ES453501A1 - Un procedimiento para la preparacion de nuevos derivados n- metilenicos de tienamicina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados n- metilenicos de tienamicina.

Info

Publication number
ES453501A1
ES453501A1 ES453501A ES453501A ES453501A1 ES 453501 A1 ES453501 A1 ES 453501A1 ES 453501 A ES453501 A ES 453501A ES 453501 A ES453501 A ES 453501A ES 453501 A1 ES453501 A1 ES 453501A1
Authority
ES
Spain
Prior art keywords
thienamycin
hydrogen
formula
carbon atoms
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES453501A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES453501A1 publication Critical patent/ES453501A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES453501A 1975-11-21 1976-11-19 Un procedimiento para la preparacion de nuevos derivados n- metilenicos de tienamicina. Expired ES453501A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63429675A 1975-11-21 1975-11-21
US67626176A 1976-04-12 1976-04-12
US73365476A 1976-10-18 1976-10-18

Publications (1)

Publication Number Publication Date
ES453501A1 true ES453501A1 (es) 1978-03-01

Family

ID=27417545

Family Applications (1)

Application Number Title Priority Date Filing Date
ES453501A Expired ES453501A1 (es) 1975-11-21 1976-11-19 Un procedimiento para la preparacion de nuevos derivados n- metilenicos de tienamicina.

Country Status (27)

Country Link
AT (1) AT358168B (cs)
AU (1) AU512383B2 (cs)
BG (1) BG34037A3 (cs)
CA (1) CA1083577A (cs)
CH (2) CH632510A5 (cs)
DD (1) DD127742A5 (cs)
DE (1) DE2652679A1 (cs)
DK (1) DK157401C (cs)
EG (1) EG12261A (cs)
ES (1) ES453501A1 (cs)
FI (1) FI62306C (cs)
FR (1) FR2332012A1 (cs)
GB (1) GB1570990A (cs)
GR (1) GR62072B (cs)
HK (1) HK29683A (cs)
HU (1) HU180865B (cs)
IE (1) IE44433B1 (cs)
IL (1) IL50911A (cs)
KE (1) KE3286A (cs)
NL (1) NL189297C (cs)
NO (1) NO153298C (cs)
NZ (1) NZ182630A (cs)
PH (1) PH16714A (cs)
PL (1) PL110937B1 (cs)
PT (1) PT65865B (cs)
SE (1) SE427841B (cs)
SG (1) SG10983G (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
SE436569B (sv) * 1977-05-05 1985-01-07 Merck & Co Inc Analogiforfarande for framstellning av tienamycinderivat
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
WO1992004054A1 (en) * 1990-08-30 1992-03-19 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Substituted amidines having high binding to the sigma receptor and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348985A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Esters of cephalosporin compounds
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
DK157401C (da) 1990-05-21
DD127742A5 (de) 1977-10-12
DE2652679C2 (cs) 1990-03-01
PT65865B (en) 1978-10-12
FI62306B (fi) 1982-08-31
NL189297B (nl) 1992-10-01
CH632510A5 (en) 1982-10-15
NL189297C (nl) 1993-03-01
AT358168B (de) 1980-08-25
NO763958L (cs) 1977-05-24
DK523576A (da) 1977-05-22
GB1570990A (en) 1980-07-09
FR2332012A1 (fr) 1977-06-17
FI62306C (fi) 1982-12-10
HK29683A (en) 1983-08-26
NO153298C (no) 1986-02-19
IL50911A0 (en) 1977-01-31
SG10983G (en) 1983-12-16
SE7612963L (sv) 1977-05-22
PH16714A (en) 1984-01-25
PL110937B1 (en) 1980-08-30
AU512383B2 (en) 1980-10-09
CH633800A5 (en) 1982-12-31
HU180865B (en) 1983-04-29
PT65865A (en) 1976-12-01
BG34037A3 (bg) 1983-06-15
KE3286A (en) 1983-06-17
EG12261A (en) 1978-12-31
NZ182630A (en) 1979-07-11
DK157401B (da) 1990-01-02
FR2332012B1 (cs) 1978-11-17
IE44433B1 (en) 1981-12-02
NL7612939A (nl) 1977-05-24
FI763308A7 (cs) 1977-05-22
IE44433L (en) 1977-05-21
ATA863476A (de) 1980-01-15
GR62072B (en) 1979-02-20
DE2652679A1 (de) 1977-06-02
IL50911A (en) 1981-01-30
AU1964776A (en) 1978-05-25
SE427841B (sv) 1983-05-09
NO153298B (no) 1985-11-11
PL193809A1 (pl) 1978-01-16
CA1083577A (en) 1980-08-12

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