ES2578513T3 - Solución acuosa que comprende 3-quinuclidinona para el tratamiento de enfermedades hiperproliferativas, autoinmunes y cardiacas - Google Patents
Solución acuosa que comprende 3-quinuclidinona para el tratamiento de enfermedades hiperproliferativas, autoinmunes y cardiacas Download PDFInfo
- Publication number
- ES2578513T3 ES2578513T3 ES11701392.0T ES11701392T ES2578513T3 ES 2578513 T3 ES2578513 T3 ES 2578513T3 ES 11701392 T ES11701392 T ES 11701392T ES 2578513 T3 ES2578513 T3 ES 2578513T3
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- Spain
- Prior art keywords
- acid
- aqueous solution
- apr
- treatment
- quinuclidinone
- Prior art date
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US296964P | 2001-06-08 | ||
| US29696410P | 2010-01-21 | 2010-01-21 | |
| EP10151326 | 2010-01-21 | ||
| EP10151326 | 2010-01-21 | ||
| PCT/EP2011/050854 WO2011089234A2 (en) | 2010-01-21 | 2011-01-21 | Method and composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2578513T3 true ES2578513T3 (es) | 2016-07-27 |
Family
ID=42212171
Family Applications (1)
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| BR112012017994B8 (pt) * | 2010-01-21 | 2020-12-08 | Aprea Ab | composição líquida, uso de uma composição líquida, e, métodos para preparar uma composição líquida e para tratamento de um distúrbio |
| CN104860994A (zh) * | 2014-02-20 | 2015-08-26 | 中国药科大学 | 3-奎宁环酮类含磷化合物的制备及其医药用途 |
| CN109280056A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 手性3-奎宁环酮类化合物、制备方法及用途 |
| WO2019173806A1 (en) * | 2018-03-09 | 2019-09-12 | Texas Tech University System | Compositions and methods for the diagnosis and treatment of alt cancer |
| US20220087987A1 (en) * | 2018-12-27 | 2022-03-24 | National Cancer Center | A method for treating swi/snf complex-deficient cancers comprising glutathione (gsh) metabolic pathway inhibitor |
| WO2021053155A1 (en) | 2019-09-18 | 2021-03-25 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein |
| EP4100407A1 (en) * | 2020-02-09 | 2022-12-14 | Newave Pharmaceutical Inc. | Quinuclidinone analogues as anticancer agents |
| CN111257458B (zh) * | 2020-02-20 | 2022-07-22 | 北京鑫开元医药科技有限公司海南分公司 | 一种3-奎宁环酮盐酸盐的检测方法及应用 |
| WO2021170772A1 (en) | 2020-02-26 | 2021-09-02 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of cd47 mediated signaling |
| WO2021180338A1 (en) | 2020-03-09 | 2021-09-16 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of dna methyltransferase post stem cell transplant |
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| US3775418A (en) * | 1970-07-15 | 1973-11-27 | American Home Prod | 3-((3-azaspiro(5,5)undecino)methyl)-3-quinuclidinol |
| US6921765B2 (en) | 2000-09-20 | 2005-07-26 | Aprea Ab | 1-Azabicyclo[2.2.2]octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors |
| US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| RU2226288C2 (ru) | 2001-07-10 | 2004-03-27 | ОПТИВА, Инк. | Многослойное оптическое покрытие |
| EP1476166B1 (en) * | 2002-02-21 | 2006-07-19 | Aprea Ab | Use of low molecular weight compounds for preparing a medicament useful in treating mutant p53 mediated diseases |
| AU2004224488B2 (en) | 2003-03-24 | 2009-09-10 | Aprea Therapeutics Ab | Pharmaceutical use of 1-azabicyclo[2.2.2]octanes and a method of testing compounds for the ability of activating inactive wt p53 |
| SE0400708D0 (sv) * | 2004-03-22 | 2004-03-22 | Aprea Ab | New compounds and use thereof |
| JP2007269786A (ja) | 2006-03-09 | 2007-10-18 | Daiichi Sankyo Healthcare Co Ltd | パンテチン含有経口液剤 |
| JP2008001606A (ja) | 2006-06-20 | 2008-01-10 | Mitsubishi Pharma Corp | ピラゾロン化合物を含有する水溶液剤 |
| JP4929352B2 (ja) | 2006-07-18 | 2012-05-09 | スペイン ファルマ ソシエダ アノニマ | 注入可能なパラセタモール液剤 |
| JP2008201778A (ja) | 2007-01-25 | 2008-09-04 | Mochida Pharmaceut Co Ltd | バンコマイシン液状製剤 |
| CN101636162A (zh) | 2007-03-01 | 2010-01-27 | 诺瓦提斯公司 | 5-(2,4-二羟基-5-异丙基-苯基)-4-(4-吗啉-4-基甲基-苯基)-异唑-3-甲酸乙基酰胺的酸加成盐、水合物和多晶型物以及包含这些形式的制剂 |
| BR112012017994B8 (pt) * | 2010-01-21 | 2020-12-08 | Aprea Ab | composição líquida, uso de uma composição líquida, e, métodos para preparar uma composição líquida e para tratamento de um distúrbio |
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2011
- 2011-01-21 BR BR112012017994A patent/BR112012017994B8/pt active IP Right Grant
- 2011-01-21 PT PT117013920T patent/PT2525796T/pt unknown
- 2011-01-21 RU RU2012135698/15A patent/RU2571566C2/ru active
- 2011-01-21 KR KR1020127021595A patent/KR101727085B1/ko active Active
- 2011-01-21 US US13/521,841 patent/US9061016B2/en active Active
- 2011-01-21 CA CA2786824A patent/CA2786824C/en active Active
- 2011-01-21 ES ES11701392.0T patent/ES2578513T3/es active Active
- 2011-01-21 EP EP11701392.0A patent/EP2525796B1/en active Active
- 2011-01-21 DK DK11701392.0T patent/DK2525796T3/en active
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- 2011-01-21 AU AU2011208681A patent/AU2011208681B2/en active Active
- 2011-01-21 WO PCT/EP2011/050854 patent/WO2011089234A2/en not_active Ceased
- 2011-01-21 JP JP2012549372A patent/JP5845193B2/ja active Active
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- 2011-01-21 CN CN201610993086.1A patent/CN106963759B/zh active Active
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2016
- 2016-06-17 CY CY20161100546T patent/CY1117659T1/el unknown
- 2016-06-20 SM SM201600189T patent/SMT201600189B/it unknown
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