ES193818A1 - PROCEDIMIENTO PARA LA PREPARACIoN DE DERIVADOS DE MORFINANO Y DE SUS SALES - Google Patents

PROCEDIMIENTO PARA LA PREPARACIoN DE DERIVADOS DE MORFINANO Y DE SUS SALES

Info

Publication number
ES193818A1
ES193818A1 ES0193818A ES193818A ES193818A1 ES 193818 A1 ES193818 A1 ES 193818A1 ES 0193818 A ES0193818 A ES 0193818A ES 193818 A ES193818 A ES 193818A ES 193818 A1 ES193818 A1 ES 193818A1
Authority
ES
Spain
Prior art keywords
formula
salts
preparation
procedure
morphinan derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0193818A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES193818A1 publication Critical patent/ES193818A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para la preparación de derivados de morfinano y de sus sales obedeciendo dichos derivados a la fórmula general **(ver fórmula)** en la cual R y R' significan H Ch OCH3 y OCOCH3 caracterizado por el hecho de que un ácido fenil-acético de la fórmula **(ver fórmula)** en la cual R'' y R''' significan H y OCH3 es tratado con la ciclohexano-(1)-il-etilamina después de que la amida así obtenida es ciclisada para obtener la 1-bencil-3 4 5 6 7 8-hexahidroisoquinoleina correspondiente de la fórmula **(ver fórmula)** que es transformada en el compuesto correspondiente N-metil-1 2 3 4 5 6 7 8-octahidrogenado y que este compuesto es calentado con agente ácido de ciclosación.
ES0193818A 1949-07-29 1950-07-07 PROCEDIMIENTO PARA LA PREPARACIoN DE DERIVADOS DE MORFINANO Y DE SUS SALES Expired ES193818A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH4731549 1949-07-29

Publications (1)

Publication Number Publication Date
ES193818A1 true ES193818A1 (es) 1951-09-16

Family

ID=38464500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0193818A Expired ES193818A1 (es) 1949-07-29 1950-07-07 PROCEDIMIENTO PARA LA PREPARACIoN DE DERIVADOS DE MORFINANO Y DE SUS SALES

Country Status (7)

Country Link
US (1) US2634273A (es)
AT (1) AT176303B (es)
CH (5) CH301667A (es)
DE (1) DE899354C (es)
DK (1) DK81182C (es)
ES (1) ES193818A1 (es)
FR (1) FR1022383A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2714107A (en) * 1955-07-26 Racemisation procedure for i-
DE1014545B (de) * 1953-11-12 1957-08-29 Hoffmann La Roche Verfahren zur Herstellung von N-Alkyl-, N-Alkenyl- oder N-Aralkyl-3-oxymorphinanen
DE1109688B (de) * 1957-10-22 1961-06-29 Berlin Chemie Veb Verfahren zur Herstellung von 1-(p-Methoxybenzyl)-10-hydroxy-dekahydroisochinolin
US4496762A (en) * 1983-03-29 1985-01-29 Eastman Kodak Company Process for the preparation of N-(2-(cyclo-hexen-1-yl)ethyl)-4-methoxybenzeneacetamide
CN102241630A (zh) * 2011-05-20 2011-11-16 杭州保灵集团有限公司 一种镇咳嗽药磷酸二甲啡烷的制备方法
CN104761495A (zh) * 2014-01-08 2015-07-08 上海医药工业研究院 一种新化合物及其制备方法和用途
AU2017242268A1 (en) * 2016-03-29 2018-10-25 Hikal Limited An improved process for the preparation of butorphanol tartrate
CN105859566A (zh) * 2016-04-12 2016-08-17 叶芳 一种环己烯乙胺及其制备方法
CN106632041B (zh) * 2016-10-11 2019-07-12 安徽省逸欣铭医药科技有限公司 一种酒石酸左洛啡烷的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB620258A (en) * 1947-01-13 1949-03-22 Hoffmann La Roche Improvements in or relating to the manufacture of hydro-phenanthrene derivatives

Also Published As

Publication number Publication date
CH301669A (de) 1954-09-15
US2634273A (en) 1953-04-07
CH301667A (de) 1954-09-15
DK81182C (da) 1956-10-15
CH280674A (de) 1952-01-31
AT176303B (de) 1953-10-10
CH301668A (de) 1954-09-15
FR1022383A (fr) 1953-03-04
DE899354C (de) 1953-12-10
CH301670A (de) 1954-09-15

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