ES2829415T3 - Algoritmo de perfil de expresión génica para calcular una puntuación de recurrencia para un paciente con cáncer de riñón - Google Patents
Algoritmo de perfil de expresión génica para calcular una puntuación de recurrencia para un paciente con cáncer de riñón Download PDFInfo
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- ES2829415T3 ES2829415T3 ES14804772T ES14804772T ES2829415T3 ES 2829415 T3 ES2829415 T3 ES 2829415T3 ES 14804772 T ES14804772 T ES 14804772T ES 14804772 T ES14804772 T ES 14804772T ES 2829415 T3 ES2829415 T3 ES 2829415T3
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Family Cites Families (54)
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| DE10126344A1 (de) | 2000-07-14 | 2002-01-24 | Max Planck Gesellschaft | Apoptose-induzierende DNA-Sequenzen |
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| WO2002079411A2 (en) * | 2001-03-29 | 2002-10-10 | Van Andel Institute | Microarray gene expression profiling in clear cell renal cell carcinoma: prognosis and drug target identification |
| JP2005500832A (ja) | 2001-06-18 | 2005-01-13 | ロゼッタ・インファーマティクス・インコーポレーテッド | 乳癌患者の診断および予後 |
| US7470509B2 (en) | 2002-02-08 | 2008-12-30 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the identification, assessment, prevention and therapy of ovarian cancer |
| US7081340B2 (en) | 2002-03-13 | 2006-07-25 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
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| BR0316111A (pt) | 2002-11-21 | 2005-09-13 | Wyeth Corp | Métodos para diagnosticar rcc e outros tumores sólidos |
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| JP4680898B2 (ja) | 2003-06-24 | 2011-05-11 | ジェノミック ヘルス， インコーポレイテッド | 癌再発の可能性の予測 |
| BRPI0412110A (pt) | 2003-07-02 | 2006-11-21 | Novartis Ag | genes regulados no cáncer ovariano como alvos prognósticos e terapêuticos |
| US20050002904A1 (en) | 2003-07-03 | 2005-01-06 | Wary Kishore K. | Uses of vascular endothelial growth factor and type I collagen inducible protein (VCIP) |
| EP3330875B1 (en) | 2003-07-10 | 2021-12-01 | Genomic Health, Inc. | Expression profile algorithm and test for prognosing breast cancer recurrence |
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| US20070224596A1 (en) | 2004-04-09 | 2007-09-27 | Mariana Nacht | Compositions and methods for the modifying hypoxia induced gene regulation |
| ES2550614T3 (es) * | 2004-04-09 | 2015-11-11 | Genomic Health, Inc. | Marcadores de expresión génica para predecir la respuesta a la quimioterapia |
| CA2564850A1 (en) * | 2004-05-04 | 2005-11-17 | Bulent Soyupak | Mn/ca ix/ ca9 and renal cancer prognosis |
| JP2008500057A (ja) | 2004-05-27 | 2008-01-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｉｍｐｄｈ経路の阻害をモニタリングするためのバイオマーカー |
| US7587279B2 (en) | 2004-07-06 | 2009-09-08 | Genomic Health | Method for quantitative PCR data analysis system (QDAS) |
| US20080119367A1 (en) | 2004-12-17 | 2008-05-22 | Mayo Foundation For Medical Education And Research | Prognosis of Renal Cell Carcinoma |
| AU2006210794A1 (en) | 2005-02-01 | 2006-08-10 | Government Of The U.S.A., As Represented By The Secretary, Department Of Health & Human Services | Biomarkers for tissue status |
| BRPI0608429A2 (pt) | 2005-02-18 | 2009-12-29 | Wyeth Corp | método e kit para prognóstico ou avaliação da eficácia do tratamento de um tumor sólido em um paciente de interesse; e método para a identificação de marcadores que sejam prognósticos de um tumor sólido |
| WO2006124022A1 (en) | 2005-05-13 | 2006-11-23 | Vanandel Research Institute | Microarray gene expression profiling in subtypes of clear cell renal cell carcinoma |
| US20090186024A1 (en) | 2005-05-13 | 2009-07-23 | Nevins Joseph R | Gene Expression Signatures for Oncogenic Pathway Deregulation |
| US20070037186A1 (en) | 2005-05-20 | 2007-02-15 | Yuqiu Jiang | Thyroid fine needle aspiration molecular assay |
| CA2611728A1 (en) | 2005-06-08 | 2006-12-14 | Millennium Pharmaceuticals, Inc. | Methods for the identification, assessment, and treatment of patients with cancer therapy |
| US20070099209A1 (en) | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US20070105133A1 (en) | 2005-06-13 | 2007-05-10 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| EP1893581B1 (en) | 2005-06-15 | 2010-01-27 | Pfizer Limited | Substituted arylpyrazoles for use against parasitites |
| CA2621070A1 (en) | 2005-09-02 | 2007-03-08 | Toray Industries, Inc. | Composition and method for diagnosing kidney cancer and estimating kidney cancer patient's prognosis |
| WO2007030882A1 (en) | 2005-09-14 | 2007-03-22 | Human Genetic Signatures Pty Ltd | Assay for a health state |
| EP2982688A3 (en) | 2005-09-30 | 2016-05-25 | Universiteit Maastricht | Tumor angiogenesis associated genes and a method for their identification |
| EP1777523A1 (en) | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| US8445198B2 (en) | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| CA2631236C (en) | 2005-12-01 | 2019-10-29 | Medical Prognosis Institute | Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| US20070141066A1 (en) | 2005-12-16 | 2007-06-21 | Genentech, Inc. | Method for Diagnosing, Prognosing and Treating Glioma |
| WO2007146668A2 (en) | 2006-06-06 | 2007-12-21 | University Of Massachusetts | Use of imp3 as a prognostic marker for cancer |
| WO2008021183A2 (en) | 2006-08-10 | 2008-02-21 | Millennium Pharmaceuticals, Inc. | For the identification, assessment, and treatment of patients with cancer therapy |
| WO2008021115A2 (en) | 2006-08-14 | 2008-02-21 | The Brigham And Women's Hospital, Inc. | Diagnostic tests using gene expression ratios |
| WO2008083098A1 (en) * | 2006-12-27 | 2008-07-10 | The Johns Hopkins University | Agents for reversing epigenetic silencing of genes |
| US20080286273A1 (en) | 2007-05-02 | 2008-11-20 | Siemens Medical Solutions Usa, Inc. | Knowledge-Based Proliferation Signatures and Methods of Use |
| EP1990417A1 (en) | 2007-05-11 | 2008-11-12 | Universität Bayreuth | Archaeal plasmid vector system |
| WO2009105640A1 (en) | 2008-02-22 | 2009-08-27 | Virginia Commonwealth University | Signatures associated with rejection or recurrence of cancer |
| CA3153682A1 (en) | 2008-11-17 | 2010-05-20 | Veracyte, Inc. | Methods and compositions of molecular profiling for disease diagnostics |
| CA2766703A1 (en) | 2009-06-26 | 2010-12-29 | Noviogendix Research B.V. | Molecular markers in kidney cancer |
| US9005891B2 (en) | 2009-11-10 | 2015-04-14 | Genomic Health, Inc. | Methods for depleting RNA from nucleic acid samples |
| CA2776751C (en) * | 2009-11-23 | 2019-07-02 | Genomic Health, Inc. | Methods to predict clinical outcome of cancer |
| EP2524055A4 (en) | 2010-01-11 | 2013-06-05 | Genomic Health Inc | METHOD FOR THE USE OF GENE EXPRESSION FOR DETERMINING THE PROBABILITY OF CLINICAL EXERCISE OF KIDNEY CANCER |
| EP2721179A4 (en) * | 2011-06-16 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | BIOMARKER COMPOSITIONS AND METHOD THEREFOR |
| US20130065782A1 (en) | 2011-08-22 | 2013-03-14 | Somalogic, Inc. | Renal Cell Carcinoma Biomarkers and Uses Thereof |
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