CN102740837B - 用于缓释活性化合物的降解性可摘式植入物 - Google Patents

用于缓释活性化合物的降解性可摘式植入物 Download PDF

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Publication number
CN102740837B
CN102740837B CN201080058303.9A CN201080058303A CN102740837B CN 102740837 B CN102740837 B CN 102740837B CN 201080058303 A CN201080058303 A CN 201080058303A CN 102740837 B CN102740837 B CN 102740837B
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China
Prior art keywords
implant
peg
polymer
tube
microparticles
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Expired - Fee Related
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CN201080058303.9A
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English (en)
Chinese (zh)
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CN102740837A (zh
Inventor
D.M.沙赫特
L.E.C.贝尔特
G.克劳斯
Q.张
I.淳
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Janssen R&D Ireland ULC
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Janssen Sciences Ireland ULC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080058303.9A 2009-12-21 2010-12-20 用于缓释活性化合物的降解性可摘式植入物 Expired - Fee Related CN102740837B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28837309P 2009-12-21 2009-12-21
US61/288373 2009-12-21
PCT/EP2010/070246 WO2011080141A2 (en) 2009-12-21 2010-12-20 Degradable removable implant for the sustained release of an active compound

Publications (2)

Publication Number Publication Date
CN102740837A CN102740837A (zh) 2012-10-17
CN102740837B true CN102740837B (zh) 2017-06-06

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CN201080058303.9A Expired - Fee Related CN102740837B (zh) 2009-12-21 2010-12-20 用于缓释活性化合物的降解性可摘式植入物

Country Status (18)

Country Link
US (3) US8784858B2 (enExample)
EP (1) EP2515877B1 (enExample)
JP (1) JP5950825B2 (enExample)
KR (1) KR101798430B1 (enExample)
CN (1) CN102740837B (enExample)
AU (1) AU2010338425B2 (enExample)
BR (1) BR112012015114B1 (enExample)
CA (1) CA2784530C (enExample)
ES (1) ES2600878T3 (enExample)
IL (1) IL219685B (enExample)
MX (1) MX2012007210A (enExample)
MY (1) MY163383A (enExample)
NZ (1) NZ600156A (enExample)
RU (1) RU2593790C2 (enExample)
SG (1) SG181759A1 (enExample)
UA (1) UA112155C2 (enExample)
WO (1) WO2011080141A2 (enExample)
ZA (1) ZA201204583B (enExample)

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CA2916425A1 (en) * 2013-06-20 2014-12-24 Mercy Medical Research Institute Extended release drug-delivery contact lenses and methods of making
ES3015612T3 (en) 2014-08-15 2025-05-06 Univ Johns Hopkins Composite material for tissue restoration
WO2016149561A1 (en) * 2015-03-17 2016-09-22 Oak Crest Institute Of Science Subdermal implants for the sustained delivery of water-soluble drugs
US11779435B2 (en) 2015-08-26 2023-10-10 Flexscrewdriver I.K.E. Dental screwdriver
CN106702597B (zh) * 2016-12-20 2019-06-18 华南理工大学 一种核-壳结构纳米纤维膜及其制备方法和应用
BR112020000506A2 (pt) 2017-07-11 2020-07-14 Sustained Nano Systems Llc formulações farmacêuticas hipercomprimidas
US20210402064A1 (en) 2018-05-09 2021-12-30 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
WO2019217765A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
CN112423739A (zh) * 2018-05-16 2021-02-26 斯贝洛克斯公司 过敏性鼻炎药物输送植入物
CN113260350A (zh) 2018-10-16 2021-08-13 三角研究所 皮下可生物降解储器装置
MX2022012202A (es) * 2020-04-07 2022-11-09 Res Triangle Inst Formulaciones de múltiples fármacos para dispositivo de depósito biodegradable subcutáneo.
EP4151673A4 (en) * 2020-05-12 2024-03-20 Laboratorios Farmacéuticos Rovi, S.A. METHOD FOR THE PURIFICATION OF BIODEGRADABLE THERMOPLASTIC POLYMER PARTICLES FOR MEDICAL AND/OR PHARMACEUTICAL USE

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US5705270A (en) * 1991-10-29 1998-01-06 Vivorx, Inc. Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor
WO2002030482A1 (en) * 2000-10-11 2002-04-18 Ethicon Gmbh Areal implant with ultrasonically detectable elements
WO2006106103A2 (en) * 2005-04-04 2006-10-12 Tibotec Pharmaceuticals Ltd. Prevention of hiv- infection with tmc278
WO2009046299A2 (en) * 2007-10-04 2009-04-09 Boston Scientific Scimed, Inc Implantable drug depot for intrathecal drug delivery system for pain management

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US5705270A (en) * 1991-10-29 1998-01-06 Vivorx, Inc. Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor
WO2002030482A1 (en) * 2000-10-11 2002-04-18 Ethicon Gmbh Areal implant with ultrasonically detectable elements
WO2006106103A2 (en) * 2005-04-04 2006-10-12 Tibotec Pharmaceuticals Ltd. Prevention of hiv- infection with tmc278
WO2009046299A2 (en) * 2007-10-04 2009-04-09 Boston Scientific Scimed, Inc Implantable drug depot for intrathecal drug delivery system for pain management

Also Published As

Publication number Publication date
AU2010338425B2 (en) 2015-07-23
US11395867B2 (en) 2022-07-26
US20200330654A1 (en) 2020-10-22
WO2011080141A3 (en) 2012-03-08
KR20120101084A (ko) 2012-09-12
RU2012131282A (ru) 2014-01-27
RU2593790C2 (ru) 2016-08-10
ES2600878T3 (es) 2017-02-13
JP2013514971A (ja) 2013-05-02
MX2012007210A (es) 2012-07-23
CA2784530C (en) 2018-05-22
ZA201204583B (en) 2022-03-30
SG181759A1 (en) 2012-07-30
IL219685B (en) 2019-03-31
UA112155C2 (uk) 2016-08-10
US8784858B2 (en) 2014-07-22
BR112012015114B1 (pt) 2023-01-10
MY163383A (en) 2017-09-15
AU2010338425A1 (en) 2012-06-07
EP2515877B1 (en) 2016-08-10
US20120277690A1 (en) 2012-11-01
KR101798430B1 (ko) 2017-11-16
US10744235B2 (en) 2020-08-18
WO2011080141A2 (en) 2011-07-07
IL219685A0 (en) 2012-07-31
US20140296799A1 (en) 2014-10-02
CN102740837A (zh) 2012-10-17
NZ600156A (en) 2015-01-30
JP5950825B2 (ja) 2016-07-13
BR112012015114A2 (pt) 2020-09-01
EP2515877A2 (en) 2012-10-31
CA2784530A1 (en) 2011-07-07

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