ES2549903T3 - Anticuerpos humanizados contra interferón alfa humano - Google Patents
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- ES2549903T3 ES2549903T3 ES09742079.8T ES09742079T ES2549903T3 ES 2549903 T3 ES2549903 T3 ES 2549903T3 ES 09742079 T ES09742079 T ES 09742079T ES 2549903 T3 ES2549903 T3 ES 2549903T3
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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| EP08103847 | 2008-05-07 | ||
| PCT/EP2009/055448 WO2009135861A2 (en) | 2008-05-07 | 2009-05-06 | Humanized antibodies against human interferon-alpha |
Publications (1)
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| ES2549903T3 true ES2549903T3 (es) | 2015-11-03 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2597265C (en) | 2005-02-10 | 2015-03-24 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| RU2013157177A (ru) * | 2011-05-25 | 2015-06-27 | МЕДИММЬЮН, ЭлЭлСи | Способы лечения системной красной волчанки, склеродермии и миозита |
| WO2013034160A1 (en) * | 2011-09-06 | 2013-03-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Methods for analyzing biological macromolecular complexes and use thereof |
| CN105358575B (zh) | 2013-03-15 | 2020-09-22 | 詹森生物科技公司 | 干扰素α和ω抗体拮抗剂 |
| EP4056591A1 (en) * | 2013-07-03 | 2022-09-14 | ImmunoQure AG | Human anti-ifn-alpha antibodies |
| TWI713453B (zh) * | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| US10689703B2 (en) * | 2015-04-27 | 2020-06-23 | National Jewish Health | Methods of identifying and treating subjects having acute respiratory distress syndrome |
| CN108204958A (zh) * | 2016-12-19 | 2018-06-26 | 伊缪泰普有限公司 | 结合测定 |
| JP2022527542A (ja) | 2019-04-04 | 2022-06-02 | ヤンセン バイオテツク，インコーポレーテツド | 抗ＩＦＮ－α／ω抗体の投与方法 |
| CN114728179A (zh) * | 2019-08-19 | 2022-07-08 | 潘迪恩运营公司 | 利用pd-1激动剂的靶向免疫耐受 |
| RU2737466C1 (ru) * | 2019-12-30 | 2020-11-30 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Гуманизированное нейтрализующее антитело к интерферону-бета человека |
| CN112500476B (zh) * | 2020-12-16 | 2024-02-23 | 南京基蛋生物医药有限公司 | 一种扩增鼠单抗重轻链基因序列的方法及其引物和筛选该引物的方法 |
| CN116355079B (zh) * | 2022-08-19 | 2023-12-26 | 上海迈科康生物科技有限公司 | 检测重组人轮状病毒vp8抗原（vp8 p[8]）的单克隆抗体及其应用 |
| WO2025247917A1 (en) * | 2024-05-28 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | ANTI-IFN-α2 AND ANTI-IFN-ω1 MONOCLONAL ANTIBODIES |
| WO2025247918A1 (en) * | 2024-05-28 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | ANTI-IFN-α2 MONOCLONAL ANTIBODIES |
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Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423147A (en) * | 1980-04-11 | 1983-12-27 | Secher David S | Monoclonal antibody to interferon-α |
| US4605394A (en) * | 1982-12-03 | 1986-08-12 | Simon V. Skurkovich | Methods for the treatment of pathological conditions by removing interferon from the organism |
| US4824432A (en) * | 1981-03-24 | 1989-04-25 | S.V.S. Laboratories, Inc. | Method for treating AIDS and other immune deficiencies and immune disorders |
| US4362155A (en) * | 1981-03-24 | 1982-12-07 | Skurkovich Simon V | Method and apparatus for the treatment of autoimmune and allergic diseases |
| DE3211263A1 (de) * | 1981-03-31 | 1983-01-27 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Human-interferon verwandte peptide, antigene und antikoerper, sowie verfahren zu deren herstellung |
| EP0139676B1 (en) * | 1983-02-04 | 1992-11-25 | Cytoclonal Pharmaceutics Inc. | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| GB2148299B (en) * | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
| FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
| WO1992018626A1 (fr) * | 1991-04-17 | 1992-10-29 | Laboratoire Europeen De Biotechnologie | POLYPEPTIDES HYDROSOLUBLES AYANT UNE HAUTE AFFINITE POUR LES INTERFERONS α ET $g(b) |
| WO1993004699A1 (en) | 1991-08-30 | 1993-03-18 | Genentech, Inc. | Therapeutic method for iddm |
| EP0563487A1 (en) * | 1992-03-31 | 1993-10-06 | Laboratoire Europeen De Biotechnologie S.A. | Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon |
| US5821078A (en) * | 1992-09-03 | 1998-10-13 | Yeda Research And Development Co. Ltd. | Nucleic acid encoding interferon-α/β binding protein |
| US5888511A (en) * | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| US5780027A (en) * | 1995-07-14 | 1998-07-14 | Meiogen Biotechnology Corporation | Methods of treatment of down syndrome by interferon antagonists |
| IL118096A0 (en) * | 1996-05-01 | 1996-09-12 | Yeda Res & Dev | Antibodies against interferon alpha/beta receptor |
| US6713609B1 (en) * | 1996-07-16 | 2004-03-30 | Genentech, Inc. | Monoclonal antibodies to type I interferon receptor |
| WO1998006431A2 (en) | 1996-08-16 | 1998-02-19 | Osther Kurt B | Method for treating diabetes |
| US5902321A (en) | 1997-07-25 | 1999-05-11 | Innovasive Devices, Inc. | Device and method for delivering a connector for surgically joining and securing flexible tissue repair members |
| US20030018174A1 (en) * | 1997-10-06 | 2003-01-23 | Genentech, Inc. | Monoclonal antibodies to IFNAR2 |
| US6331396B1 (en) | 1998-09-23 | 2001-12-18 | The Cleveland Clinic Foundation | Arrays for identifying agents which mimic or inhibit the activity of interferons |
| AUPP670698A0 (en) | 1998-10-23 | 1998-11-19 | Monash University | A method of regulation |
| KR20000034847A (ko) * | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| JP5007007B2 (ja) | 1999-11-15 | 2012-08-22 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞 |
| GB0001712D0 (en) * | 2000-01-25 | 2000-03-15 | Pharma Pacific Pty Ltd | Therapeutic peptides |
| GB0001710D0 (en) * | 2000-01-25 | 2000-03-15 | Pharma Pacific Pty Ltd | Therapeutic treatment |
| US6846486B1 (en) * | 2000-02-24 | 2005-01-25 | Advanced Biotherapy Concepts, Inc. | Method of treating allergy by administering an anti-histamine antibody |
| GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| WO2002024874A2 (en) * | 2000-09-21 | 2002-03-28 | Schering Corporation | Methods for preparing interferon producing dentitric cells |
| EP2236156A3 (en) | 2001-01-09 | 2011-01-05 | Baylor Research Institute | Methods for treating and diagnosing Psoriasis |
| DE20100503U1 (de) | 2001-01-12 | 2001-05-10 | Josef Schiele oHG, 56651 Niederzissen | Beschichtungsvorrichtung für ein langgestrecktes Werkstück |
| US7087726B2 (en) * | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| FR2822845B1 (fr) * | 2001-03-30 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques |
| WO2003068801A2 (en) * | 2002-02-11 | 2003-08-21 | Genentech, Inc. | Antibody variants with faster antigen association rates |
| EP2336185A1 (en) | 2002-03-13 | 2011-06-22 | Biogen Idec Inc. | Anti- alpha v beta 6 antibodies |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| EA013677B1 (ru) * | 2002-11-15 | 2010-06-30 | Генмаб А/С | Человеческие моноклональные антитела против cd25 и их применение |
| DK1711207T3 (da) * | 2003-12-10 | 2013-03-11 | Medarex Inc | Interferon-alpha-antistoffer og anvendelse heraf |
| TW200616662A (en) * | 2004-09-10 | 2006-06-01 | Wyeth Corp | Humanized anti-5t4 antibodies and anti-5t4 antibody/calicheamicin conjugates |
| NZ554065A (en) * | 2004-10-07 | 2010-12-24 | Univ Zuerich | Use of an anti-interferon-alpha antibody for prevention and treatment of psoriasis |
| WO2008021976A2 (en) * | 2006-08-09 | 2008-02-21 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| CA2597265C (en) * | 2005-02-10 | 2015-03-24 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| US7888481B2 (en) * | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
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| AU2009245792B2 (en) | 2012-11-01 |
| US20130101602A1 (en) | 2013-04-25 |
| US8163885B2 (en) | 2012-04-24 |
| US20110213125A1 (en) | 2011-09-01 |
| RU2532832C2 (ru) | 2014-11-10 |
| KR20110042264A (ko) | 2011-04-26 |
| JP2011519571A (ja) | 2011-07-14 |
| CN102083859B (zh) | 2014-09-17 |
| BRPI0912570A2 (pt) | 2016-04-26 |
| CA2722622C (en) | 2018-01-02 |
| IL208979A0 (en) | 2011-01-31 |
| EP2279207B1 (en) | 2015-09-09 |
| BRPI0912570B1 (pt) | 2021-04-06 |
| EP2279207A2 (en) | 2011-02-02 |
| JP5766598B2 (ja) | 2015-08-19 |
| CA2722622A1 (en) | 2009-11-12 |
| CN102083859A (zh) | 2011-06-01 |
| US8361463B2 (en) | 2013-01-29 |
| WO2009135861A3 (en) | 2010-01-28 |
| RU2010150105A (ru) | 2012-06-20 |
| MX2010012052A (es) | 2010-12-14 |
| IL208979B (en) | 2018-02-28 |
| TW200950807A (en) | 2009-12-16 |
| WO2009135861A2 (en) | 2009-11-12 |
| US8658771B2 (en) | 2014-02-25 |
| US20120195888A1 (en) | 2012-08-02 |
| ZA201008748B (en) | 2013-02-27 |
| BRPI0912570B8 (pt) | 2021-05-25 |
| KR101687032B1 (ko) | 2016-12-15 |
| AU2009245792A1 (en) | 2009-11-12 |
| HK1154251A1 (zh) | 2012-04-13 |
| TWI453032B (zh) | 2014-09-21 |
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