ES442651A1 - Procedimiento para la preparacion de las nuevas bis-(dihi- droxipropil-amidas) de acido 5-hidroxipropionilamino-2,4,6- triyodo-isoftalico facilmente solubles en agua. - Google Patents

Procedimiento para la preparacion de las nuevas bis-(dihi- droxipropil-amidas) de acido 5-hidroxipropionilamino-2,4,6- triyodo-isoftalico facilmente solubles en agua.

Info

Publication number
ES442651A1
ES442651A1 ES442651A ES442651A ES442651A1 ES 442651 A1 ES442651 A1 ES 442651A1 ES 442651 A ES442651 A ES 442651A ES 442651 A ES442651 A ES 442651A ES 442651 A1 ES442651 A1 ES 442651A1
Authority
ES
Spain
Prior art keywords
hydroxy
acid
reactive
masked
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442651A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savac AG
Original Assignee
Savac AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savac AG filed Critical Savac AG
Publication of ES442651A1 publication Critical patent/ES442651A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES442651A 1974-12-13 1975-11-14 Procedimiento para la preparacion de las nuevas bis-(dihi- droxipropil-amidas) de acido 5-hidroxipropionilamino-2,4,6- triyodo-isoftalico facilmente solubles en agua. Expired ES442651A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1658874A CH608189A5 (forum.php) 1974-12-13 1974-12-13

Publications (1)

Publication Number Publication Date
ES442651A1 true ES442651A1 (es) 1977-04-16

Family

ID=4418593

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442651A Expired ES442651A1 (es) 1974-12-13 1975-11-14 Procedimiento para la preparacion de las nuevas bis-(dihi- droxipropil-amidas) de acido 5-hidroxipropionilamino-2,4,6- triyodo-isoftalico facilmente solubles en agua.

Country Status (29)

Country Link
US (1) US4001323A (forum.php)
JP (1) JPS5182236A (forum.php)
AR (1) AR211853A1 (forum.php)
AT (2) AT340582B (forum.php)
AU (1) AU475785B2 (forum.php)
BE (1) BE836355A (forum.php)
BG (1) BG26512A3 (forum.php)
CA (1) CA1046082A (forum.php)
CH (1) CH608189A5 (forum.php)
CS (1) CS194234B2 (forum.php)
DD (1) DD122475A5 (forum.php)
DK (1) DK147336C (forum.php)
ES (1) ES442651A1 (forum.php)
FR (1) FR2293919A1 (forum.php)
GB (1) GB1472050A (forum.php)
HU (1) HU170216B (forum.php)
IE (1) IE42620B1 (forum.php)
IL (1) IL48484A (forum.php)
IN (1) IN142089B (forum.php)
MX (1) MX3174E (forum.php)
NL (1) NL157295B (forum.php)
NO (1) NO145096C (forum.php)
PH (1) PH12321A (forum.php)
PL (1) PL96082B1 (forum.php)
RO (1) RO69615A (forum.php)
SE (1) SE409993B (forum.php)
SU (1) SU628813A3 (forum.php)
YU (2) YU40448B (forum.php)
ZA (1) ZA757222B (forum.php)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
US4314055A (en) * 1975-09-29 1982-02-02 Mallinckrodt, Inc. 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids
JPS52130923A (en) * 1976-04-27 1977-11-02 Mallinckrodt Chemical Works Xxray photographic agent
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
CH626873A5 (forum.php) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
NL8002388A (nl) * 1979-05-21 1980-11-25 Mallinckrodt Inc Roentgencontrastmiddel.
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
WO1987000757A1 (en) * 1985-08-09 1987-02-12 Cook Imaging, Inc. Non-ionic polyol contrast media from ionic contrast media
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
GB8919929D0 (en) 1989-09-04 1989-10-18 Nycomed As Compositions
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5463080A (en) * 1992-08-27 1995-10-31 Bracco International B.V. 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256162B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5424056A (en) * 1993-03-01 1995-06-13 Sterling Wintrhop Inc. X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays
US5330740A (en) * 1993-03-01 1994-07-19 Sterling Winthrop Inc. Compositions of iodoaniline derivatives in film-forming materials for visualization of the gastrointestinal tract
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
IT1271469B (it) * 1993-09-10 1997-05-28 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3 diossani
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
SK8897A3 (en) 1995-05-23 1997-08-06 Fructamine Spa Process for the preparation of s-(-)-5-££2-(acetoxy)-1- -oxopropyl|amino|-2,4,6-triiodine-1,3-benzenedicarboxylic acid dichloride
DK0773924T3 (da) * 1995-05-23 1999-09-20 Fructamine Spa Fremgangsmåde til fremstilling af et dicarboxylsyredichlorid
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
HU220965B1 (hu) * 1995-09-08 2002-07-29 Bracco International B.V. Eljárás (S)-N,N'-bisz[2-hidroxi-1-(hidroxi-metil)-etil]-5-[(2-hidroxi-1-oxo-propil)-amino]-2,4,6-trijód-1,3-benzol-dikarboxamid vízből való kristályosítására
JP4104656B2 (ja) * 1995-12-19 2008-06-18 ブラッコ・リサーチ・ソシエテ・アノニム トリヨードベンゼンポリマーからなる胃腸管の画像形成用組成物
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
GB9624612D0 (en) 1996-11-26 1997-01-15 Nycomed Imaging As Process
IT1286522B1 (it) * 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289520B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289521B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la purificazione di un intermedio
CZ299420B6 (cs) * 1997-02-11 2008-07-23 Bracco International B. V. Zpusob krystalizace iopamidolu
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
US6262303B1 (en) 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
IT1302200B1 (it) * 1998-09-11 2000-07-31 Dibra Spa PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1-
GB9825095D0 (en) 1998-11-16 1999-01-13 Nycomed Imaging As Chemical process
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
SE520688C2 (sv) * 2000-04-11 2003-08-12 Bone Support Ab Ett injicerbart ersättningsmaterial för benmineral
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
IT1319671B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
SE522098C2 (sv) * 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
SE0300620D0 (sv) * 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
SE0302983D0 (sv) * 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
DK1836239T3 (da) 2005-01-13 2009-01-19 Cinv Ag Kompositmaterialer, der indeholder carbonnanopartikler
US20080213611A1 (en) * 2007-01-19 2008-09-04 Cinvention Ag Porous, non-degradable implant made by powder molding
EP2126040A1 (en) * 2007-02-28 2009-12-02 Cinvention Ag High surface cultivation system
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
US7955234B1 (en) 2007-02-28 2011-06-07 Pursley Michael G Exercise device and method
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
MX2011005236A (es) * 2008-11-18 2011-06-16 Bracco Imaging Spa Proceso para la preparacion de agente de contraste yodado.
CN102271715A (zh) 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
EP2230227A1 (en) * 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
EP2243767A1 (en) * 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
ES2443149T3 (es) 2009-07-07 2014-02-18 Bracco Imaging Spa Proceso para la preparación de un agente de yodación
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
PT105770B (pt) 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
PT2931696T (pt) 2012-12-11 2018-11-29 Bracco Imaging Spa Processo contínuo para a preparação de ácido (s)-2-acetiloxipropiónico
KR102024692B1 (ko) 2013-02-20 2019-11-04 본 서포트 아베 경화성 뼈 대체물의 향상된 세팅
RU2530159C1 (ru) * 2013-04-16 2014-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ АКАДЕМИЯ ВЕТЕРИНАРНОЙ МЕДИЦИНЫ" (ФГБОУ ВПО СПБГАВМ) Способ изготовления рентгеноконтрастной массы для вазорентгенографии при посмертных исследованиях животных
PT3066071T (pt) * 2013-11-05 2018-06-25 Bracco Imaging Spa Processo para a preparação de iopamidol
RU2703275C2 (ru) 2014-06-10 2019-10-16 Бракко Имэджинг Спа Способ получения (s)-2-ацетилоксипропионовой кислоты и ее производных
CN104230731B (zh) * 2014-09-24 2016-01-20 武汉理工大学 造影剂中间体三碘异酞酰氯的制备方法
PT108524B (pt) * 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
JP7012722B2 (ja) * 2016-12-05 2022-01-28 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 放射線画像診断剤中間体の機械化学的合成
EP3634908B1 (en) 2017-06-07 2024-03-06 Bracco Imaging S.p.A. A process for the recovery of iodine from aqueous solutions
US20240199530A1 (en) 2021-03-22 2024-06-20 Bracco Imaging S.P.A. Industrial synthesis of serinol
CN118414325A (zh) 2021-12-20 2024-07-30 伯拉考成像股份公司 制备2,4,6-三碘间苯二甲酸双酰胺的方法
CN116063195A (zh) * 2023-01-07 2023-05-05 安庆朗坤药业有限公司 一种碘帕醇中间体碘化物的制备方法
WO2024256322A1 (en) 2023-06-13 2024-12-19 Bracco Imaging Spa Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion
EP4534526A1 (en) 2023-10-04 2025-04-09 Bracco Imaging SPA Optimized process for the preparation of iopamidol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL34803A (en) * 1969-06-27 1975-03-13 Nyegaard & Co As N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them
DE2124904C3 (de) * 1971-05-15 1980-09-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Hydroxy- und Alkoxyacetamido-trijodbenzoesäuren, deren Salze mit physiologisch verträglichen Basen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel
BE788054A (fr) * 1971-08-26 1973-02-26 Bracco Ind Chimica Spa Nouvel agent de contraste radiographique et procede pour le preparer
CH583562A5 (forum.php) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
CH576256A5 (forum.php) * 1973-07-17 1976-06-15 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
DE2547789A1 (de) 1976-06-24
YU196783A (en) 1984-12-31
NL7512208A (nl) 1976-06-15
BE836355A (fr) 1976-06-08
NO145096B (no) 1981-10-05
AR211853A1 (es) 1978-03-31
PL96082B1 (pl) 1977-12-31
DK147336C (da) 1985-01-21
DD122475A5 (forum.php) 1976-10-12
ATA925075A (de) 1977-04-15
CS194234B2 (en) 1979-11-30
FR2293919B1 (forum.php) 1980-06-20
JPS5642581B2 (forum.php) 1981-10-06
YU315575A (en) 1982-02-28
JPS5182236A (en) 1976-07-19
DK567475A (da) 1976-06-14
NL157295B (nl) 1978-07-17
PH12321A (en) 1979-01-16
AU475785B2 (en) 1976-09-02
AT342579B (de) 1978-04-10
US4001323A (en) 1977-01-04
FR2293919A1 (fr) 1976-07-09
ATA925175A (de) 1977-08-15
NO145096C (no) 1982-01-13
YU40448B (en) 1986-02-28
RO69615A (ro) 1981-06-30
IL48484A (en) 1978-08-31
CA1046082A (en) 1979-01-09
IN142089B (forum.php) 1977-05-28
ZA757222B (en) 1976-11-24
DK147336B (da) 1984-06-25
AU8751675A (en) 1976-09-02
GB1472050A (en) 1977-04-27
DE2547789B2 (de) 1977-02-24
IE42620B1 (en) 1980-09-10
CH608189A5 (forum.php) 1978-12-29
IL48484A0 (en) 1976-01-30
HU170216B (forum.php) 1977-04-28
AT340582B (de) 1977-12-27
MX3174E (es) 1980-06-09
IE42620L (en) 1976-06-13
SE409993B (sv) 1979-09-17
SU628813A3 (ru) 1978-10-15
YU41540B (en) 1987-08-31
BG26512A3 (bg) 1979-04-12
SE7514076L (sv) 1976-06-14
NO754241L (forum.php) 1976-06-15

Similar Documents

Publication Publication Date Title
ES442651A1 (es) Procedimiento para la preparacion de las nuevas bis-(dihi- droxipropil-amidas) de acido 5-hidroxipropionilamino-2,4,6- triyodo-isoftalico facilmente solubles en agua.
KR870006072A (ko) 라파마이신 전구체의 제조방법
FR2492830B1 (forum.php)
GB1587663A (en) Iodinated isophthalamic acid derivatives
ES316911A1 (es) Un procedimiento para la preparacion de compuestos de valor terapeutico.
ES307471A1 (es) Procedimiento para la preparacion de derivados de fenilalanina.
ES417043A1 (es) Un procedimiento de preparacion de nuevos esteres oxiaceti-cos derivados de esteres orto-timoticos.
ES373778A1 (es) Un procedimiento para preparar imidazopiridinas sustitui- das.
ES444570A1 (es) Procedimiento para la obtencion de derivados de difenileter.
ES451466A1 (es) Procedimiento para la preparacion de nuevos derivados de 5- tiazol-metanoamina.
ES401033A1 (es) Procedimiento para la preparacion de nuevas yodometansulfo-namidas facilmente solubles en agua.
ES382018A1 (es) Procedimiento de preparacion de una composicion cosmetica para el tratamiento de cabellos grasos y pieles grasas.
ES467346A1 (es) Procedimiento para la obtencion de colorantes disazoicos consolo un grupo acido.
ES449841A1 (es) Procedimiento de preparacion de nuevos derivados de la 7h- indolizino (7, 6, 5-de) isoquinoleina.
ES393021A1 (es) Procedimiento para la preparacion de derivados de 4-sulfa- moil-meta-toluidina.
ES439058A1 (es) Procedimiento para la preparacion de uretanos aromaticos.
ES435403A1 (es) Un procedimiento de preparacion de n-(1'-alilpirrolidinil-2'-metil)-2-metoxi-4,5-azimido-benzamina
ES413391A1 (es) Procedimiento de preparacion de n-(aminoalcohil terciario)-2-alcoxi-benzamidas.
ES442394A1 (es) Procedimiento para preparar colorantes solubles en agua.
ES426842A1 (es) Procedimiento para la obtencion de amidas de acidos p - clorofenoxi - alfa,alfa - dialquil - aceticos.
ES412061A1 (es) Procedimiento para la obtencion de derivados de fenoxipro- pilamina.
JPS5462246A (en) Deterioration inhibitor for rubber
ES444483A1 (es) Un procedimiento de preparacion de nuevos derivados de acido2,3-alquilen (inferior) penam-3-carboxilico.
ES293218A1 (es) Procedimiento para la fabricación de medios de constraste radiológico
ES443151A1 (es) Procedimiento para la preparacion de derivados esterificadosde la dopamina.