ES2597705T3 - Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico - Google Patents

Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico Download PDF

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Publication number
ES2597705T3
ES2597705T3 ES12163797.9T ES12163797T ES2597705T3 ES 2597705 T3 ES2597705 T3 ES 2597705T3 ES 12163797 T ES12163797 T ES 12163797T ES 2597705 T3 ES2597705 T3 ES 2597705T3
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ES
Spain
Prior art keywords
compound
group
formula
composition
dopa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12163797.9T
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English (en)
Spanish (es)
Inventor
David Alexander Learmonth
Laszlo Erno Kiss
Pedro Nuno Leal Palma
Humberto Dos Santos Ferreira
Patrício Manuel VIEIRA ARAÚJO SOARES DA SILVA
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Bial Portela and Cia SA
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Bial Portela and Cia SA
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Publication of ES2597705T3 publication Critical patent/ES2597705T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES12163797.9T 2007-01-31 2007-10-10 Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico Active ES2597705T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07002091 2007-01-31
EP07002091 2007-01-31

Publications (1)

Publication Number Publication Date
ES2597705T3 true ES2597705T3 (es) 2017-01-20

Family

ID=38961862

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12163797.9T Active ES2597705T3 (es) 2007-01-31 2007-10-10 Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico
ES07834911.5T Active ES2644049T3 (es) 2007-01-31 2007-10-10 Régimen de dosificación para inhibidores de COMT

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES07834911.5T Active ES2644049T3 (es) 2007-01-31 2007-10-10 Régimen de dosificación para inhibidores de COMT

Country Status (24)

Country Link
US (3) US8524746B2 (https=)
EP (2) EP2481410B1 (https=)
JP (1) JP5517629B2 (https=)
KR (1) KR101522157B1 (https=)
CN (1) CN101631548B (https=)
AR (2) AR065098A1 (https=)
AU (1) AU2007346018A1 (https=)
BR (1) BRPI0721213B1 (https=)
CA (1) CA2678391C (https=)
CY (1) CY1118311T1 (https=)
DK (2) DK2481410T3 (https=)
ES (2) ES2597705T3 (https=)
HR (1) HRP20161261T8 (https=)
HU (1) HUE031317T2 (https=)
IL (1) IL200020A (https=)
LT (1) LT2481410T (https=)
MX (1) MX2009008051A (https=)
NO (1) NO20092905L (https=)
PL (1) PL2481410T3 (https=)
PT (2) PT2124947T (https=)
RU (1) RU2518483C2 (https=)
SI (1) SI2481410T1 (https=)
WO (1) WO2008094053A1 (https=)
ZA (1) ZA200905940B (https=)

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WO2013089573A1 (en) 2011-12-13 2013-06-20 BIAL - PORTELA & Cª., S.A. Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor

Also Published As

Publication number Publication date
RU2518483C2 (ru) 2014-06-10
KR101522157B9 (ko) 2024-07-31
PT2481410T (pt) 2016-10-18
EP2481410B1 (en) 2016-07-13
PL2481410T3 (pl) 2017-03-31
CA2678391C (en) 2017-01-17
US20160009699A1 (en) 2016-01-14
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US20130331416A1 (en) 2013-12-12
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BRPI0721213A2 (pt) 2014-03-18
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US9745290B2 (en) 2017-08-29
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PT2124947T (pt) 2017-10-25
HRP20161261T1 (hr) 2016-12-02
AU2007346018A2 (en) 2011-04-21
DK2124947T3 (da) 2017-11-06
EP2481410A1 (en) 2012-08-01
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RU2009132188A (ru) 2011-03-10
SI2481410T1 (sl) 2017-01-31
IL200020A (en) 2016-07-31
CN101631548B (zh) 2014-08-27
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HUE031317T2 (hu) 2017-07-28
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