ES8104812A1 - Un procedimiento para la preparacion de derivados de aceto- fenona substituidos - Google Patents

Un procedimiento para la preparacion de derivados de aceto- fenona substituidos

Info

Publication number
ES8104812A1
ES8104812A1 ES491728A ES491728A ES8104812A1 ES 8104812 A1 ES8104812 A1 ES 8104812A1 ES 491728 A ES491728 A ES 491728A ES 491728 A ES491728 A ES 491728A ES 8104812 A1 ES8104812 A1 ES 8104812A1
Authority
ES
Spain
Prior art keywords
substituted
preparation
pharmaceutical compositions
compositions containing
acyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491728A
Other languages
English (en)
Other versions
ES491728A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES491728A0 publication Critical patent/ES491728A0/es
Publication of ES8104812A1 publication Critical patent/ES8104812A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ACETOFENONA SUSTITUIDOS DE FORMULA GENERAL (I). CONSISTENTE EN OBTENER (I) POR REACCION DE UN COMPUESTO DE FORMULA GENERAL (II) CON UN OXIHALURO DE FOSFORO EN UN DISOLVENTE EN PRESENCIA DE UNA BASE, HIDROLIZANDOSE EL COMPUESTO RESULTANTE. EN LA FORMULA (I), R1 REPRESENTA UN RADICAL HIDROXILICO, FOSFONOOXILICO, AMINOGLICOSILOXILICO, TRIALQUILAMONIACILOXILICO O FUROILOXILICO, Y EN AMBAS FORMULAS (I) Y (II) R2 Y R3 REPRESENTAN, CADA UNO, UN RADICAL DE ALCOXILO Y R4 UN RADICAL DE BENCIMIDAZOLILO, FURILO, TIENILO, FENILO, ALCOXILO, ALQUILTIO, ALQUILENDIOXILO, ACILOXILO O ALCOXIALCOXILO. LOS DERIVADOS (I) PUEDEN OBTENERSE ALTERNATIVAMENTE POR REACCION DE (II) CON OTROS COMPUESTOS O INCLUSO A PARTIR DE OTROS COMPUESTOS DISTINTOS DE (II). SE APLICAN COMO INGREDIENTES EFECTIVOS PARA AGENTES ANTIVIRALES. *FORMULA*
ES491728A 1979-05-23 1980-05-22 Un procedimiento para la preparacion de derivados de aceto- fenona substituidos Expired ES8104812A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7917973 1979-05-23

Publications (2)

Publication Number Publication Date
ES491728A0 ES491728A0 (es) 1981-04-01
ES8104812A1 true ES8104812A1 (es) 1981-04-01

Family

ID=10505387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491728A Expired ES8104812A1 (es) 1979-05-23 1980-05-22 Un procedimiento para la preparacion de derivados de aceto- fenona substituidos

Country Status (25)

Country Link
US (1) US4327088A (es)
EP (1) EP0021000B1 (es)
JP (1) JPS55157534A (es)
AR (1) AR230064A1 (es)
AT (1) ATE6357T1 (es)
AU (1) AU538581B2 (es)
BR (1) BR8003235A (es)
CA (1) CA1137082A (es)
CS (1) CS212716B2 (es)
CU (1) CU35266A (es)
DE (1) DE3066676D1 (es)
DK (1) DK224980A (es)
ES (1) ES8104812A1 (es)
FI (1) FI67556C (es)
GR (1) GR67305B (es)
HU (1) HU184288B (es)
IE (1) IE49816B1 (es)
IL (1) IL60115A (es)
MC (1) MC1330A1 (es)
NO (1) NO152898C (es)
NZ (1) NZ193750A (es)
PH (1) PH16056A (es)
PT (1) PT71289B (es)
YU (1) YU140280A (es)
ZA (1) ZA802927B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6385526A (ja) * 1986-09-30 1988-04-16 Nippon Oil & Fats Co Ltd 非線形光学材料
ZA917369B (en) * 1990-09-20 1992-06-24 Merrell Dow Pharma Calcium uptake inhibitors
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
EP1175425A2 (en) 1999-01-21 2002-01-30 The Board Of Regents, The University Of Texas System Inhibitors of intestinal apical membrane na/phosphate co-transportation
US20030162753A1 (en) * 1999-01-21 2003-08-28 Peerce Brian E. Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans
EP1682486A1 (en) * 2003-10-31 2006-07-26 Lica Pharmaceuticals A/S Quaternary amino-functional chalcones
US20060270614A1 (en) * 2005-05-24 2006-11-30 Sekhar Boddupalli Use of chalcones for the treatment of viral disorders

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL76438C (es) * 1949-11-30
GB1007332A (en) * 1960-12-09 1965-10-13 Cooper Mcdougall & Robertson New halogen-containing phosphoric and thiophosphoric acid esters and formulations containing them
FR1476531A (fr) 1965-04-26 1967-04-14 Chimetron Sarl Nouvelles cétones halogénées dérivées du benzimidazole
US3583894A (en) * 1968-03-29 1971-06-08 Us Agriculture Enzyme preparation of hesperetin dihydrochalcone glucoside
US3629322A (en) * 1969-02-17 1971-12-21 Buckman Labor Inc Organic esters and their use as ultraviolet light absorbers and as heat stabilizers
GB1283981A (en) 1969-03-05 1972-08-02 Orsymonde 2,4,6-trihydroxy chalcone derivatives
GB1398528A (en) * 1971-08-17 1975-06-25 Leo Ab Pharmaceutically active secondary phosphoric acid esters
JPS5912094B2 (ja) * 1974-01-19 1984-03-21 大正製薬株式会社 カルコン体の合成法
JPS598250B2 (ja) * 1974-02-09 1984-02-23 大正製薬株式会社 カルコンエ−テルの合成法
JPS598249B2 (ja) * 1974-01-19 1984-02-23 大正製薬株式会社 カルコン類の合成法
JPS593460B2 (ja) * 1974-04-19 1984-01-24 大正製薬株式会社 カルコンルイ ノ ゴウセイホウ
JPS598251B2 (ja) * 1974-04-19 1984-02-23 大正製薬株式会社 イソプレニルカルコン類の合成法
JPS50140430A (es) * 1974-04-23 1975-11-11
FR2307820A1 (fr) * 1975-04-17 1976-11-12 Hayashibara Seibutsu Chem Inst Glycosides d'echinatine et leur preparation
DD123466A1 (es) 1975-12-01 1976-12-20
US4122191A (en) * 1976-12-20 1978-10-24 Richardson-Merrell Inc. Antirhinovirus agents
US4154756A (en) * 1977-12-15 1979-05-15 American Cyanamid Company 2-Substituted-4'-(monoalkylamino)-acetophenones
NZ192641A (en) * 1979-01-26 1984-10-19 Hoffmann La Roche Substituted acetophenones and pharmaceutical compositions

Also Published As

Publication number Publication date
PT71289A (en) 1980-06-01
YU140280A (en) 1983-12-31
EP0021000A3 (en) 1981-12-02
EP0021000B1 (de) 1984-02-22
MC1330A1 (fr) 1981-04-21
AU538581B2 (en) 1984-08-23
IL60115A0 (en) 1980-07-31
NO152898B (no) 1985-09-02
IE801068L (en) 1980-11-23
ES491728A0 (es) 1981-04-01
ZA802927B (en) 1982-01-27
US4327088A (en) 1982-04-27
CA1137082A (en) 1982-12-07
JPS55157534A (en) 1980-12-08
ATE6357T1 (de) 1984-03-15
AU5846580A (en) 1980-11-27
HU184288B (en) 1984-07-30
PT71289B (en) 1981-09-21
DE3066676D1 (en) 1984-03-29
DK224980A (da) 1980-11-24
GR67305B (es) 1981-06-29
NO801542L (no) 1980-11-24
CS212716B2 (en) 1982-03-26
EP0021000A2 (de) 1981-01-07
IL60115A (en) 1986-02-28
PH16056A (en) 1983-06-09
FI67556C (fi) 1985-04-10
NZ193750A (en) 1984-12-14
AR230064A1 (es) 1984-02-29
CU35266A (en) 1982-03-28
IE49816B1 (en) 1985-12-25
NO152898C (no) 1985-12-11
FI801661A (fi) 1980-11-21
FI67556B (fi) 1984-12-31
BR8003235A (pt) 1980-12-30

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