ES8501627A1 - Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo. - Google Patents

Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo.

Info

Publication number
ES8501627A1
ES8501627A1 ES522310A ES522310A ES8501627A1 ES 8501627 A1 ES8501627 A1 ES 8501627A1 ES 522310 A ES522310 A ES 522310A ES 522310 A ES522310 A ES 522310A ES 8501627 A1 ES8501627 A1 ES 8501627A1
Authority
ES
Spain
Prior art keywords
plasma
heat treatment
compositions obtained
instance
fractions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522310A
Other languages
English (en)
Other versions
ES522310A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23490802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8501627(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of ES8501627A1 publication Critical patent/ES8501627A1/es
Publication of ES522310A0 publication Critical patent/ES522310A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/12—Microwaves
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

METODO PARA TRATAR UNA COMPOSICION SUSTANCIALMENTE SECA QUE INCLUYE FACTOR VIII DE PLASMA SANGUINEO, PARA REDUCIR O ELIMINAR LA CAPACIDAD DE INFECCION DE LOS MICROORGANISMOS PRESENTES EN LA COMPOSICION.CONSISTE EN CALENTAR LA COMPOSICION SUSTANCIALMENTE SECA DURANTE UN PERIODO DE TIEMPO PREDETERMINADO Y A UNA TEMPERATURA PREDETERMINADA, SUFICIENTE PARA REDUCIR O ELIMINAR LA CAPACIDAD INFECCIOSA DE LOS MICROORGANISMOS. A CONTINUACION SE AN/ADE AGUA ESTERIL A LA COMPOSICION, UNA VEZ COMPLETADA DICHA OPERACION DE CALENTAMIENTO, HASTA QUE SE CONSIGUE SUSTANCIALMENTE LA SOLUBILIZACION DE DICHA COMPOSICION.
ES522310A 1982-05-13 1983-05-12 Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo. Granted ES522310A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06377863 US4456590B2 (en) 1981-11-02 1982-05-13 Heat treatment of lyphilized blood clotting factor viii concentrate

Publications (2)

Publication Number Publication Date
ES8501627A1 true ES8501627A1 (es) 1984-12-01
ES522310A0 ES522310A0 (es) 1984-12-01

Family

ID=23490802

Family Applications (5)

Application Number Title Priority Date Filing Date
ES522310A Granted ES522310A0 (es) 1982-05-13 1983-05-12 Un metodo de tratar una composicion sustancialmente seca que incluye factor viii de plasma sanguineo.
ES535745A Expired ES8505821A1 (es) 1982-05-13 1984-09-07 Un metodo de producir una vacuna para la hepatitis
ES538803A Expired ES8601701A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado de fibrinogeno
ES538801A Granted ES538801A0 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor viii de coagulacion de la sangre
ES538802A Expired ES8601700A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES535745A Expired ES8505821A1 (es) 1982-05-13 1984-09-07 Un metodo de producir una vacuna para la hepatitis
ES538803A Expired ES8601701A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado de fibrinogeno
ES538801A Granted ES538801A0 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor viii de coagulacion de la sangre
ES538802A Expired ES8601700A1 (es) 1982-05-13 1984-12-19 Un metodo para tratar un concentrado del factor ix de coagulacion de la sangre

Country Status (19)

Country Link
US (1) US4456590B2 (es)
EP (2) EP0094611B1 (es)
JP (1) JPS58213721A (es)
AR (1) AR230186A1 (es)
AT (1) AT392905B (es)
AU (3) AU554282B2 (es)
BE (1) BE896724A (es)
BR (1) BR8302504A (es)
CA (1) CA1203165A (es)
CH (1) CH665125A5 (es)
DE (3) DE171506T1 (es)
DK (1) DK171796B1 (es)
ES (5) ES522310A0 (es)
FR (1) FR2526660B1 (es)
GB (2) GB2120254B (es)
IE (1) IE55008B1 (es)
LU (1) LU84804A1 (es)
MX (1) MX172861B (es)
ZA (1) ZA833315B (es)

Families Citing this family (54)

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US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions
US4994438A (en) * 1981-11-02 1991-02-19 Cedars Sinai Medical Center Heat treatment of lyophilized plasma fractions
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
DE3230849A1 (de) * 1982-08-19 1984-02-23 Behringwerke Ag, 3550 Marburg Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung
ZA838856B (en) * 1982-12-02 1984-07-25 Usv Pharma Corp Hepatitis b and non-a-non-b-safe biological products
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JPS6054287B2 (ja) * 1983-10-19 1985-11-29 株式会社ミドリ十字 血漿蛋白の加熱処理方法
US4490361A (en) * 1983-12-02 1984-12-25 Alpha Therapeutic Corporation Virus inactivating heat treatment of plasma fractions
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US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
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US5185160A (en) * 1984-06-21 1993-02-09 Prp, Inc. Platelet membrane microvesicles
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AT390373B (de) * 1984-10-02 1990-04-25 Schwab & Co Gmbh Verfahren zur pasteurisation von plasmaproteinen bzw. von plasmaproteinfraktionen
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US5097018A (en) * 1988-05-12 1992-03-17 University Of Southern California Sequential heat treatment of blood-clotting factor products
AU2251288A (en) * 1987-05-15 1988-12-06 Alan I. Rubinstein Sequential improved method for treatment of human blood- clotting factor products
US5118795A (en) * 1987-05-15 1992-06-02 University Of Southern California Sequential heat treatment of blood-clotting factor products
US5099002A (en) * 1987-05-15 1992-03-24 University Of Southern California Sequential improved method for treatment of human blood-clotting factor products
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
US4861867A (en) * 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
ES2057191T5 (es) * 1989-01-13 2003-05-01 Mitsubishi Pharma Corp Metodo de produccion para una composicion que contiene proteinas.
US5332578A (en) * 1989-04-14 1994-07-26 Prp, Inc. Platelet membrane microparticles
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
JPH06166634A (ja) * 1992-12-01 1994-06-14 Green Cross Corp:The プラスミノーゲン含有組成物の製造方法
JP3133338B2 (ja) * 1992-12-16 2001-02-05 イムノ・アクチエンゲゼルシャフト ウイルス的に安全な生物学的組成物の調製方法
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DE4404625C2 (de) * 1994-02-14 1996-10-17 Ludwig Dr Baumgartner Verfahren zur Inaktivierung thermolabiler Viren in biologischem Material unter Beibehaltung der kollagenen Eigenschaften
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US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6632648B1 (en) * 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
DE19623293C2 (de) * 1996-06-11 1998-10-22 Biotest Pharma Gmbh Nicht-immunogene Faktor VIII-enthaltende Zusammensetzung und ein Verfahren zu ihrer Herstellung
US5837519A (en) * 1996-11-21 1998-11-17 Bayer Corporation Dry-heat viral inactivation under controlled moisture conditions
PT2130554E (pt) 1999-02-22 2012-11-19 Univ Connecticut Formulações de factor viii isentas de albumina
JP4663837B2 (ja) * 1999-12-24 2011-04-06 一般財団法人化学及血清療法研究所 第▲ｖｉｉｉ▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
FR2857267B1 (fr) 2003-07-09 2006-03-10 Lab Francais Du Fractionnement Formulation stabilisante et solubilisante pour les proteines cryoprecipitables.
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FR2894830B1 (fr) * 2005-12-19 2008-04-04 Lab Francais Du Fractionnement Procede d'inactivation virale par chauffage a sec selon la temperature de transition vitreuse
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CN111295094A (zh) 2017-10-09 2020-06-16 泰尔茂比司特生物技术有限公司 冻干容器及使用冻干容器的方法
JP2022525398A (ja) 2019-03-14 2022-05-13 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥容器用充填治具、システム及び使用方法

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Also Published As

Publication number Publication date
ES538803A0 (es) 1985-11-01
IE55008B1 (en) 1990-04-25
AU568979B2 (en) 1988-01-14
GB2120254A (en) 1983-11-30
AU1442183A (en) 1983-12-15
GB2120254B (en) 1984-06-20
DK210283A (da) 1983-11-14
GB2144428A (en) 1985-03-06
DK171796B1 (da) 1997-06-02
ES538802A0 (es) 1985-11-01
GB8312915D0 (en) 1983-06-15
CH665125A5 (de) 1988-04-29
US4456590B2 (en) 1989-05-30
US4456590A (en) 1984-06-26
ES535745A0 (es) 1985-06-16
BE896724A (fr) 1983-09-01
IE831068L (en) 1983-11-13
EP0094611B1 (en) 1986-06-11
ES8601699A1 (es) 1985-11-01
LU84804A1 (fr) 1983-11-17
AU5766086A (en) 1986-10-30
US4456590B1 (es) 1989-01-03
DE3364057D1 (en) 1986-07-17
AR230186A1 (es) 1984-03-01
AU554282B2 (en) 1986-08-14
EP0094611A3 (en) 1984-08-22
FR2526660B1 (fr) 1987-11-20
EP0171506A1 (en) 1986-02-19
AU5765986A (en) 1986-10-09
MX172861B (es) 1994-01-17
CA1203165A (en) 1986-04-15
DK210283D0 (da) 1983-05-11
ATA176783A (de) 1985-10-15
FR2526660A1 (fr) 1983-11-18
DE3382716T2 (de) 1994-03-31
ES8601701A1 (es) 1985-11-01
DE171506T1 (de) 1986-11-06
GB2144428B (en) 1986-03-12
ZA833315B (en) 1984-01-25
ES8601700A1 (es) 1985-11-01
ES538801A0 (es) 1985-11-01
EP0094611A2 (en) 1983-11-23
BR8302504A (pt) 1983-10-25
EP0171506B1 (en) 1993-09-22
ES522310A0 (es) 1984-12-01
DE3382716D1 (de) 1993-10-28
ES8505821A1 (es) 1985-06-16
AU569428B2 (en) 1988-01-28
AT392905B (de) 1991-07-10
JPS58213721A (ja) 1983-12-12
GB8332374D0 (en) 1984-01-11

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