ES2692852T3 - Derivados de heterociclilo bicíclicos como inhibidores de IRAK4 - Google Patents

Derivados de heterociclilo bicíclicos como inhibidores de IRAK4 Download PDF

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Publication number
ES2692852T3
ES2692852T3 ES15735499.4T ES15735499T ES2692852T3 ES 2692852 T3 ES2692852 T3 ES 2692852T3 ES 15735499 T ES15735499 T ES 15735499T ES 2692852 T3 ES2692852 T3 ES 2692852T3
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Prior art keywords
pyridin
carboxamide
oxazole
mmol
piperidin
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ES15735499.4T
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Spanish (es)
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Venkateshwar Rao GUMMADI
Susanta Samajdar
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Aurigene Oncology Ltd
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Aurigene Discovery Technologies Ltd
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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ES15735499.4T 2014-01-13 2015-01-12 Derivados de heterociclilo bicíclicos como inhibidores de IRAK4 Active ES2692852T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN158CH2014 2014-01-13
IN158CH2014 2014-01-13
IN3000CH2014 2014-06-20
IN3000CH2014 2014-06-20
PCT/IB2015/050217 WO2015104688A1 (en) 2014-01-13 2015-01-12 Bicyclic heterocyclyl derivatives as irak4 inhibitors

Publications (1)

Publication Number Publication Date
ES2692852T3 true ES2692852T3 (es) 2018-12-05

Family

ID=53523587

Family Applications (3)

Application Number Title Priority Date Filing Date
ES20211096T Active ES2975436T3 (es) 2014-01-13 2015-01-12 Enantiómeros (R) y (S) de n-(5-(3-hidroxipirrolidin-1-il)-2-morfolinooxazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4- il)oxazol-carboxamida como inhibidores de IRAK4 para el tratamiento del cáncer
ES18190333T Active ES2846678T3 (es) 2014-01-13 2015-01-12 Método de preparación de los derivados oxazolo[4,5-b]piridina y tiazolo[4,5-b]piridina como inhibidores de IRAK4 para el tratamiento del cáncer
ES15735499.4T Active ES2692852T3 (es) 2014-01-13 2015-01-12 Derivados de heterociclilo bicíclicos como inhibidores de IRAK4

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ES20211096T Active ES2975436T3 (es) 2014-01-13 2015-01-12 Enantiómeros (R) y (S) de n-(5-(3-hidroxipirrolidin-1-il)-2-morfolinooxazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4- il)oxazol-carboxamida como inhibidores de IRAK4 para el tratamiento del cáncer
ES18190333T Active ES2846678T3 (es) 2014-01-13 2015-01-12 Método de preparación de los derivados oxazolo[4,5-b]piridina y tiazolo[4,5-b]piridina como inhibidores de IRAK4 para el tratamiento del cáncer

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