CN102740837B - 用于缓释活性化合物的降解性可摘式植入物 - Google Patents

用于缓释活性化合物的降解性可摘式植入物 Download PDF

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Publication number
CN102740837B
CN102740837B CN201080058303.9A CN201080058303A CN102740837B CN 102740837 B CN102740837 B CN 102740837B CN 201080058303 A CN201080058303 A CN 201080058303A CN 102740837 B CN102740837 B CN 102740837B
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China
Prior art keywords
implant
peg
polymer
tube
microparticles
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Expired - Fee Related
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CN201080058303.9A
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English (en)
Chinese (zh)
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CN102740837A (zh
Inventor
D.M.沙赫特
L.E.C.贝尔特
G.克劳斯
Q.张
I.淳
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Janssen R&D Ireland ULC
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Janssen Sciences Ireland ULC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080058303.9A 2009-12-21 2010-12-20 用于缓释活性化合物的降解性可摘式植入物 Expired - Fee Related CN102740837B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28837309P 2009-12-21 2009-12-21
US61/288373 2009-12-21
PCT/EP2010/070246 WO2011080141A2 (en) 2009-12-21 2010-12-20 Degradable removable implant for the sustained release of an active compound

Publications (2)

Publication Number Publication Date
CN102740837A CN102740837A (zh) 2012-10-17
CN102740837B true CN102740837B (zh) 2017-06-06

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CN201080058303.9A Expired - Fee Related CN102740837B (zh) 2009-12-21 2010-12-20 用于缓释活性化合物的降解性可摘式植入物

Country Status (18)

Country Link
US (3) US8784858B2 (enExample)
EP (1) EP2515877B1 (enExample)
JP (1) JP5950825B2 (enExample)
KR (1) KR101798430B1 (enExample)
CN (1) CN102740837B (enExample)
AU (1) AU2010338425B2 (enExample)
BR (1) BR112012015114B1 (enExample)
CA (1) CA2784530C (enExample)
ES (1) ES2600878T3 (enExample)
IL (1) IL219685B (enExample)
MX (1) MX2012007210A (enExample)
MY (1) MY163383A (enExample)
NZ (1) NZ600156A (enExample)
RU (1) RU2593790C2 (enExample)
SG (1) SG181759A1 (enExample)
UA (1) UA112155C2 (enExample)
WO (1) WO2011080141A2 (enExample)
ZA (1) ZA201204583B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3011383A4 (en) * 2013-06-20 2016-11-30 Mercy Medical Res Inst CONTACT LENSES WITH DELAYED ACTIVE COMPOSITION AND METHOD OF MANUFACTURING
AU2015301432B2 (en) 2014-08-15 2019-11-21 The Johns Hopkins University Composite material for tissue restoration
WO2016149561A1 (en) * 2015-03-17 2016-09-22 Oak Crest Institute Of Science Subdermal implants for the sustained delivery of water-soluble drugs
US11779435B2 (en) 2015-08-26 2023-10-10 Flexscrewdriver I.K.E. Dental screwdriver
CN106702597B (zh) * 2016-12-20 2019-06-18 华南理工大学 一种核-壳结构纳米纤维膜及其制备方法和应用
EP3651800B1 (en) * 2017-07-11 2024-04-10 Sustained Nano Systems LLC Hypercompressed pharmaceutical formulations
CN112384258A (zh) 2018-05-09 2021-02-19 约翰·霍普金斯大学 用于细胞和组织递送的纳米纤维-水凝胶复合物
IL307979B2 (en) 2018-05-09 2025-08-01 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
WO2019222482A1 (en) * 2018-05-16 2019-11-21 Spirox, Inc. Allergic rhinitis drug delivery implant
AU2019362880B2 (en) * 2018-10-16 2025-05-22 Research Triangle Institute Subcutaneous biodegradable reservoir device
US20230165788A1 (en) * 2020-04-07 2023-06-01 Research Triangle Institute Multi-drug formulations for subcutaneous biodegradable reservoir device
EP4151673A4 (en) * 2020-05-12 2024-03-20 Laboratorios Farmacéuticos Rovi, S.A. METHOD FOR THE PURIFICATION OF BIODEGRADABLE THERMOPLASTIC POLYMER PARTICLES FOR MEDICAL AND/OR PHARMACEUTICAL USE

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705270A (en) * 1991-10-29 1998-01-06 Vivorx, Inc. Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor
WO2002030482A1 (en) * 2000-10-11 2002-04-18 Ethicon Gmbh Areal implant with ultrasonically detectable elements
WO2006106103A2 (en) * 2005-04-04 2006-10-12 Tibotec Pharmaceuticals Ltd. Prevention of hiv- infection with tmc278
WO2009046299A2 (en) * 2007-10-04 2009-04-09 Boston Scientific Scimed, Inc Implantable drug depot for intrathecal drug delivery system for pain management

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5645684A (en) 1994-03-07 1997-07-08 The Regents Of The University Of California Multilayer high vertical aspect ratio thin film structures
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US5651900A (en) 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
AU1979995A (en) 1994-03-07 1995-09-25 Regents Of The University Of California, The Microfabricated capsules for isolation of cell transplants
US7033603B2 (en) * 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
AU6526100A (en) 1999-08-06 2001-03-05 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
IL149005A0 (en) 1999-10-06 2002-11-10 Us Gov Health & Human Serv Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor
TW200800298A (en) 2000-01-27 2008-01-01 Zentaris Ag Compressed microparticles for dry injection
US20040115268A1 (en) 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
EP1387670B1 (en) * 2001-05-11 2008-10-15 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Immune modulation device for use in animals
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US7497855B2 (en) 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
AU2006235565A1 (en) 2005-04-11 2006-10-19 The Board Of Trustees Of The Leland Stanford Junior University Multi-layer structure having a predetermined layer pattern including an agent
US20060252049A1 (en) 2005-05-04 2006-11-09 Shuler Richard O Growth-promoting and immunizing subcutaneous implant
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
SI1981506T1 (sl) * 2006-01-20 2013-08-30 Janssen R&D Ireland Dolgoročno zdravljenje infekcije HIV s TCM278
WO2008060360A2 (en) * 2006-09-28 2008-05-22 Surmodics, Inc. Implantable medical device with apertures for delivery of bioactive agents
SI2003120T1 (sl) * 2007-06-12 2010-03-31 Concert Pharmaceuticals Inc Azapeptidni derivati kot inhibitorji hiv proteaze
US20110257111A1 (en) * 2008-10-24 2011-10-20 Harbeson Scott L Hydroxyethlamino Sulfonamide Derivatives
SG172398A1 (en) 2008-12-24 2011-07-28 Tibotec Pharm Ltd Implantable devices for treating hiv

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705270A (en) * 1991-10-29 1998-01-06 Vivorx, Inc. Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor
WO2002030482A1 (en) * 2000-10-11 2002-04-18 Ethicon Gmbh Areal implant with ultrasonically detectable elements
WO2006106103A2 (en) * 2005-04-04 2006-10-12 Tibotec Pharmaceuticals Ltd. Prevention of hiv- infection with tmc278
WO2009046299A2 (en) * 2007-10-04 2009-04-09 Boston Scientific Scimed, Inc Implantable drug depot for intrathecal drug delivery system for pain management

Also Published As

Publication number Publication date
US8784858B2 (en) 2014-07-22
EP2515877B1 (en) 2016-08-10
KR101798430B1 (ko) 2017-11-16
EP2515877A2 (en) 2012-10-31
AU2010338425A1 (en) 2012-06-07
RU2593790C2 (ru) 2016-08-10
CA2784530A1 (en) 2011-07-07
KR20120101084A (ko) 2012-09-12
WO2011080141A3 (en) 2012-03-08
AU2010338425B2 (en) 2015-07-23
ES2600878T3 (es) 2017-02-13
BR112012015114A2 (pt) 2020-09-01
IL219685A0 (en) 2012-07-31
MX2012007210A (es) 2012-07-23
IL219685B (en) 2019-03-31
WO2011080141A2 (en) 2011-07-07
CA2784530C (en) 2018-05-22
US10744235B2 (en) 2020-08-18
US11395867B2 (en) 2022-07-26
SG181759A1 (en) 2012-07-30
NZ600156A (en) 2015-01-30
UA112155C2 (uk) 2016-08-10
BR112012015114B1 (pt) 2023-01-10
ZA201204583B (en) 2022-03-30
US20200330654A1 (en) 2020-10-22
MY163383A (en) 2017-09-15
US20140296799A1 (en) 2014-10-02
CN102740837A (zh) 2012-10-17
JP5950825B2 (ja) 2016-07-13
RU2012131282A (ru) 2014-01-27
US20120277690A1 (en) 2012-11-01
JP2013514971A (ja) 2013-05-02

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