MX2009001037A - Preparacion liquida acuosa que contiene compuesto de amida. - Google Patents
Preparacion liquida acuosa que contiene compuesto de amida.Info
- Publication number
- MX2009001037A MX2009001037A MX2009001037A MX2009001037A MX2009001037A MX 2009001037 A MX2009001037 A MX 2009001037A MX 2009001037 A MX2009001037 A MX 2009001037A MX 2009001037 A MX2009001037 A MX 2009001037A MX 2009001037 A MX2009001037 A MX 2009001037A
- Authority
- MX
- Mexico
- Prior art keywords
- aqueous liquid
- liquid preparation
- amide compound
- preparation containing
- containing amide
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 3
- -1 amide compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 102000000568 rho-Associated Kinases Human genes 0.000 abstract 1
- 108010041788 rho-Associated Kinases Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Eyeglasses (AREA)
Abstract
Un objeto de la presente invención es promover la penetración de un compuesto que tiene una actividad inhibitoria de Rho-cinasa a una porción tópica, y proporcionar una preparación líquida acuosa capaz de mantener una concentración determinada de fármaco aun cuando se reduce la frecuencia de administración. La presente invención soluciona el problema mencionado anteriormente por una preparación líquida acuosa que contiene un compuesto representado por la siguiente fórmula (I) (ver fórmula I) en donde cada símbolo es como se define en la especificación, un isómero del mismo y/o una sal de adición de ácido farmacéuticamente aceptable del mismo, y un reactivo de apareamiento iónico o un polímero soluble en agua.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006209102 | 2006-07-31 | ||
PCT/JP2007/064916 WO2008016016A1 (en) | 2006-07-31 | 2007-07-30 | Aqueous liquid preparation containing amide compound |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009001037A true MX2009001037A (es) | 2009-05-15 |
Family
ID=38997192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009001037A MX2009001037A (es) | 2006-07-31 | 2007-07-30 | Preparacion liquida acuosa que contiene compuesto de amida. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20090247552A1 (es) |
EP (1) | EP2050449A4 (es) |
JP (1) | JPWO2008016016A1 (es) |
KR (1) | KR20090057223A (es) |
CN (1) | CN101495117B (es) |
AU (1) | AU2007279766A1 (es) |
BR (1) | BRPI0714782A2 (es) |
CA (1) | CA2659687A1 (es) |
MX (1) | MX2009001037A (es) |
RU (1) | RU2476219C2 (es) |
WO (1) | WO2008016016A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7470787B2 (en) | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
ES2729424T3 (es) | 2006-09-20 | 2019-11-04 | Aerie Pharmaceuticals Inc | Inhibidores de Rho cinasa |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
ES2672624T3 (es) | 2009-05-01 | 2018-06-15 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
WO2011080984A1 (en) * | 2009-12-29 | 2011-07-07 | Senju Pharmaceutical Co., Ltd. | Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction |
WO2014043625A1 (en) * | 2012-09-17 | 2014-03-20 | Bind Therapeutics, Inc. | Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same |
JP6356678B2 (ja) | 2012-09-17 | 2018-07-11 | ファイザー・インク | 治療用ナノ粒子を製造する方法 |
FI3811943T3 (fi) | 2013-03-15 | 2023-04-14 | Aerie Pharmaceuticals Inc | Yhdiste käytettäväksi silmäsairauksien hoidossa |
RU2682332C2 (ru) | 2013-09-16 | 2019-03-19 | Астразенека Аб | Терапевтические полимерные наночастицы и способы их получения и применения |
PL3116547T3 (pl) | 2014-03-14 | 2019-11-29 | Pfizer | Terapeutyczne nanocząstki zawierające środek terapeutyczny i sposoby ich wytwarzania i zastosowania |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
CN108601355B (zh) | 2015-11-17 | 2021-03-30 | 爱瑞制药公司 | 制备激酶抑制剂及其中间体的方法 |
CN109640966A (zh) | 2016-08-31 | 2019-04-16 | 爱瑞制药公司 | 眼用组合物 |
CA3057872A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4138177A (en) * | 1976-04-16 | 1979-02-06 | Valer Andrew F Van | Safety vehicle power distribution system |
US4136177A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Xanthan gum therapeutic compositions |
JPH0680054B2 (ja) | 1985-06-19 | 1994-10-12 | 吉富製薬株式会社 | ピペリジン誘導体 |
JP2563336B2 (ja) | 1987-06-01 | 1996-12-11 | エーザイ株式会社 | 角膜透過促進点眼剤 |
JP2770497B2 (ja) | 1988-11-24 | 1998-07-02 | 吉富製薬株式会社 | トランス―4―アミノ(アルキル)―1―ピリジルカルバモイルシクロヘキサン化合物およびその医薬用途 |
JP3275389B2 (ja) | 1991-09-06 | 2002-04-15 | 三菱ウェルファーマ株式会社 | 4−アミノ(アルキル)シクロヘキサン−1−カルボン酸アミド化合物 |
JP3265695B2 (ja) | 1992-05-12 | 2002-03-11 | 三菱ウェルファーマ株式会社 | 4−置換アミノ(アルキル)シクロヘキサン−1−カルボン酸アミド化合物 |
EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
DK0956865T4 (da) | 1996-08-12 | 2010-11-22 | Mitsubishi Tanabe Pharma Corp | Medikamenter omfattende Rho-kinaseinhibitor |
FR2754712B1 (fr) | 1996-10-17 | 1999-09-03 | Merck Sharp Dohme Chibret Lab | Compositions ophtalmiques |
CN1124842C (zh) * | 1997-11-05 | 2003-10-22 | 千寿制药株式会社 | 缓释滴眼剂 |
US6335335B2 (en) * | 1997-11-05 | 2002-01-01 | Senju Pharmaceutical Co., Ltd. | Prolonged-action eye drop |
DK1069913T3 (da) | 1998-04-07 | 2003-11-17 | Alcon Mfg Ltd | Gelatinering af ophthalmiske sammensætninger indeholdende xanthangummi |
ATE527993T1 (de) * | 1998-08-17 | 2011-10-15 | Senju Pharma Co | Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie |
EP1378247B1 (en) * | 2001-04-11 | 2016-08-24 | Senju Pharmaceutical Co., Ltd. | Visual function disorder improving agents |
DE60209486T2 (de) * | 2001-06-01 | 2006-08-03 | Alcon Inc. | Pyranoindazole und ihre verwendung in der glaukombehandlung |
EP1568382B1 (en) * | 2002-11-18 | 2013-11-06 | Santen Pharmaceutical Co., Ltd. | REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND beta-BLOCKER |
EP1752456B1 (en) * | 2004-06-03 | 2015-08-26 | Senju Pharmaceutical Co., Ltd. | Corneal perception recovery drug containing amide compound |
US7669262B2 (en) * | 2004-11-10 | 2010-03-02 | Allen Medical Systems, Inc. | Accessory frame for spinal surgery |
JP4818712B2 (ja) | 2004-12-28 | 2011-11-16 | 大日本印刷株式会社 | 表示素子用黒色樹脂組成物、及び表示素子用部材 |
-
2007
- 2007-07-30 CN CN2007800285930A patent/CN101495117B/zh not_active Expired - Fee Related
- 2007-07-30 KR KR1020097003798A patent/KR20090057223A/ko not_active Application Discontinuation
- 2007-07-30 AU AU2007279766A patent/AU2007279766A1/en not_active Abandoned
- 2007-07-30 WO PCT/JP2007/064916 patent/WO2008016016A1/ja active Application Filing
- 2007-07-30 JP JP2008527745A patent/JPWO2008016016A1/ja active Pending
- 2007-07-30 US US12/309,813 patent/US20090247552A1/en not_active Abandoned
- 2007-07-30 CA CA002659687A patent/CA2659687A1/en not_active Abandoned
- 2007-07-30 BR BRPI0714782-1A patent/BRPI0714782A2/pt not_active IP Right Cessation
- 2007-07-30 RU RU2009107191/15A patent/RU2476219C2/ru not_active IP Right Cessation
- 2007-07-30 EP EP07791601A patent/EP2050449A4/en not_active Withdrawn
- 2007-07-30 MX MX2009001037A patent/MX2009001037A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPWO2008016016A1 (ja) | 2009-12-24 |
RU2476219C2 (ru) | 2013-02-27 |
AU2007279766A1 (en) | 2008-02-07 |
KR20090057223A (ko) | 2009-06-04 |
CN101495117B (zh) | 2012-08-15 |
RU2009107191A (ru) | 2010-09-10 |
BRPI0714782A2 (pt) | 2013-07-16 |
US20090247552A1 (en) | 2009-10-01 |
EP2050449A4 (en) | 2010-10-06 |
CN101495117A (zh) | 2009-07-29 |
CA2659687A1 (en) | 2008-02-07 |
WO2008016016A1 (en) | 2008-02-07 |
EP2050449A1 (en) | 2009-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: SENJU PHARMACEUTICAL CO., LTD. |
|
FA | Abandonment or withdrawal |