ES8404345A1 - Un procedimiento de preparacion de derivados del acido hidroxi-2-tiofeno-acetico. - Google Patents

Un procedimiento de preparacion de derivados del acido hidroxi-2-tiofeno-acetico.

Info

Publication number
ES8404345A1
ES8404345A1 ES524648A ES524648A ES8404345A1 ES 8404345 A1 ES8404345 A1 ES 8404345A1 ES 524648 A ES524648 A ES 524648A ES 524648 A ES524648 A ES 524648A ES 8404345 A1 ES8404345 A1 ES 8404345A1
Authority
ES
Spain
Prior art keywords
acetic acid
thiophene acetic
hydroxy
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524648A
Other languages
English (en)
Other versions
ES524648A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES524648A0 publication Critical patent/ES524648A0/es
Publication of ES8404345A1 publication Critical patent/ES8404345A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO A-HIDROXI-2-TIOFENO-ACETICO, DE FORMULA ESTRUCTURAL (I), EN LA QUE R REPRESENTA UN RADICAL ALQUILO DE 1 A 4 ATOMOS DE CARBONO; Y R1, R2 Y R3, IGUALES O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO CON 1 A 4 ATOMOS DE CARBONO.CONSISTE EN HACER REACCIONAR UN PRODUCTO DE FORMULA (II) EN LA QUE X REPRESENTA UN ATOMO DE HALOGENO, CON UN PRODUCTO DE FORMULA (III), EN LA QUE R TIENE EL SIGNIFICADO INDICADO; Y A REPRESENTA UN ATOMO DE HIDROGENO, UNATOMO DE METAL ALCALINO O UN ATOMO DE UN METAL ALCALINOTERREO. EL PRODUCTO OBTENIDO SE SOMETE A HIDROLISIS DEL GRUPO MAGNESIANO, PARA OBTENER EL PRODUCTO DE FORMULA (I) BUSCADO.DE APLICACION COMO PRODUCTOS INTERMEDIOS UTILIZABLES EN LA PREPARACION DE COMPUESTOS FARMACEUTICOS, EN PARTICULAR ANTIINFLAMATORIOS.
ES524648A 1983-04-28 1983-08-01 Un procedimiento de preparacion de derivados del acido hidroxi-2-tiofeno-acetico. Expired ES8404345A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8307021A FR2545085B1 (fr) 1983-04-28 1983-04-28 Nouveau procede de preparation de derives de l'acide a-hydroxy 2-thiophene acetique

Publications (2)

Publication Number Publication Date
ES524648A0 ES524648A0 (es) 1984-05-01
ES8404345A1 true ES8404345A1 (es) 1984-05-01

Family

ID=9288331

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524648A Expired ES8404345A1 (es) 1983-04-28 1983-08-01 Un procedimiento de preparacion de derivados del acido hidroxi-2-tiofeno-acetico.

Country Status (22)

Country Link
JP (1) JPS59204185A (es)
KR (1) KR900006558B1 (es)
AT (1) AT392786B (es)
AU (1) AU559749B2 (es)
BE (1) BE897362A (es)
CA (1) CA1201443A (es)
CH (1) CH655316A5 (es)
DE (1) DE3325456A1 (es)
DK (1) DK157493C (es)
ES (1) ES8404345A1 (es)
FI (1) FI832473L (es)
FR (1) FR2545085B1 (es)
GB (1) GB2139215B (es)
HU (1) HU194206B (es)
IE (1) IE55905B1 (es)
IT (1) IT1171855B (es)
LU (1) LU84931A1 (es)
NL (1) NL8302564A (es)
NZ (1) NZ205514A (es)
PT (1) PT77010B (es)
SE (1) SE451018B (es)
ZA (1) ZA835613B (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1067828A (fr) * 1951-01-19 1954-06-18 Sterling Drug Inc Perfectionnements relatifs à un procédé de préparation de produits chimiques organiques
GB806710A (en) * 1955-07-05 1958-12-31 Metal & Thermit Corp Reactions of organomagnesium chloride complexes
GB820083A (en) * 1955-07-05 1959-09-16 Metal & Thermit Corp Reactions of organomagnesium chloride reagents
FR2068425B1 (es) * 1969-11-12 1973-01-12 Roussel Uclaf
FR2167334A1 (en) * 1972-01-13 1973-08-24 Roussel Uclaf 4-aroyl-5-alkylthiophene-2-acetic acids - with analgesic and antiinflammatory activity
GB1584120A (en) * 1977-07-21 1981-02-04 Sagami Chem Res Process for the preparation of thiophene derivatives and thiophene derivatives obtained therethrough
GB2030131B (en) * 1978-09-12 1982-12-22 Taiyo Pharma Ind Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
JPS5835145A (ja) * 1981-08-26 1983-03-01 Taisho Pharmaceut Co Ltd α−アリ−ルアルカン酸エステルの製造法

Also Published As

Publication number Publication date
DK157493B (da) 1990-01-15
AT392786B (de) 1991-06-10
DK307583A (da) 1984-10-29
ZA835613B (en) 1985-03-27
ES524648A0 (es) 1984-05-01
NL8302564A (nl) 1984-11-16
SE451018B (sv) 1987-08-24
DE3325456C2 (es) 1993-04-29
KR840008351A (ko) 1984-12-14
ATA286883A (de) 1990-11-15
GB2139215A (en) 1984-11-07
JPS59204185A (ja) 1984-11-19
HU194206B (en) 1988-01-28
PT77010A (fr) 1983-08-01
GB8323492D0 (en) 1983-10-05
IT8348823A0 (it) 1983-08-08
SE8303887D0 (sv) 1983-07-07
KR900006558B1 (ko) 1990-09-13
DK157493C (da) 1990-06-11
CH655316A5 (fr) 1986-04-15
IE55905B1 (en) 1991-02-14
AU1730983A (en) 1984-11-01
JPH0439469B2 (es) 1992-06-29
BE897362A (fr) 1984-01-25
LU84931A1 (fr) 1984-03-22
DK307583D0 (da) 1983-07-04
FR2545085B1 (fr) 1985-10-25
FR2545085A1 (fr) 1984-11-02
CA1201443A (fr) 1986-03-04
DE3325456A1 (de) 1984-10-31
PT77010B (fr) 1986-04-11
FI832473L (fi) 1984-10-29
AU559749B2 (en) 1987-03-19
NZ205514A (en) 1987-03-31
IE832074L (en) 1984-10-28
IT1171855B (it) 1987-06-10
SE8303887L (sv) 1984-10-29
GB2139215B (en) 1986-10-08
FI832473A0 (fi) 1983-07-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040223