ES2461266T3 - Derivados estables de NAD/NADH - Google Patents

Derivados estables de NAD/NADH Download PDF

Info

Publication number
ES2461266T3
ES2461266T3 ES06776486.0T ES06776486T ES2461266T3 ES 2461266 T3 ES2461266 T3 ES 2461266T3 ES 06776486 T ES06776486 T ES 06776486T ES 2461266 T3 ES2461266 T3 ES 2461266T3
Authority
ES
Spain
Prior art keywords
respectively independent
dehydrogenase
radical
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06776486.0T
Other languages
English (en)
Spanish (es)
Inventor
Joachim Hoenes
Dieter Heindl
Carina Horn
Claudia Gaessler-Dietsche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2461266T3 publication Critical patent/ES2461266T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
ES06776486.0T 2005-07-28 2006-07-28 Derivados estables de NAD/NADH Active ES2461266T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005035461A DE102005035461A1 (de) 2005-07-28 2005-07-28 Stabile NAD/NADH-Derivate
DE102005035461 2005-07-28
PCT/EP2006/007493 WO2007012494A1 (de) 2005-07-28 2006-07-28 Stabile nad/nadh-derivate

Publications (1)

Publication Number Publication Date
ES2461266T3 true ES2461266T3 (es) 2014-05-19

Family

ID=37137552

Family Applications (3)

Application Number Title Priority Date Filing Date
ES11167471.9T Active ES2453150T3 (es) 2005-07-28 2006-07-28 Derivados estables de NAD/NADH
ES11167476.8T Active ES2461624T3 (es) 2005-07-28 2006-07-28 Derivados estables de NAD/NADH
ES06776486.0T Active ES2461266T3 (es) 2005-07-28 2006-07-28 Derivados estables de NAD/NADH

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES11167471.9T Active ES2453150T3 (es) 2005-07-28 2006-07-28 Derivados estables de NAD/NADH
ES11167476.8T Active ES2461624T3 (es) 2005-07-28 2006-07-28 Derivados estables de NAD/NADH

Country Status (16)

Country Link
US (3) US8809013B2 (enExample)
EP (3) EP2364989B1 (enExample)
JP (2) JP5129133B2 (enExample)
KR (4) KR101483899B1 (enExample)
CN (2) CN103122371B (enExample)
AU (2) AU2006274140B8 (enExample)
BR (1) BRPI0614217A2 (enExample)
CA (2) CA2737123A1 (enExample)
DE (1) DE102005035461A1 (enExample)
DK (3) DK2364988T3 (enExample)
ES (3) ES2453150T3 (enExample)
MX (1) MX2008000946A (enExample)
PL (3) PL1907408T3 (enExample)
PT (3) PT2364988E (enExample)
SG (1) SG187511A1 (enExample)
WO (1) WO2007012494A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7553615B2 (en) * 2005-07-28 2009-06-30 Roche Diagnostics Operations, Inc. Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
DE102005035461A1 (de) * 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate
EP2022859A1 (de) * 2007-08-01 2009-02-11 Roche Diagnostics GmbH Verfahren und Vorrichtung zur Bestimmung der Konzentration eines Analyten mittels Fluoreszenzmessung
CN101497638B (zh) * 2008-01-30 2012-09-26 中国科学院大连化学物理研究所 一种nad+类似物及其合成和应用
EP2093284A1 (de) * 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
EP2226008A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Verfahren zur Herstellung eines analytischen Magazins
EP2226007A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Testelementmagazin mit abgedeckten Testfeldern
KR101604624B1 (ko) * 2009-02-19 2016-03-28 에프. 호프만-라 로슈 아게 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도
WO2010094427A2 (de) * 2009-02-19 2010-08-26 Roche Diagnostics Gmbh Platzsparende magazinierung analytischer hilfsmittel
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
EP2459728B1 (en) * 2009-07-27 2013-06-05 Roche Diagnostics GmbH Enzymatic synthesis of carba-NAD
WO2011012269A2 (en) 2009-07-27 2011-02-03 Roche Diagnostics Gmbh Method and substances for preparation of n-substituted pyridinium compounds
EP2459536B1 (en) 2009-07-27 2014-10-29 Roche Diagnostics GmbH Method and substances for preparation of n-substituted pyridinium compounds
EP2292751A1 (de) * 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
EP2287605A1 (de) * 2009-08-20 2011-02-23 Roche Diagnostics GmbH Vereinfachte Magazinierung integrierter Systeme
EP2333544A1 (de) 2009-12-11 2011-06-15 F. Hoffmann-La Roche AG Sterilisierbare Chemie für Testelemente
CA2782943C (en) 2009-12-16 2014-09-09 F. Hoffmann-La Roche Ag Detecting the decomposition of enzymes in a test element by means of controlled release of a protected analyte
KR101252351B1 (ko) * 2010-05-24 2013-04-08 동국대학교 산학협력단 전기효소적 합성 반응을 위한 nad(p) 유도체의 전기화학적 환원 방법
CN102453067B (zh) * 2010-10-29 2015-08-05 中国科学院大连化学物理研究所 一种nad+类似物的制备方法及其应用
WO2012101095A1 (en) 2011-01-26 2012-08-02 Roche Diagnostics Gmbh Method and substances for preparation of n-substituted pyridinium compounds
US9752990B2 (en) 2013-09-30 2017-09-05 Honeywell International Inc. Low-powered system for driving a fuel control mechanism
WO2012140027A1 (de) 2011-04-12 2012-10-18 Roche Diagnostics Gmbh Analytisches hilfsmittel
CN102863495A (zh) * 2011-07-06 2013-01-09 上海执诚生物科技股份有限公司 一种含有nad+或nadh的稳定的组合物
EP2760825B1 (de) 2011-09-28 2016-09-14 F.Hoffmann-La Roche Ag Azomediatoren
JP6128808B2 (ja) * 2011-11-15 2017-05-17 栄研化学株式会社 酵素活性の検出、測定方法およびこれを利用したキット
EP2620507A1 (en) 2012-01-25 2013-07-31 Roche Diagnostics GmbH Method for the evaluation of the quality of a test element
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
JP6111323B2 (ja) 2012-04-19 2017-04-05 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 血液中の検体濃度を測定する方法および装置
US8920628B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Systems and methods for multiple analyte analysis
US8921061B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Reagent materials and associated test elements
WO2014096184A1 (en) 2012-12-20 2014-06-26 Roche Diagnostics Gmbh Method for analyzing a sample of a body fluid
CA2896152C (en) 2012-12-20 2018-07-24 F. Hoffmann-La Roche Ag Method for evaluating medical measurement curves
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
EP2781919A1 (en) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid
WO2014180939A1 (en) 2013-05-08 2014-11-13 Roche Diagnostics Gmbh Stabilization of enzymes by nicotinic acid
HK1213296A1 (zh) * 2013-06-04 2016-06-30 豪夫迈‧罗氏有限公司 用於fret的新化合物及与其相关的方法
EP2811299A1 (en) 2013-06-07 2014-12-10 Roche Diagniostics GmbH Test element for detecting at least one analyte in a body fluid
EP3063169B1 (en) 2013-10-29 2018-10-10 F. Hoffmann-La Roche AG Nano-enzyme containers for test elements
EP3074524B1 (en) 2013-11-27 2019-11-06 Roche Diabetes Care GmbH Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
CN106164054B (zh) 2014-04-14 2019-05-07 豪夫迈·罗氏有限公司 吩嗪介导剂
CN106687812A (zh) * 2014-08-05 2017-05-17 贝克顿·迪金森公司 用于分析血液样品中的葡萄糖‑6‑磷酸脱氢酶活性的方法和组合物
WO2016026959A1 (en) 2014-08-22 2016-02-25 Roche Diagnostics Gmbh Redoxindicators
BR112017001444B1 (pt) 2014-08-25 2022-08-16 F. Hoffmann-La Roche Ag Método para detectar pelo menos um analito em uma amostra de teste, elemento sensor, dispositivo de teste, sistema de teste, uso do elemento sensor e portador de dados
KR20180087329A (ko) 2015-12-21 2018-08-01 에프. 호프만-라 로슈 아게 알칼리게네스 파에칼리스로부터의 돌연변이체 3-히드록시부티레이트 탈수소효소 뿐만 아니라 이의 관련 방법 및 용도
WO2017137491A1 (en) 2016-02-09 2017-08-17 Roche Diabetes Care Gmbh Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same
CN109804240A (zh) 2016-10-05 2019-05-24 豪夫迈·罗氏有限公司 用于多分析物诊断测试元件的检测试剂和电极布置以及其使用方法
EP3339431A1 (en) 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
CN107966555A (zh) * 2017-11-23 2018-04-27 中山市创艺生化工程有限公司 一种用于稳定保存nad或其衍生物的存储液
CN111801425B (zh) 2018-02-28 2024-02-23 豪夫迈·罗氏有限公司 用于连续分析物测量的生物相容性涂层
CN111217744A (zh) * 2018-11-26 2020-06-02 中国科学院大连化学物理研究所 一种d-氨基酸基nad+类似物及其合成和应用
WO2022132963A1 (en) 2020-12-15 2022-06-23 Abbott Diabetes Care Inc. Nad(p) depot for nad(p)-dependent enzyme-based sensors
WO2025245355A1 (en) 2024-05-24 2025-11-27 Abbott Diabetes Care Inc. Dispensed area and drop solid content tunability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53107486A (en) * 1977-02-28 1978-09-19 Wako Pure Chem Ind Ltd Stabilized nadh aqueous solution
JPS61274636A (ja) 1985-05-30 1986-12-04 西南自動車工業株式会社 活魚水槽
US5801006A (en) * 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites
JP4260245B2 (ja) * 1998-06-25 2009-04-30 株式会社三菱化学ヤトロン 還元型ニコチンアミドアデニンジヌクレオチド類の分解を防止する方法及び分解防止用試薬
US6380380B1 (en) 1999-01-04 2002-04-30 Specialty Assays, Inc. Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates
WO2001094370A1 (en) 2000-06-07 2001-12-13 Wako Pure Chemical Industries, Ltd. Coenzyme derivatives and enzymes appropriate therefor
DE10221845A1 (de) 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Verfahren und Reagenzsystem mit nicht-regenerierbarem Enzym-Coenzym-Komplex
DK1504113T3 (da) 2002-05-16 2007-03-05 Hoffmann La Roche Fremgangsmåde til fremstilling af polymerlag
DE102005035461A1 (de) * 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate

Also Published As

Publication number Publication date
CN103122371A (zh) 2013-05-29
HK1123308A1 (en) 2009-06-12
PT2364988E (pt) 2014-04-03
PL2364988T3 (pl) 2014-08-29
JP2009502844A (ja) 2009-01-29
EP2364989B1 (de) 2014-03-05
JP5650695B2 (ja) 2015-01-07
JP5129133B2 (ja) 2013-01-23
ES2453150T3 (es) 2014-04-04
BRPI0614217A2 (pt) 2011-03-22
SG187511A1 (en) 2013-02-28
KR20140003637A (ko) 2014-01-09
PT2364989E (pt) 2014-04-04
US9399790B2 (en) 2016-07-26
AU2011200465B2 (en) 2012-02-09
EP1907408A1 (de) 2008-04-09
DE102005035461A1 (de) 2007-02-15
ES2461624T3 (es) 2014-05-20
EP2364989A1 (de) 2011-09-14
AU2011200465A1 (en) 2011-02-24
AU2006274140A1 (en) 2007-02-01
CA2737123A1 (en) 2007-02-01
CN103122371B (zh) 2016-12-28
AU2006274140B8 (en) 2011-02-03
EP2364988A1 (de) 2011-09-14
CN101233144A (zh) 2008-07-30
KR101483829B1 (ko) 2015-01-16
AU2006274140B2 (en) 2010-11-11
DK2364989T3 (da) 2014-06-10
DK2364988T3 (da) 2014-05-26
EP2364988B1 (de) 2014-02-26
CA2614792A1 (en) 2007-02-01
KR20120044372A (ko) 2012-05-07
KR20110028522A (ko) 2011-03-18
PT1907408E (pt) 2014-03-28
DK1907408T3 (da) 2014-06-10
KR101483899B1 (ko) 2015-01-16
JP2012224638A (ja) 2012-11-15
PL1907408T3 (pl) 2014-07-31
US20140206024A1 (en) 2014-07-24
KR101035524B1 (ko) 2011-05-23
US20160326567A1 (en) 2016-11-10
CA2614792C (en) 2011-07-12
PL2364989T3 (pl) 2014-08-29
US20080213809A1 (en) 2008-09-04
US8809013B2 (en) 2014-08-19
MX2008000946A (es) 2008-03-27
EP1907408B1 (de) 2014-03-05
WO2007012494B1 (de) 2007-03-29
CN101233144B (zh) 2013-02-06
US10167497B2 (en) 2019-01-01
WO2007012494A1 (de) 2007-02-01
KR20080028507A (ko) 2008-03-31

Similar Documents

Publication Publication Date Title
ES2461266T3 (es) Derivados estables de NAD/NADH
US9139572B2 (en) Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
ES2350507T3 (es) Método colorimétrico y reactivo que se utiliza para el mismo.
AU2012201023B2 (en) Stable NAD/NADH derivatives
HK1181078A (en) Stable nad/nadh derivatives
HK1123308B (en) Stable nad/nadh derivatives