ES8500259A1 - "un metodo para preparar derivados de 3-metilflavona". - Google Patents

"un metodo para preparar derivados de 3-metilflavona".

Info

Publication number
ES8500259A1
ES8500259A1 ES523501A ES523501A ES8500259A1 ES 8500259 A1 ES8500259 A1 ES 8500259A1 ES 523501 A ES523501 A ES 523501A ES 523501 A ES523501 A ES 523501A ES 8500259 A1 ES8500259 A1 ES 8500259A1
Authority
ES
Spain
Prior art keywords
main chain
chain carbons
lower alkyl
methylflavone
yes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523501A
Other languages
English (en)
Other versions
ES523501A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES523501A0 publication Critical patent/ES523501A0/es
Publication of ES8500259A1 publication Critical patent/ES8500259A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3-METILFLAVONA, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R7 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON LOS COMPUESTOS DE FORMULAS (III Y IV), EN LAS QUE X ES UN METAL ALCALINO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A TEMPERATURAS ENTRE 50JC Y 130JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA, ENFERMEDADES ALERGICAS Y PARA LA INFLAMACION.
ES523501A 1982-06-23 1983-06-22 "un metodo para preparar derivados de 3-metilflavona". Expired ES8500259A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57108928A JPS58225083A (ja) 1982-06-23 1982-06-23 メチルフラボン誘導体

Publications (2)

Publication Number Publication Date
ES523501A0 ES523501A0 (es) 1984-10-01
ES8500259A1 true ES8500259A1 (es) 1984-10-01

Family

ID=14497205

Family Applications (5)

Application Number Title Priority Date Filing Date
ES523501A Expired ES8500259A1 (es) 1982-06-23 1983-06-22 "un metodo para preparar derivados de 3-metilflavona".
ES530017A Granted ES530017A0 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona
ES530019A Granted ES530019A0 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona
ES530020A Granted ES530020A0 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona
ES530016A Expired ES8504761A1 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES530017A Granted ES530017A0 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona
ES530019A Granted ES530019A0 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona
ES530020A Granted ES530020A0 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona
ES530016A Expired ES8504761A1 (es) 1982-06-23 1984-02-24 Un metodo para preparar derivados de 3-metilflavona

Country Status (7)

Country Link
US (1) US4594345A (es)
EP (1) EP0100250B1 (es)
JP (1) JPS58225083A (es)
KR (1) KR900004929B1 (es)
CA (1) CA1223012A (es)
DE (1) DE3369990D1 (es)
ES (5) ES8500259A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774229A (en) * 1982-04-05 1988-09-27 Chemex Pharmaceuticals, Inc. Modification of plant extracts from zygophyllaceae and pharmaceutical use therefor
IL89840A (en) * 1988-04-06 1996-10-31 Lipha Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them
US5116954A (en) * 1988-04-06 1992-05-26 Lipha, Lyonnaise Industrielle Pharmaceutique Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
AU5871894A (en) * 1992-12-21 1994-07-19 Mallinckrodt Medical, Inc. Polyhydric phenol compounds
ES2517690T3 (es) 2008-09-29 2014-11-03 Glaxosmithkline Llc Quinazolinona, quinolona y análogos relacionados como moduladores de sirtuina
CN111153881A (zh) * 2020-01-13 2020-05-15 辽宁海德制药有限公司 一种合成盐酸黄酮哌酯中间体3-甲基黄酮-8-羧酸的制备方法
CN114432290A (zh) * 2020-11-02 2022-05-06 苏州凯祥生物科技有限公司 甲基黄酮类化合物在制备预防或治疗急性肺损伤和/或急性呼吸窘迫综合征药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921070A (en) * 1957-11-05 1960-01-12 Recordati Lab Farmacologico S Basic esters of 3-methylflavone-8-carboxylic acid
US3350411A (en) * 1963-10-10 1967-10-31 Pharma Seceph S A Soc D Expl C Process for preparing 3-methylflavone-8-carboxylic acid
BE757821A (fr) * 1970-08-01 1971-04-01 Recordati Chem Pharm Procede de preparation de l'acide 3-propionyl-salicylique et dederives de cet acide
NZ200981A (en) * 1981-07-17 1984-10-19 Recordati Chem Pharm 3-methylflavone-8-carboxylic acid derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
ES8601956A1 (es) 1985-11-01
KR900004929B1 (ko) 1990-07-12
ES8601955A1 (es) 1985-11-16
ES530017A0 (es) 1985-11-16
ES530019A0 (es) 1985-11-01
EP0100250B1 (en) 1987-03-04
KR840005122A (ko) 1984-11-03
CA1223012A (en) 1987-06-16
ES8601957A1 (es) 1985-11-01
ES523501A0 (es) 1984-10-01
EP0100250A3 (en) 1984-08-15
US4594345A (en) 1986-06-10
DE3369990D1 (de) 1987-04-09
JPS58225083A (ja) 1983-12-27
EP0100250A2 (en) 1984-02-08
JPH0224828B2 (es) 1990-05-30
ES530016A0 (es) 1985-05-01
ES8504761A1 (es) 1985-05-01
ES530020A0 (es) 1985-11-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303