ES2536974T3 - Péptidos de epítopos del receptor de EGF y usos de los mismos - Google Patents
Péptidos de epítopos del receptor de EGF y usos de los mismos Download PDFInfo
- Publication number
- ES2536974T3 ES2536974T3 ES05723258.9T ES05723258T ES2536974T3 ES 2536974 T3 ES2536974 T3 ES 2536974T3 ES 05723258 T ES05723258 T ES 05723258T ES 2536974 T3 ES2536974 T3 ES 2536974T3
- Authority
- ES
- Spain
- Prior art keywords
- egf receptor
- epitope peptides
- receptor epitope
- seq
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54660204P | 2004-02-20 | 2004-02-20 | |
| US546602P | 2004-02-20 | ||
| US58462304P | 2004-07-01 | 2004-07-01 | |
| US584623P | 2004-07-01 | ||
| PCT/US2005/005155 WO2005081854A2 (en) | 2004-02-20 | 2005-02-18 | Egf receptor epitope peptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2536974T3 true ES2536974T3 (es) | 2015-06-01 |
Family
ID=34915579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05723258.9T Expired - Lifetime ES2536974T3 (es) | 2004-02-20 | 2005-02-18 | Péptidos de epítopos del receptor de EGF y usos de los mismos |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7767792B2 (enExample) |
| EP (2) | EP1722808B1 (enExample) |
| JP (2) | JP2008501308A (enExample) |
| KR (2) | KR101270443B1 (enExample) |
| AU (2) | AU2005216082B8 (enExample) |
| CA (1) | CA2556632C (enExample) |
| ES (1) | ES2536974T3 (enExample) |
| WO (1) | WO2005081854A2 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) * | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| CA2447139C (en) | 2001-05-11 | 2013-11-19 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| WO2004058821A2 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| AU2002319402B2 (en) * | 2001-06-28 | 2008-09-11 | Domantis Limited | Dual-specific ligand and its use |
| EP1600459A3 (en) * | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US7767792B2 (en) | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| US20070009972A1 (en) * | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
| MX2008005640A (es) * | 2005-11-02 | 2008-12-09 | Univ Duke | Quimioterapia e inmunoterapia concurrentes. |
| KR20080077238A (ko) * | 2005-12-01 | 2008-08-21 | 도만티스 리미티드 | 인터루킨 1 수용체 타입 1에 결합하는 비경쟁적 도메인항체 포맷 |
| EP2010911A4 (en) * | 2006-03-31 | 2009-05-13 | Massachusetts Inst Technology | TREATMENT OF EGF RECEPTOR MUTANTS EXPRESSING TUMORS |
| EP2068929A4 (en) * | 2006-09-15 | 2010-04-28 | Life Science Pharmaceuticals | METHOD OF DETECTING AND TREATING SKIN DISORDERS |
| CN101711284A (zh) * | 2007-01-25 | 2010-05-19 | 达娜-法勃肿瘤研究所 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| WO2008103474A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
| JP5618549B2 (ja) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Egfr抗体及びsrc阻害剤を用いる治療方法及び関連製剤 |
| USRE47534E1 (en) * | 2007-04-23 | 2019-07-23 | Ramot At Tel Aviv University Ltd. | System, method and a computer readable medium for providing an output image |
| US8877186B2 (en) | 2007-06-06 | 2014-11-04 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
| CA2696360C (en) * | 2007-08-14 | 2018-11-20 | Ludwig Institute For Cancer Research | Monoclonal antibody targeting the egfr receptor and uses thereof |
| WO2009023266A1 (en) * | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Generation of antibodies to cell-surface receptors and cancer-associated proteins including egfr family members |
| EP3492488A1 (en) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Activatable binding polypeptides and methods of identification and use thereof |
| BRPI0819693A2 (pt) | 2007-11-30 | 2020-08-18 | Glaxo Group Limited | Construção de ligação de antígeno, método para tratar um paciente que sofre de câncer ou uma doença inflamatória, sequência de polinucleotídeo, polinucleotídeo, célula hospedeira transformada ou transfectada recombinante, método para produziruma construção de ligação de antígeno, e, composição farmacêutica |
| WO2009149094A2 (en) * | 2008-06-02 | 2009-12-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cytotoxic t cell defined egfr peptide and an optimized derivative peptide |
| JP2010006705A (ja) * | 2008-06-13 | 2010-01-14 | Atlas Antibodies Ab | Her2サブセット |
| WO2009155381A1 (en) * | 2008-06-18 | 2009-12-23 | Abbott Laboratories | P/gf-1 companion diagnostic methods and products |
| US20100004306A1 (en) * | 2008-06-18 | 2010-01-07 | Abbott Laboratories | PIGF-1 Assay and kits and components thereof |
| US8741287B2 (en) * | 2008-06-18 | 2014-06-03 | Abbott Laboratories | PlGF-1 assay and kits and components thereof |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| JP2012511033A (ja) * | 2008-12-08 | 2012-05-17 | テゴファーム コーポレーション | 多価化合物の可逆阻害用マスキングリガンド |
| AU2010203353B2 (en) | 2009-01-12 | 2016-06-16 | Cytomx Therapeutics, Inc | Modified antibody compositions, methods of making and using thereof |
| JP5861223B2 (ja) | 2009-02-23 | 2016-02-16 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | プロタンパク質およびその使用方法 |
| EP2481754B1 (en) * | 2009-09-22 | 2014-06-18 | Shanghai Yijie Biotechnology Co., Ltd | Specific binding proteins and uses thereof |
| CN103539840B (zh) * | 2010-01-20 | 2015-04-01 | 上海市肿瘤研究所 | 表皮生长因子受体模拟表位肽及其应用 |
| CN102127147B (zh) * | 2010-01-20 | 2014-07-02 | 上海市肿瘤研究所 | 表皮生长因子受体模拟表位肽及其应用 |
| AU2011261161A1 (en) | 2010-06-01 | 2013-01-10 | Ludwig Institute For Cancer Research Limited | Antibodies directed to the unprocessed receptor tyrosine kinase c-Met |
| US9464136B2 (en) | 2010-08-20 | 2016-10-11 | Massachusetts Institute Of Technology | Antibody-based constructs directed against tyrosine kinase receptors |
| US20130066055A1 (en) | 2011-04-21 | 2013-03-14 | Bayer Intellectual Property Gmbh | New binder-drug conjugates (adcs) and use thereof |
| BR112014024192A2 (pt) * | 2012-03-27 | 2017-07-25 | Green Cross Corp | epítopos de antígeno superficial do receptor de fator de crescimento epidérmico e uso desses |
| JP6103832B2 (ja) | 2012-06-25 | 2017-03-29 | Hoya株式会社 | Egfr結合性ペプチド |
| AU2014372833B2 (en) | 2013-12-23 | 2019-08-22 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) |
| KR102399005B1 (ko) | 2014-03-11 | 2022-05-17 | 리제너론 파마슈티칼스 인코포레이티드 | 항-egfrviii 항체 및 그것의 용도 |
| CA2942101A1 (en) | 2014-03-21 | 2015-09-24 | Abbvie Inc. | Anti-egfr antibodies and antibody drug conjugates |
| US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
| CA3172682A1 (en) | 2015-04-23 | 2016-10-27 | Nantomics, Llc | Cancer neoepitopes |
| CN108025084B (zh) | 2015-06-22 | 2024-08-09 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物(adc)和抗体前药缀合物(apdc) |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| EP3362930A4 (en) | 2015-10-12 | 2019-06-19 | Nantomics, LLC | SYSTEMS, COMPOSITIONS, AND METHODS FOR DISCOVERING MSI AND NEOEPPITOPES THAT PROVIDE SENSITIVITY TO IMMUNE CONTROL POINTS |
| SG10202008909VA (en) | 2016-03-24 | 2020-10-29 | Bayer Pharma AG | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| WO2018114578A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| CA3047491A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| EP3931224A4 (en) | 2019-02-26 | 2023-03-01 | Janssen Biotech, Inc. | COMBINATION TREATMENTS AND PATIENT STRATIFICATION WITH ANTI-EGFR/C-MET BISPECIFIC ANTIBODIES |
| JP7727549B2 (ja) * | 2019-03-22 | 2025-08-21 | セルティス・セラピューティクス・ピーティーワイ・リミテッド | 抗her2結合分子 |
| MY208668A (en) | 2019-05-14 | 2025-05-23 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| JOP20220184A1 (ar) | 2020-02-12 | 2023-01-30 | Janssen Biotech Inc | علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14 |
| CN111647074B (zh) * | 2020-06-01 | 2023-12-19 | 皖南医学院 | 一种her3二聚化界面抗原肽、重组抗原肽、编码基因及其应用 |
| UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| JP2024527235A (ja) | 2021-06-22 | 2024-07-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗EGFRvIII抗体薬物コンジュゲート及びその使用 |
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| BRPI0518086A (pt) * | 2004-12-07 | 2008-10-28 | Genentech Inc | métodos para tratamento de cáncer, métodos de avaliação de fosforilação ou ativação de her e método de identificação |
| EP2068929A4 (en) | 2006-09-15 | 2010-04-28 | Life Science Pharmaceuticals | METHOD OF DETECTING AND TREATING SKIN DISORDERS |
| CN101711284A (zh) | 2007-01-25 | 2010-05-19 | 达娜-法勃肿瘤研究所 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| JP5618549B2 (ja) * | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Egfr抗体及びsrc阻害剤を用いる治療方法及び関連製剤 |
| CA2696360C (en) | 2007-08-14 | 2018-11-20 | Ludwig Institute For Cancer Research | Monoclonal antibody targeting the egfr receptor and uses thereof |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2005
- 2005-02-17 US US11/060,646 patent/US7767792B2/en active Active
- 2005-02-18 KR KR1020127010335A patent/KR101270443B1/ko not_active Expired - Lifetime
- 2005-02-18 AU AU2005216082A patent/AU2005216082B8/en not_active Expired
- 2005-02-18 EP EP05723258.9A patent/EP1722808B1/en not_active Expired - Lifetime
- 2005-02-18 ES ES05723258.9T patent/ES2536974T3/es not_active Expired - Lifetime
- 2005-02-18 WO PCT/US2005/005155 patent/WO2005081854A2/en not_active Ceased
- 2005-02-18 CA CA2556632A patent/CA2556632C/en not_active Expired - Lifetime
- 2005-02-18 KR KR1020067019405A patent/KR101280267B1/ko not_active Expired - Lifetime
- 2005-02-18 EP EP12164335A patent/EP2514763A1/en not_active Withdrawn
- 2005-02-18 JP JP2006554221A patent/JP2008501308A/ja active Pending
-
2010
- 2010-01-29 US US12/657,919 patent/US8652473B2/en not_active Expired - Lifetime
- 2010-09-20 AU AU2010224335A patent/AU2010224335B2/en not_active Expired
-
2011
- 2011-12-15 JP JP2011274098A patent/JP6045147B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR101270443B1 (ko) | 2013-05-31 |
| KR20120050530A (ko) | 2012-05-18 |
| CA2556632C (en) | 2016-10-11 |
| US20050255555A1 (en) | 2005-11-17 |
| AU2005216082B2 (en) | 2010-10-14 |
| AU2010224335A1 (en) | 2010-10-14 |
| US7767792B2 (en) | 2010-08-03 |
| CA2556632A1 (en) | 2005-09-09 |
| JP2008501308A (ja) | 2008-01-24 |
| JP2012102109A (ja) | 2012-05-31 |
| US20100322937A1 (en) | 2010-12-23 |
| US8652473B2 (en) | 2014-02-18 |
| AU2005216082B8 (en) | 2010-11-18 |
| WO2005081854A3 (en) | 2006-01-05 |
| JP6045147B2 (ja) | 2016-12-14 |
| EP1722808B1 (en) | 2015-04-08 |
| AU2005216082A1 (en) | 2005-09-09 |
| EP1722808A4 (en) | 2009-08-19 |
| EP1722808A2 (en) | 2006-11-22 |
| WO2005081854A2 (en) | 2005-09-09 |
| KR20070031871A (ko) | 2007-03-20 |
| EP2514763A1 (en) | 2012-10-24 |
| AU2010224335B2 (en) | 2012-04-05 |
| KR101280267B1 (ko) | 2013-07-15 |
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