CO6140037A2 - Organismos clostridium atenuados recombinados y vacuna - Google Patents
Organismos clostridium atenuados recombinados y vacunaInfo
- Publication number
- CO6140037A2 CO6140037A2 CO08110815A CO08110815A CO6140037A2 CO 6140037 A2 CO6140037 A2 CO 6140037A2 CO 08110815 A CO08110815 A CO 08110815A CO 08110815 A CO08110815 A CO 08110815A CO 6140037 A2 CO6140037 A2 CO 6140037A2
- Authority
- CO
- Colombia
- Prior art keywords
- amino acid
- acid residues
- mutein
- alpha toxin
- nro
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Feed For Specific Animals (AREA)
Abstract
1.- Una molécula de ácido nucleico que codifica una muteína sustancialmente no tóxica de toxina alfa de Clostridium perfringens; donde la toxina alfa de muteína comprende la secuencia de aminoácidos de SEC. ID. NRO.: 3 menos por lo menos 9 residuos de aminoácidos consecutivos; y donde uno de los residuos de aminoácidos eliminados es His68 2.- La molécula de ácido nucleico de la reivindicación 1, donde la toxina alfa de muteína comprende la secuencia de aminoácidos de SEC. ID. NRO.: 3 menos por lo menos 12 residuos de aminoácidos consecutivos; y donde uno de los residuos de aminoácidos eliminados es His68. 3.- La molécula de ácido nucleico de la reivindicación 2, donde la toxina alfa de muteína comprende la secuencia de aminoácidos de SEC. ID. NRO.: 3 menos por lo menos 18 residuos de aminoácidos consecutivos; y donde uno de los residuos de aminoácidos eliminados es His68. 4.- La molécula de ácido nucleico de la reivindicación 1, donde la toxina alfa de muteína comprende SEC. ID. NRO.: 3 menos 9 residuos de aminoácidos consecutivos, que abarcan desde Tyr62 hasta Trp70. 5.- La molécula de ácido nucleico de a reivindicación 1, que comprende la secuencia de ácido nucleico de SEC. ID. NRO.: 2; donde están eliminados los nucleótidos 268-294 de la molécula de ácido nucleico. 6.- La molécula de ácido nucleico de la reivindicación 5, donde los nucleótidos eliminados están reemplazados por una secuencia de nucleótidos que codifica un solo residuo Leu.7.- Una muteína sustancialmente no tóxica de toxina alfa de Clostridium perfringens; donde la toxina alfa de muteína comprende la secuencia de aminoácidos de SEC. ID. NRO.: 3 menos por lo menos 9 residuos de aminoácidos consecutivos; y donde uno de los residuos de aminoácidos eliminados es His68. 8.- La muteína sustancialmente no tóxica de toxina alfa de Clostridium perfringens de la reivindicación 7, donde la toxina alfa de muteína comprende la secuencia de aminoácidos de SEC. ID. NRO.: 3 menos por lo menos 12 residuos de aminoácidos consecutivos; y donde uno de los residuos de aminoácidos eliminados es His68.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79255306P | 2006-04-17 | 2006-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6140037A2 true CO6140037A2 (es) | 2010-03-19 |
Family
ID=38625523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO08110815A CO6140037A2 (es) | 2006-04-17 | 2008-10-17 | Organismos clostridium atenuados recombinados y vacuna |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7732187B2 (es) |
| EP (2) | EP2007420B1 (es) |
| JP (2) | JP5551933B2 (es) |
| KR (1) | KR20080110908A (es) |
| CN (1) | CN101489584B (es) |
| AR (2) | AR060471A1 (es) |
| AU (1) | AU2007240949B2 (es) |
| BR (1) | BRPI0711572A2 (es) |
| CA (1) | CA2649426C (es) |
| CO (1) | CO6140037A2 (es) |
| EC (1) | ECSP088827A (es) |
| ES (1) | ES2401810T3 (es) |
| HK (1) | HK1125315A1 (es) |
| IL (1) | IL194714A (es) |
| MX (1) | MX2008013451A (es) |
| NO (1) | NO20084810L (es) |
| NZ (1) | NZ571970A (es) |
| PE (1) | PE20080167A1 (es) |
| PL (1) | PL2007420T3 (es) |
| RU (2) | RU2445364C2 (es) |
| TW (1) | TWI338045B (es) |
| UA (2) | UA109105C2 (es) |
| WO (1) | WO2007123850A2 (es) |
| ZA (1) | ZA200808872B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077256A1 (en) | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US20060083750A1 (en) * | 1999-11-19 | 2006-04-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US8617823B2 (en) * | 2008-04-29 | 2013-12-31 | Immunexcite, Inc. | Immunomodulating compositions and methods of use thereof |
| US20130224164A1 (en) * | 2010-09-10 | 2013-08-29 | Viropharma Incorporated | Environmental Clostridial Bacteriotherapy and Related Formulations and Methods of Manufacture and Use |
| CN103998056B (zh) | 2011-07-22 | 2017-09-12 | 诺瓦蒂格姆疗法有限公司 | 用于接种抗金黄色葡萄球菌疫苗的方法和组合物 |
| CN108101983A (zh) * | 2012-03-02 | 2018-06-01 | 瑞泽恩制药公司 | 艰难梭状芽孢杆菌毒素的人源抗体 |
| PL2911688T3 (pl) | 2012-10-26 | 2020-03-31 | Intervet International B.V. | Szczepionki zapewniające ochronę krzyżową przeciwko salmonelli |
| EA030005B1 (ru) | 2013-03-15 | 2018-06-29 | Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер | Композиции и способы лечения грибковых и бактериальных патогенов |
| JP2019507759A (ja) | 2016-03-09 | 2019-03-22 | ロサンゼルス バイオメディカル リサーチ インスティテュート アット ハーバー− ユーシーエルエー メディカル センター | 外陰部膣カンジダ症の予防及び治療で使用するための方法及びキット |
| CN109602898B (zh) * | 2018-12-28 | 2022-02-22 | 江苏省农业科学院 | 一种产气荚膜梭菌α毒素基因工程疫苗及其制备方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| CN114621963A (zh) * | 2022-03-11 | 2022-06-14 | 牧原食品股份有限公司 | 一种猪魏氏梭菌a型的亚单位疫苗及其制备 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1483042A (en) * | 1974-07-29 | 1977-08-17 | Lapointe J | Anti-tumour product of bacterial origin |
| SU627610A1 (ru) | 1977-09-30 | 1980-02-05 | Zemlyakova V P | Препарат землаково в.п. против клюстридиозов животных и птиц |
| GB9115332D0 (en) * | 1991-07-16 | 1991-08-28 | Connaught Lab | Manipulation of gene copy number in bordetella |
| ES2185631T3 (es) * | 1992-05-20 | 2003-05-01 | Secr Defence | Vacunas de clostridium perfringens. |
| GB9605222D0 (en) | 1996-03-12 | 1996-05-15 | Secr Defence | Clostridium perfringens epsilon toxin vaccines |
| PT892054E (pt) * | 1997-06-20 | 2007-02-28 | Intervet Int Bv | Vacina de clostridium perfringens |
| RU2129441C1 (ru) * | 1997-12-10 | 1999-04-27 | Пирожков Михаил Константинович | Вакцина, ассоциированная против анаэробной энтеротоксемии и эшерихиоза поросят |
| US6399074B1 (en) * | 1998-07-24 | 2002-06-04 | Megan Health, Inc. | Live attenuated salmonella vaccines to control avian pathogens |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| WO2004052393A1 (en) * | 2002-12-09 | 2004-06-24 | University Of Georgia Research Foundation, Inc. | Coccidial vaccine and methods of making and using same |
| EP1694359A2 (en) * | 2003-11-10 | 2006-08-30 | UAB Research Foundation | Compositions for reducing bacterial carriage and cns invasion and methods of using same |
| MY149604A (en) | 2005-04-18 | 2013-09-13 | Schering Plough Ltd | C.perfringens alpha toxoid vaccine |
-
2007
- 2007-04-12 US US11/734,454 patent/US7732187B2/en active Active
- 2007-04-12 JP JP2009506518A patent/JP5551933B2/ja not_active Expired - Fee Related
- 2007-04-12 BR BRPI0711572-5A patent/BRPI0711572A2/pt not_active IP Right Cessation
- 2007-04-12 UA UAA201106572A patent/UA109105C2/ru unknown
- 2007-04-12 CN CN2007800225963A patent/CN101489584B/zh not_active Expired - Fee Related
- 2007-04-12 EP EP07755417A patent/EP2007420B1/en active Active
- 2007-04-12 CA CA2649426A patent/CA2649426C/en not_active Expired - Fee Related
- 2007-04-12 KR KR1020087027923A patent/KR20080110908A/ko not_active Application Discontinuation
- 2007-04-12 EP EP11157448A patent/EP2368571A1/en not_active Withdrawn
- 2007-04-12 WO PCT/US2007/009135 patent/WO2007123850A2/en active Application Filing
- 2007-04-12 PL PL07755417T patent/PL2007420T3/pl unknown
- 2007-04-12 MX MX2008013451A patent/MX2008013451A/es active IP Right Grant
- 2007-04-12 RU RU2008144913/10A patent/RU2445364C2/ru active
- 2007-04-12 AU AU2007240949A patent/AU2007240949B2/en not_active Ceased
- 2007-04-12 ES ES07755417T patent/ES2401810T3/es active Active
- 2007-04-12 RU RU2011147308/10A patent/RU2593945C2/ru active
- 2007-04-12 NZ NZ571970A patent/NZ571970A/en not_active IP Right Cessation
- 2007-04-16 PE PE2007000464A patent/PE20080167A1/es not_active Application Discontinuation
- 2007-04-16 AR ARP070101608A patent/AR060471A1/es active IP Right Grant
- 2007-04-17 TW TW096113489A patent/TWI338045B/zh not_active IP Right Cessation
- 2007-12-04 UA UAA200813301A patent/UA95951C2/ru unknown
-
2008
- 2008-10-12 IL IL194714A patent/IL194714A/en not_active IP Right Cessation
- 2008-10-16 ZA ZA200808872A patent/ZA200808872B/xx unknown
- 2008-10-16 EC EC2008008827A patent/ECSP088827A/es unknown
- 2008-10-17 CO CO08110815A patent/CO6140037A2/es unknown
- 2008-11-14 NO NO20084810A patent/NO20084810L/no not_active Application Discontinuation
-
2009
- 2009-05-08 HK HK09104268.8A patent/HK1125315A1/xx not_active IP Right Cessation
- 2009-12-17 US US12/640,645 patent/US7807456B2/en active Active
-
2010
- 2010-08-27 US US12/869,813 patent/US7972604B2/en active Active
-
2011
- 2011-01-19 AR ARP110100176A patent/AR079941A2/es not_active Application Discontinuation
-
2013
- 2013-09-17 JP JP2013191854A patent/JP2013255518A/ja active Pending
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