ES2600878T3 - Implante removible, degradable, para la liberación prolongada de un compuesto activo - Google Patents

Implante removible, degradable, para la liberación prolongada de un compuesto activo Download PDF

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Publication number
ES2600878T3
ES2600878T3 ES10803585.8T ES10803585T ES2600878T3 ES 2600878 T3 ES2600878 T3 ES 2600878T3 ES 10803585 T ES10803585 T ES 10803585T ES 2600878 T3 ES2600878 T3 ES 2600878T3
Authority
ES
Spain
Prior art keywords
microparticles
peg
tmc278
tube
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10803585.8T
Other languages
English (en)
Spanish (es)
Inventor
Deborah M. Schachter
Lieven Elvire Colette Baert
Guenter Kraus
Qiang Zhang
Iksoo Chun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Sciences Ireland ULC
Original Assignee
Janssen Sciences Ireland ULC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland ULC filed Critical Janssen Sciences Ireland ULC
Application granted granted Critical
Publication of ES2600878T3 publication Critical patent/ES2600878T3/es
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES10803585.8T 2009-12-21 2010-12-20 Implante removible, degradable, para la liberación prolongada de un compuesto activo Active ES2600878T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28837309P 2009-12-21 2009-12-21
US288373P 2009-12-21
PCT/EP2010/070246 WO2011080141A2 (en) 2009-12-21 2010-12-20 Degradable removable implant for the sustained release of an active compound

Publications (1)

Publication Number Publication Date
ES2600878T3 true ES2600878T3 (es) 2017-02-13

Family

ID=43743502

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10803585.8T Active ES2600878T3 (es) 2009-12-21 2010-12-20 Implante removible, degradable, para la liberación prolongada de un compuesto activo

Country Status (18)

Country Link
US (3) US8784858B2 (enExample)
EP (1) EP2515877B1 (enExample)
JP (1) JP5950825B2 (enExample)
KR (1) KR101798430B1 (enExample)
CN (1) CN102740837B (enExample)
AU (1) AU2010338425B2 (enExample)
BR (1) BR112012015114B1 (enExample)
CA (1) CA2784530C (enExample)
ES (1) ES2600878T3 (enExample)
IL (1) IL219685B (enExample)
MX (1) MX2012007210A (enExample)
MY (1) MY163383A (enExample)
NZ (1) NZ600156A (enExample)
RU (1) RU2593790C2 (enExample)
SG (1) SG181759A1 (enExample)
UA (1) UA112155C2 (enExample)
WO (1) WO2011080141A2 (enExample)
ZA (1) ZA201204583B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3011383A4 (en) * 2013-06-20 2016-11-30 Mercy Medical Res Inst CONTACT LENSES WITH DELAYED ACTIVE COMPOSITION AND METHOD OF MANUFACTURING
JP2017527422A (ja) 2014-08-15 2017-09-21 ザ・ジョンズ・ホプキンス・ユニバーシティー 組織修復のための複合材料
WO2016149561A1 (en) * 2015-03-17 2016-09-22 Oak Crest Institute Of Science Subdermal implants for the sustained delivery of water-soluble drugs
US11779435B2 (en) 2015-08-26 2023-10-10 Flexscrewdriver I.K.E. Dental screwdriver
CN106702597B (zh) * 2016-12-20 2019-06-18 华南理工大学 一种核-壳结构纳米纤维膜及其制备方法和应用
CA3069159A1 (en) 2017-07-11 2019-01-17 Sustained Nano Systems Llc Hypercompressed pharmaceutical formulations
EP3790602A1 (en) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
KR20210034544A (ko) 2018-05-09 2021-03-30 더 존스 홉킨스 유니버시티 향상된 연조직 대체 및 재생을 위한 나노섬유-하이드로겔 복합재료
US11590329B2 (en) * 2018-05-16 2023-02-28 Spirox, Inc. Allergic rhinitis drug delivery implant
CA3114239A1 (en) * 2018-10-16 2020-04-23 Research Triangle Institute Subcutaneous biodegradable reservoir device
AU2021252550A1 (en) * 2020-04-07 2022-11-03 Research Triangle Institute Multi-drug formulations for subcutaneous biodegradable reservoir device
EP4151673A4 (en) * 2020-05-12 2024-03-20 Laboratorios Farmacéuticos Rovi, S.A. METHOD FOR THE PURIFICATION OF BIODEGRADABLE THERMOPLASTIC POLYMER PARTICLES FOR MEDICAL AND/OR PHARMACEUTICAL USE

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182111A (en) 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
CA2121129A1 (en) * 1991-10-29 1993-05-13 Patrick Soon-Shiong Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US5651900A (en) 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
WO1995024472A1 (en) 1994-03-07 1995-09-14 The Regents Of The University Of California Microfabricated capsules for isolation of cell transplants
US5645684A (en) 1994-03-07 1997-07-08 The Regents Of The University Of California Multilayer high vertical aspect ratio thin film structures
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US7033603B2 (en) * 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
WO2001010421A1 (en) 1999-08-06 2001-02-15 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
WO2001025240A1 (en) 1999-10-06 2001-04-12 Tibotec Pharmaceuticals Ltd. HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR
TW200800298A (en) 2000-01-27 2008-01-01 Zentaris Ag Compressed microparticles for dry injection
US20040115268A1 (en) * 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
DE10050199A1 (de) * 2000-10-11 2002-04-25 Ethicon Gmbh Flächiges Implantat mit im Ultraschall detektierbaren Elementen
AU2002305079B8 (en) * 2001-05-11 2006-05-25 Ortho-Mcneil Pharmaceutical, Inc. Immune modulation device for use in animals
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
AU2003278766A1 (en) 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
TWI457136B (zh) 2005-04-04 2014-10-21 Tibotec Pharm Ltd Hiv-感染之預防
EP1872390A2 (en) 2005-04-11 2008-01-02 The Board of Trustees of the Leland Stanford Junior University Multi-layer structure having a predetermined layer pattern including an agent
US20060252049A1 (en) 2005-05-04 2006-11-09 Shuler Richard O Growth-promoting and immunizing subcutaneous implant
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
CA2636436C (en) * 2006-01-20 2014-04-01 Tibotec Pharmaceuticals Ltd. Long term treatment of hiv- infection with tmc278
US20080081064A1 (en) * 2006-09-28 2008-04-03 Surmodics, Inc. Implantable Medical Device with Apertures for Delivery of Bioactive Agents
KR20120029480A (ko) * 2007-06-12 2012-03-26 콘서트 파마슈티컬즈, 인크. 아자펩티드 유도체
US20090123508A1 (en) * 2007-10-04 2009-05-14 Boston Scientific Scimed, Inc. Implantable Drug Depot for Intrathecal Drug Delivery System for Pain Management
US20110257111A1 (en) * 2008-10-24 2011-10-20 Harbeson Scott L Hydroxyethlamino Sulfonamide Derivatives
CN102711834B (zh) 2008-12-24 2015-08-26 爱尔兰詹森科学公司 治疗hiv的可植入装置

Also Published As

Publication number Publication date
RU2593790C2 (ru) 2016-08-10
CA2784530A1 (en) 2011-07-07
US8784858B2 (en) 2014-07-22
KR101798430B1 (ko) 2017-11-16
MX2012007210A (es) 2012-07-23
CN102740837B (zh) 2017-06-06
EP2515877B1 (en) 2016-08-10
MY163383A (en) 2017-09-15
EP2515877A2 (en) 2012-10-31
US20140296799A1 (en) 2014-10-02
CA2784530C (en) 2018-05-22
RU2012131282A (ru) 2014-01-27
UA112155C2 (uk) 2016-08-10
US20200330654A1 (en) 2020-10-22
WO2011080141A3 (en) 2012-03-08
BR112012015114A2 (pt) 2020-09-01
IL219685B (en) 2019-03-31
AU2010338425A1 (en) 2012-06-07
KR20120101084A (ko) 2012-09-12
JP2013514971A (ja) 2013-05-02
US10744235B2 (en) 2020-08-18
JP5950825B2 (ja) 2016-07-13
US11395867B2 (en) 2022-07-26
NZ600156A (en) 2015-01-30
AU2010338425B2 (en) 2015-07-23
IL219685A0 (en) 2012-07-31
CN102740837A (zh) 2012-10-17
US20120277690A1 (en) 2012-11-01
ZA201204583B (en) 2022-03-30
BR112012015114B1 (pt) 2023-01-10
WO2011080141A2 (en) 2011-07-07
SG181759A1 (en) 2012-07-30

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