ES8405007A1 - Procedimiento de preparacion de derivados de la quinuclidina - Google Patents
Procedimiento de preparacion de derivados de la quinuclidinaInfo
- Publication number
- ES8405007A1 ES8405007A1 ES524978A ES524978A ES8405007A1 ES 8405007 A1 ES8405007 A1 ES 8405007A1 ES 524978 A ES524978 A ES 524978A ES 524978 A ES524978 A ES 524978A ES 8405007 A1 ES8405007 A1 ES 8405007A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- reacted
- formula
- derivatives substituted
- quinuclidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE LA QUINUCLIDINA, DE FORMULA ESTRUCTURAL (I), EN LA QUE X ES UN ATOMO DE HIDROGENO, CLORO, BROMO O YODO.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR, EN UN DISOLVENTE APROPIADO Y EN PRESENCIA DE UNA CANTIDAD CATALITICA DE UN HALOGENURO DE METAL DE TRANSICION, UN 3-METILENQUINUCLIDINA, DE FORMULA ESTRUCTURAL (II), CON UN HIDRURO DE ALUMINIO; SEGUNDA, EL PRODUCTO OBTENIDO EN LA REACCION ANTERIOR SE HACE REACCIONAR IN SITU CON UN ESTER; Y POR ULTIMO, SE APLICA SOBRE EL PRODUCTO FORMADO EN LAREACCION ANTERIOR UN REACTIVO ELECTROFILO SUSCEPTIBLE DE CEDER UN ATOMO, PARA OBTENER EL COMPUESTO DE FORMULA (I) BUSCADO.DE APLICACION COMO PRODUCTOS INTERMEDIARIOS EN LA PREPARACION DE MEDICAMENTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8214215A FR2531955A1 (fr) | 1982-08-17 | 1982-08-17 | Nouveau procede de preparation de derives de la quinuclidine substitues en position 3 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES524978A0 ES524978A0 (es) | 1984-05-16 |
ES8405007A1 true ES8405007A1 (es) | 1984-05-16 |
Family
ID=9276912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524978A Expired ES8405007A1 (es) | 1982-08-17 | 1983-08-16 | Procedimiento de preparacion de derivados de la quinuclidina |
Country Status (21)
Country | Link |
---|---|
US (1) | US4546185A (es) |
EP (1) | EP0102283B1 (es) |
JP (1) | JPS5953484A (es) |
AT (1) | AT389512B (es) |
AU (1) | AU557602B2 (es) |
BR (1) | BR8304411A (es) |
CA (1) | CA1199639A (es) |
DE (1) | DE3368062D1 (es) |
DK (1) | DK161834C (es) |
ES (1) | ES8405007A1 (es) |
FI (1) | FI73212C (es) |
FR (1) | FR2531955A1 (es) |
GR (1) | GR79193B (es) |
HU (1) | HU189731B (es) |
IE (1) | IE55846B1 (es) |
IL (1) | IL69125A0 (es) |
MA (1) | MA19879A1 (es) |
MX (1) | MX159102A (es) |
NO (1) | NO161318C (es) |
PT (1) | PT77197B (es) |
ZA (1) | ZA836022B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3827117A1 (de) * | 1988-08-10 | 1990-02-15 | Ruetgerswerke Ag | Verfahren zur herstellung von chinuclidin-3-methanol |
US5278170A (en) * | 1989-04-13 | 1994-01-11 | Beecham Group P.L.C. | Azabicylo oxime compounds |
ATE269330T1 (de) * | 1989-04-13 | 2004-07-15 | Beecham Group Plc | Chemische verbindungen |
WO1991007402A1 (en) * | 1989-11-17 | 1991-05-30 | Pfizer Inc. | Azabicyclo amides and esters as 5-ht3 receptor antagonists |
US5446050A (en) * | 1989-11-17 | 1995-08-29 | Pfizer Inc. | Azabicyclo amides and esters as 5-HT3 receptor antagonists |
WO1994013289A1 (fr) * | 1992-12-10 | 1994-06-23 | Tsentr Po Khimii Lekarstvennykh Sredstv | Compose pharmaceutique a proprietes antiulcereuses |
DE69601328T2 (de) * | 1995-06-05 | 1999-05-27 | Air Prod & Chem | Hydroxymethylchinuclidin-Katalysatorzusammensetzungen zur Herstellung von Polyurethanschäumen |
US5710191A (en) * | 1995-06-05 | 1998-01-20 | Air Products And Chemicals, Inc. | Hydroxymethyl quinuclidine catalyst compositions for making polyurethane foams |
FR2777278B1 (fr) * | 1998-04-09 | 2000-06-30 | Pf Medicament | Nouveau procede de preparation de la 3-hydroxymethyl quinuclidine, intermediaire de synthese de la mequitazine |
CN113929679B (zh) * | 2020-07-14 | 2023-08-11 | 北京博诺安科科技有限公司 | 一种3-氯甲基-1-氮杂双环[2.2.2]辛烷盐酸盐及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1250534A (es) * | 1969-03-03 | 1971-10-20 | ||
FR2052991A1 (en) * | 1969-06-20 | 1971-04-16 | Sogeras | N-(dibenzo (bf) azepines quinuclidines |
JPS53103426A (en) * | 1977-02-18 | 1978-09-08 | Sato Masao | Method of hydroalumination of olefin |
JPS6023117B2 (ja) * | 1980-11-10 | 1985-06-05 | 日産化学工業株式会社 | オレフインのハイドロアルミネ−シヨン法 |
-
1982
- 1982-08-17 FR FR8214215A patent/FR2531955A1/fr active Granted
-
1983
- 1983-06-30 IL IL69125A patent/IL69125A0/xx not_active IP Right Cessation
- 1983-07-12 GR GR71916A patent/GR79193B/el unknown
- 1983-08-02 DE DE8383401606T patent/DE3368062D1/de not_active Expired
- 1983-08-02 EP EP83401606A patent/EP0102283B1/fr not_active Expired
- 1983-08-09 CA CA000434200A patent/CA1199639A/fr not_active Expired
- 1983-08-11 HU HU832826A patent/HU189731B/hu not_active IP Right Cessation
- 1983-08-11 IE IE1890/83A patent/IE55846B1/en not_active IP Right Cessation
- 1983-08-11 US US06/522,288 patent/US4546185A/en not_active Expired - Fee Related
- 1983-08-12 PT PT77197A patent/PT77197B/pt not_active IP Right Cessation
- 1983-08-16 MA MA20101A patent/MA19879A1/fr unknown
- 1983-08-16 AU AU18050/83A patent/AU557602B2/en not_active Ceased
- 1983-08-16 FI FI832939A patent/FI73212C/fi not_active IP Right Cessation
- 1983-08-16 ES ES524978A patent/ES8405007A1/es not_active Expired
- 1983-08-16 JP JP58149530A patent/JPS5953484A/ja active Granted
- 1983-08-16 BR BR8304411A patent/BR8304411A/pt unknown
- 1983-08-16 AT AT0293983A patent/AT389512B/de not_active IP Right Cessation
- 1983-08-16 DK DK374483A patent/DK161834C/da not_active IP Right Cessation
- 1983-08-16 ZA ZA836022A patent/ZA836022B/xx unknown
- 1983-08-16 MX MX198399A patent/MX159102A/es unknown
- 1983-08-16 NO NO832945A patent/NO161318C/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO832945L (no) | 1984-02-20 |
AT389512B (de) | 1989-12-27 |
EP0102283A1 (fr) | 1984-03-07 |
DE3368062D1 (en) | 1987-01-15 |
GR79193B (es) | 1984-10-22 |
FI832939A0 (fi) | 1983-08-16 |
US4546185A (en) | 1985-10-08 |
FR2531955B1 (es) | 1984-12-21 |
MX159102A (es) | 1989-04-19 |
FR2531955A1 (fr) | 1984-02-24 |
IL69125A0 (en) | 1983-10-31 |
ZA836022B (en) | 1984-04-25 |
DK161834B (da) | 1991-08-19 |
IE831890L (en) | 1984-02-17 |
BR8304411A (pt) | 1984-03-27 |
DK374483D0 (da) | 1983-08-16 |
NO161318C (no) | 1989-08-02 |
PT77197B (fr) | 1986-02-03 |
CA1199639A (fr) | 1986-01-21 |
FI73212C (fi) | 1987-09-10 |
MA19879A1 (fr) | 1984-04-01 |
FI832939A (fi) | 1984-02-18 |
JPH0233716B2 (es) | 1990-07-30 |
AU1805083A (en) | 1984-02-23 |
PT77197A (fr) | 1983-09-01 |
JPS5953484A (ja) | 1984-03-28 |
FI73212B (fi) | 1987-05-29 |
IE55846B1 (en) | 1991-01-30 |
DK374483A (da) | 1984-02-18 |
NO161318B (no) | 1989-04-24 |
EP0102283B1 (fr) | 1986-12-03 |
ES524978A0 (es) | 1984-05-16 |
AU557602B2 (en) | 1986-12-24 |
ATA293983A (de) | 1989-05-15 |
DK161834C (da) | 1992-01-20 |
HU189731B (en) | 1986-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040601 |