ES394917A1 - 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes - Google Patents

1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes

Info

Publication number
ES394917A1
ES394917A1 ES394917A ES394917A ES394917A1 ES 394917 A1 ES394917 A1 ES 394917A1 ES 394917 A ES394917 A ES 394917A ES 394917 A ES394917 A ES 394917A ES 394917 A1 ES394917 A1 ES 394917A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
radical
signifies
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES394917A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES394917A1 publication Critical patent/ES394917A1/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • EFIXED CONSTRUCTIONS
    • E04BUILDING
    • E04HBUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
    • E04H13/00Monuments; Tombs; Burial vaults; Columbaria
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Architecture (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Structural Engineering (AREA)
  • Civil Engineering (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedure for the preparation of new racemic or optically active 1-phenoxy-2-hydroxy-3-alcoholylaminopropanes of the general formula **(See formula)** where R means an alcohol group with 1 to 5 carbon atoms; R1 signifies a nitrile (-C = N), carboxy, hydroxy, amino, nitro or trifluoromethyl group or an alcoholic, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, hydroxyalkyl, alkoxyalkoxy, dialkoxylaminoalkyl, dialkoxylaminoalkyl group nitriloalkoxy, alkoxycarbonyl, alkylaminocarbonyl, alcoholylthio, acyl, acyloxy or acylamino with up to 5 carbon atoms, an aryl, aralkoxy, aryloxy, aralkoxy or arylamino group with up to 10 carbon atoms or a halogen atom; stands for hydrogen, a halogen atom, a nitrile group or an alcohol, alkoxy or alkenyl group with up to 5 carbon atoms or together with R1 a 3,4-methylenedioxy group (without other substituents); R3 signifies hydrogen, a halogen atom, an alcohol or alkoxy group with up to 5 carbon atoms; and n signifies an integer from 2 to 7, as well as its physiologically compatible acid addition salts, characterized in that a urea derivative of the general formula is hydrolyzed or pyrolyzed **(See formula)** where R, R1 to R3 and n have the meanings mentioned above and R4 as well as R5 (which may be the same or different) signify hydrogen or an alcoholic radical (preferably lower alcoholic), an aralcohyl radical (preferably the benzyl radical) or a aryl radical (preferably the phenyl radical), and because eventually the racemic compounds obtained from formula I are transformed, by reaction with appropriate auxiliary acids, into their diastereoisomeric salts, and the latter are separated by fractional crystallization. (Machine-translation by Google Translate, not legally binding)
ES394917A 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes Expired ES394917A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1937477A DE1937477C3 (en) 1969-07-23 1969-07-23 I-phenoxy-2-hydroxy-3- (l -methylcycloalkylamino) propane, process for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
ES394917A1 true ES394917A1 (en) 1974-12-01

Family

ID=5740681

Family Applications (8)

Application Number Title Priority Date Filing Date
ES382014A Expired ES382014A1 (en) 1969-07-23 1970-07-21 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394917A Expired ES394917A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394913A Expired ES394913A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394916A Expired ES394916A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394918A Expired ES394918A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394919A Expired ES394919A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394915A Expired ES394915A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394914A Expired ES394914A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES382014A Expired ES382014A1 (en) 1969-07-23 1970-07-21 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes

Family Applications After (6)

Application Number Title Priority Date Filing Date
ES394913A Expired ES394913A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394916A Expired ES394916A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394918A Expired ES394918A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394919A Expired ES394919A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394915A Expired ES394915A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes
ES394914A Expired ES394914A1 (en) 1969-07-23 1971-09-09 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes

Country Status (17)

Country Link
US (1) US3755413A (en)
JP (5) JPS5133106B1 (en)
AT (9) AT306703B (en)
BE (1) BE753774A (en)
BG (9) BG17508A3 (en)
CH (10) CH537360A (en)
CS (9) CS170528B2 (en)
DE (1) DE1937477C3 (en)
DK (1) DK140281B (en)
ES (8) ES382014A1 (en)
FR (1) FR2059551B1 (en)
GB (1) GB1314896A (en)
NL (1) NL169874C (en)
PL (9) PL90038B1 (en)
RO (9) RO59089A (en)
SE (1) SE370391B (en)
YU (5) YU34395B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021576A (en) * 1969-07-23 1977-05-03 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing a 1-(2'-ethynyl-phenoxy)-2-hydroxy-3-(cycloalkyl-amino)-propane and method of use
US3937706A (en) * 1969-07-23 1976-02-10 Boehringer Ingelheim Gmbh 1-(2'ethynyl-phenoxy)-2-hydroxy-3-(cycloalkyl-amino)-propanes and salts thereof
US4120978A (en) * 1970-01-08 1978-10-17 Ciba-Geigy Corporation Pharmaceutical composition for inhibiting and blocking cardioselective beta-receptors
US4038313A (en) * 1970-01-08 1977-07-26 Ciba-Geigy Corporation Cycloalkylureido phenoxy propanolamines
SE354851B (en) * 1970-02-18 1973-03-26 Haessle Ab
US4145442A (en) * 1972-04-04 1979-03-20 Aktiebolaget Hassle Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
US4038414A (en) * 1972-06-08 1977-07-26 Ciba-Geigy Corporation Amines and processes for their manufacture
US4035420A (en) * 1972-07-06 1977-07-12 Aktiebolaget Hassle Substituted ureido alkylene phenoxy propanolamines
DE2309887C2 (en) * 1973-02-28 1983-11-10 C.H. Boehringer Sohn, 6507 Ingelheim 1-aryloxy-2-hydroxy-3-alkynylaminopropane derivatives and their physiologically acceptable acid addition salts, pharmaceutical preparations and manufacturing processes for the compounds
US4220659A (en) * 1974-02-22 1980-09-02 Boehringer Ingelheim Gmbh 1-Phenoxy-2-hydroxy-3-alkynylamino-propanes and salts thereof
DE2540552A1 (en) * 1974-09-12 1976-03-25 American Cyanamid Co CYCLOALKYL DERIVATIVES OF 1-ARYLOXY-3-AMINO-2-PROPANOLS
US4165384A (en) * 1974-11-01 1979-08-21 Aktiebolaget Hassle Amide substituted phenoxy propanol amines
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4471127A (en) * 1981-09-08 1984-09-11 Ciba-Geigy Corporation 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
JPS6364630U (en) * 1986-10-17 1988-04-28

Also Published As

Publication number Publication date
ES394914A1 (en) 1974-12-01
SE370391B (en) 1974-10-14
JPS5210863B1 (en) 1977-03-26
RO59211A (en) 1976-01-15
ES394918A1 (en) 1974-12-01
AT306704B (en) 1973-04-25
FR2059551B1 (en) 1974-09-20
DE1937477C3 (en) 1980-04-10
AT306703B (en) 1973-04-25
DE1937477B2 (en) 1979-08-02
DK140281C (en) 1979-12-10
CH536809A (en) 1973-06-29
US3755413A (en) 1973-08-28
CS170527B2 (en) 1976-08-27
YU34396B (en) 1979-07-10
AT304475B (en) 1973-01-10
YU254675A (en) 1979-04-30
FR2059551A1 (en) 1971-06-04
BG17505A3 (en) 1973-11-10
PL90030B1 (en) 1976-12-31
CS170529B2 (en) 1976-08-27
YU255175A (en) 1978-06-30
CH536812A (en) 1973-06-29
AT304477B (en) 1973-01-10
BG17751A3 (en) 1973-12-25
BG17749A3 (en) 1973-12-25
RO60112A (en) 1976-08-15
CH536813A (en) 1973-06-29
YU34113B (en) 1978-12-31
CH550140A (en) 1974-06-14
ES394913A1 (en) 1974-12-16
RO60111A (en) 1976-06-15
PL90038B1 (en) 1976-12-31
AT304474B (en) 1973-01-10
CS170532B2 (en) 1976-08-27
YU186070A (en) 1978-12-31
RO59209A (en) 1976-01-15
CS170531B2 (en) 1976-08-27
PL79772B1 (en) 1975-06-30
AT304476B (en) 1973-01-10
YU34663B (en) 1979-12-31
YU254575A (en) 1979-04-30
CS170528B2 (en) 1976-08-27
YU34395B (en) 1979-07-10
ES382014A1 (en) 1973-06-16
CS170526B2 (en) 1976-08-27
JPS5133106B1 (en) 1976-09-17
PL90028B1 (en) 1976-12-31
RO56318A (en) 1974-09-01
RO59210A (en) 1976-01-15
BG19132A3 (en) 1975-04-30
RO59089A (en) 1975-11-15
BG17507A3 (en) 1973-11-10
YU254475A (en) 1978-12-31
BG17506A3 (en) 1973-11-10
CH570363A5 (en) 1975-12-15
CS170525B2 (en) 1976-08-27
PL90029B1 (en) 1976-12-31
CH550139A (en) 1974-06-14
ES394915A1 (en) 1974-12-16
BG17508A3 (en) 1973-11-10
NL169874B (en) 1982-04-01
BE753774A (en) 1971-01-22
AT303706B (en) 1972-12-11
CH536810A (en) 1973-06-29
DK140281B (en) 1979-07-23
PL90027B1 (en) 1976-12-31
CH575376A5 (en) 1976-05-14
PL90025B1 (en) 1976-12-31
BG17750A3 (en) 1973-12-25
ES394916A1 (en) 1974-12-16
CH537360A (en) 1973-05-31
GB1314896A (en) 1973-04-26
BG18852A3 (en) 1975-03-20
NL7010928A (en) 1971-01-26
YU34662B (en) 1979-12-31
PL90039B1 (en) 1976-12-31
DE1937477A1 (en) 1971-02-04
CS170524B2 (en) 1976-08-27
JPS5210862B1 (en) 1977-03-26
NL169874C (en) 1982-09-01
CS170530B2 (en) 1976-08-27
CH536811A (en) 1973-06-29
JPS5238556B1 (en) 1977-09-29
PL90026B1 (en) 1976-12-31
RO59112A (en) 1976-01-15
JPS5210861B1 (en) 1977-03-26
RO59159A (en) 1976-02-15
AT304478B (en) 1973-01-10
ES394919A1 (en) 1974-12-01
AT306702B (en) 1973-04-25

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