ES467513A1 - Un procedimiento para la preparacion de un compuesto - Google Patents

Un procedimiento para la preparacion de un compuesto

Info

Publication number
ES467513A1
ES467513A1 ES467513A ES467513A ES467513A1 ES 467513 A1 ES467513 A1 ES 467513A1 ES 467513 A ES467513 A ES 467513A ES 467513 A ES467513 A ES 467513A ES 467513 A1 ES467513 A1 ES 467513A1
Authority
ES
Spain
Prior art keywords
clavulanic
image
formula
group
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467513A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB10082/77A external-priority patent/GB1582864A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES467513A1 publication Critical patent/ES467513A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de derivados del ácido clavulánico de fórmula (II): **(Fórmula)** donde R1 es un grupo tal que CO2R1 es un grupo éster; R3 es un átomo de hidrógeno o un grupo alquilo de 1 a 4 átomos de carbono; R4 es un átomo de hidrógeno o un grupo alquilo de 1 a 4 átomo de carbono y R5 es un grupo tal que el radical CR3R4R5 es un grupo orgánico inerte de hasta 18 átomos de carbono.
ES467513A 1977-03-10 1978-03-02 Un procedimiento para la preparacion de un compuesto Expired ES467513A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1011677 1977-03-10
GB10082/77A GB1582864A (en) 1977-03-10 1977-03-10 Chemical process for the preparation of clavulanic acid derivatives

Publications (1)

Publication Number Publication Date
ES467513A1 true ES467513A1 (es) 1979-08-01

Family

ID=26247246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467513A Expired ES467513A1 (es) 1977-03-10 1978-03-02 Un procedimiento para la preparacion de un compuesto

Country Status (19)

Country Link
JP (1) JPS53112894A (es)
AR (1) AR216505A1 (es)
AT (1) AT359188B (es)
AU (1) AU519232B2 (es)
CH (1) CH632760A5 (es)
DE (1) DE2808116A1 (es)
DK (1) DK139377A (es)
ES (1) ES467513A1 (es)
FI (1) FI65252C (es)
FR (1) FR2383184A1 (es)
GR (1) GR64160B (es)
HK (1) HK15084A (es)
IE (1) IE46478B1 (es)
IL (1) IL54078A0 (es)
KE (1) KE3337A (es)
MX (1) MX4864E (es)
NL (1) NL7802596A (es)
NO (1) NO771106L (es)
SE (1) SE442748B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862254D1 (en) * 1977-12-02 1983-06-16 Beecham Group Plc A process for the preparation of ether derivatives of clavulanic acid
JPS58187371A (ja) * 1982-04-27 1983-11-01 Nec Corp 印字濃度制御回路
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573503A (en) * 1975-12-17 1980-08-28 Glaxo Lab Ltd Clavulanic acid derivatives

Also Published As

Publication number Publication date
IE780477L (en) 1978-09-10
SE7704085L (sv) 1978-09-11
KE3337A (en) 1983-11-25
ATA145178A (de) 1980-03-15
AU519232B2 (en) 1981-11-19
FR2383184B1 (es) 1980-08-29
NL7802596A (nl) 1978-09-12
DE2808116A1 (de) 1978-09-21
CH632760A5 (en) 1982-10-29
DK139377A (da) 1978-09-11
FI771146A (fi) 1978-09-11
IL54078A0 (en) 1978-04-30
AT359188B (de) 1980-10-27
JPS53112894A (en) 1978-10-02
HK15084A (en) 1984-02-24
NO771106L (no) 1978-09-12
SE442748B (sv) 1986-01-27
MX4864E (es) 1982-11-10
IE46478B1 (en) 1983-06-29
FI65252C (fi) 1984-04-10
FI65252B (fi) 1983-12-30
AR216505A1 (es) 1979-12-28
AU3384078A (en) 1979-09-06
FR2383184A1 (fr) 1978-10-06
GR64160B (en) 1980-02-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202