for making same |
EP0378208B2 (en) * | 1989-01-13 | 2003-01-15 | Mitsubishi Pharma Corporation | Production method for protein-containing composition |
US5332578A (en) * | 1989-04-14 | 1994-07-26 | Prp, Inc. | Platelet membrane microparticles |
AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
AT399818B (de) * | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
JPH06166634A (ja) * | 1992-12-01 | 1994-06-14 | Green Cross Corp:The | プラスミノーゲン含有組成物の製造方法 |
JP3133338B2 (ja) * | 1992-12-16 | 2001-02-05 | イムノ・アクチエンゲゼルシャフト | ウイルス的に安全な生物学的組成物の調製方法 |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
DE4404625C2 (de) * | 1994-02-14 | 1996-10-17 | Ludwig Dr Baumgartner | Verfahren zur Inaktivierung thermolabiler Viren in biologischem Material unter Beibehaltung der kollagenen Eigenschaften |
DE4441167C1 (de) * | 1994-11-18 | 1996-03-14 | Fraunhofer Ges Forschung | Verfahren zur Trocknung von Blutplasma |
US20030143518A1 (en) * | 1994-11-18 | 2003-07-31 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Method of drying blood plasma |
GB9424732D0 (en) * | 1994-12-08 | 1995-02-08 | Common Services Agency | Heat treated blood plasma proteins |
US5741894A (en) * | 1995-09-22 | 1998-04-21 | Baxter International, Inc. | Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
DE19623293C2 (de) * | 1996-06-11 | 1998-10-22 | Biotest Pharma Gmbh | Nicht-immunogene Faktor VIII-enthaltende Zusammensetzung und ein Verfahren zu ihrer Herstellung |
US5837519A (en) * | 1996-11-21 | 1998-11-17 | Bayer Corporation | Dry-heat viral inactivation under controlled moisture conditions |
DK2193809T3 (en) | 1999-02-22 | 2015-05-26 | Univ Connecticut | The albumin-free Factor VIII formulation |
JP4663837B2 (ja) * | 1999-12-24 | 2011-04-06 | 一般財団法人化学及血清療法研究所 | 第▲viii▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物 |
FR2857267B1 (fr) | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
AU2006274835B2 (en) | 2005-07-29 | 2012-05-24 | Abbott Laboratories Gmbh | Processes for the manufacture of sterilized pancreatin powder |
FR2894830B1 (fr) * | 2005-12-19 | 2008-04-04 | Lab Francais Du Fractionnement | Procede d'inactivation virale par chauffage a sec selon la temperature de transition vitreuse |
MX339060B (es) | 2008-11-07 | 2016-05-09 | Baxter Int | Formulaciones del factor viii. |
CN111295094A (zh) | 2017-10-09 | 2020-06-16 | 泰尔茂比司特生物技术有限公司 | 冻干容器及使用冻干容器的方法 |
JP2022525742A (ja) | 2019-03-14 | 2022-05-19 | テルモ ビーシーティー バイオテクノロジーズ,エルエルシー | 凍結乾燥用ローディングトレイ組立体及びシステム |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3100737A (en) * | 1958-02-05 | 1963-08-13 | Auerswald Wilhelm | Method of preparing a plasma protein solution free of active hepatitis virus and product produced thereby |
US3041242A (en) * | 1958-06-17 | 1962-06-26 | Sr Courtland H Barr | Gas and heat sterilization of dried human plasma |
US3859168A (en) * | 1967-06-22 | 1975-01-07 | Behringwerke Ag | Process of inactivating rabies virus |
DE1617350C3 (de) * | 1967-06-22 | 1979-09-06 | Behringwerke Ag, 3550 Marburg | Verfahren zur Inaktivierung von biologischem Material |
US3579631A (en) * | 1968-05-21 | 1971-05-18 | Aubrey P Stewart Jr | Sterilization of materials containing protein |
GB1471336A (en) * | 1973-04-16 | 1977-04-21 | Armour Pharma | Process for the purification and sterilisation of acidophilic biologicals- |
US3998516A (en) * | 1973-05-15 | 1976-12-21 | Mabuchi Motor Co. Ltd. | Adapter |
JPS6015B2 (ja) * | 1977-07-16 | 1985-01-05 | 株式会社新潟鐵工所 | 水溶性かつ熱凝固性を有する殺菌された血粉の製造方法 |
US4250139A (en) * | 1979-02-01 | 1981-02-10 | Collagen Corporation | Microwave sterilization of dry protein |
DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
JPS56135418A (en) * | 1980-03-27 | 1981-10-22 | Green Cross Corp:The | Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human |
DE3043857A1 (de) * | 1980-11-21 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii |
DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
JPS57140724A (en) * | 1981-02-25 | 1982-08-31 | Green Cross Corp:The | Heat-treatment of aqueous solution containing cold insoluble globulin |
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
US4456590B2 (en) * | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate |
-
1982
- 1982-05-13 US US06377863 patent/US4456590B2/en not_active Expired - Lifetime
-
1983
- 1983-05-09 IE IE1068/83A patent/IE55008B1/en not_active IP Right Cessation
- 1983-05-10 AU AU14421/83A patent/AU554282B2/en not_active Expired
- 1983-05-10 ZA ZA833315A patent/ZA833315B/xx unknown
- 1983-05-11 DE DE8383104642T patent/DE3364057D1/de not_active Expired
- 1983-05-11 DK DK210283A patent/DK171796B1/da not_active IP Right Cessation
- 1983-05-11 EP EP85103962A patent/EP0171506B1/en not_active Expired - Lifetime
- 1983-05-11 BE BE0/210752A patent/BE896724A/fr not_active IP Right Cessation
- 1983-05-11 CH CH2598/83A patent/CH665125A5/de not_active IP Right Cessation
- 1983-05-11 GB GB8312915A patent/GB2120254B/en not_active Expired
- 1983-05-11 EP EP83104642A patent/EP0094611B1/en not_active Expired
- 1983-05-11 DE DE198585103962T patent/DE171506T1/de active Pending
- 1983-05-11 AR AR29298783A patent/AR230186A1/es active
- 1983-05-11 DE DE19833382716 patent/DE3382716T2/de not_active Expired - Fee Related
- 1983-05-12 BR BR8302504A patent/BR8302504A/pt unknown
- 1983-05-12 MX MX026844A patent/MX172861B/es unknown
- 1983-05-12 ES ES522310A patent/ES522310A0/es active Granted
- 1983-05-12 CA CA000427988A patent/CA1203165A/en not_active Expired
- 1983-05-12 JP JP58083434A patent/JPS58213721A/ja active Pending
- 1983-05-13 AT AT1767/83A patent/AT392905B/de not_active IP Right Cessation
- 1983-05-13 LU LU84804A patent/LU84804A1/fr unknown
- 1983-05-13 FR FR8308000A patent/FR2526660B1/fr not_active Expired
- 1983-12-05 GB GB8332374A patent/GB2144428B/en not_active Expired
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1984
- 1984-09-07 ES ES535745A patent/ES8505821A1/es not_active Expired
- 1984-12-19 ES ES538803A patent/ES538803A0/es active Granted
- 1984-12-19 ES ES538802A patent/ES8601700A1/es not_active Expired
- 1984-12-19 ES ES538801A patent/ES8601699A1/es not_active Expired
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1986
- 1986-05-21 AU AU57660/86A patent/AU568979B2/en not_active Expired
- 1986-05-21 AU AU57659/86A patent/AU569428B2/en not_active Expired
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Date | Code | Title | Description |
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FD1A | Patent lapsed |
Effective date: 20040604 |