ES8101606A1 - Un procedimiento para la preparacion de esteres y eteres fa-cilmente hidrolizables de derivados acilados - Google Patents

Un procedimiento para la preparacion de esteres y eteres fa-cilmente hidrolizables de derivados acilados

Info

Publication number
ES8101606A1
ES8101606A1 ES488687A ES488687A ES8101606A1 ES 8101606 A1 ES8101606 A1 ES 8101606A1 ES 488687 A ES488687 A ES 488687A ES 488687 A ES488687 A ES 488687A ES 8101606 A1 ES8101606 A1 ES 8101606A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
corresponding pharmaceutical
cephalosporin derivatives
triazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488687A
Other languages
English (en)
Other versions
ES488687A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH588278A external-priority patent/CH641468A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES488687A0 publication Critical patent/ES488687A0/es
Publication of ES8101606A1 publication Critical patent/ES8101606A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)
  • Reinforcement Elements For Buildings (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ETERES Y ESTERES HIDROLIZABLES. CONSISTE EN SOMETER A UN ACIDO CARBOXILICO O UN ENOL DE FORMULA GENERAL (I) A UNA ESTERIFICACION O ETERIFICACION. OPCIONALMENTE EL PRODUCTO OBTENIDO SE AISLA EN FORMA DE SAL O HIDRATO DE DICHA SAL. *FORMULA* LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 40GC. LA PREPARACION DE LOS HIDRATOS TIENE LUGAR DE FORMA ANFOMATICA O COMO RESULTADO DE LAS PROPIEDADES HIGROSCOPICAS DE UN PRODUCTO INICIALMENTE ANHIDRO. PARA LA PREPARACION CONTROLADA PUEDE EXPONERSE A UNA ATMOSFERA HUMEDA UN ACIDO CARBOXILICO, COMPLETA O PARCIALMENTE ANHIDRO, A UNA TEMPERATURA ENTRE 10 Y 40GC.
ES488687A 1978-05-30 1980-02-16 Un procedimiento para la preparacion de esteres y eteres fa-cilmente hidrolizables de derivados acilados Expired ES8101606A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (de) 1978-05-30 1978-05-30 Cephemderivate.
CH224879 1979-03-08

Publications (2)

Publication Number Publication Date
ES488687A0 ES488687A0 (es) 1980-12-16
ES8101606A1 true ES8101606A1 (es) 1980-12-16

Family

ID=25689901

Family Applications (2)

Application Number Title Priority Date Filing Date
ES480990A Expired ES480990A1 (es) 1978-05-30 1979-05-29 Un procedimiento para la preparacion de derivados acilados.
ES488687A Expired ES8101606A1 (es) 1978-05-30 1980-02-16 Un procedimiento para la preparacion de esteres y eteres fa-cilmente hidrolizables de derivados acilados

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES480990A Expired ES480990A1 (es) 1978-05-30 1979-05-29 Un procedimiento para la preparacion de derivados acilados.

Country Status (40)

Country Link
EP (2) EP0045525B1 (es)
JP (2) JPS54157596A (es)
AT (3) AT367764B (es)
BG (1) BG50163A3 (es)
BR (1) BR7903368A (es)
CA (1) CA1141373A (es)
CS (1) CS219254B2 (es)
CU (1) CU35088A (es)
CY (1) CY1182A (es)
DD (1) DD143911A5 (es)
DE (4) DE2966946D1 (es)
DK (1) DK149282C (es)
EG (1) EG14153A (es)
ES (2) ES480990A1 (es)
FI (1) FI65434C (es)
FR (2) FR2427337A1 (es)
GB (2) GB2099418B (es)
GR (1) GR72242B (es)
HK (1) HK31383A (es)
HU (1) HU183089B (es)
IE (1) IE49047B1 (es)
IL (1) IL57392A (es)
IS (1) IS1203B6 (es)
IT (1) IT1121517B (es)
KE (1) KE3268A (es)
LU (1) LU81325A1 (es)
MC (1) MC1259A1 (es)
MT (1) MTP845B (es)
MY (1) MY8400127A (es)
NL (1) NL7904083A (es)
NO (1) NO159797C (es)
NZ (1) NZ190532A (es)
OA (1) OA06263A (es)
PH (1) PH15148A (es)
PL (1) PL122458B1 (es)
PT (1) PT69698A (es)
RO (1) RO77560A (es)
SE (1) SE437522B (es)
SG (1) SG10483G (es)
YU (3) YU42485B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI67385C (fi) * 1979-11-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
CA1154009A (en) * 1980-03-25 1983-09-20 Roland Reiner Cephalosporin derivatives
AU536771B2 (en) * 1980-03-25 1984-05-24 F. Hoffmann-La Roche Ag Cephalosporin derivatives
GR75706B (es) * 1980-06-30 1984-08-02 Sanofi Sa
US4308267A (en) 1980-07-03 1981-12-29 Smithkline Corporation 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
DK379581A (da) * 1980-10-06 1982-04-07 Hoffmann La Roche Fremgangsmaade til fremstilling af acylderivater
FR2494278A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine, leurs preparations et les medicaments qui les contiennent
EP0058250A3 (de) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporinderivate, deren Herstellung und entsprechende pharmazeutische Präparate
EP0185220A3 (de) * 1984-12-19 1987-09-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Zwischenprodukte zur Herstellung von Cephalosporinen
DE3775798D1 (de) 1986-03-19 1992-02-20 Banyu Pharma Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
RU2021274C1 (ru) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Способ получения аминотиазолильных производных цефалоспорина
KR950014571B1 (ko) * 1991-11-18 1995-12-08 제일제당주식회사 세펨 유도체의 제조방법
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
KR100197788B1 (ko) * 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
DE102011117421A1 (de) 2011-11-02 2013-05-02 Hans-Peter Gabel Pharmazeutische Zusammensetzung zur Behandlung von Borreliose
RU2504548C1 (ru) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) ПРОИЗВОДНОЕ β-ЛАКТАМНОГО АНТИБИОТИКА ЦЕФТРИАКСОНА

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH609989A5 (en) * 1974-06-21 1979-03-30 Hoffmann La Roche Process for the preparation of acyl derivatives
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DK162391C (da) 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
DE2715385A1 (de) 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
JPS5329936A (en) * 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins

Also Published As

Publication number Publication date
AU4736679A (en) 1979-12-06
ATE7229T1 (de) 1984-05-15
PL122458B1 (en) 1982-07-31
AT367764B (de) 1982-07-26
DK149282B (da) 1986-04-21
IT7923049A0 (it) 1979-05-28
ATA390479A (de) 1981-12-15
GB2022090B (en) 1982-12-15
DK149282C (da) 1986-09-01
GB2022090A (en) 1979-12-12
DE2922036C2 (de) 1983-02-17
FI791703A (fi) 1979-12-01
PT69698A (en) 1979-06-01
MTP845B (en) 1980-07-21
SE7904682L (sv) 1979-12-01
EP0045525A2 (de) 1982-02-10
JPS613795B2 (es) 1986-02-04
OA06263A (fr) 1981-06-30
IL57392A (en) 1982-05-31
IT1121517B (it) 1986-04-02
HK31383A (en) 1983-09-02
EP0005830A1 (de) 1979-12-12
CU35088A (en) 1982-08-24
FI65434B (fi) 1984-01-31
YU74485A (en) 1987-12-31
DE2966946D1 (en) 1984-05-30
GB2099418A (en) 1982-12-08
CS219254B2 (en) 1983-03-25
FR2509312B1 (es) 1984-06-29
PH15148A (en) 1982-08-24
CA1141373A (en) 1983-02-15
YU42485B (en) 1988-10-31
MC1259A1 (fr) 1980-01-14
NZ190532A (en) 1983-03-15
HU183089B (en) 1984-04-28
ES488687A0 (es) 1980-12-16
NO159797C (no) 1989-02-08
BR7903368A (pt) 1979-12-11
FR2509312A1 (fr) 1983-01-14
FR2427337A1 (fr) 1979-12-28
LU81325A1 (de) 1980-12-16
KE3268A (en) 1983-05-13
SE437522B (sv) 1985-03-04
EP0005830B1 (de) 1982-09-22
YU45256B (en) 1992-05-28
FI65434C (fi) 1984-05-10
IS1203B6 (is) 1986-03-24
IE49047B1 (en) 1985-07-24
PL215972A1 (es) 1980-02-11
GR72242B (es) 1983-10-04
GB2099418B (en) 1983-06-02
BG50163A3 (en) 1992-05-15
YU123379A (en) 1983-04-30
NO159797B (no) 1988-10-31
NO791776L (no) 1979-12-03
EP0045525A3 (en) 1982-02-17
EP0045525B1 (de) 1984-04-25
DD143911A5 (de) 1980-09-17
EG14153A (en) 1983-03-31
DK222679A (da) 1979-12-01
SG10483G (en) 1983-12-16
IS2490A7 (is) 1979-12-01
DE2922036A1 (de) 1979-12-06
YU74585A (en) 1987-12-31
JPS54157596A (en) 1979-12-12
NL7904083A (nl) 1979-12-04
ES480990A1 (es) 1980-08-16
JPS6016994A (ja) 1985-01-28
YU45257B (en) 1992-05-28
IE791041L (en) 1979-11-30
CY1182A (en) 1983-10-07
IL57392A0 (en) 1979-09-30
DE2963720D1 (en) 1982-11-04
AU524230B2 (en) 1982-09-09
JPS613355B2 (es) 1986-01-31
ATE1586T1 (de) 1982-10-15
DE2954159C2 (de) 1983-10-06
MY8400127A (en) 1984-12-31
RO77560A (ro) 1982-04-12

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ES8101606A1 (es) Un procedimiento para la preparacion de esteres y eteres fa-cilmente hidrolizables de derivados acilados