ES3032009T3 - Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof - Google Patents

Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof

Info

Publication number
ES3032009T3
ES3032009T3 ES23175506T ES23175506T ES3032009T3 ES 3032009 T3 ES3032009 T3 ES 3032009T3 ES 23175506 T ES23175506 T ES 23175506T ES 23175506 T ES23175506 T ES 23175506T ES 3032009 T3 ES3032009 T3 ES 3032009T3
Authority
ES
Spain
Prior art keywords
urolithin
certain embodiments
relates
aforementioned compounds
autophagy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES23175506T
Other languages
English (en)
Spanish (es)
Inventor
Christopher L Rinsch
William Blanco-Bose
Bernard Schneider
Laurent Mouchiroud
Dongryeol Ryu
Penelope Andreux
Johan Auwerx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amazentis SA
Original Assignee
Amazentis SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48782652&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES3032009(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amazentis SA filed Critical Amazentis SA
Application granted granted Critical
Publication of ES3032009T3 publication Critical patent/ES3032009T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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ES23175506T 2012-06-27 2013-06-27 Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof Active ES3032009T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261665137P 2012-06-27 2012-06-27
US201261712886P 2012-10-12 2012-10-12
US201361791137P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
ES3032009T3 true ES3032009T3 (en) 2025-07-14

Family

ID=48782652

Family Applications (2)

Application Number Title Priority Date Filing Date
ES23175506T Active ES3032009T3 (en) 2012-06-27 2013-06-27 Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof
ES13735543T Active ES2968368T3 (es) 2012-06-27 2013-06-27 Mejorar la autofagia o aumentar la longevidad mediante la administración de urolitinas o precursores de las mismas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13735543T Active ES2968368T3 (es) 2012-06-27 2013-06-27 Mejorar la autofagia o aumentar la longevidad mediante la administración de urolitinas o precursores de las mismas

Country Status (16)

Country Link
US (10) US11020373B2 (enExample)
EP (3) EP4566677A3 (enExample)
JP (5) JP6422163B2 (enExample)
KR (4) KR20230116091A (enExample)
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Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230116091A (ko) * 2012-06-27 2023-08-03 아마젠티스 에스에이 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식향상 또는 장수 증가
EP2945622B1 (en) * 2013-01-18 2022-11-30 Mans, Jean-Pierre Composition comprising urolithin b and testosterone, leucine and/or creatine for muscle growth
HK1222590A1 (zh) * 2013-09-09 2017-07-07 Natreon, Inc. 通过使用二苯-α-吡喃酮调节体重的增长
EP2862568A1 (en) 2013-10-15 2015-04-22 Centre National de la Recherche Scientifique (CNRS) Compositions comprising urolithins and uses thereof for the stimulation of insulin secretion
WO2015100213A2 (en) 2013-12-23 2015-07-02 Amazentis Sa Process-scale synthesis of urolithins
GB201323008D0 (en) 2013-12-24 2014-02-12 Amazentis As Compounds and uses thereof
GB201413228D0 (en) 2014-07-25 2014-09-10 Nugerontix Ltd Polyphenol compositions
EP3233075A4 (en) * 2014-12-19 2018-10-24 Halo Life Science, LLC Use of ellagic acid dihydrate in food products and nutraceuticals
WO2016167225A1 (ja) * 2015-04-13 2016-10-20 住友精化株式会社 ２－ハロゲン化安息香酸類の製造方法
JP6740548B2 (ja) * 2015-05-15 2020-08-19 公立大学法人岡山県立大学 ウロリチン類を含有する育毛剤、及び、ウロリチン類を含有する５αレダクターゼ活性阻害剤
JP2017014154A (ja) * 2015-07-01 2017-01-19 公立大学法人岡山県立大学 ウロリチン類を含有するヒアルロン酸産生促進剤
JP6799767B2 (ja) * 2015-07-07 2020-12-16 公立大学法人岡山県立大学 ウロリチン類を含有するメラニン産生抑制剤
GB201515391D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
CA3009432A1 (en) * 2015-12-24 2017-06-29 Amazentis Sa Compositions comprising nicotinamide riboside and a urolithin
JP6791478B2 (ja) * 2016-05-26 2020-11-25 株式会社ダイセル ウロリチン類を含有するアンジオテンシン変換酵素阻害剤
JP2017210444A (ja) * 2016-05-26 2017-11-30 株式会社ダイセル ウロリチン類を含有するリパーゼ阻害剤
ES2985944T3 (es) * 2016-06-29 2024-11-07 Halo Life Science Llc Método de preparación de una sal de ellagato de dicolinio de poco olor y otras sales orgánicas de colina de poco olor
EP3481411A4 (en) 2016-07-11 2020-07-22 University of North Texas Health Science Center at Fort Worth TREATING GLAUCOMA AND OTHER EYE DISEASES
WO2018085419A1 (en) 2016-11-01 2018-05-11 Jian Feng Method of producing naive pluripotent stem cells
EP3354645A1 (en) 2017-01-26 2018-08-01 Patheon Austria GmbH & Co KG Process for preparing urolithins
EP3592425A1 (en) 2017-03-08 2020-01-15 Amazentis SA Methods for improving mitophagy in subjects
CA3055669A1 (en) 2017-03-08 2018-09-13 Amazentis Sa Skin treatment methods
WO2018162650A1 (en) 2017-03-08 2018-09-13 Amazentis Sa Methods for improving mitophagy in subjects
JP2019097566A (ja) * 2017-12-07 2019-06-24 大正製薬株式会社 体内時計調整用組成物
CN111479580B (zh) * 2017-12-20 2024-08-06 雀巢产品有限公司 采用自噬诱发剂和高蛋白质的组合来诱发自噬的组合物和方法
CN111491656A (zh) * 2017-12-20 2020-08-04 雀巢产品有限公司 采用高蛋白质诱发自噬的组合物和方法
AU2018408840A1 (en) * 2018-02-19 2020-09-10 Natreon, Inc. Synergistic combinations of Urolithins A and B for improving cognitive capacity or cognitive function
WO2019163437A1 (ja) 2018-02-21 2019-08-29 株式会社ダイセル ウロリチン類を含有する破骨細胞分化抑制剤
RU2020128799A (ru) * 2018-02-27 2022-03-28 Амазентис Са Промышленный синтез уролитина а
WO2019187918A1 (ja) * 2018-03-29 2019-10-03 国立大学法人 琉球大学 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化ｉＰＳ細胞等の混入を除去する方法
WO2019211294A1 (en) 2018-04-30 2019-11-07 Amazentis Sa Urolithin a as immune enhancer
JP2021523942A (ja) * 2018-05-15 2021-09-09 ユニバーシティ・オブ・ルイスビル・リサーチ・ファウンデーション・インコーポレイテッドＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｌｏｕｉｓｖｉｌｌｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ， Ｉｎｃ． 療法における使用のためのウロリシンａおよびその誘導体
KR20210016407A (ko) 2018-06-05 2021-02-15 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 대사 장애 및 비알코올성 지방 간 질환의 치료를 위한 활성제 및 그 사용 방법
EP3801587A4 (en) * 2018-06-05 2022-08-10 Flagship Pioneering Innovations V, Inc. ACYLATED CATECHIN POLYPHENOLS AND METHODS OF USE THEREOF FOR THE TREATMENT OF CANCER
CN108676013B (zh) * 2018-06-25 2021-01-01 中国医学科学院医药生物技术研究所 具有自噬激活活性的黄醇酮类化合物、其制备方法及其制药应用
CN109316478A (zh) * 2018-11-06 2019-02-12 上海出入境检验检疫局动植物与食品检验检疫技术中心 一种尿石素a在制备抗衰老的药物、化妆品中的应用及药物、化妆品
PL245399B1 (pl) 2018-11-29 2024-07-15 Univ Warszawski Medyczny Kompozycja farmaceutyczna zawierająca urolitynę A lub jej pochodną do zastosowania zewnętrznego miejscowego w leczeniu, hamowaniu i zapobieganiu chorobom skóry i błon śluzowych o podłożu zapalnym
CN113260360A (zh) * 2019-01-18 2021-08-13 雀巢产品有限公司 用于增加干细胞功能的试剂和方法
CN110066284B (zh) * 2019-02-01 2021-06-04 贵阳倍隆生物科技有限公司 一种一锅法合成鞣花酸的方法
CN110229167B (zh) * 2019-05-22 2020-11-24 珠海萱嘉君行健康产业发展有限公司 一种利用五倍子制备鞣花酸的方法、制得的鞣花酸及其应用
CN111995610A (zh) * 2019-05-27 2020-11-27 首都医科大学 一种尿石素类化合物用于治疗胶质母细胞瘤药物的应用
EP3986420A1 (en) * 2019-06-18 2022-04-27 Mitopower LLC Nicotinyl riboside compounds and their uses
US20220184015A1 (en) * 2019-06-20 2022-06-16 Societe Des Produits Nestle S.A. Compositions and methods to potentiate musculoskeletal effect of one or more anabolic amino acids on bone health
GB201912107D0 (en) 2019-08-22 2019-10-09 Amazentis Sa Combination
GB201915191D0 (en) * 2019-10-21 2019-12-04 Floratek Gmbh Novel heterocyclic compounds
GB201916046D0 (en) 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CN114760996A (zh) * 2019-11-27 2022-07-15 雀巢产品有限公司 与间接ampk活化剂化合物组合的直接ampk活化剂化合物、组合物、方法和其用途
JP2023503869A (ja) * 2019-11-27 2023-02-01 ソシエテ・デ・プロデュイ・ネスレ・エス・アー ベンゾクマリンａｍｐｋ活性化剤化合物、組成物、方法、及びその使用
CN113018305A (zh) * 2019-12-24 2021-06-25 兰州大学 一种化合物在制备治疗阿尔兹海默症药物中的应用
EP4106747A4 (en) * 2020-02-20 2024-02-21 The Royal Institution for the Advancement of Learning / McGill University Use of castalagin or analogs thereof for anti-cancer efficacy and to increase the response to immune checkpoint inhibitors
US20240000753A1 (en) * 2020-07-17 2024-01-04 The Trustees Of Columbia University In The City Of New York Methods and compositions to increase lifespan and healthspan by mimicking the effects of time-restricted feeding
CN111983058B (zh) * 2020-07-30 2023-06-23 云南中医药大学 中药抗非酒精性脂肪肝活性物质的筛选方法
US20220071952A1 (en) * 2020-09-04 2022-03-10 Natreon, Inc. Methods of treating and preventing hepatotoxicity
CN115884685B (zh) 2020-09-25 2025-07-04 雀巢产品有限公司 使用黄原胶来稳定水性基质中的至少一种尿石素的组合物和方法
KR102623664B1 (ko) 2020-12-10 2024-01-12 서울대학교산학협력단 유로리틴 a를 이용한 당뇨성 알츠하이머병의 치료 조성물 및 치료 방법
MX2023008677A (es) 2021-01-27 2023-10-03 Vandria Sa Derivados de urolitinas y métodos para su uso.
CN112716938A (zh) * 2021-02-25 2021-04-30 新疆医科大学 鞣花酸在制备缓解眼组织病变的药物中的用途
KR102677423B1 (ko) * 2021-09-17 2024-06-21 조선대학교산학협력단 망기페린을 포함하는 자가포식 활성화용 조성물
KR102690860B1 (ko) * 2021-10-13 2024-08-05 한국해양과학기술원 남극 진균 균주 Pleosporales sp. SF-7343 유래 대사화합물을 포함하는 염증질환 예방 또는 치료용 조성물
CA3235524A1 (en) * 2021-10-28 2023-05-04 Societe Des Produits Nestle S.A. Compositions and methods using a combination of nutrients to support cognition and emotional health in a mammal
US20230277669A1 (en) 2022-02-24 2023-09-07 Amazentis Sa Uses of urolithins
WO2023180214A1 (en) 2022-03-22 2023-09-28 Amazentis Sa Compositions
AU2023283046A1 (en) * 2022-06-06 2025-01-09 Amazentis Sa Urolithins for improving cardiac function and health
EP4561556A2 (en) * 2022-07-27 2025-06-04 Vandria SA Therapeutic uses of urolithin derivatives
CN115433151A (zh) * 2022-09-02 2022-12-06 苏州大学 一种6，7，8-三羟基香豆素的制备方法
CN115581689B (zh) * 2022-10-17 2024-05-14 常州大学 尿石素b酰胺类衍生物的应用
GB202219317D0 (en) 2022-12-20 2023-02-01 Amazentis Sa Methods for improving mitophagy in subjects
GB202308224D0 (en) 2023-06-01 2023-07-19 Amazentis Sa Formulation
CN116966188A (zh) * 2023-07-14 2023-10-31 天津医科大学总医院 丁香素在制备治疗和/或预防炎症性肠病药物中的应用
GB202312220D0 (en) 2023-08-09 2023-09-20 Amazentis Sa Formulation
WO2025076497A1 (en) * 2023-10-06 2025-04-10 Northeast Ohio Medical University Combination treatment of tau pathology
FR3153996A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d'au moins l’urolithine C sur une peau sensible
FR3153998A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d’iso-urolithine A sur une peau sensible
WO2025078645A1 (en) * 2023-10-13 2025-04-17 L'oreal Cosmetic use of at least urolithin b or c on a sensitive skin
FR3153997A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d'au moins l’urolithine B sur une peau sensible
GB202316295D0 (en) 2023-10-24 2023-12-06 Amazentis Sa Composition
GB202319994D0 (en) 2023-12-22 2024-02-07 Amazentis Sa Compositions for use
CN117771237B (zh) * 2024-02-27 2024-05-03 南昌医学院 一种松香烷型二萜化合物的用途和制备方法
WO2025194036A1 (en) * 2024-03-14 2025-09-18 Washington University Autophagy enhancers
WO2025224366A1 (en) 2024-04-26 2025-10-30 Amazentis Sa Immune health improvers
WO2025252771A1 (en) 2024-06-03 2025-12-11 Amazentis Sa Urolithin combinations
CN119792272B (zh) * 2025-02-07 2025-10-03 陕西中鸿科瑞再生医学研究院有限公司 一种改善睡眠的组合物及其制备方法与制剂

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6479103A (en) 1987-06-09 1989-03-24 Lion Corp External preparation
EP1100589B1 (en) 1998-07-30 2005-01-19 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of propionyl l-carnitine and acetyl l-carnitine in the preparation of medicaments with anticancer activity
US6440436B1 (en) 2001-05-18 2002-08-27 Natreon Inc. Process for preparing purified shilajit composition from native shilajit
US7365193B2 (en) 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
US20050171079A1 (en) 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use
US20050282781A1 (en) 2004-06-18 2005-12-22 Shibnath Ghosal Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
US20060257337A1 (en) 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
JP2009528381A (ja) 2006-02-28 2009-08-06 パロマ ファーマシューティカルズ，インク． 細胞増殖および血管新生を特徴とする疾患を治療する組成物および方法
ES2646177T3 (es) * 2006-04-26 2017-12-12 The Regents Of The University Of California Usos terapéuticos de las urolitinas
US8894993B2 (en) * 2006-08-04 2014-11-25 Natreon Inc. Mitochondria-targeted antioxidants
WO2008139123A2 (fr) * 2007-05-11 2008-11-20 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
WO2008139124A2 (fr) * 2007-05-11 2008-11-20 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
TW200929211A (en) 2007-12-17 2009-07-01 Etron Technology Inc Method of reducing current of memory in self-refreshing mode
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
AU2009228303B2 (en) 2008-03-25 2015-08-13 Paloma Pharmaceuticals, Inc. Methods of treating fibrotic disorders
ES2685947T3 (es) * 2009-04-10 2018-10-15 Haiyan Qi Agentes antienvejecimiento
JP5385686B2 (ja) 2009-06-05 2014-01-08 サントリーホールディングス株式会社 血小板凝集抑制剤
UA108856C2 (uk) * 2009-07-24 2015-06-25 Пунікалін (punicalin) та пунікалагін (punicalagin) для захисту здоров'я головного мозку при нейродегенеративних розладах
CN105497014B (zh) 2010-12-23 2021-03-30 阿马曾提斯公司 用于改善线粒体功能的组合物和方法
WO2012113835A1 (en) 2011-02-22 2012-08-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) C-glucosidic ellagitannin compounds for use for altering the supramolecular arrangement of actin and for the treatment of osteoporosis, cancer, bacterial infection and viral infection
KR20230116091A (ko) 2012-06-27 2023-08-03 아마젠티스 에스에이 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식향상 또는 장수 증가
CA3009432A1 (en) 2015-12-24 2017-06-29 Amazentis Sa Compositions comprising nicotinamide riboside and a urolithin

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