ES2771208T3 - Composiciones de factor VIII y métodos de preparación y uso de las mismas - Google Patents
Composiciones de factor VIII y métodos de preparación y uso de las mismas Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261599400P | 2012-02-15 | 2012-02-15 | |
| PCT/US2012/046326 WO2013122617A1 (en) | 2012-02-15 | 2012-07-11 | Factor viii compositions and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2771208T3 true ES2771208T3 (es) | 2020-07-06 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| ES19165518T Active ES2935489T3 (es) | 2012-02-15 | 2012-07-11 | Composiciones de factor VIII y métodos de preparación y uso de las mismas |
| ES12868427T Active ES2771208T3 (es) | 2012-02-15 | 2012-07-11 | Composiciones de factor VIII y métodos de preparación y uso de las mismas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19165518T Active ES2935489T3 (es) | 2012-02-15 | 2012-07-11 | Composiciones de factor VIII y métodos de preparación y uso de las mismas |
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| US (3) | US10421798B2 (OSRAM) |
| EP (3) | EP4194465A1 (OSRAM) |
| JP (6) | JP6256882B2 (OSRAM) |
| KR (1) | KR102097263B1 (OSRAM) |
| CN (5) | CN111574632A (OSRAM) |
| AU (3) | AU2012327217B2 (OSRAM) |
| BR (1) | BR112014020694A2 (OSRAM) |
| CA (1) | CA2864904C (OSRAM) |
| CL (2) | CL2014002166A1 (OSRAM) |
| CO (1) | CO7051009A2 (OSRAM) |
| CY (1) | CY1122800T1 (OSRAM) |
| DK (2) | DK3564260T5 (OSRAM) |
| EA (1) | EA201491470A1 (OSRAM) |
| ES (2) | ES2935489T3 (OSRAM) |
| FI (1) | FI3564260T3 (OSRAM) |
| HR (2) | HRP20221531T1 (OSRAM) |
| HU (2) | HUE060629T2 (OSRAM) |
| IL (1) | IL234108B (OSRAM) |
| LT (2) | LT3564260T (OSRAM) |
| MX (2) | MX369862B (OSRAM) |
| MY (1) | MY188897A (OSRAM) |
| PH (2) | PH12014501849B1 (OSRAM) |
| PL (2) | PL2814840T3 (OSRAM) |
| PT (2) | PT3564260T (OSRAM) |
| RS (2) | RS63870B1 (OSRAM) |
| SG (2) | SG11201404885RA (OSRAM) |
| SI (2) | SI3564260T1 (OSRAM) |
| WO (1) | WO2013122617A1 (OSRAM) |
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| EP3178835B1 (en) * | 2009-02-03 | 2019-04-10 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
| US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| RS59670B1 (sr) | 2012-01-12 | 2020-01-31 | Bioverativ Therapeutics Inc | Himerni polipeptidi faktora viii i njihove upotrebe |
| EA201491388A1 (ru) | 2012-02-15 | 2015-01-30 | Байоджен Айдек Ма Инк. | Рекомбинантные белки фактора viii |
| DK3564260T5 (da) | 2012-02-15 | 2024-09-02 | Bioverativ Therapeutics Inc | Faktor viii-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf |
| KR102057356B1 (ko) | 2012-02-27 | 2019-12-18 | 아뮤닉스 파마슈티컬스, 인크. | Ｘｔｅｎ 콘주게이트 조성물 및 그의 제조 방법 |
| CN104661674A (zh) | 2012-07-11 | 2015-05-27 | 阿穆尼克斯运营公司 | 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途 |
| DK3889173T5 (da) | 2013-02-15 | 2024-08-05 | Bioverativ Therapeutics Inc | Optimeret faktor viii-gen |
| TWI745671B (zh) | 2013-03-15 | 2021-11-11 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
| EP3013359A4 (en) * | 2013-06-28 | 2017-01-25 | Biogen MA Inc. | Thrombin cleavable linker |
| WO2014210558A1 (en) | 2013-06-28 | 2014-12-31 | Biogen Idec Ma Inc. | Thrombin cleavable linker with xten and its uses thereof |
| WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
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| US9322037B2 (en) * | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| CN114736305B (zh) | 2014-01-10 | 2023-05-05 | 比奥贝拉蒂治疗公司 | 因子viii嵌合蛋白及其用途 |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| WO2016198521A1 (en) * | 2015-06-10 | 2016-12-15 | Novo Nordisk A/S | Fviii fusion proteins |
| MX2018001497A (es) | 2015-08-03 | 2018-05-15 | Bioverativ Therapeutics Inc | Proteinas de fusion de factor ix y metodos para producirlas y usarlas. |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| AU2016353353B2 (en) | 2015-11-13 | 2020-07-09 | Takeda Pharmaceutical Company Limited | Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A |
| EA036944B1 (ru) * | 2015-11-13 | 2021-01-19 | Баксалта Инкорпорейтед | Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a |
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| TW201536811A (zh) | 2013-05-31 | 2015-10-01 | Biogen Idec Inc | 嵌合ｆｖｉｉ－ｘｔｅｎ分子及其用途 |
| WO2014198699A2 (en) | 2013-06-12 | 2014-12-18 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
| EP3013359A4 (en) | 2013-06-28 | 2017-01-25 | Biogen MA Inc. | Thrombin cleavable linker |
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| WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
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