PE20200697A1 - Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso - Google Patents

Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso

Info

Publication number
PE20200697A1
PE20200697A1 PE2019002621A PE2019002621A PE20200697A1 PE 20200697 A1 PE20200697 A1 PE 20200697A1 PE 2019002621 A PE2019002621 A PE 2019002621A PE 2019002621 A PE2019002621 A PE 2019002621A PE 20200697 A1 PE20200697 A1 PE 20200697A1
Authority
PE
Peru
Prior art keywords
mtsp
polypeptide
modified
polypeptides
serine protease
Prior art date
Application number
PE2019002621A
Other languages
English (en)
Inventor
Edwin L Madison
Vanessa Soros
Mikhail Popkov
Original Assignee
Catalyst Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalyst Biosciences Inc filed Critical Catalyst Biosciences Inc
Publication of PE20200697A1 publication Critical patent/PE20200697A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21109—Matriptase (3.4.21.109)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UN POLIPEPTIDO DE SERINA PROTEASA 1 TIPO MEMBRANA MODIFICADA (MTSP-1) QUE COMPRENDE UNA O MAS MODIFICACIONES DE AMINOACIDOS SELECCIONADOS DE ENTRE I41S, Q38H, D60bT, F60eS o R, Y60gW, ins97aV, D96K, F97G, G151H o N, y Q192T, MEDIANTE LOS CUALES EL POLIPEPTIDO MTSP-1 MODIFICADO HA INCREMENTADO LA ACTIVIDAD/ESPECIFICIDAD PARA LA PROTEINA DE COMPLEMENTO C3 COMPARADA CON LA FORMA ACTIVA NO MODIFICADA DEL POLIPEPTIDO MTSP-1, EN DONDE: EL POLIPEPTIDO MTSP-1 MODIFICADO ESCINDE UN SITIO OBJETIVO EN LA PROTEINA DE COMPLEMENTO HUMANA C3 QUE INACTIVA C3, PARA INHIBIR DE ESTA MANERA O REDUCIR LA ACTIVACION DE COMPLEMENTO COMPARADA CON UNA FORMA ACTIVA DEL POLIPEPTIDO MTSP-1 MODIFICADO QUE NO CONTIENE LAS MODIFICACIONES DE AMINOACIDOS; Y EL POLIPEPTIDO MTSP-1 MODIFICADO COMPRENDE LA SECUENCIA DE AMINOACIDOS EXPUESTA EN CUALQUIERA DE SEQ ID NOS: 1-4, O UN FRAGMENTO CATALITICAMENTE ACTIVO O FORMA DEL MISMO QUE INCLUYE LAS MODIFICACIONES DE AMINOACIDOS. DICHOS POLIPEPTIDOS MTSP-1 MODIFICADOS SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS ISQUEMICOS Y POR REPERFUSION, INCLUYENDO INFARTO AL MIOCARDIO Y APOPLEJIA, SEPSIS, ENFERMEDADES AUTOINMUNITARIAS
PE2019002621A 2017-06-22 2018-06-21 Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso PE20200697A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523735P 2017-06-22 2017-06-22
US201862664051P 2018-04-27 2018-04-27
PCT/US2018/038844 WO2018237201A1 (en) 2017-06-22 2018-06-21 MODIFIED MEMBRANE-LIKE SERINE PROTEASE-1 POLYPEPTIDES (MTSP-1) AND METHODS OF USE

Publications (1)

Publication Number Publication Date
PE20200697A1 true PE20200697A1 (es) 2020-06-16

Family

ID=63015005

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019002621A PE20200697A1 (es) 2017-06-22 2018-06-21 Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso

Country Status (18)

Country Link
US (5) US10781435B2 (es)
EP (1) EP3641801A1 (es)
JP (2) JP7091373B2 (es)
KR (1) KR20200030063A (es)
CN (1) CN111107870A (es)
AU (2) AU2018290281B2 (es)
BR (1) BR112019027583A2 (es)
CA (2) CA3067851C (es)
CL (3) CL2019003813A1 (es)
CO (1) CO2020000584A2 (es)
IL (2) IL308949A (es)
JO (1) JOP20190288A1 (es)
MX (1) MX2019015402A (es)
NZ (1) NZ760116A (es)
PE (1) PE20200697A1 (es)
PH (1) PH12019502838A1 (es)
SG (3) SG11201912071QA (es)
WO (1) WO2018237201A1 (es)

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BR112019027583A2 (pt) 2020-10-06
CA3067851A1 (en) 2018-12-27
US11807882B2 (en) 2023-11-07
SG10202110492YA (en) 2021-11-29
US11401513B2 (en) 2022-08-02
SG11201912071QA (en) 2020-01-30
CL2021003080A1 (es) 2022-08-12
CO2020000584A2 (es) 2020-05-05
AU2018290281A1 (en) 2020-01-30
JOP20190288A1 (ar) 2019-12-16
IL308949A (en) 2024-01-01
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