ES2622716T3 - Oligonucleótido y nucleósido artificial en puente con guanidina - Google Patents
Oligonucleótido y nucleósido artificial en puente con guanidina Download PDFInfo
- Publication number
- ES2622716T3 ES2622716T3 ES13838365.8T ES13838365T ES2622716T3 ES 2622716 T3 ES2622716 T3 ES 2622716T3 ES 13838365 T ES13838365 T ES 13838365T ES 2622716 T3 ES2622716 T3 ES 2622716T3
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- Prior art keywords
- group
- amino
- nucleic acid
- compound
- oxo
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012208906 | 2012-09-21 | ||
| JP2012208906 | 2012-09-21 | ||
| JP2013022360 | 2013-02-07 | ||
| JP2013022360 | 2013-02-07 | ||
| PCT/JP2013/075370 WO2014046212A1 (ja) | 2012-09-21 | 2013-09-19 | グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2622716T3 true ES2622716T3 (es) | 2017-07-07 |
Family
ID=50341516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13838365.8T Active ES2622716T3 (es) | 2012-09-21 | 2013-09-19 | Oligonucleótido y nucleósido artificial en puente con guanidina |
Country Status (9)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2957567B1 (en) | 2013-02-18 | 2019-06-05 | Shionogi & Co., Ltd. | Nucleoside and nucleotide, having nitrogen-containing hetercycle structure |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| US11234995B2 (en) | 2016-01-07 | 2022-02-01 | Osaka University | α-synuclein expression inhibitor |
| JP7138349B2 (ja) * | 2017-02-21 | 2022-09-16 | 国立大学法人大阪大学 | 核酸化合物およびオリゴヌクレオチド |
| WO2018155450A1 (ja) | 2017-02-21 | 2018-08-30 | 国立大学法人大阪大学 | アンチセンスオリゴ核酸 |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| CN111107875A (zh) | 2017-08-31 | 2020-05-05 | 田边三菱制药株式会社 | 含有il-33拮抗剂的子宫内膜异位症治疗剂 |
| CA3099778A1 (en) * | 2018-05-10 | 2019-11-14 | Nippon Shinyaku Co., Ltd. | Method for preparing oligonucleic acid compound |
| WO2020027227A1 (ja) | 2018-07-31 | 2020-02-06 | 国立大学法人大阪大学 | オリゴヌクレオチドを含有する小細胞肺癌治療薬 |
| WO2020050307A1 (ja) | 2018-09-05 | 2020-03-12 | 国立大学法人大阪大学 | Ａｒｌ４ｃを標的分子とするアンチセンスオリゴヌクレオチド、及び当該アンチセンスオリゴヌクレオチドを使用した核酸医薬 |
| IL283103B2 (en) * | 2018-11-12 | 2025-04-01 | Mitsubishi Tanabe Pharma Corp | ALNA cross-linked artificial nucleic acid |
| JP7413362B2 (ja) | 2019-03-29 | 2024-01-15 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| TW202104595A (zh) | 2019-03-29 | 2021-02-01 | 日商田邊三菱製藥股份有限公司 | 用來調節ｄｕｘ４的表現之化合物、方法及醫藥組成物 |
| CN113905744A (zh) | 2019-05-31 | 2022-01-07 | 阿利戈斯治疗公司 | 经修饰的间隙子寡核苷酸及其使用方法 |
| KR20220010023A (ko) * | 2019-06-20 | 2022-01-25 | 에프. 호프만-라 로슈 아게 | 방사성동위원소 표지된 moem 유형 올리고뉴클레오타이드 및 이의 제조 공정 |
| EP4151237A4 (en) | 2020-05-12 | 2024-08-14 | Mitsubishi Tanabe Pharma Corporation | Compound, method and pharmaceutical composition for regulating expression of ataxin 3 |
| EP4219517A4 (en) | 2020-09-25 | 2024-09-25 | Riken Genesis Co., Ltd. | NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF |
| CN116507727A (zh) | 2020-11-06 | 2023-07-28 | 住友制药株式会社 | Rps25基因的表达和/或功能调节剂 |
| US20240148775A1 (en) | 2021-02-25 | 2024-05-09 | Osaka University | Oligonucleotide for inducing n-exon skipping during rest mrna precursor processing |
| JP2024105742A (ja) * | 2021-05-26 | 2024-08-07 | ルクサナバイオテク株式会社 | 心疾患治療薬 |
| US20250084411A1 (en) | 2021-05-28 | 2025-03-13 | Sumitomo Pharma Co., Ltd. | Antisense Nucleic Acid |
| CN113552198B (zh) * | 2021-05-31 | 2024-03-26 | 武汉维尔博生物科技有限公司 | 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法 |
| WO2023026994A1 (ja) | 2021-08-21 | 2023-03-02 | 武田薬品工業株式会社 | ヒトトランスフェリンレセプター結合ペプチド－薬物コンジュゲート |
| WO2023093960A1 (en) * | 2021-11-26 | 2023-06-01 | Syddansk Universitet | Modified peptide-oligonucleotide conjugate |
| WO2023127857A1 (ja) | 2021-12-27 | 2023-07-06 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| JP2025509552A (ja) * | 2022-03-17 | 2025-04-11 | アリゴス セラピューティクス，インコーポレーテッド | 修飾ギャップマーオリゴマー及びその使用方法 |
| WO2024101446A1 (ja) | 2022-11-10 | 2024-05-16 | ルクサナバイオテク株式会社 | 架橋部にグアニジノ構造を有する修飾ヌクレオシドおよびそれを用いたオリゴヌクレオチドの製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132418A (en) * | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4973679A (en) * | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US5696253A (en) * | 1994-06-30 | 1997-12-09 | The Regents Of The University Of California | Polynucleoside chain with 3'→5' guanidyl linkages |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| ES2431586T3 (es) * | 2002-02-13 | 2013-11-27 | Takeshi Imanishi | Análogos de nucleósidos y derivado de oligonucleótido que comprende un análogo de nucleótido del mismo |
| EP1661905B9 (en) * | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| WO2007026824A1 (ja) | 2005-08-31 | 2007-03-08 | Osaka University | オリゴヌクレオチド類縁体 |
| AU2010312751B2 (en) | 2009-10-29 | 2014-07-24 | Osaka University | Bridged artificial nucleoside and nucleotide |
| US8536323B2 (en) * | 2010-04-21 | 2013-09-17 | Pierce Biotechnology, Inc. | Modified nucleotides |
| US9206216B2 (en) * | 2010-04-21 | 2015-12-08 | Pierce Biotechnology, Inc. | Modified nucleotides methods and kits |
-
2013
- 2013-09-19 CN CN201380057335.0A patent/CN104768964B/zh active Active
- 2013-09-19 KR KR1020157010144A patent/KR101707437B1/ko active Active
- 2013-09-19 WO PCT/JP2013/075370 patent/WO2014046212A1/ja active Application Filing
- 2013-09-19 US US14/428,646 patent/US10377789B2/en active Active
- 2013-09-19 JP JP2014536921A patent/JP6048982B2/ja active Active
- 2013-09-19 ES ES13838365.8T patent/ES2622716T3/es active Active
- 2013-09-19 IN IN2238DEN2015 patent/IN2015DN02238A/en unknown
- 2013-09-19 EP EP13838365.8A patent/EP2899197B1/en active Active
- 2013-09-19 CA CA2885719A patent/CA2885719C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6048982B2 (ja) | 2016-12-21 |
| US10377789B2 (en) | 2019-08-13 |
| CA2885719C (en) | 2017-07-11 |
| CA2885719A1 (en) | 2014-03-27 |
| CN104768964A (zh) | 2015-07-08 |
| KR101707437B1 (ko) | 2017-02-16 |
| EP2899197A4 (en) | 2016-03-09 |
| US20150266917A1 (en) | 2015-09-24 |
| EP2899197A1 (en) | 2015-07-29 |
| WO2014046212A1 (ja) | 2014-03-27 |
| CN104768964B (zh) | 2017-03-29 |
| KR20150056647A (ko) | 2015-05-26 |
| IN2015DN02238A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-08-21 |
| JPWO2014046212A1 (ja) | 2016-08-18 |
| EP2899197B1 (en) | 2017-03-22 |
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