MX2009005984A - Formulaciones con alta concentracion de proteina que contiene manitol. - Google Patents
Formulaciones con alta concentracion de proteina que contiene manitol.Info
- Publication number
- MX2009005984A MX2009005984A MX2009005984A MX2009005984A MX2009005984A MX 2009005984 A MX2009005984 A MX 2009005984A MX 2009005984 A MX2009005984 A MX 2009005984A MX 2009005984 A MX2009005984 A MX 2009005984A MX 2009005984 A MX2009005984 A MX 2009005984A
- Authority
- MX
- Mexico
- Prior art keywords
- protein concentration
- formulations containing
- high protein
- containing mannitol
- concentration formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención proporciona un método para inhibir agregación inducida por manitol de una proteína en una formulación líquida al incrementar la concentración de proteína a una cantidad mayor de 50 mg/ml. La presente invención también proporciona métodós para almacenar y preparar una formulación líquida que contiene manitol y una concentración de proteína mayor de 50 mg/ml.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87352606P | 2006-12-06 | 2006-12-06 | |
PCT/US2007/086507 WO2008070721A2 (en) | 2006-12-06 | 2007-12-05 | High protein concentration formulations containing mannitol |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005984A true MX2009005984A (es) | 2009-06-16 |
Family
ID=39493053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005984A MX2009005984A (es) | 2006-12-06 | 2007-12-05 | Formulaciones con alta concentracion de proteina que contiene manitol. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20080139792A1 (es) |
EP (1) | EP2089001A2 (es) |
JP (1) | JP2010512336A (es) |
KR (1) | KR20090086632A (es) |
CN (1) | CN101631535A (es) |
AU (1) | AU2007329333A1 (es) |
BR (1) | BRPI0720125A2 (es) |
CA (1) | CA2671571A1 (es) |
IL (1) | IL198977A0 (es) |
MX (1) | MX2009005984A (es) |
RU (1) | RU2009120200A (es) |
WO (1) | WO2008070721A2 (es) |
ZA (1) | ZA200903953B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2681752A1 (en) | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human 1l-12 antibodies |
CA2707483A1 (en) * | 2007-11-30 | 2009-06-11 | Wolfgang Fraunhofer | Protein formulations and methods of making same |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
JP2011520889A (ja) * | 2008-05-15 | 2011-07-21 | バクスター・インターナショナル・インコーポレイテッド | 安定な医薬製剤 |
NZ592644A (en) * | 2008-11-28 | 2013-09-27 | Abbott Lab | Stable antibody compositions and methods for stabilizing same |
EP2403873A1 (en) | 2009-03-05 | 2012-01-11 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
KR20120038406A (ko) * | 2009-05-04 | 2012-04-23 | 애보트 바이오테크놀로지 리미티드 | 인간 항?TNF?α 항체의 안정한 고 단백질 농도 제형 |
PL3438126T3 (pl) | 2009-09-03 | 2021-03-08 | Ablynx N.V. | Stabilne formulacje polipeptydów i ich zastosowanie |
WO2016202713A1 (en) * | 2015-06-15 | 2016-12-22 | F. Hoffmann-La Roche Ag | Method of freezing protein solutions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA902663B (en) * | 1989-04-07 | 1991-12-24 | Syntex Inc | Interleukin-1 formulation |
US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
WO2004055164A2 (en) * | 2002-12-13 | 2004-07-01 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
WO2006014965A2 (en) * | 2004-07-27 | 2006-02-09 | Human Genome Sciences, Inc. | Pharmaceutical formulation and process |
-
2007
- 2007-12-05 AU AU2007329333A patent/AU2007329333A1/en not_active Abandoned
- 2007-12-05 KR KR1020097013969A patent/KR20090086632A/ko not_active Application Discontinuation
- 2007-12-05 BR BRPI0720125-7A patent/BRPI0720125A2/pt not_active Application Discontinuation
- 2007-12-05 JP JP2009540450A patent/JP2010512336A/ja not_active Withdrawn
- 2007-12-05 RU RU2009120200/15A patent/RU2009120200A/ru not_active Application Discontinuation
- 2007-12-05 CN CN200780045479A patent/CN101631535A/zh active Pending
- 2007-12-05 WO PCT/US2007/086507 patent/WO2008070721A2/en active Application Filing
- 2007-12-05 MX MX2009005984A patent/MX2009005984A/es not_active Application Discontinuation
- 2007-12-05 CA CA002671571A patent/CA2671571A1/en not_active Abandoned
- 2007-12-05 US US11/950,986 patent/US20080139792A1/en not_active Abandoned
- 2007-12-05 EP EP07868997A patent/EP2089001A2/en not_active Withdrawn
-
2009
- 2009-05-26 IL IL198977A patent/IL198977A0/en unknown
- 2009-06-05 ZA ZA200903953A patent/ZA200903953B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL198977A0 (en) | 2010-02-17 |
CA2671571A1 (en) | 2008-06-12 |
US20080139792A1 (en) | 2008-06-12 |
ZA200903953B (en) | 2010-03-31 |
RU2009120200A (ru) | 2011-01-20 |
KR20090086632A (ko) | 2009-08-13 |
WO2008070721A2 (en) | 2008-06-12 |
WO2008070721A3 (en) | 2008-09-18 |
CN101631535A (zh) | 2010-01-20 |
EP2089001A2 (en) | 2009-08-19 |
BRPI0720125A2 (pt) | 2014-01-28 |
JP2010512336A (ja) | 2010-04-22 |
AU2007329333A1 (en) | 2008-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |