ES2648188T3 - Composiciones y métodos para la modulación de amidasas específicas para N-aciletanolaminas para ser usadas en la terapia de enfermedades inflamatorias - Google Patents
Composiciones y métodos para la modulación de amidasas específicas para N-aciletanolaminas para ser usadas en la terapia de enfermedades inflamatorias Download PDFInfo
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- ES2648188T3 ES2648188T3 ES12716671.8T ES12716671T ES2648188T3 ES 2648188 T3 ES2648188 T3 ES 2648188T3 ES 12716671 T ES12716671 T ES 12716671T ES 2648188 T3 ES2648188 T3 ES 2648188T3
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- acylethanolamines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Abstract
Un compuesto de fórmula general (I)**Fórmula** sus enantiómeros, diastereoisómeros, racematos y mezclas, polimorfos, sales o solvatos, que es 2-pentadecil-2- oxazol.
Description
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-MEA-OXA mg 100,00 -Aceite vegetal mg 400,00 -Lecitina de soja mg 60,00 -Monoestearato de glicerilo mg 12,00 -Revestimiento gastrorresistente basado en macrogol 400, copolímero de ácido metacrílico-acrilato de etilo (1:1),
polisorbato 80 Ejemplo G. Microgránulos para uso sublingual Una dosificación de 1 g de microgránulos para absorción sublingual: -PEA-OXA mg 600,00 -Sorbitol en polvo mg 384,00 -Palmitato de sacarosa mg 13,00 -Polisorbato 80 (origen vegetal) mg 3,00 -Revestimiento gastrorresistente basado en macrogol 400, copolímero de ácido metacrílico-acrilato de etilo (1:1),
polisorbato 80 Ejemplo H. Botellas con recipiente con tapón para uso oral Una dosis de 5 ml de suspensión esterilizada, para uso pediátrico, en una botella con recipiente con tapón
desprendible, contiene: En el recipiente con tapón desprendible: -PEA-OXA mg 50,00 -Lactosa mg 50,00 En la botella: -Carboximetilcelulosa mg 25,00 -Agua bidestilada c.s. hasta ml 5,00 Ejemplo I. Microgránulos disgregables en la boca para uso oral Una dosificación de 5 g de microgránulos disgregables en la boca contiene: -PEA-OXA mg 300,00 -PEA ultramicronizada mg 150,00 -Luteolina mg 100 mg -Azúcar no cariogénica mg 200 mg -Excipientes farmacológicamente aceptables c.s. hasta g 5,00
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Claims (1)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IT2012/000050 WO2013121449A1 (en) | 2012-02-17 | 2012-02-17 | Compositions and methods for the modulation of specific amidases for n-acylethanolamines for use in the therapy of inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2648188T3 true ES2648188T3 (es) | 2017-12-29 |
Family
ID=46000230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12716671.8T Active ES2648188T3 (es) | 2012-02-17 | 2012-02-17 | Composiciones y métodos para la modulación de amidasas específicas para N-aciletanolaminas para ser usadas en la terapia de enfermedades inflamatorias |
Country Status (13)
Country | Link |
---|---|
US (1) | US9512091B2 (es) |
EP (1) | EP2814489B1 (es) |
JP (1) | JP5982016B2 (es) |
KR (1) | KR101854879B1 (es) |
CN (1) | CN104244948B (es) |
AR (1) | AR090066A1 (es) |
AU (1) | AU2012327209B2 (es) |
CA (1) | CA2864259C (es) |
DK (1) | DK2814489T3 (es) |
ES (1) | ES2648188T3 (es) |
IN (1) | IN2014DN06850A (es) |
PT (1) | PT2814489T (es) |
WO (1) | WO2013121449A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2772252T3 (es) * | 2014-03-21 | 2020-07-07 | Epitech Group S P A | Preparaciones oftálmicas, intraarticulares o intravesicales que contienen N-acil-etanolaminas |
DK2965765T3 (da) | 2014-07-08 | 2019-07-22 | Epitech Group S P A | Anvendelse af adelmidrol til behandling af epiteldysfunktioner |
KR20180044259A (ko) * | 2015-06-16 | 2018-05-02 | 머독 칠드런스 리서치 인스티튜트 | 크론병 치료 방법 |
RU2737893C2 (ru) | 2015-08-11 | 2020-12-04 | Айсью Медсинз Б.В. | Пэгилированная липидная наночастица с биоактивным липофильным соединением |
MY191276A (en) * | 2016-10-09 | 2022-06-13 | Shenzhen Eulikan Biotechnology Co Ltd | Use of antimicrobial agent combination in preparing composition for vagina, composition for vagina and method for preparing the same |
JP7014959B2 (ja) | 2017-03-10 | 2022-02-02 | ダイキン工業株式会社 | 庫内空気調節装置及びそれを備えたコンテナ用冷凍装置 |
US10143639B2 (en) * | 2017-03-22 | 2018-12-04 | William Robert McDaniel | Use of adelmidrol and other topical or oral cannabinomimetic or aliamide mast cell inhibitors to treat dermatoheliosis, seborrheic keratoses, and androgenetic alopecia |
SG10201802129QA (en) * | 2017-07-05 | 2019-02-27 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
SG10201807034XA (en) | 2017-09-05 | 2019-04-29 | Frimline Private Ltd | A pharmaceutical composition for improving or preventing progression of Chronic Kidney Disease |
EP3574899A1 (en) * | 2018-05-28 | 2019-12-04 | Université de Bourgogne | Oleic acid derivatives, pharmaceutical composition or food composition comprising said oleic acid derivatives, and their uses |
FR3098394B1 (fr) * | 2019-07-12 | 2022-07-08 | Expanscience Lab | Composition comprenant au moins une oxazoline pour inhiber la croissance de levure du genre Malassezia impliquée notamment dans les croûtes de lait |
EP4331577A1 (en) * | 2022-08-30 | 2024-03-06 | Unifarco S.p.A. | A nutraceutic tablet comprising palmitoylethanolamide |
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NZ226043A (en) * | 1987-09-23 | 1991-05-28 | Ici Australia Operations | Explosive composition: ammonium nitrate prills |
DE3824982A1 (de) * | 1987-11-10 | 1989-05-18 | Henkel Kgaa | 2-(11-hydroxy-8-heptadecenyl- oder 11,8- bzw. 11,9-heptadecadienyl)oxazolin, sowie verfahren zur herstellung gegebenenfalls substituierter hoeherer 2-(alkyl- bzw. alkenyl)-oxazoline |
JPH0747636B2 (ja) * | 1988-12-05 | 1995-05-24 | 東レ株式会社 | 熱可塑性ポリアミド樹脂組成物 |
DE3914155A1 (de) * | 1989-04-28 | 1990-10-31 | Henkel Kgaa | Verfahren zur herstellung von 5,6-dihydro-4h-1,3-oxazinen |
DE4104789A1 (de) * | 1991-02-16 | 1992-08-20 | Henkel Kgaa | Cyclische polyiminoether |
DE4229020A1 (de) * | 1992-09-03 | 1994-03-10 | Henkel Kgaa | Verfahren zur Herstellung von þ-Alkanoylaminoalkyl-substituierten quartären Ammoniumsalzen |
US5698017A (en) * | 1996-09-27 | 1997-12-16 | Xerox Corporation | Oxazoline hot melt ink compositions |
US6462054B1 (en) | 2000-03-27 | 2002-10-08 | The Scripps Research Institute | Inhibitors of fatty acid amide hydrolase |
US6706674B2 (en) * | 2001-01-17 | 2004-03-16 | The Andrew Jergens Company | Nonaqueous hair styling composition and method of use |
FR2834216B1 (fr) | 2001-12-27 | 2004-04-30 | Pharmascience Lab | Composition cosmetique ou pharmaceutique comprenant au moins une oxazoline pour inhiber la migration des cellules de langerhans, et ses utilisations |
MXPA05003762A (es) * | 2002-10-08 | 2005-07-22 | Scripps Research Inst | Inhibidores de hidrolasa de amida de acido graso. |
FR2885128B1 (fr) * | 2005-04-27 | 2007-07-06 | Expanscience Laboratoires Sa | Composition cosmetique a visee depigmentante ou eclaircissante comprenant au moins une oxazoline, a titre de principe actif depigmentant ou eclaircissant |
US7905361B2 (en) * | 2007-02-05 | 2011-03-15 | Dow Global Technologies Llc | Modified polyamide membrane |
US20110184026A1 (en) | 2008-06-19 | 2011-07-28 | Boger Dale L | C4-substituted alpha-keto oxazoles |
WO2011085216A2 (en) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating parkinson's disease and restless legs syndrome |
-
2012
- 2012-02-17 WO PCT/IT2012/000050 patent/WO2013121449A1/en active Application Filing
- 2012-02-17 JP JP2014557171A patent/JP5982016B2/ja active Active
- 2012-02-17 DK DK12716671.8T patent/DK2814489T3/en active
- 2012-02-17 ES ES12716671.8T patent/ES2648188T3/es active Active
- 2012-02-17 US US14/378,185 patent/US9512091B2/en active Active
- 2012-02-17 EP EP12716671.8A patent/EP2814489B1/en active Active
- 2012-02-17 PT PT127166718T patent/PT2814489T/pt unknown
- 2012-02-17 IN IN6850DEN2014 patent/IN2014DN06850A/en unknown
- 2012-02-17 CN CN201280072492.4A patent/CN104244948B/zh active Active
- 2012-02-17 AU AU2012327209A patent/AU2012327209B2/en active Active
- 2012-02-17 CA CA2864259A patent/CA2864259C/en active Active
- 2012-02-17 KR KR1020147025782A patent/KR101854879B1/ko active IP Right Grant
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2013
- 2013-02-14 AR ARP130100461A patent/AR090066A1/es unknown
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Publication number | Publication date |
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CN104244948A (zh) | 2014-12-24 |
EP2814489B1 (en) | 2017-08-23 |
US20150057269A1 (en) | 2015-02-26 |
WO2013121449A8 (en) | 2013-12-12 |
AU2012327209A1 (en) | 2013-10-31 |
DK2814489T3 (en) | 2017-10-30 |
EP2814489A1 (en) | 2014-12-24 |
US9512091B2 (en) | 2016-12-06 |
CA2864259A1 (en) | 2013-08-22 |
CN104244948B (zh) | 2016-11-16 |
PT2814489T (pt) | 2017-10-23 |
AR090066A1 (es) | 2014-10-15 |
WO2013121449A1 (en) | 2013-08-22 |
KR101854879B1 (ko) | 2018-05-04 |
IN2014DN06850A (es) | 2015-06-26 |
JP5982016B2 (ja) | 2016-08-31 |
JP2015511239A (ja) | 2015-04-16 |
AU2012327209A8 (en) | 2015-01-22 |
AU2012327209B2 (en) | 2016-05-19 |
CA2864259C (en) | 2019-06-11 |
KR20140147819A (ko) | 2014-12-30 |
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