ES2664509T3 - Derivados de pramlintida - Google Patents
Derivados de pramlintida Download PDFInfo
- Publication number
- ES2664509T3 ES2664509T3 ES12729417.1T ES12729417T ES2664509T3 ES 2664509 T3 ES2664509 T3 ES 2664509T3 ES 12729417 T ES12729417 T ES 12729417T ES 2664509 T3 ES2664509 T3 ES 2664509T3
- Authority
- ES
- Spain
- Prior art keywords
- pramlintide
- glu14
- carboxy
- alpha
- butyryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 1033
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Diabetes (AREA)
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- Biochemistry (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Obesity (AREA)
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- Neurology (AREA)
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- Heart & Thoracic Surgery (AREA)
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| EP11169405 | 2011-06-10 | ||
| US201161496113P | 2011-06-13 | 2011-06-13 | |
| US201161496113P | 2011-06-13 | ||
| PCT/EP2012/060899 WO2012168431A2 (en) | 2011-06-10 | 2012-06-08 | Polypeptides |
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| ES2664509T3 true ES2664509T3 (es) | 2018-04-19 |
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| IL (1) | IL229258B (enExample) |
| MX (1) | MX341324B (enExample) |
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| PL (1) | PL2718316T3 (enExample) |
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| SI (1) | SI2718316T1 (enExample) |
| WO (3) | WO2012168430A2 (enExample) |
| ZA (1) | ZA201309174B (enExample) |
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| WO2012168430A2 (en) | 2011-06-10 | 2012-12-13 | Novo Nordisk A/S | Polypeptides |
| US8575091B1 (en) * | 2012-04-19 | 2013-11-05 | Novo Nordisk A/S | Amylin analogues and pharmaceutical compositions thereof |
| GEP201706762B (en) | 2013-05-28 | 2017-10-25 | Takeda Pharmaceuticals Co | Peptide compound |
| AR097701A1 (es) * | 2013-09-19 | 2016-04-13 | Zealand Pharma As | Análogos de amilina |
| TW201625671A (zh) * | 2014-09-04 | 2016-07-16 | 諾佛 儂迪克股份有限公司 | 新穎澱粉素及降鈣素受體促效劑 |
| JP2018012644A (ja) * | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| MX366174B (es) | 2014-12-23 | 2019-07-01 | Colgate Palmolive Co | Composicion de cuidado oral. |
| CN105985995A (zh) * | 2015-01-29 | 2016-10-05 | 暨南大学 | 一种利用家蚕生物反应器生产普兰林肽(pa)的方法 |
| JP6769984B2 (ja) * | 2015-03-18 | 2020-10-14 | ジーランド ファーマ アクティーゼルスカブ | アミリン類似体 |
| CN106554405B (zh) * | 2015-09-30 | 2020-04-24 | 深圳翰宇药业股份有限公司 | 一种多肽及其用途、制备方法 |
| CN106928086B (zh) * | 2015-12-31 | 2019-05-31 | 深圳翰宇药业股份有限公司 | 一种长链化合物的制备方法 |
| WO2017204219A1 (ja) | 2016-05-24 | 2017-11-30 | 武田薬品工業株式会社 | ペプチド化合物 |
| US10071140B2 (en) | 2016-09-09 | 2018-09-11 | Zealand Pharma A/S | Amylin analogues |
| JP7076442B2 (ja) | 2016-11-07 | 2022-05-27 | ノヴォ ノルディスク アー／エス | Ｐｅｇ化合物のｄｃｈｂｓ活性エステル及びその使用 |
| JP6633777B2 (ja) | 2017-08-24 | 2020-01-22 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１組成物及びその使用 |
| CN113195524A (zh) | 2018-10-11 | 2021-07-30 | 因塔西亚治疗公司 | 人类胰淀素类似物多肽和使用方法 |
| CN119455003A (zh) | 2019-02-12 | 2025-02-18 | Ambrx公司 | 包含抗体-tlr激动剂缀合物的组合物、方法和用途 |
| JP7505713B2 (ja) * | 2019-02-22 | 2024-06-25 | ロヨラ メリーマウント ユニバーシティ | アミロイドペプチドバリアント |
| EP4058047A1 (en) | 2019-11-11 | 2022-09-21 | Boehringer Ingelheim International GmbH | Npy2 receptor agonists |
| AU2021208601B2 (en) * | 2020-02-18 | 2025-06-05 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
| KR20230045088A (ko) | 2020-08-07 | 2023-04-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 가용성 npy2 수용체 작용제 |
| AU2021327396A1 (en) | 2020-08-20 | 2023-03-23 | Ambrx, Inc. | Antibody-TLR agonist conjugates, methods and uses thereof |
| JP2023544959A (ja) | 2020-09-24 | 2023-10-26 | グブラ エー／エス | 改善されたアミリン受容体（ｈＡＭＹ３Ｒ）効力を有するｈＡＭ１５－５２類似体 |
| TWI850611B (zh) | 2020-12-18 | 2024-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
| TWI815327B (zh) * | 2021-03-03 | 2023-09-11 | 美商美國禮來大藥廠 | 長效澱粉素受體促效劑及其用途 |
| MX2023011480A (es) | 2021-04-03 | 2023-12-06 | Ambrx Inc | Conjugados anticuerpo anti-her2-fármaco y usos de estos. |
| WO2022248419A2 (en) | 2021-05-22 | 2022-12-01 | Adocia | Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition |
| EP4144362A1 (en) | 2021-09-06 | 2023-03-08 | Adocia | Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition |
| EP4129324A1 (en) | 2021-08-02 | 2023-02-08 | Adocia | Compositions comprising at least an amylin receptor agonist and a glp-1 receptor agonist |
| AU2022386166A1 (en) | 2021-11-10 | 2024-06-20 | I2O Therapeutics, Inc. | Ionic liquid compositions |
| TWI876242B (zh) | 2021-12-13 | 2025-03-11 | 丹麥商諾佛 儂迪克股份有限公司 | 包括環糊精的醫藥調配物 |
| CN118973602A (zh) | 2022-03-30 | 2024-11-15 | 诺和诺德股份有限公司 | 配制方法 |
| EP4534553A1 (en) * | 2022-05-27 | 2025-04-09 | Hangzhou Sciwind Biosciences Co., Ltd. | Human amylin analog, and derivative and use thereof |
| CN119923269A (zh) | 2022-09-19 | 2025-05-02 | 西兰制药公司 | 组合治疗 |
| US12116388B2 (en) | 2022-12-22 | 2024-10-15 | Novo Nordisk A/S | Amylin receptor agonists |
| EP4638480A1 (en) | 2022-12-22 | 2025-10-29 | Novo Nordisk A/S | Amylin receptor agonists |
| GB2641696A (en) * | 2023-02-10 | 2025-12-10 | Hangzhou Sciwind Biosciences Co Ltd | Polypeptide and derivative thereof, composition, and use thereof |
| TW202500183A (zh) | 2023-06-15 | 2025-01-01 | 丹麥商諾佛 儂迪克股份有限公司 | 包括環糊精的醫藥調配物 |
| WO2024261076A1 (en) | 2023-06-21 | 2024-12-26 | Zealand Pharma A/S | Weight loss |
| AU2024312389A1 (en) | 2023-06-21 | 2025-12-04 | Zealand Pharma A/S | Analogues with improved properties |
| WO2025003471A1 (en) | 2023-06-30 | 2025-01-02 | Zealand Pharma A/S | Combination therapy |
| WO2025114501A1 (en) | 2023-11-30 | 2025-06-05 | Novo Nordisk A/S | Tri-agonists of the glp-1, gip, and amylin receptors |
| WO2025160082A1 (en) * | 2024-01-23 | 2025-07-31 | Viking Therapeutics, Inc. | Amylin analogs |
| WO2025168049A1 (zh) * | 2024-02-07 | 2025-08-14 | 江苏恒瑞医药股份有限公司 | 胰岛淀粉样多肽类似物及其医药用途 |
| EP4603080A1 (en) | 2024-02-16 | 2025-08-20 | Adocia | Composition comprising semaglutide, cagrilintide and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals |
| EP4603079A1 (en) | 2024-02-16 | 2025-08-20 | Adocia | Composition comprising a peptide having an isoelectric point of less than 6.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals |
| WO2025172605A1 (en) | 2024-02-16 | 2025-08-21 | Adocia | Composition comprising a peptide having an isoelectric point of less than 6.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals |
| WO2025172606A1 (en) | 2024-02-16 | 2025-08-21 | Adocia | Composition comprising semaglutide, cagrilintide and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals |
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| ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
| US6410511B2 (en) | 1997-01-08 | 2002-06-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| JP4372345B2 (ja) | 1998-02-13 | 2009-11-25 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 新規な混合アミリン活性化合物 |
| WO1999057147A1 (fr) * | 1998-04-30 | 1999-11-11 | Kirin Brewery Company, Limited | Mutants de la thrombopoietine humaine |
| AU4930299A (en) * | 1998-07-31 | 2000-02-21 | Kirin Beer Kabushiki Kaisha | Remedies for neuropathy containing as the active ingredient galectin-1 or its derivatives |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1730186A2 (en) * | 2004-03-31 | 2006-12-13 | Xencor, Inc. | Bmp-7 variants with improved properties |
| CN101400698A (zh) * | 2006-03-15 | 2009-04-01 | 诺沃-诺迪斯克有限公司 | 胰岛淀粉样多肽衍生物 |
| WO2008086086A2 (en) * | 2007-01-05 | 2008-07-17 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
| EP2036923A1 (en) | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Improved derivates of amylin |
| EP2293811A1 (en) | 2008-06-25 | 2011-03-16 | Novo Nordisk A/S | Derivatised hybrid peptides of amylin and salmon calcitonin |
| JP5703226B2 (ja) * | 2008-10-21 | 2015-04-15 | ノヴォ ノルディスク アー／エス | アミリン誘導体 |
| JP5850848B2 (ja) | 2009-11-25 | 2016-02-03 | ノヴォ ノルディスク アー／エス | ポリペプチドの製造方法 |
| WO2012168430A2 (en) * | 2011-06-10 | 2012-12-13 | Novo Nordisk A/S | Polypeptides |
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