ES2721173T3 - Sustancias de relleno de grano fino para películas de reacción fotométricas - Google Patents
Sustancias de relleno de grano fino para películas de reacción fotométricas Download PDFInfo
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- ES2721173T3 ES2721173T3 ES09753073T ES09753073T ES2721173T3 ES 2721173 T3 ES2721173 T3 ES 2721173T3 ES 09753073 T ES09753073 T ES 09753073T ES 09753073 T ES09753073 T ES 09753073T ES 2721173 T3 ES2721173 T3 ES 2721173T3
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
- G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Un elemento de prueba de diagnóstico (110) para detectar un analito en una muestra (126) de fluido corporal, en particular, sangre entera, que comprende al menos un campo de prueba (116) que tiene al menos un reactivo de detección, en el que el reactivo de detección está diseñado para sufrir al menos un cambio detectable en presencia del analito, en particular, un cambio óptico, en el que el campo de prueba (116) presenta al menos una capa de detección que comprende el reactivo de detección (118), en el que la capa de detección (118) presenta partículas (137), en las que al menos 90 % de todas las partículas (137) de la capa de detección (118) presentan un tamaño de partícula real inferior a 10 micrómetros, en las que se emplea un procedimiento de microscopía electrónica para determinar la distribución de tamaño de las partículas, en el que solo las partículas a partir de un tamaño de 200 nanómetros se tienen en cuenta para determinar la distribución de tamaño de las partículas, en el que el campo de prueba (116) presenta un lado de aplicación (128) para aplicar la muestra (126) y un lado de detección (120) para detectar un cambio en el reactivo de detección, en particular, un cambio óptico, en el que el campo de prueba (116) presenta además al menos una capa de separación (122), en la que la capa de separación (122) está dispuesta del lado más cercano al lado de aplicación (128) de la capa de detección (118), en la que la capa de separación (122) comprende al menos un pigmento, caracterizado por que al menos 70 % de todas las partículas (137) de la capa de detección (118) presenta un tamaño de partícula real inferior a 900 nanómetros.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08168666 | 2008-11-07 | ||
PCT/EP2009/064757 WO2010052306A1 (de) | 2008-11-07 | 2009-11-06 | Feinkörnige füllstoffe für photometrische reaktionsfilme |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2721173T3 true ES2721173T3 (es) | 2019-07-29 |
Family
ID=40410316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09753073T Active ES2721173T3 (es) | 2008-11-07 | 2009-11-06 | Sustancias de relleno de grano fino para películas de reacción fotométricas |
Country Status (19)
Country | Link |
---|---|
US (3) | US20120040386A1 (es) |
EP (2) | EP2366102B1 (es) |
JP (1) | JP5981140B2 (es) |
KR (2) | KR20130020807A (es) |
CN (2) | CN102209898B (es) |
AU (1) | AU2009312781C1 (es) |
BR (1) | BRPI0921608A2 (es) |
CA (1) | CA2743068C (es) |
ES (1) | ES2721173T3 (es) |
HK (2) | HK1162673A1 (es) |
HU (1) | HUE044628T2 (es) |
MX (1) | MX2011003602A (es) |
NZ (1) | NZ591742A (es) |
PL (1) | PL2359136T3 (es) |
PT (1) | PT2359136T (es) |
RU (1) | RU2532359C2 (es) |
TR (1) | TR201905816T4 (es) |
WO (2) | WO2010052306A1 (es) |
ZA (1) | ZA201103253B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2532359C2 (ru) * | 2008-11-07 | 2014-11-10 | Ф.Хоффманн-Ля Рош Аг | Мелкозернистые наполнители для фотометрических реактивных пленок |
US20130342684A1 (en) * | 2011-01-19 | 2013-12-26 | Teknologian Tutkimuskeskus Vtt | Method and System for Determining Particle Size Information |
EP2607492A1 (de) | 2011-12-22 | 2013-06-26 | Roche Diagniostics GmbH | Verfahren zur Bestimmung einer Analytkonzentration |
EP2839267B1 (de) | 2012-04-19 | 2019-12-04 | F.Hoffmann-La Roche Ag | Verfahren und vorrichtung zur bestimmung einer analytkonzentration in blut |
JP6039965B2 (ja) * | 2012-08-22 | 2016-12-07 | 森永製菓株式会社 | イムノクロマトグラフィー用デバイス |
US10114032B2 (en) * | 2013-05-23 | 2018-10-30 | Nippon Telegraph And Telephone Corporation | Blood coagulation test method |
JP6071785B2 (ja) * | 2013-07-12 | 2017-02-01 | 株式会社堀場製作所 | 濃度測定装置 |
DE102013110011B4 (de) * | 2013-09-12 | 2018-07-12 | Gert Horstmeyer | Verfahren und Einrichtung zur Analyse von Ölen und technischen Betriebsflüssigkeiten und zur qualifizierten Bewertung der Betriebszustände von Aggregaten |
RU2723537C2 (ru) | 2014-01-24 | 2020-06-15 | Ф. Хоффманн-Ля Рош Аг | Способ изготовления однокодовых и бескодовых тест-полосок |
EP2905618A1 (en) | 2014-02-05 | 2015-08-12 | Roche Diagnostics GmbH | Use of rare metals as key components |
CN104251823B (zh) | 2014-09-11 | 2017-01-11 | 天津起跑线生物信息技术有限公司 | 精液液化能力量化测试方法 |
EP4033235A1 (en) * | 2014-11-03 | 2022-07-27 | Roche Diabetes Care GmbH | Methods of use of electrode arrangements for electrochemical test elements |
KR102170067B1 (ko) * | 2014-12-19 | 2020-10-27 | 에프. 호프만-라 로슈 아게 | 적어도 하나의 분석물을 전기 화학적으로 검출하기 위한 테스트 엘리먼트 |
US11061026B2 (en) * | 2017-02-17 | 2021-07-13 | MFB Fertility, Inc. | System of evaluating corpus luteum function by recurrently evaluating progesterone non-serum bodily fluids on multiple days |
CN109142252A (zh) * | 2018-09-29 | 2019-01-04 | 重庆迈联医疗科技有限公司 | 一种模块化的血脂检测仪 |
ES2921005T3 (es) * | 2018-10-31 | 2022-08-16 | Hoffmann La Roche | Dispositivos y procedimiento para medir una concentración de analito en una muestra de líquido corporal |
US20220168727A1 (en) * | 2019-03-24 | 2022-06-02 | Mehul BALDWA | Biosensor for detection of analytes in a fluid |
DE102021208185A1 (de) | 2021-07-29 | 2023-02-02 | Carl Zeiss Microscopy Gmbh | Probenträger und dessen Verwendung sowie Verfahren, insbesondere zur Detektion von Pathogenen |
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- 2009-11-06 KR KR1020127033205A patent/KR20130020807A/ko not_active Application Discontinuation
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