ES2568680T3 - Boratos como inhibidores de arginasa - Google Patents

Boratos como inhibidores de arginasa Download PDF

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Publication number
ES2568680T3
ES2568680T3 ES11779904.9T ES11779904T ES2568680T3 ES 2568680 T3 ES2568680 T3 ES 2568680T3 ES 11779904 T ES11779904 T ES 11779904T ES 2568680 T3 ES2568680 T3 ES 2568680T3
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Spain
Prior art keywords
amino
boronopropyl
alkylene
aryl
carboxylic acid
Prior art date
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Active
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ES11779904.9T
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English (en)
Spanish (es)
Inventor
Michael Van Zandt
Jr. Gunnar Erik Jagdmann
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Mars Inc
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Mars Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES11779904.9T 2010-10-26 2011-10-19 Boratos como inhibidores de arginasa Active ES2568680T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40676010P 2010-10-26 2010-10-26
US406760P 2010-10-26
PCT/US2011/056844 WO2012058065A1 (en) 2010-10-26 2011-10-19 Boronates as arginase inhibitors

Publications (1)

Publication Number Publication Date
ES2568680T3 true ES2568680T3 (es) 2016-05-03

Family

ID=44913403

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11779904.9T Active ES2568680T3 (es) 2010-10-26 2011-10-19 Boratos como inhibidores de arginasa
ES16150285T Active ES2794006T3 (es) 2010-10-26 2011-10-19 Inhibidores de arginasa como agentes terapéuticos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES16150285T Active ES2794006T3 (es) 2010-10-26 2011-10-19 Inhibidores de arginasa como agentes terapéuticos

Country Status (19)

Country Link
US (5) US9233985B2 (enExample)
EP (3) EP3719024A1 (enExample)
JP (1) JP5909239B2 (enExample)
CN (2) CN106008569B9 (enExample)
AU (1) AU2011320732B2 (enExample)
BR (1) BR112013010099B1 (enExample)
CA (1) CA2815536C (enExample)
DK (1) DK2632927T3 (enExample)
ES (2) ES2568680T3 (enExample)
HK (1) HK1223104A1 (enExample)
HR (1) HRP20160305T1 (enExample)
HU (1) HUE027317T2 (enExample)
IL (1) IL225926A (enExample)
MX (1) MX336381B (enExample)
PL (1) PL2632927T3 (enExample)
RS (1) RS54750B1 (enExample)
SI (1) SI2632927T1 (enExample)
SM (1) SMT201600141B (enExample)
WO (1) WO2012058065A1 (enExample)

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IL225926A0 (en) 2013-06-27
CA2815536A1 (en) 2012-05-03
EP2632927A1 (en) 2013-09-04
CN106008569A (zh) 2016-10-12
SI2632927T1 (sl) 2016-08-31
EP2632927B1 (en) 2016-02-10
CN103249737B (zh) 2016-06-08
HRP20160305T1 (hr) 2016-07-01
SMT201600141B (it) 2016-07-01
DK2632927T3 (en) 2016-04-11
MX2013004491A (es) 2013-11-04
EP3034509A1 (en) 2016-06-22
IL225926A (en) 2016-09-29
BR112013010099B1 (pt) 2021-08-10
HK1223104A1 (en) 2017-07-21
HK1225390A1 (zh) 2017-09-08
PL2632927T3 (pl) 2016-09-30
US9440995B2 (en) 2016-09-13
JP5909239B2 (ja) 2016-04-26
JP2013542223A (ja) 2013-11-21
HUE027317T2 (en) 2016-10-28
AU2011320732A1 (en) 2013-11-21
US10098902B2 (en) 2018-10-16
CN103249737A (zh) 2013-08-14
BR112013010099A2 (pt) 2016-09-06
WO2012058065A1 (en) 2012-05-03
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US20190054101A1 (en) 2019-02-21
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US20150191492A1 (en) 2015-07-09
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ES2794006T3 (es) 2020-11-17
US20200246362A1 (en) 2020-08-06
US11389464B2 (en) 2022-07-19
US20120129806A1 (en) 2012-05-24
EP3034509B1 (en) 2020-04-22
RS54750B1 (sr) 2016-10-31
US10603330B2 (en) 2020-03-31
US9233985B2 (en) 2016-01-12
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