EA201070194A1 - Стабильная жидкая фармацевтическая композиция на основе тразодона - Google Patents

Стабильная жидкая фармацевтическая композиция на основе тразодона

Info

Publication number
EA201070194A1
EA201070194A1 EA201070194A EA201070194A EA201070194A1 EA 201070194 A1 EA201070194 A1 EA 201070194A1 EA 201070194 A EA201070194 A EA 201070194A EA 201070194 A EA201070194 A EA 201070194A EA 201070194 A1 EA201070194 A1 EA 201070194A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
trazodone
stable liquid
liquid pharmaceutical
composition based
Prior art date
Application number
EA201070194A
Other languages
English (en)
Other versions
EA016822B1 (ru
Inventor
Марчелло Маркетти
Франческа Марьетти
Лорелла Раньи
Паоло Скарпетти
Мауро Валенти
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA201070194A1 publication Critical patent/EA201070194A1/ru
Publication of EA016822B1 publication Critical patent/EA016822B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

Стабильная жидкая фармацевтическая композиция, содержащая водный раствор фармацевтически приемлемой кислотно-аддитивной соли тразодона, отличающаяся тем, что указанная фармацевтическая композиция обладает значением рН между 5,0 и 6,0 и содержит по меньшей мере два сорастворителя, выбранных из группы, содержащей гликоли и полигликоли.
EA201070194A 2007-07-31 2008-07-22 Стабильная жидкая фармацевтическая композиция на основе тразодона EA016822B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001573A ITMI20071573A1 (it) 2007-07-31 2007-07-31 Composizione farmaceutica liquida stabile a base di trazodone
PCT/EP2008/059605 WO2009016069A2 (en) 2007-07-31 2008-07-22 Stable liquid pharmaceutical composition based on trazodone

Publications (2)

Publication Number Publication Date
EA201070194A1 true EA201070194A1 (ru) 2010-06-30
EA016822B1 EA016822B1 (ru) 2012-07-30

Family

ID=38858941

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070194A EA016822B1 (ru) 2007-07-31 2008-07-22 Стабильная жидкая фармацевтическая композиция на основе тразодона

Country Status (25)

Country Link
US (1) US10292931B2 (ru)
EP (2) EP2494955B1 (ru)
JP (1) JP5426548B2 (ru)
KR (1) KR101493370B1 (ru)
CN (1) CN101784257B (ru)
AR (1) AR068327A1 (ru)
AU (1) AU2008281858B2 (ru)
BR (1) BRPI0814658A2 (ru)
CA (1) CA2692975C (ru)
CY (1) CY1116189T1 (ru)
DK (2) DK2182920T3 (ru)
EA (1) EA016822B1 (ru)
ES (2) ES2399569T3 (ru)
GE (1) GEP20125525B (ru)
HK (2) HK1176280A1 (ru)
HR (1) HRP20150349T1 (ru)
IL (1) IL203167A (ru)
IT (1) ITMI20071573A1 (ru)
MX (1) MX2010001092A (ru)
PL (2) PL2494955T3 (ru)
PT (2) PT2182920E (ru)
SG (1) SG183659A1 (ru)
SI (2) SI2494955T1 (ru)
UA (1) UA102376C2 (ru)
WO (1) WO2009016069A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071603A1 (it) 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
RU2706700C1 (ru) * 2019-09-24 2019-11-20 Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях
JP2022549473A (ja) 2019-09-26 2022-11-25 アンジェリーニ ソシエタ ペル アチオニ 小児用トラゾドン組成物およびその治療法
CN111568861A (zh) * 2020-05-25 2020-08-25 河北科星药业有限公司 畜禽用盐酸溴己新口服液及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154832A (en) * 1974-08-26 1979-05-15 Bruno Silvestrini Novel treatment for acute organic cerebral syndromes (strokes)
IT1233412B (it) * 1987-12-02 1992-03-30 Acraf Uso del trazodone
EP1113785B1 (en) * 1998-07-24 2005-04-13 Seo Hong Yoo Clear aqueous solutions of bile acids
AU2003903597A0 (en) * 2003-07-11 2003-07-24 Jakov Vaisman Treatment of premature ejaculation
ITMI20071603A1 (it) 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata

Also Published As

Publication number Publication date
SI2182920T1 (sl) 2013-04-30
JP5426548B2 (ja) 2014-02-26
HK1176280A1 (en) 2013-07-26
CY1116189T1 (el) 2017-02-08
AR068327A1 (es) 2009-11-11
HRP20150349T1 (hr) 2015-05-22
AU2008281858A1 (en) 2009-02-05
DK2182920T3 (da) 2013-03-04
MX2010001092A (es) 2010-03-01
PT2182920E (pt) 2013-03-07
US10292931B2 (en) 2019-05-21
CN101784257A (zh) 2010-07-21
EP2182920B1 (en) 2012-12-26
KR20100038112A (ko) 2010-04-12
US20100256159A1 (en) 2010-10-07
EP2494955A2 (en) 2012-09-05
IL203167A (en) 2017-08-31
BRPI0814658A2 (pt) 2015-02-18
PL2182920T3 (pl) 2013-05-31
JP2010534703A (ja) 2010-11-11
EP2182920A2 (en) 2010-05-12
ES2399569T3 (es) 2013-04-02
CN101784257B (zh) 2012-11-28
CA2692975A1 (en) 2009-02-05
DK2494955T3 (en) 2015-04-13
PL2494955T3 (pl) 2015-06-30
EP2494955A3 (en) 2012-10-03
WO2009016069A3 (en) 2009-03-19
PT2494955E (pt) 2015-03-04
ES2531241T3 (es) 2015-03-12
KR101493370B1 (ko) 2015-02-13
AU2008281858B2 (en) 2014-02-27
WO2009016069A2 (en) 2009-02-05
ITMI20071573A1 (it) 2009-02-01
SI2494955T1 (sl) 2015-04-30
HK1138207A1 (en) 2010-08-20
CA2692975C (en) 2016-01-12
WO2009016069A4 (en) 2009-05-14
EA016822B1 (ru) 2012-07-30
UA102376C2 (ru) 2013-07-10
GEP20125525B (en) 2012-05-25
SG183659A1 (en) 2012-09-27
EP2494955B1 (en) 2015-01-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU