ES2600878T3 - Implante removible, degradable, para la liberación prolongada de un compuesto activo - Google Patents
Implante removible, degradable, para la liberación prolongada de un compuesto activo Download PDFInfo
- Publication number
- ES2600878T3 ES2600878T3 ES10803585.8T ES10803585T ES2600878T3 ES 2600878 T3 ES2600878 T3 ES 2600878T3 ES 10803585 T ES10803585 T ES 10803585T ES 2600878 T3 ES2600878 T3 ES 2600878T3
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- microparticles
- peg
- tmc278
- tube
- drugs
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Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Surgery (AREA)
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- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28837309P | 2009-12-21 | 2009-12-21 | |
| US288373P | 2009-12-21 | ||
| PCT/EP2010/070246 WO2011080141A2 (en) | 2009-12-21 | 2010-12-20 | Degradable removable implant for the sustained release of an active compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2600878T3 true ES2600878T3 (es) | 2017-02-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10803585.8T Active ES2600878T3 (es) | 2009-12-21 | 2010-12-20 | Implante removible, degradable, para la liberación prolongada de un compuesto activo |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8784858B2 (enExample) |
| EP (1) | EP2515877B1 (enExample) |
| JP (1) | JP5950825B2 (enExample) |
| KR (1) | KR101798430B1 (enExample) |
| CN (1) | CN102740837B (enExample) |
| AU (1) | AU2010338425B2 (enExample) |
| BR (1) | BR112012015114B1 (enExample) |
| CA (1) | CA2784530C (enExample) |
| ES (1) | ES2600878T3 (enExample) |
| IL (1) | IL219685B (enExample) |
| MX (1) | MX2012007210A (enExample) |
| MY (1) | MY163383A (enExample) |
| NZ (1) | NZ600156A (enExample) |
| RU (1) | RU2593790C2 (enExample) |
| SG (1) | SG181759A1 (enExample) |
| UA (1) | UA112155C2 (enExample) |
| WO (1) | WO2011080141A2 (enExample) |
| ZA (1) | ZA201204583B (enExample) |
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| HK1224020A1 (zh) * | 2013-06-20 | 2017-08-11 | Mercy Medical Research Institute | 延长释放药物传递的隐形眼镜及其制造方法 |
| CA2957970A1 (en) | 2014-08-15 | 2016-02-18 | The Johns Hopkins University Technology Ventures | Composite material for tissue restoration |
| WO2016149561A1 (en) * | 2015-03-17 | 2016-09-22 | Oak Crest Institute Of Science | Subdermal implants for the sustained delivery of water-soluble drugs |
| US11779435B2 (en) | 2015-08-26 | 2023-10-10 | Flexscrewdriver I.K.E. | Dental screwdriver |
| CN106702597B (zh) * | 2016-12-20 | 2019-06-18 | 华南理工大学 | 一种核-壳结构纳米纤维膜及其制备方法和应用 |
| CA3069159A1 (en) | 2017-07-11 | 2019-01-17 | Sustained Nano Systems Llc | Hypercompressed pharmaceutical formulations |
| IL307979B2 (en) | 2018-05-09 | 2025-08-01 | Univ Johns Hopkins | Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration |
| EP3790602A1 (en) | 2018-05-09 | 2021-03-17 | The Johns Hopkins University | Nanofiber-hydrogel composites for cell and tissue delivery |
| US11590329B2 (en) * | 2018-05-16 | 2023-02-28 | Spirox, Inc. | Allergic rhinitis drug delivery implant |
| MX2021003633A (es) * | 2018-10-16 | 2021-05-27 | Res Triangle Inst | Dispositivo de depósito biodegradable subcutáneo. |
| MX2022012202A (es) * | 2020-04-07 | 2022-11-09 | Res Triangle Inst | Formulaciones de múltiples fármacos para dispositivo de depósito biodegradable subcutáneo. |
| EP4151673A4 (en) * | 2020-05-12 | 2024-03-20 | Laboratorios Farmacéuticos Rovi, S.A. | METHOD FOR THE PURIFICATION OF BIODEGRADABLE THERMOPLASTIC POLYMER PARTICLES FOR MEDICAL AND/OR PHARMACEUTICAL USE |
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| US5182111A (en) | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
| EP0610441A4 (en) * | 1991-10-29 | 1996-01-10 | Clover Cons Ltd | CROSSLINKABLE POLYSACCHARIDES, POLYCATIONS AND LIPIDS CAN BE USED TO ENCODE AND DISPENSE MEDICINAL PRODUCTS. |
| US5645684A (en) | 1994-03-07 | 1997-07-08 | The Regents Of The University Of California | Multilayer high vertical aspect ratio thin film structures |
| US5651900A (en) | 1994-03-07 | 1997-07-29 | The Regents Of The University Of California | Microfabricated particle filter |
| US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
| US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
| EP0749474A4 (en) | 1994-03-07 | 1997-09-17 | Univ California | MICRO-MADE CAPSULES FOR INSULATING CELL TRANSPLANTS |
| US7033603B2 (en) | 1999-08-06 | 2006-04-25 | Board Of Regents The University Of Texas | Drug releasing biodegradable fiber for delivery of therapeutics |
| AU6526100A (en) | 1999-08-06 | 2001-03-05 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| PL204924B1 (pl) | 1999-10-06 | 2010-02-26 | Tibotec Pharm Ltd | Heksahydrofuro [2,3-b] furanylo-3-N-{3(1,3-benzodioksolilo-5-sulfonylo) (izobutylo) amino] -1-benzylo-2-hydroksypropylo} karbaminian oraz jego zastosowanie |
| TW200800298A (en) | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
| US20040115268A1 (en) * | 2000-04-26 | 2004-06-17 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| DE10050199A1 (de) * | 2000-10-11 | 2002-04-25 | Ethicon Gmbh | Flächiges Implantat mit im Ultraschall detektierbaren Elementen |
| US6958158B2 (en) * | 2001-05-11 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc. | Immune modulation device for use in animals |
| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| AU2003278766A1 (en) | 2002-09-04 | 2004-03-29 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| US20040156878A1 (en) * | 2003-02-11 | 2004-08-12 | Alireza Rezania | Implantable medical device seeded with mammalian cells and methods of treatment |
| TW201414495A (zh) | 2005-04-04 | 2014-04-16 | Tibotec Pharm Ltd | Ｈｉｖ-感染之預防 |
| CA2603851A1 (en) | 2005-04-11 | 2006-10-19 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Multi-layer structure having a predetermined layer pattern including an agent |
| US20060252049A1 (en) | 2005-05-04 | 2006-11-09 | Shuler Richard O | Growth-promoting and immunizing subcutaneous implant |
| US7261529B2 (en) | 2005-09-07 | 2007-08-28 | Southwest Research Institute | Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| PT1981506E (pt) * | 2006-01-20 | 2013-06-25 | Janssen R & D Ireland | Tratamento a longo prazo da infeção pelo vih com tmc278 |
| WO2008060360A2 (en) * | 2006-09-28 | 2008-05-22 | Surmodics, Inc. | Implantable medical device with apertures for delivery of bioactive agents |
| EP2116532B1 (en) * | 2007-06-12 | 2011-12-07 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives as HIV protease inhibitors |
| US20090123508A1 (en) * | 2007-10-04 | 2009-05-14 | Boston Scientific Scimed, Inc. | Implantable Drug Depot for Intrathecal Drug Delivery System for Pain Management |
| WO2010047819A1 (en) * | 2008-10-24 | 2010-04-29 | Concert Pharmaceuticals, Inc. | Hydroxyethylamino sulfonamide derivatives |
| RU2546529C2 (ru) | 2008-12-24 | 2015-04-10 | Тиботек Фармасьютикалз | Имплантируемые устройства для лечения вич |
-
2010
- 2010-12-20 AU AU2010338425A patent/AU2010338425B2/en active Active
- 2010-12-20 ES ES10803585.8T patent/ES2600878T3/es active Active
- 2010-12-20 MY MYPI2012002730A patent/MY163383A/en unknown
- 2010-12-20 JP JP2012543843A patent/JP5950825B2/ja not_active Expired - Fee Related
- 2010-12-20 KR KR1020127016179A patent/KR101798430B1/ko active Active
- 2010-12-20 US US13/515,380 patent/US8784858B2/en active Active
- 2010-12-20 WO PCT/EP2010/070246 patent/WO2011080141A2/en not_active Ceased
- 2010-12-20 RU RU2012131282/15A patent/RU2593790C2/ru active
- 2010-12-20 BR BR112012015114-2A patent/BR112012015114B1/pt not_active IP Right Cessation
- 2010-12-20 MX MX2012007210A patent/MX2012007210A/es active IP Right Grant
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- 2010-12-20 UA UAA201206035A patent/UA112155C2/uk unknown
- 2010-12-20 CN CN201080058303.9A patent/CN102740837B/zh not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2784530A1 (en) | 2011-07-07 |
| MY163383A (en) | 2017-09-15 |
| ZA201204583B (en) | 2022-03-30 |
| JP2013514971A (ja) | 2013-05-02 |
| BR112012015114B1 (pt) | 2023-01-10 |
| NZ600156A (en) | 2015-01-30 |
| AU2010338425A1 (en) | 2012-06-07 |
| AU2010338425B2 (en) | 2015-07-23 |
| US20120277690A1 (en) | 2012-11-01 |
| IL219685A0 (en) | 2012-07-31 |
| WO2011080141A2 (en) | 2011-07-07 |
| RU2593790C2 (ru) | 2016-08-10 |
| US8784858B2 (en) | 2014-07-22 |
| WO2011080141A3 (en) | 2012-03-08 |
| IL219685B (en) | 2019-03-31 |
| MX2012007210A (es) | 2012-07-23 |
| EP2515877B1 (en) | 2016-08-10 |
| CA2784530C (en) | 2018-05-22 |
| KR20120101084A (ko) | 2012-09-12 |
| US20200330654A1 (en) | 2020-10-22 |
| JP5950825B2 (ja) | 2016-07-13 |
| CN102740837B (zh) | 2017-06-06 |
| EP2515877A2 (en) | 2012-10-31 |
| UA112155C2 (uk) | 2016-08-10 |
| SG181759A1 (en) | 2012-07-30 |
| US10744235B2 (en) | 2020-08-18 |
| US11395867B2 (en) | 2022-07-26 |
| CN102740837A (zh) | 2012-10-17 |
| BR112012015114A2 (pt) | 2020-09-01 |
| KR101798430B1 (ko) | 2017-11-16 |
| US20140296799A1 (en) | 2014-10-02 |
| RU2012131282A (ru) | 2014-01-27 |
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