ES8502114A1 - Un procedimiento para preparar una beta-lactama. - Google Patents

Un procedimiento para preparar una beta-lactama.

Info

Publication number
ES8502114A1
ES8502114A1 ES524698A ES524698A ES8502114A1 ES 8502114 A1 ES8502114 A1 ES 8502114A1 ES 524698 A ES524698 A ES 524698A ES 524698 A ES524698 A ES 524698A ES 8502114 A1 ES8502114 A1 ES 8502114A1
Authority
ES
Spain
Prior art keywords
analogs
oxoazetidin
acetic acids
yloxy acetic
yloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524698A
Other languages
English (en)
Other versions
ES524698A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8502114A1 publication Critical patent/ES8502114A1/es
Publication of ES524698A0 publication Critical patent/ES524698A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA BETA-LACTAMA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA BETA-LACTAMA QUE TIENE UN GRUPO HIDROXILO EN LA POSICION 1, PARA OBTENER UN COMPUESTO DE FORMULA (I), Y CUANDO EL SUSTITUYENTE AMINO EN LA POSICION 1 ESTA PROTEGIDO, SEPARAR OPCIONALMENTE DICHO GRUPO PROTECTOR PARA FORMAR UN PRODUCTO QUE TIENE UN SUSTITUYENTE AMINO EN LA POSICION 1 Y OPCIONALMENTE ACILAR DICHO PRODUCTO PARA FORMAR OTRO QUE TENGA UN SUSTITUYENTE ACILAMINO EN LA POSICION 1. DONDE R1 ES ACILO, H U OTROS, R2 ES H O METOXILO, R3 Y R4 SON H, ALQUILO U OTROS Y R5 Y R6 SON H, ALQUILO, ALQUILENO U OTROS.SE UTILIZAN EN FARMACIA COMO COMPUESTOS ANTIBACTERIANOS.
ES524698A 1982-08-04 1983-08-03 Un procedimiento para preparar una beta-lactama. Granted ES524698A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40494582A 1982-08-04 1982-08-04

Publications (2)

Publication Number Publication Date
ES8502114A1 true ES8502114A1 (es) 1984-12-16
ES524698A0 ES524698A0 (es) 1984-12-16

Family

ID=23601669

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524698A Granted ES524698A0 (es) 1982-08-04 1983-08-03 Un procedimiento para preparar una beta-lactama.

Country Status (33)

Country Link
US (1) US4939253A (es)
JP (1) JPS5993046A (es)
KR (1) KR900001211B1 (es)
AR (1) AR241158A1 (es)
AT (1) AT382367B (es)
AU (1) AU568086B2 (es)
BE (1) BE897466A (es)
CH (1) CH655309A5 (es)
CS (4) CS243498B2 (es)
DD (1) DD213919A5 (es)
DE (1) DE3328047A1 (es)
DK (1) DK354683A (es)
ES (1) ES524698A0 (es)
FI (1) FI832675A (es)
FR (1) FR2531427A1 (es)
GB (1) GB2125794B (es)
GR (1) GR79368B (es)
HU (1) HU191058B (es)
IE (1) IE55839B1 (es)
IL (1) IL69381A (es)
IN (1) IN160955B (es)
IT (1) IT1224129B (es)
LU (1) LU84947A1 (es)
NL (1) NL8302746A (es)
NO (1) NO832801L (es)
NZ (1) NZ205111A (es)
PL (3) PL243308A1 (es)
PT (1) PT77155B (es)
RO (1) RO86511B (es)
SE (1) SE8304256L (es)
SU (1) SU1329617A3 (es)
YU (1) YU43324B (es)
ZA (1) ZA835470B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs
US4548747A (en) * 1983-05-02 1985-10-22 E. R. Squibb & Sons, Inc. 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones
EP0127177B1 (en) * 1983-05-31 1988-12-21 E.R. Squibb & Sons, Inc. [[(3-Acylamino-2-oxo-1-azetidinyl)oxy]methyl]phosphinic acids
US4534896A (en) * 1983-06-13 1985-08-13 E. R. Squibb & Sons, Inc. 3-Acylamino-2-oxoazetidine-1-(β-oxopropionic acid)
US4548751A (en) * 1983-08-03 1985-10-22 E. R. Squibb & Sons, Inc. (2-Oxo-1-azetidinyloxy)-2-propenoic acid
AU581180B2 (en) * 1983-08-26 1989-02-16 E.R. Squibb & Sons, Inc. 1-(1h-tetrazol-5-ylalkoxy)-2-azetidinones
CA1243679A (en) * 1983-09-14 1988-10-25 Henner Straub 3-ACYLAMINO-2-OXO-1-AZETIDINYL-.beta.-OXYPROPIONATES
EP0135194A1 (en) * 1983-09-16 1985-03-27 Takeda Chemical Industries, Ltd. Azetidinones and their production
WO1985004876A1 (en) * 1984-04-24 1985-11-07 Takeda Chemical Industries, Ltd. 2-azetidinone derivatives and process for their preparation
US4576749A (en) * 1983-10-03 1986-03-18 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones
US4559335A (en) * 1983-10-03 1985-12-17 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethyloxy (or thio) carbonyl-2-azetidinones
US4551277A (en) * 1983-11-09 1985-11-05 E. R. Squibb & Sons, Inc. 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid
US4581170A (en) * 1984-08-03 1986-04-08 E. R. Squibb & Sons, Inc. N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
EG18314A (en) * 1985-09-26 1993-02-28 Squibb & Sons Inc Process for preparing of 2-oxo-1((substituted sulfonyl)amino)carbonyl)-azitidines
US5112968A (en) * 1989-07-28 1992-05-12 E. R. Squibb & Sons, Inc. Monobactam hydrazide derivatives
JP2008520686A (ja) * 2004-11-17 2008-06-19 スミスクライン・ビーチャム・コーポレイション 新規な抗菌化合物の使用
RS52068B (en) * 2005-12-07 2012-06-30 Basilea Pharmaceutica Ag. USEFUL MANOBACTAM ANTIBIOTICS
WO2014164526A1 (en) * 2013-03-13 2014-10-09 Rempex Pharmaceuticals, Inc. Oxamazin antibiotics
US20140275007A1 (en) * 2013-03-14 2014-09-18 Rempex Pharmaceuticals, Inc. Oxamazin antibiotics

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ205240A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
EP0048953B1 (en) * 1980-09-29 1988-03-09 E.R. Squibb & Sons, Inc. Beta-lactam antibiotics
US4337197A (en) * 1980-10-31 1982-06-29 E. R. Squibb & Sons, Inc. O-sulfated β-lactam hydroxamic acids and intermediates
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs

Also Published As

Publication number Publication date
RO86511A (ro) 1985-03-15
IL69381A (en) 1987-07-31
NO832801L (no) 1984-02-06
YU43324B (en) 1989-06-30
DK354683A (da) 1984-02-05
PL257440A1 (en) 1986-10-07
IE55839B1 (en) 1991-01-30
PT77155B (en) 1986-01-28
YU162783A (en) 1986-02-28
SE8304256L (sv) 1984-02-05
FI832675A (fi) 1984-02-05
NL8302746A (nl) 1984-03-01
CS26783A2 (en) 1985-08-31
US4939253A (en) 1990-07-03
RO86511B (ro) 1985-03-31
AR241158A1 (es) 1991-12-30
AT382367B (de) 1987-02-25
ZA835470B (en) 1984-04-25
AU568086B2 (en) 1987-12-17
ATA281283A (de) 1986-07-15
FI832675A0 (fi) 1983-07-22
CS243498B2 (en) 1986-06-12
PL243308A1 (en) 1985-12-17
IL69381A0 (en) 1983-11-30
IN160955B (es) 1987-08-22
SU1329617A3 (ru) 1987-08-07
KR840005814A (ko) 1984-11-19
GB2125794A (en) 1984-03-14
GB8320497D0 (en) 1983-09-01
FR2531427A1 (fr) 1984-02-10
GB2125794B (en) 1985-12-18
NZ205111A (en) 1986-06-11
AU1755683A (en) 1984-02-09
KR900001211B1 (ko) 1990-02-28
CS26885A2 (en) 1985-08-31
SE8304256D0 (sv) 1983-08-03
CH655309A5 (fr) 1986-04-15
PL257441A1 (en) 1986-10-07
FR2531427B1 (es) 1985-04-19
AR241158A2 (es) 1991-12-30
ES524698A0 (es) 1984-12-16
LU84947A1 (fr) 1984-03-23
IE831830L (en) 1984-02-04
CS243499B2 (en) 1986-06-12
BE897466A (fr) 1984-02-06
DD213919A5 (de) 1984-09-26
HU191058B (en) 1986-12-28
IT8322430A0 (it) 1983-08-04
CS575983A2 (en) 1985-08-15
IT1224129B (it) 1990-09-26
DE3328047A1 (de) 1984-02-09
GR79368B (es) 1984-10-22
JPS5993046A (ja) 1984-05-29
CS243474B2 (en) 1986-06-12
CS26785A2 (en) 1985-08-15
PT77155A (en) 1983-09-01
DK354683D0 (da) 1983-08-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303