ES2531599T3 - Utilización de triglicéridos docosahexaenoicos para el tratamiento de enfermedades tumorales - Google Patents
Utilización de triglicéridos docosahexaenoicos para el tratamiento de enfermedades tumorales Download PDFInfo
- Publication number
- ES2531599T3 ES2531599T3 ES06754856.0T ES06754856T ES2531599T3 ES 2531599 T3 ES2531599 T3 ES 2531599T3 ES 06754856 T ES06754856 T ES 06754856T ES 2531599 T3 ES2531599 T3 ES 2531599T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- docosahexaenoic
- triglycerides
- tumor diseases
- docosahexaenoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 150000003626 triacylglycerols Chemical class 0.000 title 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 150000002314 glycerols Chemical class 0.000 abstract 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 abstract 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 abstract 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 abstract 1
- -1 docosahexaenoyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Utilización de un aceite enriquecido en ácido docosahexaenoico (DHA) para la fabricación de una composición farmacéutica destinada al tratamiento de una enfermedad tumoral, estando dicho ácido docosahexaenoico en un porcentaje de al menos el 50% en peso con respecto al total de ácidos grasos en dicho aceite; en la que dicho "aceite enriquecido en ácido docosahexaenoico" significa derivados de glicerol naturales o sintéticos que contienen 50-100% en peso del grupo docosahexaenoílo en base al contenido total de ácidos grasos, estando dichos derivados de glicerol en forma de triglicérido.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200501141 | 2005-05-12 | ||
ES200501141A ES2264886B1 (es) | 2005-05-12 | 2005-05-12 | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
PCT/EP2006/061833 WO2006120120A1 (en) | 2005-05-12 | 2006-04-26 | Use of docosahexaenoic glycerides for the treatment of tumorous diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2531599T3 true ES2531599T3 (es) | 2015-03-17 |
Family
ID=36809521
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200501141A Active ES2264886B1 (es) | 2005-05-12 | 2005-05-12 | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
ES06754856.0T Active ES2531599T3 (es) | 2005-05-12 | 2006-04-26 | Utilización de triglicéridos docosahexaenoicos para el tratamiento de enfermedades tumorales |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200501141A Active ES2264886B1 (es) | 2005-05-12 | 2005-05-12 | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
Country Status (13)
Country | Link |
---|---|
US (3) | US20080207947A1 (es) |
EP (1) | EP1881824B1 (es) |
JP (2) | JP5893235B2 (es) |
CA (1) | CA2614192C (es) |
DK (1) | DK1881824T3 (es) |
ES (2) | ES2264886B1 (es) |
HK (1) | HK1113319A1 (es) |
IL (1) | IL187274A (es) |
NO (1) | NO336953B1 (es) |
NZ (1) | NZ563301A (es) |
PL (1) | PL1881824T3 (es) |
PT (1) | PT1881824E (es) |
WO (1) | WO2006120120A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2264886B1 (es) * | 2005-05-12 | 2008-02-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
BRPI0613358A8 (pt) * | 2005-07-08 | 2017-12-26 | Dsm Ip Assets Bv | ácidos de gordura poli - insaturada para o tratamento da demência e condições relacionadas à pré-demência |
RU2437583C2 (ru) * | 2005-12-21 | 2011-12-27 | Бруди Текнолоджи, С.Л. | Применение дгк (dha), эпк (epa) или эпк, полученных из дгк, для лечения патологии, связанной с окислительным повреждением клетки, a также их нетерапевтические применения |
ES2277557B1 (es) | 2005-12-21 | 2008-07-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo. |
US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
NZ586249A (en) * | 2007-12-19 | 2012-05-25 | Prometic Biosciences Inc | A combination of medium-chain length fatty acids, salts or triglycerides, gemcitabine, and optionally erlotinib, for the treatment of pancreatic cancer |
WO2011103510A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha ester emulsions |
WO2011103514A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha triglyceride emulsions |
WO2011103512A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha free fatty acid emulsions |
JP5847475B2 (ja) * | 2010-07-26 | 2016-01-20 | 富士フイルム株式会社 | 油脂含有組成物、及びそれを含む経口製剤 |
ES2753387T3 (es) | 2013-04-22 | 2020-04-08 | Smartfish As | Uso de una composición que comprende aceite de pescado y zumo para el tratamiento y/o tratamiento posterior del cáncer |
KR101665253B1 (ko) | 2015-06-19 | 2016-10-25 | 순천향대학교 산학협력단 | 도코사헥사에노산 및 트리아신 씨를 포함하는 것을 특징으로 하는 자궁내막암 치료 및 예방용 조성물 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3721137A1 (de) * | 1987-06-26 | 1989-01-05 | Dietl Hans | Fettemulsion zur intravenoesen anwendung |
US5147854A (en) * | 1990-05-22 | 1992-09-15 | Hoffmann-La Roche Inc. | Tgf-b compositions and method |
JP2572692B2 (ja) * | 1991-07-24 | 1997-01-16 | ボーソー油脂 株式会社 | ドコサヘキサエン酸トリグリセリドの製造法 |
JPH05139968A (ja) * | 1991-11-14 | 1993-06-08 | Sagami Chem Res Center | メダラシン活性促進剤 |
JPH0616548A (ja) * | 1992-06-30 | 1994-01-25 | Sagami Chem Res Center | 組織異常増殖抑制剤 |
JPH06116585A (ja) * | 1992-10-09 | 1994-04-26 | Kanegafuchi Chem Ind Co Ltd | 油脂の精製方法 |
JP3526632B2 (ja) * | 1994-08-22 | 2004-05-17 | 旭化成ケミカルズ株式会社 | 高度不飽和脂肪酸含有油脂 |
JPH1057086A (ja) * | 1996-08-20 | 1998-03-03 | Asahi Chem Ind Co Ltd | 高濃度ドコサヘキサエン酸モノグリセリドの製造方法 |
WO2001017524A1 (en) * | 1999-09-09 | 2001-03-15 | Efa Sciences Llc. | Methods for treating cell proliferative disorders including cancer |
JP2002180082A (ja) * | 2000-12-11 | 2002-06-26 | Maruha Corp | 摂取物 |
US20040052837A1 (en) * | 2002-06-27 | 2004-03-18 | William Stillwell | Lipid conjugated anti-cancer drugs and methods of use thereof |
ES2264886B1 (es) * | 2005-05-12 | 2008-02-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
-
2005
- 2005-05-12 ES ES200501141A patent/ES2264886B1/es active Active
-
2006
- 2006-04-26 ES ES06754856.0T patent/ES2531599T3/es active Active
- 2006-04-26 US US11/913,994 patent/US20080207947A1/en not_active Abandoned
- 2006-04-26 WO PCT/EP2006/061833 patent/WO2006120120A1/en not_active Application Discontinuation
- 2006-04-26 EP EP06754856.0A patent/EP1881824B1/en active Active
- 2006-04-26 DK DK06754856.0T patent/DK1881824T3/en active
- 2006-04-26 JP JP2008510532A patent/JP5893235B2/ja active Active
- 2006-04-26 CA CA2614192A patent/CA2614192C/en not_active Expired - Fee Related
- 2006-04-26 PT PT06754856T patent/PT1881824E/pt unknown
- 2006-04-26 NZ NZ563301A patent/NZ563301A/en not_active IP Right Cessation
- 2006-04-26 PL PL06754856T patent/PL1881824T3/pl unknown
-
2007
- 2007-11-08 IL IL187274A patent/IL187274A/en active IP Right Grant
- 2007-12-11 NO NO20076382A patent/NO336953B1/no not_active IP Right Cessation
-
2008
- 2008-07-29 HK HK08108365.2A patent/HK1113319A1/xx not_active IP Right Cessation
-
2009
- 2009-08-31 US US12/550,780 patent/US9271954B2/en active Active
-
2014
- 2014-06-23 JP JP2014128247A patent/JP6038841B2/ja active Active
-
2016
- 2016-01-25 US US15/005,181 patent/US20170333381A9/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PL1881824T3 (pl) | 2015-06-30 |
IL187274A0 (en) | 2008-06-05 |
EP1881824A1 (en) | 2008-01-30 |
JP6038841B2 (ja) | 2016-12-07 |
CA2614192C (en) | 2014-03-18 |
NO336953B1 (no) | 2015-11-30 |
ES2264886A1 (es) | 2007-01-16 |
US9271954B2 (en) | 2016-03-01 |
CA2614192A1 (en) | 2006-11-16 |
US20090318553A1 (en) | 2009-12-24 |
DK1881824T3 (en) | 2015-02-23 |
JP5893235B2 (ja) | 2016-03-23 |
US20160193175A1 (en) | 2016-07-07 |
JP2008540484A (ja) | 2008-11-20 |
US20080207947A1 (en) | 2008-08-28 |
HK1113319A1 (en) | 2008-10-03 |
EP1881824B1 (en) | 2014-12-24 |
PT1881824E (pt) | 2015-03-26 |
JP2014208677A (ja) | 2014-11-06 |
US20170333381A9 (en) | 2017-11-23 |
WO2006120120A1 (en) | 2006-11-16 |
NO20076382L (no) | 2008-02-08 |
ES2264886B1 (es) | 2008-02-01 |
IL187274A (en) | 2011-11-30 |
NZ563301A (en) | 2010-08-27 |
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