ES8500259A1 - "un metodo para preparar derivados de 3-metilflavona". - Google Patents
"un metodo para preparar derivados de 3-metilflavona".Info
- Publication number
- ES8500259A1 ES8500259A1 ES523501A ES523501A ES8500259A1 ES 8500259 A1 ES8500259 A1 ES 8500259A1 ES 523501 A ES523501 A ES 523501A ES 523501 A ES523501 A ES 523501A ES 8500259 A1 ES8500259 A1 ES 8500259A1
- Authority
- ES
- Spain
- Prior art keywords
- main chain
- chain carbons
- lower alkyl
- methylflavone
- yes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3-METILFLAVONA, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R7 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON LOS COMPUESTOS DE FORMULAS (III Y IV), EN LAS QUE X ES UN METAL ALCALINO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A TEMPERATURAS ENTRE 50JC Y 130JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA, ENFERMEDADES ALERGICAS Y PARA LA INFLAMACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57108928A JPS58225083A (ja) | 1982-06-23 | 1982-06-23 | メチルフラボン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES523501A0 ES523501A0 (es) | 1984-10-01 |
ES8500259A1 true ES8500259A1 (es) | 1984-10-01 |
Family
ID=14497205
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523501A Expired ES8500259A1 (es) | 1982-06-23 | 1983-06-22 | "un metodo para preparar derivados de 3-metilflavona". |
ES530017A Granted ES530017A0 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
ES530019A Granted ES530019A0 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
ES530020A Granted ES530020A0 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
ES530016A Expired ES8504761A1 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530017A Granted ES530017A0 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
ES530019A Granted ES530019A0 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
ES530020A Granted ES530020A0 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
ES530016A Expired ES8504761A1 (es) | 1982-06-23 | 1984-02-24 | Un metodo para preparar derivados de 3-metilflavona |
Country Status (7)
Country | Link |
---|---|
US (1) | US4594345A (es) |
EP (1) | EP0100250B1 (es) |
JP (1) | JPS58225083A (es) |
KR (1) | KR900004929B1 (es) |
CA (1) | CA1223012A (es) |
DE (1) | DE3369990D1 (es) |
ES (5) | ES8500259A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4774229A (en) * | 1982-04-05 | 1988-09-27 | Chemex Pharmaceuticals, Inc. | Modification of plant extracts from zygophyllaceae and pharmaceutical use therefor |
IL89840A (en) * | 1988-04-06 | 1996-10-31 | Lipha | Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them |
US5116954A (en) * | 1988-04-06 | 1992-05-26 | Lipha, Lyonnaise Industrielle Pharmaceutique | Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety |
US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
AU5871894A (en) * | 1992-12-21 | 1994-07-19 | Mallinckrodt Medical, Inc. | Polyhydric phenol compounds |
ES2517690T3 (es) | 2008-09-29 | 2014-11-03 | Glaxosmithkline Llc | Quinazolinona, quinolona y análogos relacionados como moduladores de sirtuina |
CN111153881A (zh) * | 2020-01-13 | 2020-05-15 | 辽宁海德制药有限公司 | 一种合成盐酸黄酮哌酯中间体3-甲基黄酮-8-羧酸的制备方法 |
CN114432290A (zh) * | 2020-11-02 | 2022-05-06 | 苏州凯祥生物科技有限公司 | 甲基黄酮类化合物在制备预防或治疗急性肺损伤和/或急性呼吸窘迫综合征药物中的应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2921070A (en) * | 1957-11-05 | 1960-01-12 | Recordati Lab Farmacologico S | Basic esters of 3-methylflavone-8-carboxylic acid |
US3350411A (en) * | 1963-10-10 | 1967-10-31 | Pharma Seceph S A Soc D Expl C | Process for preparing 3-methylflavone-8-carboxylic acid |
BE757821A (fr) * | 1970-08-01 | 1971-04-01 | Recordati Chem Pharm | Procede de preparation de l'acide 3-propionyl-salicylique et dederives de cet acide |
NZ200981A (en) * | 1981-07-17 | 1984-10-19 | Recordati Chem Pharm | 3-methylflavone-8-carboxylic acid derivatives and pharmaceutical compositions |
-
1982
- 1982-06-23 JP JP57108928A patent/JPS58225083A/ja active Granted
-
1983
- 1983-06-13 DE DE8383401211T patent/DE3369990D1/de not_active Expired
- 1983-06-13 EP EP83401211A patent/EP0100250B1/en not_active Expired
- 1983-06-22 ES ES523501A patent/ES8500259A1/es not_active Expired
- 1983-06-22 CA CA000430936A patent/CA1223012A/en not_active Expired
- 1983-06-23 KR KR1019830002831A patent/KR900004929B1/ko not_active IP Right Cessation
- 1983-06-24 US US06/507,692 patent/US4594345A/en not_active Expired - Fee Related
-
1984
- 1984-02-24 ES ES530017A patent/ES530017A0/es active Granted
- 1984-02-24 ES ES530019A patent/ES530019A0/es active Granted
- 1984-02-24 ES ES530020A patent/ES530020A0/es active Granted
- 1984-02-24 ES ES530016A patent/ES8504761A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8601956A1 (es) | 1985-11-01 |
KR900004929B1 (ko) | 1990-07-12 |
ES8601955A1 (es) | 1985-11-16 |
ES530017A0 (es) | 1985-11-16 |
ES530019A0 (es) | 1985-11-01 |
EP0100250B1 (en) | 1987-03-04 |
KR840005122A (ko) | 1984-11-03 |
CA1223012A (en) | 1987-06-16 |
ES8601957A1 (es) | 1985-11-01 |
ES523501A0 (es) | 1984-10-01 |
EP0100250A3 (en) | 1984-08-15 |
US4594345A (en) | 1986-06-10 |
DE3369990D1 (de) | 1987-04-09 |
JPS58225083A (ja) | 1983-12-27 |
EP0100250A2 (en) | 1984-02-08 |
JPH0224828B2 (es) | 1990-05-30 |
ES530016A0 (es) | 1985-05-01 |
ES8504761A1 (es) | 1985-05-01 |
ES530020A0 (es) | 1985-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |