ES8601700A1 - Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre - Google Patents

Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre

Info

Publication number
ES8601700A1
ES8601700A1 ES538802A ES538802A ES8601700A1 ES 8601700 A1 ES8601700 A1 ES 8601700A1 ES 538802 A ES538802 A ES 538802A ES 538802 A ES538802 A ES 538802A ES 8601700 A1 ES8601700 A1 ES 8601700A1
Authority
ES
Spain
Prior art keywords
plasma
heat treatment
compositions obtained
instance
fractions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538802A
Other languages
English (en)
Other versions
ES538802A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23490802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8601700(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of ES538802A0 publication Critical patent/ES538802A0/es
Publication of ES8601700A1 publication Critical patent/ES8601700A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/12—Microwaves
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

METODO PARA TRATAR UN CONCENTRADO DEL FACTOR IX DE COAGULACION DE LA SANGRE. COMPRENDE: LIOFILIZAR UN CONCENTRADO DEL FACTOR IX DE COAGULACION DE LA SANGRE, SEGUIDO DE CALENTAMIENTO DEL CONCENTRADO DEL FACTOR IX DE COAGULACION DE LA SANGRE A UNA TEMPERATURA PREDETERMINADA DE 60C, DURANTE UN PERIODO DE TIEMPO PARA CONVERTIR EN NO INFECCIOSO AL VIRUS DE LA HEPATITIS NO DE TIPO A, AL VIRUS DE LA HEPATITIS NO DE TIPO B, A UN VIRUS RELACIONADO CON EL CITOMEGALOVIRUS DEL SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (AIDS) O AL VIRUS EPTSTEIN-BARR, PRESENTES EN EL CONCENTRADO DEL FACTOR IX DE COAGULACION DE LA SANGRE. SE EMPLEA UN CONCENTRADO ESENCIALMENTE EXENTO DE LOS FACTORES II, VII, X, XII Y XIII O SUS FORMAS ACTIVAS, QUE TIENE UNA RELACION DE UNIDADES ANTIHEMOFIILICAS DE CUALQUIER ENZIMA DE COAGULACION DE LA SANGRE DE 10:1 A 500:1, Y DONDE EL FACTOR ANTIHEMOFILICO ESTA PURIFICADO HASTA UNA ACTIVIDAD POR PESO UNITARIO DE PROTEINA MAYOR QUE LA CONCENTRACION DEL FACTOR EN EL PLASMA HUMANO NORMAL.
ES538802A 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre Expired ES8601700A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06377863 US4456590B2 (en) 1981-11-02 1982-05-13 Heat treatment of lyphilized blood clotting factor viii concentrate

Publications (2)

Publication Number Publication Date
ES538802A0 ES538802A0 (es) 1985-11-01
ES8601700A1 true ES8601700A1 (es) 1985-11-01

Family

ID=23490802

Family Applications (5)

Application Number Title Priority Date Filing Date
ES522310A Expired ES8501627A1 (es) 1982-05-13 1983-05-12 Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo.
ES535745A Granted ES535745A0 (es) 1982-05-13 1984-09-07 Un metodo de producir una vacuna para la hepatitis
ES538801A Granted ES538801A0 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor viii de coagulacion de la sangre
ES538803A Expired ES8601701A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado de fibrinogeno
ES538802A Expired ES8601700A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES522310A Expired ES8501627A1 (es) 1982-05-13 1983-05-12 Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo.
ES535745A Granted ES535745A0 (es) 1982-05-13 1984-09-07 Un metodo de producir una vacuna para la hepatitis
ES538801A Granted ES538801A0 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor viii de coagulacion de la sangre
ES538803A Expired ES8601701A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado de fibrinogeno

Country Status (19)

Country Link
US (1) US4456590B2 (es)
EP (2) EP0171506B1 (es)
JP (1) JPS58213721A (es)
AR (1) AR230186A1 (es)
AT (1) AT392905B (es)
AU (3) AU554282B2 (es)
BE (1) BE896724A (es)
BR (1) BR8302504A (es)
CA (1) CA1203165A (es)
CH (1) CH665125A5 (es)
DE (3) DE3382716T2 (es)
DK (1) DK171796B1 (es)
ES (5) ES8501627A1 (es)
FR (1) FR2526660B1 (es)
GB (2) GB2120254B (es)
IE (1) IE55008B1 (es)
LU (1) LU84804A1 (es)
MX (1) MX172861B (es)
ZA (1) ZA833315B (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
US4994438A (en) * 1981-11-02 1991-02-19 Cedars Sinai Medical Center Heat treatment of lyophilized plasma fractions
DE3230849A1 (de) * 1982-08-19 1984-02-23 Behringwerke Ag, 3550 Marburg Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung
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US5281579A (en) * 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
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US5099002A (en) * 1987-05-15 1992-03-24 University Of Southern California Sequential improved method for treatment of human blood-clotting factor products
US5097018A (en) * 1988-05-12 1992-03-17 University Of Southern California Sequential heat treatment of blood-clotting factor products
US5118795A (en) * 1987-05-15 1992-06-02 University Of Southern California Sequential heat treatment of blood-clotting factor products
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
US4861867A (en) * 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
DE69011136T3 (de) * 1989-01-13 2003-10-23 Mitsubishi Pharma Corp Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung.
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GB9424732D0 (en) * 1994-12-08 1995-02-08 Common Services Agency Heat treated blood plasma proteins
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US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
DE19623293C2 (de) * 1996-06-11 1998-10-22 Biotest Pharma Gmbh Nicht-immunogene Faktor VIII-enthaltende Zusammensetzung und ein Verfahren zu ihrer Herstellung
US5837519A (en) * 1996-11-21 1998-11-17 Bayer Corporation Dry-heat viral inactivation under controlled moisture conditions
JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
JP4663837B2 (ja) * 1999-12-24 2011-04-06 一般財団法人化学及血清療法研究所 第▲ｖｉｉｉ▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
FR2857267B1 (fr) 2003-07-09 2006-03-10 Lab Francais Du Fractionnement Formulation stabilisante et solubilisante pour les proteines cryoprecipitables.
EP1913138B1 (en) * 2005-07-29 2016-08-24 Abbott Laboratories GmbH Processes for the manufacture of pancreatin powder with low virus content
FR2894830B1 (fr) 2005-12-19 2008-04-04 Lab Francais Du Fractionnement Procede d'inactivation virale par chauffage a sec selon la temperature de transition vitreuse
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
JP7495426B2 (ja) 2019-03-14 2024-06-04 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥容器用充填治具、システム及び使用方法

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Also Published As

Publication number Publication date
ES538803A0 (es) 1985-11-01
EP0171506B1 (en) 1993-09-22
AR230186A1 (es) 1984-03-01
US4456590B2 (en) 1989-05-30
BE896724A (fr) 1983-09-01
CH665125A5 (de) 1988-04-29
IE55008B1 (en) 1990-04-25
FR2526660A1 (fr) 1983-11-18
EP0094611A3 (en) 1984-08-22
EP0171506A1 (en) 1986-02-19
DE3382716T2 (de) 1994-03-31
ES522310A0 (es) 1984-12-01
ES8601701A1 (es) 1985-11-01
ES538802A0 (es) 1985-11-01
GB2120254A (en) 1983-11-30
MX172861B (es) 1994-01-17
EP0094611A2 (en) 1983-11-23
DK210283D0 (da) 1983-05-11
GB2144428B (en) 1986-03-12
GB2120254B (en) 1984-06-20
AU569428B2 (en) 1988-01-28
AU568979B2 (en) 1988-01-14
ES8601699A1 (es) 1985-11-01
EP0094611B1 (en) 1986-06-11
AU5765986A (en) 1986-10-09
ES8505821A1 (es) 1985-06-16
ZA833315B (en) 1984-01-25
AU5766086A (en) 1986-10-30
US4456590A (en) 1984-06-26
FR2526660B1 (fr) 1987-11-20
DK171796B1 (da) 1997-06-02
GB8312915D0 (en) 1983-06-15
AU554282B2 (en) 1986-08-14
GB2144428A (en) 1985-03-06
DK210283A (da) 1983-11-14
JPS58213721A (ja) 1983-12-12
IE831068L (en) 1983-11-13
DE3364057D1 (en) 1986-07-17
ES538801A0 (es) 1985-11-01
US4456590B1 (es) 1989-01-03
ES8501627A1 (es) 1984-12-01
DE3382716D1 (de) 1993-10-28
DE171506T1 (de) 1986-11-06
AT392905B (de) 1991-07-10
ATA176783A (de) 1985-10-15
GB8332374D0 (en) 1984-01-11
LU84804A1 (fr) 1983-11-17
AU1442183A (en) 1983-12-15
CA1203165A (en) 1986-04-15
BR8302504A (pt) 1983-10-25
ES535745A0 (es) 1985-06-16

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