ES2475201T3 - Agentes dirigidos contra CD138 y usos de los mismos - Google Patents
Agentes dirigidos contra CD138 y usos de los mismos Download PDFInfo
- Publication number
- ES2475201T3 ES2475201T3 ES08863602.2T ES08863602T ES2475201T3 ES 2475201 T3 ES2475201 T3 ES 2475201T3 ES 08863602 T ES08863602 T ES 08863602T ES 2475201 T3 ES2475201 T3 ES 2475201T3
- Authority
- ES
- Spain
- Prior art keywords
- antibody
- nbt062
- cells
- seq
- immunoconjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1663007P | 2007-12-26 | 2007-12-26 | |
US16630P | 2007-12-26 | ||
PCT/EP2008/068266 WO2009080829A1 (fr) | 2007-12-26 | 2008-12-23 | Agents ciblant cd138 et leurs applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2475201T3 true ES2475201T3 (es) | 2014-07-10 |
Family
ID=40456217
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08863602.2T Active ES2475201T3 (es) | 2007-12-26 | 2008-12-23 | Agentes dirigidos contra CD138 y usos de los mismos |
ES14170861T Active ES2748299T3 (es) | 2007-12-26 | 2008-12-23 | Agentes dirigidos contra CD138 y usos de los mismos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14170861T Active ES2748299T3 (es) | 2007-12-26 | 2008-12-23 | Agentes dirigidos contra CD138 y usos de los mismos |
Country Status (23)
Country | Link |
---|---|
US (2) | US9221914B2 (fr) |
EP (2) | EP2801584B1 (fr) |
JP (2) | JP5990365B2 (fr) |
KR (1) | KR101626416B1 (fr) |
CN (1) | CN101952315B (fr) |
AR (1) | AR069981A1 (fr) |
AU (1) | AU2008339910B2 (fr) |
BR (1) | BRPI0821447A2 (fr) |
CA (1) | CA2710453C (fr) |
CR (1) | CR11593A (fr) |
DK (1) | DK2238168T3 (fr) |
ES (2) | ES2475201T3 (fr) |
HK (2) | HK1149033A1 (fr) |
HR (1) | HRP20140604T1 (fr) |
IL (1) | IL206554A (fr) |
MX (1) | MX341344B (fr) |
PL (2) | PL2801584T3 (fr) |
PT (1) | PT2238168E (fr) |
RU (1) | RU2537265C2 (fr) |
SI (1) | SI2238168T1 (fr) |
TW (1) | TWI552759B (fr) |
WO (1) | WO2009080829A1 (fr) |
ZA (1) | ZA201004325B (fr) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060045877A1 (en) * | 2004-08-30 | 2006-03-02 | Goldmakher Viktor S | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
PL2801584T3 (pl) | 2007-12-26 | 2019-12-31 | Biotest Ag | Środki mające za cel CD138 i ich zastosowania |
EP2240516B1 (fr) * | 2007-12-26 | 2015-07-08 | Biotest AG | Procédés et agents permettant d'améliorer le ciblage de cellules tumorales exprimant cd138 |
CN101965366B (zh) * | 2007-12-26 | 2016-04-27 | 生物测试股份公司 | 靶向cd138的免疫缀合物及其应用 |
SG10201401976YA (en) * | 2009-05-06 | 2014-10-30 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
EP2699268A2 (fr) | 2011-04-21 | 2014-02-26 | Seattle Genetics, Inc. | Nouveaux conjugués liant-principe actif (adc) et leur utilisation |
EP3559049A4 (fr) | 2011-10-28 | 2019-12-04 | Teva Pharmaceuticals Australia Pty Ltd | Produits de recombinaison de polypeptide et utilisations de ceux-ci |
EP2788030B1 (fr) | 2011-12-08 | 2018-06-20 | Biotest AG | Utilisations d'immunoconjugués ciblant cd138 |
CN104837502B (zh) | 2012-10-12 | 2018-08-10 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
CN103103197A (zh) * | 2013-01-30 | 2013-05-15 | 百奇生物科技(苏州)有限公司 | 抗cd138单克隆抗体可变区序列及其制备方法和应用 |
WO2014138704A1 (fr) * | 2013-03-07 | 2014-09-12 | Baylor College Of Medicine | Ciblage de cd138 dans le cancer |
JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びその結合体 |
AU2013388126B2 (en) | 2013-04-29 | 2019-03-07 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2b |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
NZ720736A (en) | 2013-12-23 | 2020-08-28 | Bayer Pharma AG | Antibody drug conjugates (adcs) with kinesin spindel protein (ksp) |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
ES2785551T3 (es) | 2014-06-30 | 2020-10-07 | Glykos Finland Oy | Derivado de sacárido de una carga útil tóxica y sus conjugados con anticuerpos |
JP7113618B2 (ja) | 2014-07-15 | 2022-08-05 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法用の操作された細胞 |
US10648554B2 (en) | 2014-09-02 | 2020-05-12 | Polaris Industries Inc. | Continuously variable transmission |
US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
KR102639037B1 (ko) | 2014-10-29 | 2024-02-20 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 인터페론 α2b 변이체 |
TWI588259B (zh) * | 2015-03-06 | 2017-06-21 | Methods for screening antigen-specific fusion tumor cells | |
CN108025084A (zh) | 2015-06-22 | 2018-05-11 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物(adc)和抗体前药缀合物(apdc) |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
RU2611685C2 (ru) * | 2015-07-20 | 2017-02-28 | Илья Владимирович Духовлинов | Гуманизированное моноклональное антитело, специфичное к синдекану-1 |
WO2017060322A2 (fr) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Conjugué anticorps-médicament (adc) inhibiteur de ptefb |
WO2017162663A1 (fr) | 2016-03-24 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Promédicaments de principes actifs cytotoxiques contenant des groupes fissibles par voie enzymatique |
JP7022707B2 (ja) | 2016-06-15 | 2022-02-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ksp阻害剤および抗cd123抗体を含む特異的抗体-薬物-コンジュゲート(adc) |
EP3525829A1 (fr) | 2016-10-11 | 2019-08-21 | Medimmune Limited | Conjugués anticorps-médicament associés à des agents thérapeutiques à médiation immunitaire |
CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
WO2018114798A1 (fr) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Promédicaments de principes actifs cytotoxiques contenant des groupes divisibles par voie enzymatique |
KR102583006B1 (ko) | 2016-12-21 | 2023-09-27 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc) |
US10697532B2 (en) | 2016-12-22 | 2020-06-30 | Polaris Industries Inc. | Housing for a transmission |
WO2018199176A1 (fr) * | 2017-04-26 | 2018-11-01 | Mitsubishi Tanabe Pharma Corporation | Agents de liaison à syndécane-1 (cd138) et leurs utilisations |
EP3619535A4 (fr) | 2017-05-05 | 2020-12-30 | University of Technology Sydney | Procédé de pronostic du cancer |
DK3538645T3 (da) | 2017-06-20 | 2021-04-19 | Inst Curie | Immunceller der mangler suv39h1 |
BR112020005419A2 (pt) * | 2017-10-02 | 2020-09-29 | Visterra, Inc. | moléculas de anticorpo para cd138 e seus usos |
AU2018360801A1 (en) | 2017-11-01 | 2020-05-14 | Celgene Corporation | Process for producing a T cell composition |
EP3703688A2 (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics, Inc. | Anticorps et récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
WO2019089858A2 (fr) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Procédés d'évaluation ou de surveillance d'une réponse à une thérapie cellulaire |
US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
WO2019090003A1 (fr) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Récepteurs d'antigènes chimériques spécifiques de l'antigène de maturation des cellules b (bcma) |
CA3084514A1 (fr) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Procede de generation de compositions therapeutiques de cellules modifiees |
WO2019111249A1 (fr) | 2017-12-05 | 2019-06-13 | The Medical Research Infrastructure And Health Services Fund Of The Tel Aviv Medical Center | Lymphocytes t comprenant des récepteurs antigéniques chimériques anti-cd38 et anti-cd138 et leurs utilisations |
WO2019113556A1 (fr) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Formulation de milieux sans sérum pour la culture de cellules et ses procédés d'utilisation |
EP3720480A2 (fr) | 2017-12-08 | 2020-10-14 | Juno Therapeutics, Inc. | Marqueurs phénotypiques pour thérapie cellulaire et procédés associés |
SG11202005272SA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Process for producing a composition of engineered t cells |
CA3183788A1 (fr) | 2018-03-19 | 2019-09-26 | Polaris Industries Inc. | Transmission a variation continue |
CA3094207C (fr) | 2018-03-19 | 2023-03-07 | Ronald ZURBRUEGG | Cvt electronique avec embrayage a friction |
CN113286616A (zh) | 2018-05-23 | 2021-08-20 | Adc治疗有限公司 | 分子佐剂 |
EP3833759A1 (fr) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Procédés pour évaluer des acides nucléiques intégrés |
JP2022506598A (ja) | 2018-11-01 | 2022-01-17 | ジュノー セラピューティクス インコーポレイテッド | Gタンパク質共役受容体クラスcグループ5メンバーd(gprc5d)に特異的なキメラ抗原受容体 |
WO2020092848A2 (fr) | 2018-11-01 | 2020-05-07 | Juno Therapeutics, Inc. | Méthodes pour le traitement au moyen de récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
WO2020223571A1 (fr) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cellules exprimant un récepteur chimérique à partir d'un locus cd247 modifié, polynucléotides et procédés associés |
KR20220016475A (ko) | 2019-05-01 | 2022-02-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 tgfbr2 유전자 좌에서 재조합 수용체를 발현하는 세포, 관련 폴리뉴클레오티드 및 방법 |
KR20220044939A (ko) * | 2019-06-17 | 2022-04-12 | 비스테라, 인크. | Cd138에 대한 인간화 항체 분자 및 이의 용도 |
CA3146895A1 (fr) | 2019-07-23 | 2021-01-28 | Mnemo Therapeutics | Cellules immunitaires defectueuses pour suv39h1 |
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CN115916223A (zh) | 2020-04-10 | 2023-04-04 | 朱诺治疗学股份有限公司 | 与用靶向b细胞成熟抗原的嵌合抗原受体工程化的细胞疗法相关的方法和用途 |
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