ES2693122T3 - Composición - Google Patents
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- Publication number
- ES2693122T3 ES2693122T3 ES12740119.8T ES12740119T ES2693122T3 ES 2693122 T3 ES2693122 T3 ES 2693122T3 ES 12740119 T ES12740119 T ES 12740119T ES 2693122 T3 ES2693122 T3 ES 2693122T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- composition
- solution
- compositions
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims abstract description 69
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- 239000000243 solution Substances 0.000 description 40
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 3
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- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
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- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
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- 239000002799 interferon inducing agent Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
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- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
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- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- XNPUQBBDBSSZQX-UHFFFAOYSA-M 2-methyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1C XNPUQBBDBSSZQX-UHFFFAOYSA-M 0.000 description 1
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- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201161510624P | 2011-07-22 | 2011-07-22 | |
| US201161510624P | 2011-07-22 | ||
| PCT/EP2012/064139 WO2013014052A1 (en) | 2011-07-22 | 2012-07-19 | Composition |
Publications (1)
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|---|---|
| ES2693122T3 true ES2693122T3 (es) | 2018-12-07 |
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| ES12740119.8T Active ES2693122T3 (es) | 2011-07-22 | 2012-07-19 | Composición |
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| EP (1) | EP2734186B1 (OSRAM) |
| JP (1) | JP2014520874A (OSRAM) |
| KR (1) | KR101916928B1 (OSRAM) |
| CN (1) | CN103841958A (OSRAM) |
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| BR (1) | BR112014001425A2 (OSRAM) |
| CA (1) | CA2841361A1 (OSRAM) |
| CY (1) | CY1120802T1 (OSRAM) |
| DK (1) | DK2734186T3 (OSRAM) |
| ES (1) | ES2693122T3 (OSRAM) |
| HR (1) | HRP20181667T1 (OSRAM) |
| LT (1) | LT2734186T (OSRAM) |
| PL (1) | PL2734186T3 (OSRAM) |
| PT (1) | PT2734186T (OSRAM) |
| RS (1) | RS57995B1 (OSRAM) |
| RU (1) | RU2631482C2 (OSRAM) |
| SI (1) | SI2734186T1 (OSRAM) |
| SM (1) | SMT201800642T1 (OSRAM) |
| WO (1) | WO2013014052A1 (OSRAM) |
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| EP2734186B1 (en) | 2011-07-22 | 2018-09-12 | GlaxoSmithKline LLC | Composition |
| CA2880576A1 (en) | 2012-08-24 | 2014-02-27 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
| CA2890198A1 (en) | 2012-11-20 | 2014-05-30 | Diane Mary Coe | Novel compounds |
| RU2643371C2 (ru) | 2012-11-20 | 2018-02-01 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Новые соединения |
| NZ707319A (en) | 2012-11-20 | 2019-09-27 | Glaxosmithkline Llc | 5h-pyrrolo[3,2-d]pyrimidin-4-amine compounds and their use in the treatment of allergic diseases and other inflammatory conditions |
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| US7067664B1 (en) | 1995-06-06 | 2006-06-27 | Pfizer Inc. | Corticotropin releasing factor antagonists |
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| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
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| CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| CA2396276A1 (en) | 2000-01-07 | 2001-07-12 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
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| GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
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| DE60237425D1 (de) | 2002-03-28 | 2010-10-07 | Univerzita Palackeho V Olomouc | PyrazoloÄ4,3-dÜpyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung |
| US20040063658A1 (en) | 2002-05-06 | 2004-04-01 | Roberts Christopher Don | Nucleoside derivatives for treating hepatitis C virus infection |
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-
2012
- 2012-07-19 EP EP12740119.8A patent/EP2734186B1/en active Active
- 2012-07-19 JP JP2014520661A patent/JP2014520874A/ja active Pending
- 2012-07-19 BR BR112014001425A patent/BR112014001425A2/pt not_active IP Right Cessation
- 2012-07-19 RS RS20181346A patent/RS57995B1/sr unknown
- 2012-07-19 US US14/234,070 patent/US10112946B2/en not_active Expired - Fee Related
- 2012-07-19 WO PCT/EP2012/064139 patent/WO2013014052A1/en not_active Ceased
- 2012-07-19 CA CA2841361A patent/CA2841361A1/en not_active Abandoned
- 2012-07-19 SI SI201231421T patent/SI2734186T1/sl unknown
- 2012-07-19 AU AU2012289042A patent/AU2012289042A1/en not_active Abandoned
- 2012-07-19 DK DK12740119.8T patent/DK2734186T3/en active
- 2012-07-19 KR KR1020147004436A patent/KR101916928B1/ko not_active Expired - Fee Related
- 2012-07-19 LT LTEP12740119.8T patent/LT2734186T/lt unknown
- 2012-07-19 SM SM20180642T patent/SMT201800642T1/it unknown
- 2012-07-19 HR HRP20181667TT patent/HRP20181667T1/hr unknown
- 2012-07-19 PL PL12740119T patent/PL2734186T3/pl unknown
- 2012-07-19 CN CN201280036096.6A patent/CN103841958A/zh active Pending
- 2012-07-19 RU RU2013157398A patent/RU2631482C2/ru not_active IP Right Cessation
- 2012-07-19 ES ES12740119.8T patent/ES2693122T3/es active Active
- 2012-07-19 PT PT12740119T patent/PT2734186T/pt unknown
-
2016
- 2016-04-20 AU AU2016202513A patent/AU2016202513B2/en not_active Ceased
-
2018
- 2018-09-27 US US16/143,969 patent/US20190023707A1/en not_active Abandoned
- 2018-10-31 CY CY181101125T patent/CY1120802T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190023707A1 (en) | 2019-01-24 |
| RU2631482C2 (ru) | 2017-09-22 |
| PT2734186T (pt) | 2018-12-17 |
| AU2012289042A1 (en) | 2014-03-13 |
| US20140288099A1 (en) | 2014-09-25 |
| BR112014001425A2 (pt) | 2017-11-21 |
| LT2734186T (lt) | 2018-12-10 |
| CN103841958A (zh) | 2014-06-04 |
| KR20140049001A (ko) | 2014-04-24 |
| DK2734186T3 (en) | 2019-01-07 |
| US10112946B2 (en) | 2018-10-30 |
| SI2734186T1 (sl) | 2018-11-30 |
| RS57995B1 (sr) | 2019-01-31 |
| HRP20181667T1 (hr) | 2018-12-14 |
| AU2016202513B2 (en) | 2018-03-22 |
| PL2734186T3 (pl) | 2019-01-31 |
| JP2014520874A (ja) | 2014-08-25 |
| RU2013157398A (ru) | 2015-08-27 |
| CA2841361A1 (en) | 2013-01-31 |
| EP2734186B1 (en) | 2018-09-12 |
| CY1120802T1 (el) | 2019-12-11 |
| EP2734186A1 (en) | 2014-05-28 |
| WO2013014052A1 (en) | 2013-01-31 |
| KR101916928B1 (ko) | 2018-11-08 |
| SMT201800642T1 (it) | 2019-01-11 |
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