ES2535716T3 - Compuestos de 6-aminoisoquinolina y métodos para preparar los mismos - Google Patents
Compuestos de 6-aminoisoquinolina y métodos para preparar los mismos Download PDFInfo
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- ES2535716T3 ES2535716T3 ES12007093.3T ES12007093T ES2535716T3 ES 2535716 T3 ES2535716 T3 ES 2535716T3 ES 12007093 T ES12007093 T ES 12007093T ES 2535716 T3 ES2535716 T3 ES 2535716T3
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- alkyl
- aryl
- heteroaryl
- hydroxyl
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- 238000000034 method Methods 0.000 title description 6
- NGFCTYXFMDWFRQ-UHFFFAOYSA-N isoquinolin-6-amine Chemical class C1=NC=CC2=CC(N)=CC=C21 NGFCTYXFMDWFRQ-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 abstract description 12
- -1 C1-C4-alkyl-aryl Chemical group 0.000 abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 3
- 125000001544 thienyl group Chemical group 0.000 abstract description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002950 monocyclic group Chemical group 0.000 abstract 3
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
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- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 2
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000003700 epoxy group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
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- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
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- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- OXGBCSQEKCRCHN-UHFFFAOYSA-N octadecan-2-ol Chemical compound CCCCCCCCCCCCCCCCC(C)O OXGBCSQEKCRCHN-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
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- 239000003208 petroleum Substances 0.000 description 1
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- XEIOPEQGDSYOIH-MURFETPASA-N propan-2-yl (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC(C)C XEIOPEQGDSYOIH-MURFETPASA-N 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
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- 239000003590 rho kinase inhibitor Substances 0.000 description 1
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Classifications
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- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
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| US12/009,326 US8455514B2 (en) | 2008-01-17 | 2008-01-17 | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US9326 | 2008-01-17 |
Publications (1)
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| ES2535716T3 true ES2535716T3 (es) | 2015-05-14 |
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| ES09702189T Active ES2397928T3 (es) | 2008-01-17 | 2009-01-15 | Compuestos de 6- y 7-aminoisoquinolina y métodos para preparar y usar los mismos |
| ES12007092.5T Active ES2465572T3 (es) | 2008-01-17 | 2009-01-15 | Compuestos de 6-aminoisoquinolinas y métodos para preparar los mismos |
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| ES12007092.5T Active ES2465572T3 (es) | 2008-01-17 | 2009-01-15 | Compuestos de 6-aminoisoquinolinas y métodos para preparar los mismos |
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| EP (4) | EP2546237A1 (enExample) |
| JP (1) | JP5551613B2 (enExample) |
| AU (1) | AU2009206075B2 (enExample) |
| CA (2) | CA2712443C (enExample) |
| ES (3) | ES2535716T3 (enExample) |
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| WO2007008926A1 (en) * | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) * | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2553827T3 (es) * | 2009-05-01 | 2015-12-14 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedad |
| BR112013015604B1 (pt) * | 2010-12-22 | 2021-11-03 | D. Western Therapeutics Institute, Inc | Derivado de isoquinolina-6-sulfonamida, composição farmacêutica compreendendo o mesmo e uso do dito composto para tratar ou prevenir glaucoma, hipertensão ocular ou doença cardiovascular |
| HUE061618T2 (hu) | 2013-03-15 | 2023-07-28 | Aerie Pharmaceuticals Inc | Vegyület szemrendellenességek kezelésére |
| CA2958879A1 (en) | 2014-08-22 | 2016-02-25 | Auckland Uniservices Limited | Channel modulators |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
| WO2017184343A1 (en) | 2016-04-20 | 2017-10-26 | Hubbell Incorporated | Electrical clamps |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| CN110381946A (zh) | 2017-02-28 | 2019-10-25 | 兴和株式会社 | 医药制剂 |
| KR20250026381A (ko) | 2017-02-28 | 2025-02-25 | 알콘 인코포레이티드 | 의약 |
| KR20230124753A (ko) | 2017-02-28 | 2023-08-25 | 코와 가부시키가이샤 | 의약품 |
| EP3603642B1 (en) | 2017-03-27 | 2024-01-10 | Alcon Inc. | Pharmaceutical preparation |
| JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
| US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US20220119350A1 (en) * | 2019-02-22 | 2022-04-21 | Glaukos Corporation | Compounds for the treatment of ocular disease |
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| US4456757A (en) * | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| JPS5993054A (ja) * | 1982-11-18 | 1984-05-29 | Asahi Chem Ind Co Ltd | イソキノリンスルホン酸アミド誘導体 |
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-
2008
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- 2009-01-15 CA CA2712443A patent/CA2712443C/en active Active
- 2009-01-15 ES ES12007093.3T patent/ES2535716T3/es active Active
- 2009-01-15 EP EP12007089A patent/EP2546237A1/en not_active Withdrawn
- 2009-01-15 CA CA2923336A patent/CA2923336A1/en not_active Abandoned
- 2009-01-15 AU AU2009206075A patent/AU2009206075B2/en not_active Ceased
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- 2009-01-15 EP EP12007093.3A patent/EP2546239B1/en active Active
- 2009-01-15 ES ES09702189T patent/ES2397928T3/es active Active
- 2009-01-15 WO PCT/US2009/031117 patent/WO2009091898A2/en not_active Ceased
- 2009-01-15 ES ES12007092.5T patent/ES2465572T3/es active Active
- 2009-01-15 EP EP09702189A patent/EP2252589B1/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2011510014A (ja) | 2011-03-31 |
| EP2252589B1 (en) | 2012-11-21 |
| US8455514B2 (en) | 2013-06-04 |
| AU2009206075B2 (en) | 2014-06-12 |
| US20090186917A1 (en) | 2009-07-23 |
| EP2546239B1 (en) | 2015-04-08 |
| ES2397928T3 (es) | 2013-03-12 |
| WO2009091898A2 (en) | 2009-07-23 |
| CA2712443A1 (en) | 2009-07-23 |
| EP2546238A1 (en) | 2013-01-16 |
| WO2009091898A3 (en) | 2009-11-05 |
| CA2923336A1 (en) | 2009-07-23 |
| JP5551613B2 (ja) | 2014-07-16 |
| EP2546239A1 (en) | 2013-01-16 |
| ES2465572T3 (es) | 2014-06-06 |
| EP2546237A1 (en) | 2013-01-16 |
| AU2009206075A1 (en) | 2009-07-23 |
| EP2252589A2 (en) | 2010-11-24 |
| US20100144713A1 (en) | 2010-06-10 |
| EP2546238B1 (en) | 2014-04-02 |
| CA2712443C (en) | 2016-05-03 |
| US8871757B2 (en) | 2014-10-28 |
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