ES8101605A1 - Un procedimiento para la preparacion de esteres y eteres de cefalosporina. - Google Patents
Un procedimiento para la preparacion de esteres y eteres de cefalosporina.Info
- Publication number
- ES8101605A1 ES8101605A1 ES482574A ES482574A ES8101605A1 ES 8101605 A1 ES8101605 A1 ES 8101605A1 ES 482574 A ES482574 A ES 482574A ES 482574 A ES482574 A ES 482574A ES 8101605 A1 ES8101605 A1 ES 8101605A1
- Authority
- ES
- Spain
- Prior art keywords
- ethers
- image
- lower alkyl
- cephalosporines
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 4
- 150000002170 ethers Chemical class 0.000 title abstract 4
- 125000001271 cephalosporin group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 aminocarbonylmethyl Chemical group 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ESTERES Y ESTERES DE CEFALOSPORINA. CONSISTE EN HACER REACCIONAR UN ACIDO CARBOXILICO DE FORMULA GENERAL (I) CON UN HALURO, PREFERENTEMENTE UN YODURO, CONTENIENDO EL GRUPO DE ESTER DESEADO. LA REACCION PUEDE ACELERARSE CON AYUDA DE UNA BASE, TAL COMO UN HIDROXIDO DE METAL ALCALINO O CARBONATO O AMINA ORGANICA, TAL COMO LA TRIETILAMINA. LA ESTERIFICACION, ETERIFICACION, SE LLEVA A CABO PREFERENTEMENTE EN UN DISOLVENTE ORGANICO INERTE, TAL COMO LA DIMETILACETAMIDA, TRIAMIDA DE ACIDO HEXAMETILFOSFORICO, SULFOXIDO DE DIMETILO O DIMETILFORMAMIDA. LA REACCION TIENE LUGAR A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 40GC. *FORMULA* TRATAMIENTO Y PROFILAXIS DE INFECCIONES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH778678 | 1978-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8101605A1 true ES8101605A1 (es) | 1980-12-16 |
| ES482574A0 ES482574A0 (es) | 1980-12-16 |
Family
ID=4330453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482574A Granted ES482574A0 (es) | 1978-07-19 | 1979-07-18 | Un procedimiento para la preparacion de esteres y eteres de cefalosporina. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4292428A (es) |
| EP (1) | EP0008372B1 (es) |
| JP (1) | JPS5515492A (es) |
| KR (1) | KR830000678B1 (es) |
| AT (1) | ATE2331T1 (es) |
| AU (1) | AU529233B2 (es) |
| CA (1) | CA1151641A (es) |
| DE (1) | DE2964607D1 (es) |
| DK (1) | DK295279A (es) |
| ES (1) | ES482574A0 (es) |
| FI (1) | FI782683A (es) |
| GR (1) | GR72943B (es) |
| HU (1) | HU183012B (es) |
| IL (1) | IL57795A (es) |
| MC (1) | MC1277A1 (es) |
| NO (1) | NO782998L (es) |
| NZ (1) | NZ191003A (es) |
| PH (1) | PH15899A (es) |
| PT (1) | PT69939A (es) |
| ZA (1) | ZA793501B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526977A (en) * | 1981-10-07 | 1985-07-02 | American Home Products Corporation | 2-(3-Amino-5-isoxazolyl)-2-oxyimino-acetic acids |
| JPS61267585A (ja) * | 1985-01-16 | 1986-11-27 | Fujisawa Pharmaceut Co Ltd | セフアロスポラン酸誘導体もしくはその薬理学的に許容しうる塩 |
| US4698338A (en) * | 1986-02-19 | 1987-10-06 | Eli Lilly And Company | 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091211A (en) * | 1974-05-05 | 1978-05-23 | Hoffmann-La Roche Inc. | Cephalosporins |
| CA1100129A (en) * | 1974-08-02 | 1981-04-28 | William H.W. Lunn | Cephalosporin compounds |
| GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
| AU510280B2 (en) * | 1976-08-30 | 1980-06-19 | Bristol-Myers Company | Antibacterial cephalosporin agents |
| GB1599232A (en) * | 1977-06-03 | 1981-09-30 | Hoffmann La Roche | 7-(2-oximinoacetamido)-cephalosporin derivatives |
| US4178443A (en) * | 1977-06-03 | 1979-12-11 | Hoffmann-La Roche Inc. | Derivatives of 7 [-substituted oxyimins acetamido] cephalosporins |
-
1978
- 1978-09-01 FI FI782683A patent/FI782683A/fi unknown
- 1978-09-01 NO NO782998A patent/NO782998L/no unknown
-
1979
- 1979-06-25 US US06/051,669 patent/US4292428A/en not_active Expired - Lifetime
- 1979-07-11 MC MC791394A patent/MC1277A1/xx unknown
- 1979-07-11 HU HU79HO2165A patent/HU183012B/hu unknown
- 1979-07-12 AU AU48880/79A patent/AU529233B2/en not_active Ceased
- 1979-07-12 ZA ZA00793501A patent/ZA793501B/xx unknown
- 1979-07-12 CA CA000331646A patent/CA1151641A/en not_active Expired
- 1979-07-12 DK DK295279A patent/DK295279A/da not_active Application Discontinuation
- 1979-07-13 NZ NZ191003A patent/NZ191003A/en unknown
- 1979-07-13 IL IL57795A patent/IL57795A/xx unknown
- 1979-07-17 JP JP8996079A patent/JPS5515492A/ja active Pending
- 1979-07-17 PH PH22791A patent/PH15899A/en unknown
- 1979-07-17 GR GR59621A patent/GR72943B/el unknown
- 1979-07-18 PT PT69939A patent/PT69939A/pt unknown
- 1979-07-18 ES ES482574A patent/ES482574A0/es active Granted
- 1979-07-19 DE DE7979102552T patent/DE2964607D1/de not_active Expired
- 1979-07-19 AT AT79102552T patent/ATE2331T1/de not_active IP Right Cessation
- 1979-07-19 EP EP79102552A patent/EP0008372B1/de not_active Expired
- 1979-07-19 KR KR1019790002405A patent/KR830000678B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| DK295279A (da) | 1980-01-20 |
| DE2964607D1 (en) | 1983-03-03 |
| MC1277A1 (fr) | 1980-05-23 |
| AU529233B2 (en) | 1983-06-02 |
| PH15899A (en) | 1983-04-15 |
| NZ191003A (en) | 1984-05-31 |
| CA1151641A (en) | 1983-08-09 |
| HU183012B (en) | 1984-04-28 |
| IL57795A0 (en) | 1979-11-30 |
| JPS5515492A (en) | 1980-02-02 |
| ZA793501B (en) | 1980-07-30 |
| FI782683A (fi) | 1980-01-20 |
| KR830000678B1 (ko) | 1983-03-28 |
| AU4888079A (en) | 1980-01-24 |
| IL57795A (en) | 1982-09-30 |
| PT69939A (en) | 1979-08-01 |
| NO782998L (no) | 1980-01-22 |
| GR72943B (es) | 1984-01-16 |
| EP0008372A1 (de) | 1980-03-05 |
| EP0008372B1 (de) | 1983-01-26 |
| ES482574A0 (es) | 1980-12-16 |
| US4292428A (en) | 1981-09-29 |
| ATE2331T1 (de) | 1983-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19851217 |