ES8401034A1 - Derivados de quinolina. - Google Patents
Derivados de quinolina.Info
- Publication number
- ES8401034A1 ES8401034A1 ES512960A ES512960A ES8401034A1 ES 8401034 A1 ES8401034 A1 ES 8401034A1 ES 512960 A ES512960 A ES 512960A ES 512960 A ES512960 A ES 512960A ES 8401034 A1 ES8401034 A1 ES 8401034A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- stands
- compounds
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- -1 heteroaryl radical Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical compound [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003420 antiserotonin agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLINA Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, R, R, R, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA HS-A-NRR O CON UNA DE SUS SALES DE ADICION DE ACIDO, EN LAS QUE HAL ES HALOGENO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, TAL COMO HIDRURO SODICO, A LA TEMPERATURA AMBIENTEO SUPERIOR.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE DISFUNCIONES DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8117642 | 1981-06-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES512960A0 ES512960A0 (es) | 1983-12-01 |
| ES8401034A1 true ES8401034A1 (es) | 1983-12-01 |
Family
ID=10522379
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES512960A Expired ES8401034A1 (es) | 1981-06-09 | 1982-06-09 | Derivados de quinolina. |
| ES519006A Granted ES519006A0 (es) | 1981-06-09 | 1983-01-14 | Procedimiento para preparar 2-(2-dimetilaminoetiltio)-3-fenilquinolina. |
| ES525298A Granted ES525298A0 (es) | 1981-06-09 | 1983-09-01 | Procedimiento para preparar derivados de quinolina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519006A Granted ES519006A0 (es) | 1981-06-09 | 1983-01-14 | Procedimiento para preparar 2-(2-dimetilaminoetiltio)-3-fenilquinolina. |
| ES525298A Granted ES525298A0 (es) | 1981-06-09 | 1983-09-01 | Procedimiento para preparar derivados de quinolina |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4435405A (es) |
| EP (1) | EP0066993B1 (es) |
| JP (1) | JPS58965A (es) |
| AR (1) | AR230437A1 (es) |
| AT (1) | ATE11534T1 (es) |
| AU (1) | AU556719B2 (es) |
| CA (1) | CA1189077A (es) |
| CS (1) | CS238624B2 (es) |
| DE (1) | DE3262122D1 (es) |
| DK (1) | DK152428C (es) |
| ES (3) | ES8401034A1 (es) |
| FI (1) | FI77451C (es) |
| GR (1) | GR76452B (es) |
| HU (1) | HU186523B (es) |
| IE (1) | IE53064B1 (es) |
| IL (1) | IL65852A (es) |
| IN (1) | IN158970B (es) |
| NO (1) | NO161066C (es) |
| NZ (1) | NZ200878A (es) |
| PH (1) | PH18503A (es) |
| PL (1) | PL135871B1 (es) |
| PT (1) | PT75024B (es) |
| SU (1) | SU1192618A3 (es) |
| YU (2) | YU43269B (es) |
| ZA (1) | ZA823586B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE27152T1 (de) * | 1982-04-07 | 1987-05-15 | Ici Plc | Chinolin-derivate. |
| DE3377796D1 (en) * | 1982-05-04 | 1988-09-29 | Ici Plc | Quinoline derivatives |
| US4585866A (en) * | 1982-06-09 | 1986-04-29 | Merrell Dow Pharmaceuticals Inc. | Treatment of migraine with substituted tropyl benzoate derivatives |
| GB8308601D0 (en) * | 1983-03-29 | 1983-05-05 | Ici Plc | Heterocyclic compounds |
| JPS60166406A (ja) * | 1984-02-09 | 1985-08-29 | 株式会社イナックス | 乾式プレス装置の坏土充填方法 |
| GB8630071D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
| JP2733511B2 (ja) * | 1988-10-22 | 1998-03-30 | 日本臓器製薬株式会社 | 新規アミノアルカン誘導体 |
| JPH03147803A (ja) * | 1989-11-06 | 1991-06-24 | Tiger Mach Seisakusho:Kk | 表面多色変化模様のあるコンクリートブロックの製造方法 |
| US6566361B2 (en) | 1999-06-30 | 2003-05-20 | Laboratories, Upsa | Azapirone pain treatment |
| FR2795645B1 (fr) | 1999-06-30 | 2001-09-21 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| EP1216988A4 (en) | 1999-09-28 | 2005-04-20 | Nihon Nohyaku Co Ltd | THIOALKYLAMINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| FR2810664B1 (fr) * | 2000-06-27 | 2004-12-24 | Adir | Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB0306604D0 (en) * | 2003-03-21 | 2003-04-30 | Curidium Ltd | Second medical use |
| ATE511396T1 (de) * | 2007-02-28 | 2011-06-15 | Thromboserin Ltd | Therapeutische zusammensetzungen enthaltend thromboserin oder dessen salze zur verwendung in der prophylaxe oder behandlung von thrombose in patienten mit blutungsrisiko |
| EP2236511A4 (en) | 2007-12-21 | 2011-04-13 | Alla Chem Llc | LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049379B (de) | 1959-01-29 | Farbenfabriken Bayer Aktiengesellschaft, Leverkusen-Bayerwerk | Verfahren zur Herstellung von 4 - (tert.-Aminoalkylmercapto)chinolinverbindungen | |
| DE430960C (de) | 1924-07-11 | 1926-06-23 | J G Farbenindustrie Akt Ges | Verfahren zur Darstellung von basischen AEthern von Chinolinderivaten |
| US1572768A (en) | 1925-06-26 | 1926-02-09 | Winthrop Chem Co Inc | Pharmaceutical product |
| US1860286A (en) | 1929-05-16 | 1932-05-24 | Soc Of Chemical Ind | Basic ethers of aryl-quinolines |
| GB1511390A (en) * | 1975-12-04 | 1978-05-17 | Pfizer Ltd | Imidazolylalkyl sulphide antifungal agents |
| US4343805A (en) | 1978-12-16 | 1982-08-10 | John Wyeth & Brother Limited | Heterocyclic compounds |
-
1982
- 1982-05-19 IN IN381/DEL/82A patent/IN158970B/en unknown
- 1982-05-20 AU AU83863/82A patent/AU556719B2/en not_active Expired
- 1982-05-21 DE DE8282302607T patent/DE3262122D1/de not_active Expired
- 1982-05-21 AT AT82302607T patent/ATE11534T1/de not_active IP Right Cessation
- 1982-05-21 EP EP82302607A patent/EP0066993B1/en not_active Expired
- 1982-05-23 IL IL65852A patent/IL65852A/xx not_active IP Right Cessation
- 1982-05-24 ZA ZA823586A patent/ZA823586B/xx unknown
- 1982-05-25 IE IE1243/82A patent/IE53064B1/en not_active IP Right Cessation
- 1982-05-26 US US06/382,116 patent/US4435405A/en not_active Expired - Lifetime
- 1982-05-27 GR GR68281A patent/GR76452B/el unknown
- 1982-05-28 PH PH27361A patent/PH18503A/en unknown
- 1982-06-02 FI FI821965A patent/FI77451C/fi not_active IP Right Cessation
- 1982-06-02 CA CA000404277A patent/CA1189077A/en not_active Expired
- 1982-06-07 HU HU821828A patent/HU186523B/hu unknown
- 1982-06-08 SU SU823450275A patent/SU1192618A3/ru active
- 1982-06-08 NZ NZ200878A patent/NZ200878A/en unknown
- 1982-06-08 PT PT75024A patent/PT75024B/pt unknown
- 1982-06-08 PL PL1982236836A patent/PL135871B1/pl unknown
- 1982-06-08 CS CS824253A patent/CS238624B2/cs unknown
- 1982-06-08 NO NO821904A patent/NO161066C/no not_active IP Right Cessation
- 1982-06-08 JP JP57097043A patent/JPS58965A/ja active Granted
- 1982-06-08 YU YU1232/82A patent/YU43269B/xx unknown
- 1982-06-09 ES ES512960A patent/ES8401034A1/es not_active Expired
- 1982-06-09 DK DK257782A patent/DK152428C/da not_active IP Right Cessation
-
1983
- 1983-01-14 ES ES519006A patent/ES519006A0/es active Granted
- 1983-08-30 AR AR294046A patent/AR230437A1/es active
- 1983-09-01 ES ES525298A patent/ES525298A0/es active Granted
-
1984
- 1984-11-08 YU YU1882/84A patent/YU42905B/xx unknown
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